Plant productivity enhancement by combining chemical agents with transgenic modifications

专利摘要:

公开号:AU2008240710A1
申请号:U2008240710
申请日:2008-04-23
公开日:2008-10-30
发明作者:Egon Haden；Timothy Hudelson；Bryan Mckersie；Dirk Voeste；Xi-Qing Wang
申请人:BASF SE；
IPC主号:A01N43-56

专利说明:
WO 2008/129060 1 PCT/EP2008/054924 Plant Produtivity Enhancement by Combining Chemical Agents with Transgenic Modifications The present invention relates to the enhancement of plant productivity by combining chemical agents with transgenic modifications. 5 Chemical amendments and transgenic modifications can both increase plant perform ance. Chemical agents can be applied e.g. as a seed coating or as a spray on a grow ing plant. When applied as a coating, chemical amendments may improve seed resis tance to biotic and abiotic stresses and stimulate and/or improve germination as well as early germination. Seedlings are thus better able to establish in the greenhouse or 10 the field. Spray applications on growing plants may affect growth by e.g. enhancing plant metabolism, inducing plant vigor, modifying plant canopy and stem architecture, or by improving fruit set. Many products that enhance plant performance or improve grain quality and quantity are on the market. For instance, fipronil is a broad-spectrum insecticide from the in 15 secticide chemistry class of phenyl pyrazoles. It is highly effective against all major insect pests in crop and non-crop markets. The most important applications are soil and seed treatment in crops and termite control in non-crops. Fipronil has been re ported to enhance overall root system and root hair development, increase tiller num ber and productivity, increase photosynthetic capacity (plant greenness), increase leaf 20 area and plant height, stimulate early flowering and grain maturation leading to signifi cant increases in yield (Fipronil-Worldwide technical Bulletin, BASF). Transgenic plants, such as Round-up ready crops, have exhibited enhanced produc tivity, primarily due to elimination of competition for water and nutrients with weeds. Round-up ready crops are not susceptible to the herbicide when applied at field rates 25 (24-32 oz/A). Most weeds are susceptible to the herbicide, allowing more of the avail able nutrients to be sequestered by the crop plants and, therefore, increase yield. Combinations of chemical, physical, biological, and transgenic approaches are used in integrated pest management (IPM). For example, a transgenic plant with increased resistance is the so called Bt corn (Bt = Bacillus thuringiensis), which has been modi 30 fied to increase levels of certain crystal proteins. Bt is effective at controlling Lepidop tera larvae, most notably the corn borer (http://www.extension.umn.edu/distribution/cropsystems/DC7055.html#ch2). The pro tein is selective, generally not harming insects of other orders, such as the Tricho gramma minutum wasp, which is also used to control corn borer 35 (http://ipmworld.umn.edu/chapters/chippen.htm). Crops carrying the Bt gene, there fore, have been considered compatible with biological control programs. A combination of a transgenic event having activity against corn rootworm and treat ment of the seed with certain pesticides provides unexpectedly synergistic advan- WO 2008/129060 2 PCT/EP2008/054924 tages to seeds having such treatment, showing unexpectedly superior efficacy in the protection against damage by corn rootworm is disclosed in US 6,593,273. According to the teaching of the W01999035913 treating transgenic useful plants which carry one or more genes expressing a pesticidal active ingredient, or which are 5 tolerant against herbicides or which are resistant against the attack of fungi, with a nitroimino-or nitroguanidino-compound for controlling pests, has a synergistic effect on the pests to be controlled. A method for increasing the vigor and the yield of an agronomic plant is known from US 20030060371, US 20040023081 or US 20030114308. The method includes treat 10 ment of a plant with herbicides or other pesticides, whereby the plant is a transgenic plant having a transgenic event that confers resistance to the herbicide or pesticide which is employed. The advantages of applying chemicals and/or chemical compositions comprising at least one active ingredient on the transgenic plants themselves to improve perform 15 ance, however, are unknown. There is no known product system, which combines agrochemical application with transgenic modifications to enhance plant productivity and grain quality. Object of the present invention is a new process for increasing plant health and/or controlling pests. 20 A further object is a method which integrates chemicals and transgenic material to improve plant performance. The object is achieved according to the invention by providing the present method. Summarized, the present invention relates to a method for increasing plant health and/or controlling pests in plants with at least one transgenic modification related to 25 yield increase as compared to a corresponding wild-type plant comprising treating the location where the plant with at least one transgenic modification is growing or is ex pected to grow and/or the transgenic plant with at least one transgenic modification or propagation material of the plant with at least one transgenic modification with an ef fective amount of a chemical composition comprising at least one active ingredient. 30 In one embodiment of the invention the method of the invention comprises a) treating the location where the plant with at least one transgenic modification is growing or is expected to grow and/or treating the plant with at least one transgenic modification or propagation material of the plant with at least one transgenic modification with an effective amount of a chemical composition compris 35 ing at least one active ingredient and WO 2008/129060 3 PCT/EP2008/054924 b) cultivating a transgenic plant with increased plant health and increased productivity as compared to a corresponding non-treated plant and growing said plant under conditions which permit the development of the plant. In one embodiment the invention is related to a method for increasing plant productiv 5 ity which comprises an increase in plant health and/or pest control. Surprisingly, it has now been found that treating that plant with at least one transgenic modification related to yield increase with an effective amount of a chemical composi tion comprising at least one active ingredient results in a synergistic effect. 10 Synergistic effect in the present context means that a) the use of a pesticide in combination with a transgenic modification exceeds the additive effect, to be expected on the pests to be controlled and thus extends the range of action of the active ingredient and of the active principle expressed by the transgenic plant and/or 15 b) results in an increase in plant health and increased yield. The term "synergistic", however, is to be understood in this connection as synergistic pesticidal activity and/or synergistic plant health effects. 20 Synergistic pesticidal activity means extension of the pesticidal spectrum of action to other pests, for example to resistant strains; and/orreduction in the application rate of the pesticides, and/or sufficient control of the pests with the aid of the pesticides even at an application rate of the pesticides alone and the transgenic plant alone are en tirely ineffective. 25 In one embodiment of the invention at least one transgenic modification of said plant does not confer resistance to the active ingredient which is employed. According to the present invention, "increasing the plant productivity" means that cer tain plant traits are increased or improved by a measurable or noticeable amount over 30 the same factor of the control, e.g. the plant produced under the same conditions, but without the application of the present invention, such as selected from the group con sisting of: delay of senescence, root growth, longer panicles, increased or improved plant stand, the plant weight, plant height, emergence, improved visual appearance, improved protein content, more developed root system, tillering increase, increase in 35 plant height, bigger leaf blade, less dead basal leaves, stronger tillers, greener leaf color, pigment content, photosynthetic activity, less fertilizers needed, less seeds needed, more productive tillers, earlier flowering, early grain maturity, less plant verse (lodging), increased shoot growth, early and improved germination, improved vitality of the plant, improved quality of the plant, improved quality of the fruits or vegetables (or WO 2008/129060 4 PCT/EP2008/054924 other products produced by the plant), improved self defence mechanism of the plant such as induced tolerance against fungi, bacteria, viruses and/or insects. Synergistic pest control means as stated above that the use of a pesticide in combina tion with a transgenic modification exceeds the additive effect, to be expected on the 5 pests to be controlled and thus extends the range of action of the pesticides and of the activity caused by the transgenic modification expressed by the transgenic plant and may be accompanied by effects such as improved self defence mechanism of the plant such as induced tolerance against fungi, bacteria, viruses and/or insects, but is not limited to improved self defence mechanism of the plant such as induced toler 10 ance against fungi, bacteria, viruses and/or insects. Pests mean not only insects, nematodes or arachnids but also phytophatogenic fungi. In one embodiment of the invention, increased plant productivity means plants with improvements in fresh weight (FW), dry weight, and/or plant volume. In one embodiment of the invention, increased plant productivity means e.g. plants 15 with increased internode length, representing better plant growth and/or green vs. yellow plant material, representing greater photosynthetic capacity than the control. In one embodiment of the invention, increased plant productivity means plants with increased greenness, internode length, leaf angle, implying that leaves were laying flatter and thus received more photosynthetic radiation, and/or increased plant area, 20 representing more leaf surface area for photosynthesis than the control. In one embodiment of the invention, increased plant productivity means plants with increased the yield and/or improved vigor. In one embodiment of the invention, increased plant productivity means plants with an increase in any of the aforementioned traits or any combination of two or more of the 25 aforementioned traits. In one embodiment of the invention, an increased yield means an increase in a trait selected from the group consisting of biomass production, grain yield, starch content, oil content or protein content. In one embodiment of the invention, an increased yield is obtained based upon an 30 increase in plant productivity, e.g. increased plant health and/or pest control. According to the present invention, "increased plant health" means that certain plant characteristics are increased or improved as compared to the wild-type plant such as selected from the group consisting of: delay of senescence, root growth, longer pani cles, plant weight, plant height, emergence, improved visual appearance, protein con 35 tent, oil content, starch content, more developed root system (improved root growth), WO 2008/129060 5 PCT/EP2008/054924 reduced ethylene (reduced production and/or inhibition of reception), tillering increase, increase in plant height, bigger leaf blade, less dead basal leaves, stronger tillers, greener leaf color, pigment content, photosynthetic activity, less input needed (such as fertilizers or water), less seeds needed, enhanced plant vigor, more productive 5 tillers, earlier flowering, early grain maturity, less plant verse (lodging), increased shoot growth, increased plant stand and early and better germination, improved vital ity of the plant, improved quality of the plant, improved quality of the fruits or vegeta bles (or other products produced by the plant), improved self-defense mechanism of the plant such as induced and improved tolerance against stress factors such as heat 10 stress, cold stress, drought stress, UV stress and/or salt stress. Advantageous proper ties, obtained especially from treated seeds, are selected from the group cocsisting of improved germination and field establishment, better vigor, more homogen field estab lishment. Advantageous properties, obtained especially from foliar and/or in-furrow application are e.g. improved plant growth and plant development, better growth, 15 more tillers, greener leaves, larger leaves, more biomass, better roots, improved abiotic stress tolerance of the plants, more grain yield, more biomass harvested, im proved quality of the harvest (content of fatty acids, metabolites, oil etc.), more mar ketable products (e.g. improved size), improved process (e.g. longer shelf-life, better extraction of compounds), improved quality of seeds (for being seeded in the follow 20 ing seasons for seed production); or any other advantages familiar to a person skilled in the art. In one embodiment of the invention, increased plant health means plants with an in crease in any of the aforementioned traits or any combination of two or more of the aforementioned traits. 25 In one embodiment the invention provides a method for controlling pests and/or in creasing plant health in plants with at least one transgenic modification related to yield increase comprising the application of a composition comprising at least one pesticide to the pests, or to the plant with at least one transgenic modification or propagation material of the plant with at least one transgenic modification. 30 According to the present invention, "pest control" or "controlling pests" means in one embodiment efficiently combating one or more pests selected from the group consisting of: insects from the order of the lepidopterans (Lepidoptera), e.g. Agrotis ypsilon, Agrotis segetum, Alabama argillacea, Anticarsia gemmatalis, Argyresthia conjugella, 35 Autographa gamma, Bupalus piniarius, Cacoecia murinana, Capua reticulana, Cheimatobia brumata, Choristoneura fumiferana, Choristoneura occidentalis, Cirphis unipuncta, Cydia pomonella, Dendrolimus pini, Diaphania nitidalis, Diatraea grandiosella, Earias insulana, Elasmopalpus lignosellus, Eupoecilia ambiguella, Evetria bouliana, Feltia subterranea, Galleria mellonella, Grapholitha funebrana, WO 2008/129060 6 PCT/EP2008/054924 Grapholitha molesta, Heliothis armigera, Heliothis virescens, Heliothis zea, Hellula undalis, Hibernia defoliaria, Hyphantria cunea, Hyponomeuta malinellus, Keiferia lycopersicella, Lambdina fiscellaria, Laphygma exigua, Leucoptera coffeella, Leucoptera scitella, Lithocolletis blancardella, Lobesia botrana, Loxostege sticticalis, 5 Lymantria dispar, Lymantria monacha, Lyonetia clerkella, Malacosoma neustria, Mamestra brassicae, Orgyia pseudotsugata, Ostrinia nubilalis, Panolis flammea, Pectinophora gossypiella, Peridroma saucia, Phalera bucephala, Phthorimaea operculella, Phyllocnistis citrella, Pieris brassicae, Plathypena scabra, Plutella xylostella, Pseudoplusia includens, Rhyacionia frustrana, Scrobipalpula absoluta, 10 Sitotroga cerealella, Sparganothis pilleriana, Spodoptera frugiperda, Spodoptera littoralis, Spodoptera litura, Thaumatopoea pityocampa, Tortrix viridana, Trichoplusia ni and Zeiraphera canadensis, beetles (Coleoptera), e.g. Agrilus sinuatus, Agriotes lineatus, Agriotes obscurus, Amphimallus solstitialis, Anisandrus dispar, Anthonomus grandis, Anthonomus 15 pomorum, Aphthona euphoridae, Athous haemorrhoidalis, Atomaria linearis, Blastophagus piniperda, Blitophaga undata, Bruchus rufimanus, Bruchus pisorum, Bruchus lentis, Byctiscus betulae, Cassida nebulosa, Cerotoma trifurcata, Cetonia aurata, Ceuthorrhynchus assimilis, Ceuthorrhynchus napi, Chaetocnema tibialis, Conoderus vespertinus, Crioceris asparagi, Ctenicera ssp., Diabrotica longicornis, 20 Diabrotica semipunctata, Diabrotica 12-punctata Diabrotica speciosa, Diabrotica virgifera, Epilachna varivestis, Epitrix hirtipennis, Eutinobothrus brasiliensis, Hylobius abietis, Hypera brunneipennis, Hypera postica, Ips typographus, Lema bilineata, Lema melanopus, Leptinotarsa decemlineata, Limonius californicus, Lissorhoptrus oryzophilus, Melanotus communis, Meligethes aeneus, Melolontha hippocastani, 25 Melolontha melolontha, Oulema oryzae, Otiorrhynchus sulcatus, Otiorrhynchus ovatus, Phaedon cochleariae, Phyllobius pyri, Phyllotreta chrysocephala, Phyllophaga sp., Phyllopertha horticola, Phyllotreta nemorum, Phyllotreta striolata, Popillia japonica, Sitona lineatus and Sitophilus granaria, flies, mosquitoes (Diptera), e.g. Aedes aegypti, Aedes albopictus, Aedes vexans, An 30 astrepha ludens, Anopheles maculipennis, Anopheles crucians, Anopheles albi manus, Anopheles gambiae, Anopheles freeborni, Anopheles leucosphyrus, Anophe les minimus, Anopheles quadrimaculatus, Calliphora vicina, Ceratitis capitata, Chry somya bezziana, Chrysomya hominivorax, Chrysomya macellaria, Chrysops discalis, Chrysops silacea, Chrysops atlanticus, Cochliomyia hominivorax, Contarinia sorghi 35 cola Cordylobia anthropophaga, Culicoides furens, Culex pipiens, Culex nigripalpus, Culex quinquefasciatus, Culex tarsalis, Culiseta inornata, Culiseta melanura, Dacus cucurbitae, Dacus oleae, Dasineura brassicae, Delia antique, Delia coarctata, Delia platura, Delia radicum, Dermatobia hominis, Fannia canicularis, Geomyza Tripunctata, Gasterophilus intestinalis, Glossina morsitans, Glossina palpalis, Glossina fuscipes, 40 Glossina tachinoides, Haematobia irritans, Haplodiplosis equestris, Hippelates spp., WO 2008/129060 7 PCT/EP2008/054924 Hylemyia platura, Hypoderma lineata, Leptoconops torrens, Liriomyza sativae, Lirio myza trifolii, Lucilia caprina, Lucilia cuprina, Lucilia sericata, Lycoria pectoralis, Man sonia titillanus, Mayetiola destructor, Musca autumnalis, Musca domestica, Muscina stabulans, Oestrus ovis, Opomyza forum, Oscinella frit, Pegomya hysocyami, Phorbia 5 antiqua, Phorbia brassicae, Phorbia coarctata, Phlebotomus argentipes, Psorophora columbiae, Psila rosae, Psorophora discolor, Prosimulium mixtum, Rhagoletis cerasi, Rhagoletis pomonella, Sarcophaga haemorrhoidalis, Sarcophaga spp., Simulium vit tatum, Stomoxys calcitrans, Tabanus bovinus, Tabanus atratus, Tabanus lineola, and Tabanus similis, Tipula oleracea, and Tipula paludosa 10 thrips (Thysanoptera), e.g. Dichromothrips corbetti, Dichromothrips ssp., Frankliniella fusca, Frankliniella occidentalis, Frankliniella tritici, Scirtothrips citri, Thrips oryzae, Thrips palmi and Thrips tabaci, termites (Isoptera), e.g. Calotermes flavicollis, Leucotermes flavipes, Heterotermes aureus, Reticulitermes flavipes, Reticulitermes virginicus, Reticulitermes lucifugus, 15 Reticulitermes santonensis, Reticulitermes grassei, Termes natalensis, and Coptotermes formosanus, cockroaches (Blattaria - Blattodea), e.g. Blattella germanica, Blattella asahinae, Pe riplaneta americana, Periplaneta japonica, Periplaneta brunnea, Periplaneta fuliggi nosa, Periplaneta australasiae, and Blatta orientalis, 20 bugs, aphids, leafhoppers, whiteflies, scale insects, cicadas (Hemiptera), e.g. Acros ternum hilare, Blissus leucopterus, Cyrtopeltis notatus, Dysdercus cingulatus, Dysder cus intermedius, Eurygaster integriceps, Euschistus impictiventris, Leptoglossus phyl lopus, Lygus lineolaris, Lygus pratensis, Nezara viridula, Piesma quadrata, Solubea insularis , Thyanta perditor, Acyrthosiphon onobrychis, Adelges laricis, Aphidula na 25 sturtii, Aphis fabae, Aphis forbesi, Aphis pomi, Aphis gossypii, Aphis grossulariae, Aphis schneideri, Aphis spiraecola, Aphis sambuci, Acyrthosiphon pisum, Aula corthum solani, Bemisia argentifolii, Brachycaudus cardui, Brachycaudus helichrysi, Brachycaudus persicae, Brachycaudus prunicola, Brevicoryne brassicae, Capitopho rus horni, Cerosipha gossypii, Chaetosiphon fragaefolii, Cryptomyzus ribis, Dreyfusia 30 nordmannianae, Dreyfusia piceae, Dysaphis radicola, Dysaulacorthum pseudosolani, Dysaphis plantaginea, Dysaphis pyri, Empoasca fabae, Hyalopterus pruni, Hypero myzus lactucae, Macrosiphum avenae, Macrosiphum euphorbiae, Macrosiphon rosae, Megoura viciae, Melanaphis pyrarius, Metopolophium dirhodum, Myzus persicae, Myzus ascalonicus, Myzus cerasi, Myzus varians, Nasonovia ribis-nigri, Nilaparvata 35 lugens, Pemphigus bursarius, Perkinsiella saccharicida, Phorodon humuli, Psylla mali, Psylla piri, Rhopalomyzus ascalonicus, Rhopalosiphum maidis, Rhopalosiphum padi, Rhopalosiphum insertum, Sappaphis mala, Sappaphis mali, Schizaphis graminum, Schizoneura lanuginosa, Sitobion avenae, Trialeurodes vaporariorum, Toxoptera au- WO 2008/129060 8 PCT/EP2008/054924 rantiland, Viteus vitifoli, Cimex lectularius, Cimex hemipterus, Reduvius seniis, Tria toma spp., and Arilus critatus. ants, bees, wasps, sawflies (Hymenoptera), e.g. Athalia rosae, Atta cephalotes, Atta capiguara, Atta cephalotes, Atta laevigata, Atta robusta, Atta sexdens, Atta texana, 5 Crematogaster spp., Hoplocampa minuta, Hoplocampa testudinea, Lasius niger, Monomorium pharaonis, Solenopsis geminata, Solenopsis invicta, Solenopsis richteri, Solenopsis xyloni, Pogonomyrmex barbatus, Pogonomyrmex californicus, Pheidole megacephala, Dasymutilla occidentalis, Bombus spp., Vespula squamosa, Paravespula vulgaris, Paravespula pennsylvanica, Paravespula germanica, 10 Dolichovespula maculata, Vespa crabro, Polistes rubiginosa, Camponotus floridanus, and Linepithema humile, crickets, grasshoppers, locusts (Orthoptera), e.g. Acheta domestica, Gryllotalpa gryllotalpa, Locusta migratoria, Melanoplus bivittatus, Melanoplus femurrubrum, Melanoplus mexicanus, Melanoplus sanguinipes, Melanoplus spretus, Nomadacris 15 septemfasciata, Schistocerca americana, Schistocerca gregaria, Dociostaurus maroccanus, Tachycines asynamorus, Oedaleus senegalensis, Zonozerus variegatus, Hieroglyphus daganensis, Kraussaria angulifera, Calliptamus italicus, Chortoicetes terminifera, and Locustana pardalina, Arachnoidea, such as arachnids (Acarina), e.g. of the families Argasidae, lxodidae 20 and Sarcoptidae, such as Amblyomma americanum, Amblyomma variegatum, Ambry omma maculatum, Argas persicus, Boophilus annulatus, Boophilus decoloratus, Boophilus microplus, Dermacentor silvarum, Dermacentor andersoni, Dermacentor variabilis, Hyalomma truncatum, Ixodes ricinus, Ixodes rubicundus, Ixodes scapularis, Ixodes holocyclus, Ixodes pacificus, Ornithodorus moubata, Ornithodorus hermsi, Or 25 nithodorus turicata, Ornithonyssus bacoti, Otobius megnini, Dermanyssus ga/lnae, Psoroptes ovis, Rhipicephalus sanguineus, Rhipicephalus appendiculatus, Rhipicephalus evertsi, Sarcoptes scabiei, and Eriophyidae spp. such as Aculus schlechtendali, Phyllocoptrata oleivora and Eriophyes sheldoni; Tarsonemidae spp. such as Phytonemus pallidus and Polyphagotarsonemus latus; Tenuipalpidae spp. 30 such as Brevipa/pus phoenicis; Tetranychidae spp. such as Tetranychus cinnabari nus, Tetranychus kanzawai, Tetranychus pacificus, Tetranychus telarius and Tetrany chus urticae, Panonychus ulmi, Panonychus citri, and Oligonychus pratensis; Ara neida, e.g. Latrodectus mactans, and Loxosceles reclusa, fleas (Siphonaptera), e.g. Ctenocephalides felis, Ctenocephalides canis, Xenopsylla 35 cheopis, Pulex irritans, Tunga penetrans, and Nosopsyllus fasciatus, silverfish, firebrat (Thysanura), e.g. Lepisma saccharina and Thermobia domestica, centipedes (Chilopoda), e.g. Scutigera coleoptrata, WO 2008/129060 9 PCT/EP2008/054924 millipedes (Diplopoda), e.g. Narceus spp., Earwigs (Dermaptera), e.g. forficula auricularia, lice (Phthiraptera), e.g. Pediculus humanus capitis, Pediculus humanus corporis, Pthirus pubis, Haematopinus eurysternus, Haematopinus suis, Linognathus vituli, 5 Bovicola bovis, Menopon gallinae, Menacanthus stramineus and Solenopotes capillatus. According to the present invention, "pest control" or "controlling pests" means in one embodiment efficiently combating the pest selected from the group consisting of: phytopathogenic fungi, including soil-borne fungi, which derive especially from the 10 classes of the Plasmodiophoromycetes, Peronosporomycetes (syn. Oomycetes), Chytridiomycetes, Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes (syn. Fungi imperfecti). According to the present invention, "pest control" or "controlling pests" means in one embodiment efficiently controlling the plant diseases selected from the group 15 consisting of: Albugo spp. (white rust) on ornamentals, vegetables (e. g. A. candida) and sunflowers (e. g. A. tragopogonis); Alternaria spp. (Alternaria leaf spot) on vegetables, rape (A. brassicola or brassicae), sugar beets (A. tenuis), fruits, rice, soybeans, potatoes (e. g. A. solani or A. alternata), tomatoes (e. g. A. solani or A. alternata) and wheat; 20 Aphanomyces spp. on sugar beets and vegetables; Ascochyta spp. on cereals and vegetables, e. g. A. tritici (anthracnose) on wheat and A. hordes on barley; Bipolaris and Drechslera spp. (teleomorph: Cochliobolus spp.) on corn (e. g. D. maydis), cere als (e. g. B. sorokiniana: spot blotch), rice (e. g. B. oryzae) and turfs; Blumeria (for merly Erysiphe) graminis (powdery mildew) on cereals (e. g. on wheat or barley); Bo 25 trytis cinerea (teleomorph: Botryotinia fuckeliana: grey mold) on fruits and berries (e. g. strawberries), vegetables (e. g. lettuce, carrots, celery and cabbages), rape, flowers, vines, forestry plants and wheat; Bremia lactucae (downy mildew) on lettuce; Ceratocystis (syn. Ophiostoma) spp. (rot or wilt) on broad-leaved trees and ever greens, e. g. C. u/mi (Dutch elm disease) on elms; Cercospora spp. (Cercospora leaf 30 spots) on corn, rice, sugar beets (e. g. C. beticola), sugar cane, vegetables, coffee, soybeans (e. g. C. sojina or C. kikuchii) and rice; Cladosporium spp. on tomatoes (e. g. C. fulvum: leaf mold) and cereals, e. g. C. herbarum (black ear) on wheat; Claviceps purpurea (ergot) on cereals; Cochliobolus (anamorph: He/minthosporium of Bipolaris) spp. (leaf spots) on corn (C. carbonum), cereals (e. g. C. sativus, anamorph: 35 B. sorokiniana) and rice (e. g. C. miyabeanus, anamorph: H. oryzae); Colletotrichum (teleomorph: Glomere/la) spp. (anthracnose) on cotton (e. g. C. gossypii), corn (e. g. C. graminicola), soft fruits, potatoes (e. g. C. coccodes: black dot), beans (e. g. C. lindemuthianum) and soybeans (e. g. C. truncatum or C. gloeosporioides); Corticium spp., e. g. C. sasakii (sheath blight) on rice; Corynespora cassiicola (leaf spots) on 40 soybeans and ornamentals; Cycloconium spp., e. g. C. oleaginum on olive trees; Cyl indrocarpon spp. (e. g. fruit tree canker or young vine decline, teleomorph: Nectria or Neonectria spp.) on fruit trees, vines (e. g. C. /iriodendri, teleomorph: Neonectria lirio dendri: Black Foot Disease) and ornamentals; Dematophora (teleomorph: Rosellinia) necatrix (root and stem rot) on soybeans; Diaporthe spp., e. g. D. phaseo/orum 45 (damping off) on soybeans; Drechslera (syn. Helminthosporium, teleomorph: Pyreno phora) spp. on corn, cereals, such as barley (e. g. D. teres, net blotch) and wheat (e. g. D. tritici-repentis: tan spot), rice and turf; Esca (dieback, apoplexy) on vines, caused by Formitiporia (syn. Phe//inus) punctata, F. mediterranea, Phaeomonie//a chlamydospora (earlier Phaeoacremonium chlamydosporum), Phaeoacremonium 50 aleophilum and/or Botryosphaeria obtusa; Elsinoe spp. on pome fruits (E. pyri), soft fruits (E. veneta: anthracnose) and vines (E. ampelina: anthracnose); Entyloma WO 2008/129060 10 PCT/EP2008/054924 oryzae (leaf smut) on rice; Epicoccum spp. (black mold) on wheat; Erysiphe spp. (powdery mildew) on sugar beets (E. betae), vegetables (e. g. E. pisi), such as cucur bits (e. g. E. cichoracearum), cabbages, rape (e. g. E. cruciferarum); Eutypa lata (Eutypa canker or dieback, anamorph: Cytosporina lata, syn. Libertella blepharis) on 5 fruit trees, vines and ornamental woods; Exserohilum (syn. Helminthosporium) spp. on corn (e. g. E. turcicum); Fusarium (teleomorph: Gibberella) spp. (wilt, root or stem rot) on various plants, such as F. graminearum or F. culmorum (root rot, scab or head blight) on cereals (e. g. wheat or barley), F. oxysporum on tomatoes, F. solani on soy beans and F. verticillioides on corn; Gaeumannomyces graminis (take-all) on cereals 10 (e. g. wheat or barley) and corn; Gibberella spp. on cereals (e. g. G. zeae) and rice (e. g. G. fujikuroi: Bakanae disease); Glomerella cingulata on vines, pome fruits and other plants and G. gossypil on cotton; Grainstaining complex on rice; Guignardia bidwellil (black rot) on vines; Gymnosporangium spp. on rosaceous plants and juni pers, e. g. G. sabinae (rust) on pears; Helminthosporium spp. (syn. Drechslera, 15 teleomorph: Cochliobolus) on corn, cereals and rice; Hemileia spp., e. g. H. vastatrix (coffee leaf rust) on coffee; Isariopsis clavispora (syn. Cladosporium vitis) on vines; Macrophomina phaseolina (syn. phaseoli) (root and stem rot) on soybeans and cot ton; Microdochium (syn. Fusarium) nivale (pink snow mold) on cereals (e. g. wheat or barley); Microsphaera diffusa (powdery mildew) on soybeans; Monilinia spp., e. g. M. 20 laxa, M. fructicola and M. fructigena (bloom and twig blight, brown rot) on stone fruits and other rosaceous plants; Mycosphaerella spp. on cereals, bananas, soft fruits and ground nuts, such as e. g. M. graminicola (anamorph: Septoria tritici, Septoria blotch) on wheat or M. fijiensis (black Sigatoka disease) on bananas; Peronospora spp. (downy mildew) on cabbage (e. g. P. brassicae), rape (e. g. P. parasitica), onions 25 (e. g. P. destructor), tobacco (P. tabacina) and soybeans (e. g. P. manshurica); Pha kopsora pachyrhizi and P. meibomiae (soybean rust) on soybeans; Phialophora spp. e. g. on vines (e. g. P. tracheiphila and P. tetraspora) and soybeans (e. g. P. gregata: stem rot); Phoma fingam (root and stem rot) on rape and cabbage and P. betae (root rot, leaf spot and damping-off) on sugar beets; Phomopsis spp. on sunflowers, vines 30 (e. g. P. viticola: can and leaf spot) and soybeans (e. g. stem rot: P. phaseoli, teleo morph: Diaporthe phaseolorum); Physoderma maydis (brown spots) on corn; Phy tophthora spp. (wilt, root, leaf, fruit and stem root) on various plants, such as paprika and cucurbits (e. g. P. capsici), soybeans (e. g. P. megasperma, syn. P. sojae), pota toes and tomatoes (e. g. P. infestans: late blight) and broad-leaved trees (e. g. P. 35 ramorum: sudden oak death); Plasmodiophora brassicae (club root) on cabbage, rape, radish and other plants; Plasmopara spp., e. g. P. viticola (grapevine downy mildew) on vines and P. halstedii on sunflowers; Podosphaera spp. (powdery mildew) on rosaceous plants, hop, pome and soft fruits, e. g. P. leucotricha on apples; Po lymyxa spp., e. g. on cereals, such as barley and wheat (P. graminis) and sugar beets 40 (P. betae) and thereby transmitted viral diseases; Pseudocercosporel/a her potrichoides (eyespot, teleomorph: Tapesia yallundae) on cereals, e. g. wheat or bar ley; Pseudoperonospora (downy mildew) on various plants, e. g. P. cubensis on cu curbits or P. humili on hop; Pseudopezicula tracheiphila (red fire disease or ,rotbren ner', anamorph: Phialophora) on vines; Puccinia spp. (rusts) on various plants, e. g. P. 45 triticina (brown or leaf rust), P. strilformis (stripe or yellow rust), P. hordes (dwarf rust), P. graminis (stem or black rust) or P. recondita (brown or leaf rust) on cereals, such as e. g. wheat, barley or rye, and asparagus (e. g. P. asparagi); Pyrenophora (anamorph: Drechslera) tritici-repentis (tan spot) on wheat or P. teres (net blotch) on barley; Pyricularia spp., e. g. P. oryzae (teleomorph: Magnaporthe grisea, rice blast) on rice 50 and P. grisea on turf and cereals; Pythium spp. (damping-off) on turf, rice, corn, wheat, cotton, rape, sunflowers, soybeans, sugar beets, vegetables and various other plants (e. g. P. ultimum or P. aphanidermatum); Ramularia spp., e. g. R. collo-cygni (Ramularia leaf spots, Physiological leaf spots) on barley and R. beticola on sugar beets; Rhizoctonia spp. on cotton, rice, potatoes, turf, corn, rape, potatoes, sugar 55 beets, vegetables and various other plants, e. g. R. solani (root and stem rot) on soy beans, R. solani (sheath blight) on rice or R. cerealis (Rhizoctonia spring blight) on wheat or barley; Rhizopus stolonifer (black mold, soft rot) on strawberries, carrots, cabbage, vines and tomatoes; Rhynchosporium secalis (scald) on barley, rye and triticale; Sarocladium oryzae and S. attenuatum (sheath rot) on rice; Sclerotinia spp. 60 (stem rot or white mold) on vegetables and field crops, such as rape, sunflowers (e. g. S. sclerotiorum) and soybeans (e. g. S. rolfsii or S. sc/erotiorum); Septoria spp. on various plants, e. g. S. glycines (brown spot) on soybeans, S. tritici (Septoria blotch) on wheat and S. (syn. Stagonospora) nodorum (Stagonospora blotch) on cereals; WO 2008/129060 11 PCT/EP2008/054924 Uncinula (syn. Erysiphe) necator (powdery mildew, anamorph: Oidium tuckeri) on vines; Setospaeria spp. (leaf blight) on corn (e. g. S. turcicum, syn. Helminthosporium turcicum) and turf; Sphacelotheca spp. (smut) on corn, (e. g. S. reiliana: head smut), sorghum und sugar cane; Sphaerotheca fuliginea (powdery mildew) on cucurbits; 5 Spongospora subterranea (powdery scab) on potatoes and thereby transmitted viral diseases; Stagonospora spp. on cereals, e. g. S. nodorum (Stagonospora blotch, teleomorph: Leptosphaeria [syn. Phaeosphaeria] nodorum) on wheat; Synchytrium endobioticum on potatoes (potato wart disease); Taphrina spp., e. g. T. deformans (leaf curl disease) on peaches and T. pruni (plum pocket) on plums; Thielaviopsis spp. 10 (black root rot) on tobacco, pome fruits, vegetables, soybeans and cotton, e. g. T. basicola (syn. Chalara elegans); Tilletia spp. (common bunt or stinking smut) on cere als, such as e. g. T. tritici (syn. T. caries, wheat bunt) and T. controversa (dwarf bunt) on wheat; Typhula incarnata (grey snow mold) on barley or wheat; Urocystis spp., e. g. U. occulta (stem smut) on rye; Uromyces spp. (rust) on vegetables, such as 15 beans (e. g. U. appendiculatus, syn. U. phaseoli) and sugar beets (e. g. U. betae); Ustilago spp. (loose smut) on cereals (e. g. U. nuda and U. avaenae), corn (e. g. U. maydis: corn smut) and sugar cane; Venturia spp. (scab) on apples (e. g. V. in aequalis) and pears; and Vertici//ium spp. (wilt) on various plants, such as fruits and ornamentals, vines, soft fruits, vegetables and field crops, e. g. V. dahliae on straw 20 berries, rape, potatoes and tomatoes. Further harmful fungi are selected from the group consisting of : Ascomycetes such as Ophiostoma spp., Ceratocystis spp., Aureobasidium pullulans, Sclerophoma spp., Chaetomium spp., Humicola spp., Petriella spp., Trichurus spp.; Basidiomycetes such as Coniophora spp., Coriolus spp., Gloeophyllum spp., Lentinus spp., Pleurotus spp., 25 Poria spp., Serpula spp. and Tyromyces spp., Deuteromycetes such as Aspergillus spp., Cladosporium spp., Penicillium spp., Trichorma spp., Alternaria spp., Paecilomy ces spp. and Zygomycetes such as Mucorspp., and in addition in the protection of stored products the following yeast fungi are worthy of note: Candida spp. and Sac charomyces cerevisae. 30 According to the present invention, "pesticide" means a composition comprising in free form or in agrochemically useful salt form as active ingredient and at least one auxiliary. In one embodiment the invention relates to compositions and to the use of these for controlling harmful plants. 35 According to the invention, the term "transgenic plant" means a plant with transgenic modification. A "plant with transgenic modification" means a plant whose genetic material has been altered using techniques in genetics generally known as recombinant DNA technol ogy. 40 The plant has at least one transgenic modification as compared with the wild-type plant, but it may have further transgenic modifications, so in total 2, 3, 4, 5, 6, 7, 8, 9 or even more. The term "wild-type" means a plant without the aforementioned modification. The terms "wild type", "control" or "reference" are exchangeable and can be a cell or a 45 part of a plant such as an organelle or tissue, or a plant, which was not modified or treated according to the herein described process according to the invention. Accord ingly, the plant used as wild type, control or reference corresponds to the plant as WO 2008/129060 12 PCT/EP2008/054924 much as possible and is in any other property but in the result of the process of the invention as identical to the subject matter of the invention as possible. Thus, the wild type, control or reference is treated identically or as identical as possible, saying that only conditions or properties might be different which do not influence the quality of 5 the tested property. Preferably, any comparison is carried out under analogous conditions. The term "analogous conditions" means that all conditions such as, for example, culture or growing conditions, assay conditions (such as buffer composition, temperature, sub strates, pathogen strain, concentrations and the like) are kept identical between the 10 experiments to be compared. The "reference", "control", or "wild type" is preferably a subject, e.g. an organelle, a cell, a tissue, in particular a plant, which was not modified or treated according to the herein described process and is in any other property as similar to the subject matter of the invention as possible, preferably 95%, more preferred are 98%, even more pre 15 ferred are 99,00%, in particular 99,10%, 99,30%, 99,50%, 99,70%, 99,90%, 99,99%, 99, 999% or more. In one embodiment the transgenic plant used according to the invention with at least one transgenic modification as compared to a corresponding wild-type plant is a plant selected from the group according to table A: 20 Table A Al a) Plant with one or more increased or generated -activities in a plant cell conferring an altered trait as compared with the wild type, b) Plant with one or more increased or generated activities in a plant cell conferring an altered trait as compared with the wild type, whereby said trait is not resistance against the active ingredient of the inventionZ. A2 a) Plant with one or more reduced, repressed or deleted activities in a plant cell conferring an altered trait as compared with the wild type, b) Plant with one or more reduced, repressed or deleted activities in a plant cell conferring an altered trait as compared with the wild type, whereby said trait is not resistance against the active ingredient of the invention, The term "activity" of a compound refers to the function of a compound in a biological system such as a cell, an organ or an organism. For example, the term "activity" of a WO 2008/129060 13 PCT/EP2008/054924 compound refers to the enzymatic function, regulatory function or its function as bind ing partner, transporter, regulator, or carrier, etc. of a compound. The term "plant" includes according to the invention a plant cell, organelle, a plant tissue or a part thereof, such as seed, root, tuber, fruit, leave, flower, plant propaga 5 tion material etc. The term "plant propagation material" as used herein includes all the generative parts of the plant such as seeds and vegetative plant material such as cuttings and tubers (e.g. potatoes), which can be used for the multiplication of the plant. This includes seeds, roots, fruits, tubers, bulbs, rhizomes, shoots, sprouts and other parts of the 10 plants. Seedlings and young plants, which are to be transplanted after germination or after emergence from soil, may also be included. These plant propagation materials may be treated prophylactically with a plant protection compound either at or before planting or transplanting. For the purposes of the invention, as a rule the plural is intended to encompass the 15 singular and vice versa. Unless otherwise specified, the terms "polynucleotides", "nucleic acid" and "nucleic acid molecule" are interchangeably in the present context. Unless otherwise specified, the terms "peptide", "polypeptide" and "protein" are interchangeably in the present context. The term "sequence" may relate to polynucleotides, nucleic acids, nucleic 20 acid molecules, peptides, polypeptides and proteins, depending on the context in which the term "sequence" is used. The terms "gene(s)", "polynucleotide", "nucleic acid sequence", "nucleotide sequence", or "nucleic acid molecule(s)" as used herein refer to a polymeric form of nucleotides of any length, either ribonucleotides or deoxy ribonucleotides. The terms refer only to the primary structure of the molecule. 25 Thus, the terms "gene(s)", "polynucleotide", "nucleic acid sequence", "nucleotide se quence", or "nucleic acid molecule(s)" as used herein include double- and single stranded DNA and/or RNA. They also include known types of modifications, e.g., me thylation, "caps", substitutions of one or more of the naturally occurring nucleotides with an analog. Preferably, the DNA or RNA sequence comprises a coding sequence 30 encoding the herein defined polypeptide. A "coding sequence" is a nucleotide sequence, which is transcribed into a RNA, e.g. a regulatory RNA, such as a miRNA, a ta-siRNA, cosuppression molecule, a RNAi, a ribozyme, etc. or into a mRNA which is translated into a polypeptide when placed un der the control of appropriate regulatory sequences. The boundaries of the coding 35 sequence are determined by a translation start codon at the 5-terminus and a transla tion stop codon at the 3'-terminus. A coding sequence can include, but is not limited to mRNA, cDNA, recombinant nucleotide sequences or genomic DNA, while introns may be present as well under certain circumstances.
WO 2008/129060 14 PCT/EP2008/054924 As used in the present context a nucleic acid molecule may also encompass the un translated sequence located at the 3' and at the 5' end of the coding gene region, for example at least 500, preferably 200, especially preferably 100, nucleotides of the sequence upstream of the 5' end of the coding region and at least 100, preferably 50, 5 especially preferably 20, nucleotides of the sequence downstream of the 3' end of the coding gene region. Using antisense, RNAi, snRNA, dsRNA, siRNA, miRNA, ta siRNA, cosuppression, ribozyme etc. technology, the coding regions as well as the 5' and/or 3'-regions can advantageously be used. However, it is often advantageous only to choose the coding region for cloning and 10 expression purposes. In one embodiment of the present invention, "transgenic modification" means an in creased or generated activity of a polypeptide which is the expression product of a coding region of a gene. "Polypeptide" refers to a polymer of amino acid (amino acid sequence) and does not 15 refer to a specific length of the molecule. Thus peptides and oligopeptides are in cluded within the definition of polypeptide. This term does also refer to or include post translational modifications of the polypeptide, for example, glycosylations, acetyla tions, phosphorylations and the like. Included within the definition are, for example, polypeptides containing one or more analogs of an amino acid (including, for exam 20 ple, unnatural amino acids, etc.), polypeptides with substituted linkages, as well as other modifications known in the art, both naturally occurring and non-naturally occur ring. Plants and plant cells according to table Al are disclosed in W02004018687, W02004092398, W02006032708 which are incorporated by reference. 25 Plants and plant cells according to table A2 are disclosed in W02004092349, W02006032707 which are incorporated by reference. The methods for generating such transgenic plants are widely known to those skilled in the art and described, for example, in the publications mentioned above, which are incorporated by reference. 30 In one embodiment transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant used in the process of the invention are plants as disclosed or generated from plant cells as disclosed in the publications as depicted in table B, column 2. The publications as depicted in table B, column 2 are herewith incorporated by refer 35 ence.
WO 2008/129060 15 PCT/EP2008/054924 In one embodiment transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant used in the process of the invention are plants with one or more increased or generated activities selected from the group consisting of the activities as depicted in table B, column 5. 5 In one embodiment transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant used in the process of the invention are plants with one or more increased or generated activities selected from the group consisting of the activities as depicted in SEQ ID NO: 1 to 270 or homologs thereof. In one embodiment, the method for producing a transgenic plant with at least one 10 transgenic modification as compared to a corresponding wild-type plant comprises one or more of the following steps a) stabilizing a protein conferring the increased expression of a protein encoded by the nucleic acid molecule as depicted in table B, column 1 or 3 or of the polypeptid as depicted in SEQ ID NO: 1 to 15 270; b) stabilizing a mRNA conferring the increased expression of a protein encoded by the nucleic acid molecule as depicted in table B, column 1 or 3 or its homologs or of a mRNA encoding the polypep tide as depicted in SEQ ID NO: 1 to 270; 20 c) increasing the specific activity of a protein conferring the in creased expression of a protein encoded by the nucleic acid mole cule as depicted in table B, column 1 or 3 or of the polypeptide o as depicted in SEQ ID NO: 1 to 270 or decreasing the inhibitory regula tion of the polypeptide as depicted in SEQ ID NO: 1 to 270; 25 d) generating or increasing the expression of an endogenous or artificial transcription factor mediating the expression of a protein conferring the increased expression of a protein encoded by the nu cleic acid molecule as depicted in table B, column 1 or 3 or of the polypeptide as depicted in SEQ ID NO: 1 to 270; 30 e) stimulating activity of a protein conferring the increased ex pression of a protein encoded by the nucleic acid molecule as de picted in table B, column 1 or 3 or a polypeptide as depicted in SEQ ID NO: I to 270; f) expressing a transgenic gene encoding a protein conferring 35 the increased expression of a polypeptide encoded by the nucleic acid molecule as depicted in table B, column 1 or 3 or a polypeptide as depicted in SEQ ID NO: 1 to 270; and/or WO 2008/129060 16 PCT/EP2008/054924 g) increasing the copy number of a gene conferring the in creased expression of a nucleic acid molecule encoding a polypep tide encoded by the nucleic acid molecule as depicted in table B, column 1 or 3 or the polypeptide as depicted in SEQ ID NO: 1 to 5 270, and/or ; h) increasing the expression of the endogenous gene encoding the polypeptide as depicted in SEQ ID NO: 1 to 270 or its homologs by adding positive expression or removing negative expression ele ments, e.g. homologous recombination can be used to either intro 10 duce positive regulatory elements like for plants the 35S enhancer into the promoter or to remove repressor elements form regulatory regions. Further gene conversion methods can be used to disrupt repressor elements or to enhance to acitivty of positive elements positive elements can be randomly introduced in plants by T-DNA or 15 transposon mutagenesis and lines can be identified in which the positive elements have be integrated near to a gene of the invention, the expression of which is thereby enhanced; and/or i) modulating growth conditions of the plant in such a manner, 20 that the expression or activity of the gene encoding the protein as depicted in SEQ ID NO: 1 to 270 or the protein itself is enhanced; j) selecting of organisms with expecially high activity of the pro teins of the invention from natural or from mutagenized resources and breeding them into the target organisms, eg the elite crops. 25 In one embodiment transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant used in the process of the invention are plants with one or more increased or generated activities selected from the group consisting of the polypeptides encoded by: 30 a) a nucleic acid molecule encoding the polypeptide as depicted in any of the SEQ ID NO: 1 to 270 or the homologs as depicted in SEQ ID NO: 271 to 273; b) a nucleic acid molecule as depicted in table B, column 1 or 3; c) a nucleic acid molecule, which, as a result of the degeneracy of the ge 35 netic code, can be derived from a polypeptide sequence as depicted in table B, column 1 or 3 and/or in SEQ ID NO: 1 to 270; WO 2008/129060 17 PCT/EP2008/054924 d) a nucleic acid molecule having at least 30 % identity with the nucleic acid molecule sequence of a polynucleotide comprising the nucleic acid mole cule according to a) to c); e) a nucleic acid molecule encoding a polypeptide having at least 30 % 5 identity with the amino acid sequence of the polypeptide encoded by the nucleic acid molecule of (a) to (c) and having the activity represented by a nucleic acid molecule of (a) to (c) ; f) nucleic acid molecule which hybridizes with a nucleic acid molecule of (a) to (c) under stringent hybridization conditions; 10 g) a nucleic acid molecule encoding a polypeptide which can be isolated with the aid of monoclonal or polyclonal antibodies made against a poly peptide encoded by one of the nucleic acid molecules of (a) to (e) and having the activity represented by the nucleic acid molecule comprising a polynucleotide of (a) to (c); 15 h) a nucleic acid molecule encoding a polypeptide comprising the consen sus sequence or one or more polypeptide motifs resulting from 2 ore more of the polypeptides as depicted in table B, column 1 or 3 and/or in SEQ ID NO: I to 270 and/or a consensus sequence as depicted in SEQ ID NO: 274 to 277; 20 h) a nucleic acid molecule encoding a polypeptide having the activity repre sented by a protein as depicted in table B, column 1 or 3 or 5 and/or SEQ ID NO: 1 to 270; i) nucleic acid molecule which comprises a polynucleotide, which is ob tained by amplifying a cDNA library or a genomic library using the primers 25 for the polynucleotides as depicted in table B, column 1 or 3 and/or SEQ ID NO: 1 to 270 which do not start at their 5'-end with the nucleotides ATA; and j) a nucleic acid molecule which is obtainable by screening a suitable nu 30 cleic acid library under stringent hybridization conditions with a probe comprising a complementary sequence of a nucleic acid molecule of (a) or (b) or with a fragment thereof, having at least 15 nt, preferably 20 nt, 30 nt, 50 nt, 100 nt, 200 nt or 500 nt of a nucleic acid molecule comple mentary to a nucleic acid molecule sequence characterized in (a) to (e) 35 and encoding a polypeptide having the activity represented by a protein comprising a polypeptide as depicted in table B, column 1 or 3 and/or SEQ ID NO: 1 to 270. In one embodiment transgenic plants with at least one transgenic modification as 40 compared to a corresponding wild-type plant used in the process of the invention are plants with one or more increased or generated activities selected from the group WO 2008/129060 18 PCT/EP2008/054924 consisting of the yield increasing proteins which confers an increase in yield, plant health and/or plant productivity as compared to a corresponding non-transformed wild-type plant. In one embodiment transgenic plants with at least one transgenic modification as 5 compared to a corresponding wild-type plant used in the process of the invention are plants with one or more increased or generated activities selected from the group consisting of the SRP (stress related proteins) which confers an increase in tolerance and/or resistance to environmental stress as compared to a corresponding non transformed wild-type plant. 10 In one embodiment transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant used in the process of the invention are plantswith one or more increased or generated activities selected from the group con sisting of the SRP (stress related proteins) which confers an increase in drought resis tance as compared to a corresponding non-transformed wild-type plant. 15 In one embodiment transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant used in the process of the invention are plants with one or more increased or generated activities selected from the group consisting of the yield increasing proteins as shown in table B and/or SEQ ID NO: 1 to 270. 20 In one embodiment transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant used in the process of the invention are plants with one or more increased or generated activities selected from the group consisting of the yield increasing proteins as shown in table B and/or SEQ ID NO: 1 to 270. 25 As used herein, the term "environmental stress" refers to any sub-optimal growing condition and includes, but is not limited to, sub-optimal conditions associated with salinity, drought, temperature, metal, chemical, pathogenic and oxidative stresses, or combinations thereof. In preferred embodiments, environmental stress is drought and low water content. Wherein drought stress means any environmental stress which 30 leads to a lack of water content in plants, lack of water uptake potential or reduction of water supply to the plants. In one embodiment of the invention the term "increased tolerance and/or resistance to environmental stress" relates to an increased resistance to water stress, which is pro duced as a secondary stress by chilling, freezing, heat, and salt, as a tertiary stress by 35 radiation, and, of course, as a primary stress during drought. In a preferred embodiment of the invention the term "increased tolerance and/or resis tance to environmental stress" relates to an increased drought resistance.
WO 2008/129060 19 PCT/EP2008/054924 In one embodiment transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant used in the process of the invention are plants with an increased or generated activities of a polypeptide with an activity as indicated in table B, column 5, line No 1, 5, 7,10, 11, 12, 16, 19, 20, 21, 23, 25, 27, 5 28,30,31,33,37,39,40,42,43,91,105,107,112,150,159,164, 165, 166,167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178,182, 186, 187, 188, 189, 190, 194, 196, 203, 204, 205, 206, 207, 209, 210, 211, 213, and/or SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 ,12 ,13 ,14 ,15 ,16 , 17,18, 19, 20, 21,22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 46, 53, 266 respectively plants with an increased or generated activi 10 ties of a polypeptide according to the sequence number as depicted in table B, col umn 3, line No 1, 5, 7,10, 11, 12, 16, 19, 20, 21, 23, 25, 27, 28, 30, 31, 33, 37, 39, 40, 42,43,91,105,107,112,150,159,164,165,166,167,168,169,170,171,172, 173, 174, 175, 176, 177, 178,182, 186, 187, 188, 189, 190, 194, 196, 203, 204, 205, 206, 207, 209, 210, 211, 213, and/or SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 ,12 15 ,13 ,14 ,15 ,16 , 17,18, 19, 20, 21,22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 46, 53, 266 respectively plants with an increased or generated expression of the gene as depicted in table B, column 1, line No 1, 5, 7,10, 11, 12, 16, 19, 20, 21, 23, 25, 27, 28, 30,31,33,37,39,40,42,43,91,105,107,112,150,159,164,165,166,167,168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178,182, 186, 187, 188, 189, 190, 194, 20 196, 203, 204, 205, 206, 207, 209, 210, 211, 213 and/or SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 ,12 ,13 ,14 ,15 ,16 , 17,18, 19, 20, 21,22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 46, 53, 266. In one embodiment transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant used in the process of the invention are 25 plants with an increased or generated activitiy of a polypeptide with an activity of a transcription factor, preferably of the subfamily of an "AP2 DOMAIN CONTAINING DEHYDRATION RESPONSIVE ELEMENT BINDING PROTEIN 1", preferably as de picted in SEQ ID NO: 1 and in table B, line 23, encoded by the gene EST163t. In one embodiment the present invention relates to a method for increasing the plant 30 health and plant productivity which comprises a) treating the locus where the plant with at least one transgenic modification is grow ing or is expected to grow, and/or the seeds and/or the plant with at least one trans genic modification from which the transgenic plant grows with an effective amount of a chemical composition comprising at least one active ingredient and 35 b) cultivating and growing said seed and/or plant under conditions which permit the development of the plant, and whereby the detection of increased plant health and/or increased plant productiv ity comprises at least one of the following steps: WO 2008/129060 20 PCT/EP2008/054924 i) growing transgenic seedlings and/or plants in a greenhouse under optimal, well wa ter conditions, preferably administrating supplemental nutrients and light, ii) collecting phenotyic data in an imaging procedure, iii) harvesting the plants for determining fresh weight, dry weight and/or plant volume 5 and standardize and correlate the data from the imaging procedure with the physio logical features, iv) measuring with the imaging system, preferably scanalyzer, the plant volume, inter node length, greenness, yellowness, leaf angle, area of the leaves, number of leaves and/or stem length of the plants 10 v) comparing the data of chemically treated plants with non treated plants In one embodiment transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant used in the process of the invention are plants with one or more increased or generated activities selected from the group consisting of homologs of the above mentioned polypeptides and/or homologs of the 15 nucleic acid molecules encoding said polypeptides. These homologs which are advantageously for the process according to the invention can be isolated based on their homology to the nucleic acid molecules disclosed herein using the sequences or part thereof as hybridization probe and following stan dard hybridization techniques under stringent hybridization conditions. In this context, 20 it is possible to use, for example, isolated nucleic acid molecules of at least 15, 20, 25, 30, 35, 40, 50, 60 or more nucleotides, preferably of at least 15, 20 or 25 nucleo tides in length which hybridize under stringent conditions with the above-described nucleic acid molecules, in particular with those which encompass a nucleotide se quence of the nucleic acid molecule used in the process of the invention or encoding 25 a protein used in the invention or of the nucleic acid molecule of the invention. Nucleic acid molecules with 30, 50, 100, 250 or more nucleotides may also be used. The term "homology" means that the respective nucleic acid molecules or encoded proteins are functionally and/or structurally equivalent. The nucleic acid molecules that are homologous to the nucleic acid molecules described above and that are deriva 30 tives of said nucleic acid molecules are, for example, variations of said nucleic acid molecules which represent modifications having the same biological function, in par ticular encoding proteins with the same or substantially the same biological function. They may be naturally occurring variations, such as sequences from other plant varie ties or species, or mutations. These mutations may occur naturally or may be obtained 35 by mutagenesis techniques. The allelic variations may be naturally occurring allelic variants as well as synthetically produced or genetically engineered variants. Structur ally equivalents can, for example, be identified by testing the binding of said polypep- WO 2008/129060 21 PCT/EP2008/054924 tide to antibodies or computer based predictions. Structurally equivalent to have the similar immunological characteristic, e.g. comprise similar epitopes. By "hybridizing" it is meant that such nucleic acid molecules hybridize under conven tional hybridization conditions, preferably under stringent conditions such as described 5 by, e.g., Sambrook (Molecular Cloning; A Laboratory Manual, 2nd Edition, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY (1989)) or in Current Protocols in Molecular Biology, John Wiley & Sons, N. Y. (1989), 6.3.1-6.3.6. Homolog polypeptides are polypeptides which comprises an amino acid sequence at least about 50% identical to an amino acid sequence shown in SEQ ID NO: 1 to 270. 10 Preferably, the protein encoded by the nucleic acid molecule is at least about 60% identical to the sequence shown in SEQ ID NO: 1 to 270, more preferably at least about 70% identical to one of the sequences shown in SEQ ID NO: 1 to 270, even more preferably at least about 80%, 90%, 95% homologous to the sequence shown in SEQ ID NO: 1 to 270, and most preferably at least about 96%, 97%, 98%, or 99% 15 identical to the sequence shown in SEQ ID NO: 1 to 270. To determine the percentage homology (= identity, herein used interchangeably) of two amino acid sequences or of two nucleic acid molecules, the sequences are writ ten one underneath the other for an optimal comparison (for example gaps may be inserted into the sequence of a protein or of a nucleic acid in order to generate an 20 optimal alignment with the other protein or the other nucleic acid). The amino acid residues or nucleic acid molecules at the corresponding amino acid positions or nucleotide positions are then compared. If a position in one sequence is occupied by the same amino acid residue or the same nucleic acid molecule as the corresponding position in the other sequence, the molecules are homologous at this 25 position (i.e. amino acid or nucleic acid "homology" as used in the present context corresponds to amino acid or nucleic acid "identity". The percentage homology be tween the two sequences is a function of the number of identical positions shared by the sequences (i.e. % homology = number of identical positions/total number of posi tions x 100). The terms "homology" and "identity" are thus to be considered as syno 30 nyms. For the determination of the percentage homology (= identity) of two or more amino acids or of two or more nucleotide sequences several computer software programs have been developed. The homology of two or more sequences can be calculated with for example the software fasta, which presently has been used in the version 35 fasta 3 (W. R. Pearson and D. J. Lipman (1988), Improved Tools for Biological Se quence Comparison.PNAS 85:2444- 2448; W. R. Pearson (1990) Rapid and Sensitive Sequence Comparison with FASTP and FASTA, Methods in Enzymology 183:63 - 98; W. R. Pearson and D. J. Lipman (1988) Improved Tools for Biological Sequence Comparison.PNAS 85:2444- 2448; W. R. Pearson (1990); Rapid and Sensitive Se- WO 2008/129060 22 PCT/EP2008/054924 quence Comparison with FASTP and FASTAMethods in Enzymology 183:63 - 98). Another useful program for the calculation of homologies of different sequences is the standard blast program, which is included in the Biomax pedant software (Biomax, Munich, Federal Republic of Germany). This leads unfortunately sometimes to subop 5 timal results since blast does not always include complete sequences of the subject and the querry. Nevertheless as this program is very efficient it can be used for the comparison of a huge number of sequences. The following settings are typically used for such a comparisons of sequences: -p Program Name [String]; -d Database [String]; default = nr; -i Query File [File In]; 10 default = stdin; -e Expectation value (E) [Real]; default = 10.0; -m alignment view options: 0 = pairwise; 1 = query-anchored showing identities; 2 = query-anchored no identities; 3 = flat query-anchored, show identities; 4 = flat query-anchored, no identi ties; 5 = query-anchored no identities and blunt ends; 6 = flat query-anchored, no identities and blunt ends; 7 = XML Blast output; 8 = tabular; 9 tabular with comment 15 lines [Integer]; default = 0; -o BLAST report Output File [File Out] Optional; default = stdout; -F Filter query sequence (DUST with blastn, SEG with others) [String]; default = T; -G Cost to open a gap (zero invokes default behavior) [Integer]; default = 0; -E Cost to extend a gap (zero invokes default behavior) [Integer]; default = 0; -X X dro poff value for gapped alignment (in bits) (zero invokes default behavior); blastn 30, 20 megablast 20, tblastx 0, all others 15 [Integer]; default = 0; -1 Show GI's in deflines [T/F]; default = F; -q Penalty for a nucleotide mismatch (blastn only) [Integer]; default = -3; -r Reward for a nucleotide match (blastn only) [Integer]; default = 1; -v Number of database sequences to show one-line descriptions for (V) [Integer]; default = 500; -b Number of database sequence to show alignments for (B) [Integer]; default = 250; 25 -f Threshold for extending hits, default if zero; blastp 11, blastn 0, blastx 12, tblastn 13; tblastx 13, megablast 0 [Integer]; default = 0; -g Perfom gapped alignment (not available with tblastx) [T/F]; default = T; -Q Query Genetic code to use [Integer]; de fault = 1; -D DB Genetic code (for tblast[nx] only) [Integer]; default = 1; -a Number of processors to use [Integer]; default = 1; -O SeqAlign file [File Out] Optional; -J Be 30 lieve the query defline [T/F]; default = F; -M Matrix [String]; default = BLOSUM62; -W Word size, default if zero (blastn 11, megablast 28, all others 3) [Integer]; default = 0; -z Effective length of the database (use zero for the real size) [Real]; default = 0; -K Number of best hits from a region to keep (off by default, if used a value of 100 is recommended) [Integer]; default = 0; -P 0 for multiple hit, 1 for single hit [Integer]; 35 default = 0; -Y Effective length of the search space (use zero for the real size) [Real]; default = 0; -S Query strands to search against database (for blast[nx], and tblastx); 3 is both, 1 is top, 2 is bottom [Integer]; default = 3; -T Produce HTML output [T/F]; de fault = F; -1 Restrict search of database to list of GI's [String] Optional; -U Use lower case filtering of FASTA sequence [T/F] Optional; default = F; -y X dropoff value for 40 ungapped extensions in bits (0.0 invokes default behavior); blastn 20, megablast 10, all others 7 [Real]; default = 0.0; -Z X dropoff value for final gapped alignment in bits (0.0 invokes default behavior); blastn/megablast 50, tblastx 0, all others 25 [Integer]; WO 2008/129060 23 PCT/EP2008/054924 default = 0; -R PSI-TBLASTN checkpoint file [File In] Optional; -n MegaBlast search [T/F]; default = F; -L Location on query sequence [String] Optional; -A Multiple Hits window size, default if zero (blastn/megablast 0, all others 40 [Integer]; default = 0; -w Frame shift penalty (OOF algorithm for blastx) [Integer]; default = 0; -t Length of the 5 largest intron allowed in tblastn for linking HSPs (0 disables linking) [Integer]; default = 0. Results of high quality are reached by using the algorithm of Needleman and Wunsch or Smith and Waterman. Therefore programs based on said algorithms are preferred. Advantageously the comparisons of sequences can be done with the program PileUp 10 (J. Mol. Evolution., 25, 351-360, 1987, Higgins et al., CABIOS, 5 1989: 151-153) or preferably with the programs Gap and BestFit, which are respectively based on the algorithms of Needleman and Wunsch [J. Mol. Biol. 48; 443-453 (1970)] and Smith and Waterman [Adv. Apple. Math. 2; 482-489 (1981)]. Both programs are part of the GCG software-package [Genetics Computer Group, 575 Science Drive, Madison, 15 Wisconsin, USA 53711 (1991); Altschul et al. (1997) Nucleic Acids Res. 25:3389 et seq.]. Therefore preferably the calculations to determine the perentages of sequence homology are done with the program Gap over the whole range of the sequences. The following standard adjustments for the comparison of nucleic acid sequences were used: gap weight: 50, length weight: 3, average match: 10.000, average mis 20 match: 0.000. Preferred transgenicplants are, for example, selected from the families Aceraceae, Anacardiaceae, Apiaceae, Asteraceae, Brassicaceae, Cactaceae, Cucurbitaceae, Euphorbiaceae, Fabaceae, Malvaceae, Nymphaeaceae, Papaveraceae, Rosaceae, 25 Salicaceae, Solanaceae, Arecaceae, Bromeliaceae, Cyperaceae, Iridaceae, Liliaceae, Orchidaceae, Gentianaceae, Labiaceae, Magnoliaceae, Ranunculaceae, Carifol aceae, Rubiaceae, Scrophulariaceae, Caryophyllaceae, Ericaceae, Polygonaceae, Violaceae, Juncaceae or Poaceae and preferably from a plant selected from the group of the families Apiaceae, Asteraceae, Brassicaceae, Cucurbitaceae, Fabaceae, 30 Papaveraceae, Rosaceae, Solanaceae, Liliaceae or Poaceae. Preferred are crop plants such as plants advantageously selected from the group of the genus peanut, oilseed rape, canola, cotton, sunflower, sugar cane, safflower, olive, sesame, hazel nut, almond, avocado, bay, pumpkin/squash, linseed, soybeans, pistachio, borage, maize, wheat, rye, oats, sorghum and millet, triticale, rice, barley, cassava, potato, 35 sugar beet, egg plant, alfalfa, and perennial grasses and forage plants, oil palm, vegetables (brassicas, root vegetables, tuber vegetables, pod vegetables, fruiting vegetables, onion vegetables, leafy vegetables and stem vegetables), buckwheat, Jerusalem artichoke, broad bean, vetches, lentil, dwarf bean, lupin, clover, potato, tomato, lettuce, onions and Lucerne.
WO 2008/129060 24 PCT/EP2008/054924 In one prefered embodiment, the transgenic plant is selected from the families Aceraceae, Anacardiaceae, Apiaceae, Asteraceae, Brassicaceae, Cactaceae, Cucur bitaceae, Euphorbiaceae, Fabaceae, Malvaceae, Nymphaeaceae, Papaveraceae, Rosaceae, Salicaceae, Solanaceae, Arecaceae, Bromeliaceae, Cyperaceae, Irida 5 ceae, Liliaceae, Orchidaceae, Gentianaceae, Labiaceae, Magnoliaceae, Ranuncu laceae, Carifolaceae, Rubiaceae, Scrophulariaceae, Caryophyllaceae, Ericaceae, Polygonaceae, Violaceae, Juncaceae or Poaceae and preferably from a plant se lected from the group of the families Apiaceae, Asteraceae, Brassicaceae, Cucurbita ceae, Fabaceae, Papaveraceae, Rosaceae, Solanaceae, Liliaceae or Poaceae. Pre 10 ferred are crop plants and in particular plants mentioned herein above as host plants such as the families and genera mentioned above for example preferred the species Anacardium occidentale, Calendula officinalis, Carthamus tinctorius, Cichorium inty bus, Cynara scolymus, Helianthus annus, Tagetes lucida, Tagetes erecta, Tagetes tenuifolia; Daucus carota; Corylus avellana, Corylus colurna, Borago officinalis; Bras 15 sica napus, Brassica rapa ssp., Sinapis arvensis Brassica juncea, Brassica juncea var. juncea, Brassica juncea var. crispifolia, Brassica juncea var. foliosa, Brassica ni gra, Brassica sinapioides, Melanosinapis communis, Brassica oleracea, Arabidopsis thaliana, Anana comosus, Ananas ananas, Bromelia comosa, Carica papaya, Canna bis sative, lpomoea batatus, lpomoea pandurata, Convolvulus batatas, Convolvulus 20 tiliaceus, lpomoea fastigiata, lpomoea tiliacea, lpomoea triloba, Convolvulus pandura tus, Beta vulgaris, Beta vulgaris var. altissima, Beta vulgaris var. vulgaris, Beta mari tima, Beta vulgaris var. perennis, Beta vulgaris var. conditiva, Beta vulgaris var. escu lenta, Cucurbita maxima, Cucurbita mixta, Cucurbita pepo, Cucurbita moschata, Olea europaea, Manihot utilissima, Janipha manihot,, Jatropha manihot., Manihot a/pil, 25 Manihot dulcis, Manihot manihot, Manihot melanobasis, Manihot esculenta, Ricinus communis, Pisum sativum, Pisum arvense, Pisum humile, Medicago sativa, Medicago falcata, Medicago varia, Glycine max Dolichos soja, Glycine graciis, Glycine hispida, Phaseolus max, Soja hispida, Soja max, Cocos nucifera, Pelargonium grossularioides, Oleum cocoas, Laurus nobilis, Persea americana, Arachis hypogaea, Linum usitatis 30 simum, Linum humile, Linum austriacum, Linum bienne, Linum angustifolium, Linum catharticum, Linum flavum, Linum grandiflorum, Adenolinum grandiflorum, Linum lewisi, Linum narbonense, Linum perenne, Linum perenne var. lewisii, Linum prat ense, Linum trigynum, Punica granatum, Gossypium hirsutum, Gossypium arboreum, Gossypium barbadense, Gossypium herbaceum, Gossypium thurberi, Musa nana, 35 Musa acuminata, Musa paradisiaca, Musa spp., Elaeis guineensis, Papaver orientale, Papaver rhoeas, Papaver dubium, Sesamum indicum, Piper aduncum, Piper amalago, Piper angustifolium, Piper auritum, Piper betel, Piper cubeba, Piper longum, Piper nigrum, Piper retrofractum, Artanthe adunca, Artanthe elongata, Peperomia elongata, Piper elongatum, Steffensia elongata, , Hordeum vulgare, Hordeum juba 40 tum, Hordeum murinum, Hordeum secalinum, Hordeum distichon Hordeum aegiceras, Hordeum hexastichon., Hordeum hexastichum, Hordeum irregulare, Hordeum sati- WO 2008/129060 25 PCT/EP2008/054924 vum, Hordeum secalinum, Avena sativa, Avena fatua, Avena byzantina, Avena fatua var. sativa, Avena hybrida, Sorghum bicolor, Sorghum halepense, Sorghum sacchara tum, Sorghum vulgare, Andropogon drummondii, Holcus bicolor, Holcus sorghum, Sorghum aethiopicum, Sorghum arundinaceum, Sorghum caffrorum, Sorghum cer 5 nuum, Sorghum dochna, Sorghum drummondii, Sorghum durra, Sorghum guineense, Sorghum lanceolatum, Sorghum nervosum, Sorghum saccharatum, Sorghum subgla brescens, Sorghum verticilliflorum, Sorghum vulgare, Holcus halepensis, Sorghum miliaceum millet, Panicum militaceum, Zea mays, Triticum aestivum, Triticum durum, Triticum turgidum, Triticum hybernum, Triticum macha, Triticum sativum or Triticum 10 vulgare, Cofea spp., Coffea arabica, Coffea canephora, Coffea liberica, Capsicum annuum, Capsicum annuum var. glabriusculum, Capsicum frutescens, Capsicum an nuum, Nicotiana tabacum, Solanum tuberosum, Solanum melongena, Lycopersicon esculentum, Lycopersicon lycopersicum., Lycopersicon pyriforme, Solanum integri folium, Solanum lycopersicum Theobroma cacao or Camellia sinensis. 15 Anacardiaceae such as the genera Pistacia, Mangifera, Anacardium e.g. the species Pistacia vera [istachios, Pistazie], Mangifer indica [Mango] or Anacardium occiden tale [Cashew]; Asteraceae such as the genera Calendula, Carthamus, Centaurea, Cichorium, Cynara, Helianthus, Lactuca, Locusta, Tagetes, Valeriana e.g. the species Calendula officinalis [Marigold], Carthamus tinctorius [safflower], Centaurea cyanus 20 [cornflower], Cichorium intybus [blue daisy], Cynara scolymus [Artichoke], Helianthus annus [sunflower], Lactuca sativa, Lactuca crispa, Lactuca esculenta, Lactuca scari ola L. ssp. sativa, Lactuca scariola L. var. integrata, Lactuca scariola L. var. integrifo lia, Lactuca sativa subsp. romana, Locusta communis, Valeriana locusta [lettuce], Tagetes lucida, Tagetes erecta or Tagetes tenuifolia [Marigold]; Apiaceae such as the 25 genera Daucus e.g. the species Daucus carota [carrot]; Betulaceae such as the gen era Corylus e.g. the species Corylus avellana or Corylus colurna [hazelnut]; Boragina ceae such as the genera Borago e.g. the species Borago officinalis [borage]; Brassi caceae such as the genera Brassica, Melanosinapis, Sinapis, Arabadopsis e.g. the species Brassica napus, Brassica rapa ssp. [canola, oilseed rape, turnip rape], 30 Sinapis arvensis Brassica juncea, Brassica juncea var. juncea, Brassica juncea var. crispifolia, Brassica juncea var. foliosa, Brassica nigra, Brassica sinapioides, Melanos inapis communis [mustard], Brassica oleracea [fodder beet] or Arabidopsis thaliana; Bromeliaceae such as the genera Anana, Bromelia e.g. the species Anana comosus, Ananas ananas or Bromelia comosa [ineapple]; Caricaceae such as the genera 35 Carica e.g. the species Carica papaya [apaya]; Cannabaceae such as the genera Cannabis e.g. the species Cannabis sative [hemp], Convolvulaceae such as the gen era lpomea, Convolvulus e.g. the species Ipomoea batatus, Ipomoea pandurata, Convolvulus batatas, Convolvulus tiliaceus, Ipomoea fastigiata, Ipomoea tiliacea, Ipomoea triloba or Convolvulus panduratus [sweet potato, Man of the Earth, wild po 40 tato], Chenopodiaceae such as the genera Beta, i.e. the species Beta vulgaris, Beta WO 2008/129060 26 PCT/EP2008/054924 vulgaris var. altissima, Beta vulgaris var. Vulgaris, Beta maritima, Beta vulgaris var. perennis, Beta vulgaris var. conditiva or Beta vulgaris var. esculenta [sugar beet]; Cu curbitaceae such as the genera Cucubita e.g. the species Cucurbita maxima, Cucur bita mixta, Cucurbita pepo or Cucurbita moschata [umpkin, squash]; Elaeagnaceae 5 such as the genera Elaeagnus e.g. the species Olea europaea [olive]; Ericaceae such as the genera Kalmia e.g. the species Kalmia latifolia, Kalmia angustifolia, Kalmia microphylla, Kalmia polifolia, Kalmia occidentalis, Cistus chamaerhodendros or Kalmia lucida [American laurel, broad-leafed laurel, calico bush, spoon wood, sheep laurel, alpine laurel, bog laurel, western bog-laurel, swamp-laurel]; Euphorbiaceae such as 10 the genera Manihot, Janipha, Jatropha, Ricinus e.g. the species Manihot utilissima, Janipha manihot,, Jatropha manihot., Manihot aipil, Manihot dulcis, Manihot manihot, Manihot melanobasis, Manihot esculenta [manihot, arrowroot, tapioca, cassava] or Ricinus communis (castor bean, Castor Oil Bush, Castor Oil Plant, Palma Christi, Wonder Tree]; Fabaceae such as the genera Pisum, Albizia, Cathormion, Feuillea, 15 Inga, Pithecolobium, Acacia, Mimosa, Medicajo, Glycine, Dolichos, Phaseolus, Soja e.g. the species Pisum sativum, Pisum arvense, Pisum humile [ea], Albizia berteri ana, Albizia julibrissin, Albizia lebbeck, Acacia berteriana, Acacia littoralis, Albizia berteriana, Albizzia berteriana, Cathormion berteriana, Feuillea berteriana, Inga fra grans, Pithecellobium berterianum, Pithecellobium fragrans, Pithecolobium berteri 20 anum, Pseudalbizzia berteriana, Acacia julibrissin, Acacia nemu, Albizia nemu, Feuilleea julibrissin, Mimosa julibrissin, Mimosa speciosa, Sericanrda julibrissin, Aca cia lebbeck, Acacia macrophylla, Albizia lebbek, Feuilleea lebbeck, Mimosa lebbeck, Mimosa speciosa [bastard logwood, silk tree, East Indian Walnut], Medicago sativa, Medicago falcata, Medicago varia [alfalfa] Glycine max Dolichos soja, Glycine gracilis, 25 Glycine hispida, Phaseolus max, Soja hispida or Soja max [soybean]; Geraniaceae such as the genera Pelargonium, Cocos, Oleum e.g. the species Cocos nucifera, Pe largonium grossularioides or Oleum cocois [coconut]; Gramineae such as the genera Saccharum e.g. the species Saccharum officinarum; Juglandaceae such as the gen era Juglans, Wallia e.g. the species Juglans regia, Juglans ailanthifolia, Juglans sie 30 boldiana, Juglans cinerea, Wallia cinerea, Juglans bixbyi, Juglans californica, Juglans hindsii, Juglans intermedia, Juglans jamaicensis, Juglans major, Juglans microcarpa, Juglans nigra or Wallia nigra [walnut, black walnut, common walnut, persian walnut, white walnut, butternut, black walnut]; Lauraceae such as the genera Persea, Laurus e.g. the species laurel Laurus nobilis [bay, laurel, bay laurel, sweet bay], Persea 35 americana Persea americana, Persea gratissima or Persea persea [avocado]; Legu minosae such as the genera Arachis e.g. the species Arachis hypogaea [eanut]; Linaceae such as the genera Linum, Adenolinum e.g. the species Linum usitatis simum, Linum humile, Linum austriacum, Linum bienne, Linum angustifolium, Linum catharticum, Linum flavum, Linum grandiflorum, Adenolinum grandiflorum, Linum 40 lewisii, Linum narbonense, Linum perenne, Linum perenne var. lewisi, Linum prat ense or Linum trigynum [flax, linseed]; Lythrarieae such as the genera Punica e.g. the WO 2008/129060 27 PCT/EP2008/054924 species Punica granatum [omegranate]; Malvaceae such as the genera Gossypium e.g. the species Gossypium hirsutum, Gossypium arboreum, Gossypium barbadense, Gossypium herbaceum or Gossypium thurberi [cotton]; Musaceae such as the genera Musa e.g. the species Musa nana, Musa acuminata, Musa paradisiaca, Musa spp. 5 [banana]; Onagraceae such as the genera Camissonia, Oenothera e.g. the species Oenothera biennis or Camissonia brevipes [rimrose, evening primrose]; Palmae such as the genera Elacis e.g. the species Elaeis guineensis [oil plam]; Papaveraceae such as the genera Papaver e.g. the species Papaver orientale, Papaver rhoeas, Papaver dubium [oppy, oriental poppy, corn poppy, field poppy, shirley poppies, field poppy, 10 long-headed poppy, long-pod poppy]; Pedaliaceae such as the genera Sesamum e.g. the species Sesamum indicum [sesame]; Piperaceae such as the genera Piper, Ar tanthe, Peperomia, Steffensia e.g. the species Piper aduncum, Piper amalago, Piper angustifolium, Piper auritum, Piper betel, Piper cubeba, Piper longum, Piper nigrum, Piper retrofractum, Artanthe adunca, Artanthe elongata, Peperomia elongata, Piper 15 elongatum, Steffensia elongata. [Cayenne pepper, wild pepper]; Poaceae such as the genera Hordeum, Secale, Avena, Sorghum, Andropogon, Holcus, Panicum, Oryza, Zea, Triticum e.g. the species Hordeum vulgare, Hordeum jubatum, Hordeum muri num, Hordeum secalinum, Hordeum distichon Hordeum aegiceras, Hordeum hexasti chon., Hordeum hexastichum, Hordeum irregulare, Hordeum sativum, Hordeum se 20 calinum [barley, pearl barley, foxtail barley, wall barley, meadow barley], Secale ce reale {rye], Avena sativa, Avena fatua, Avena byzantina, Avena fatua var. sativa, Avena hybrida [oat], Sorghum bicolor, Sorghum halepense, Sorghum saccharatum, Sorghum vulgare, Andropogon drummondii, Holcus bicolor, Holcus sorghum, Sor ghum aethiopicum, Sorghum arundinaceum, Sorghum caffrorum, Sorghum cernuum, 25 Sorghum dochna, Sorghum drummondii, Sorghum durra, Sorghum guineense, Sor ghum lanceolatum, Sorghum nervosum, Sorghum saccharatum, Sorghum subgla brescens, Sorghum verticilliflorum, Sorghum vulgare, Holcus halepensis, Sorghum miliaceum millet, Panicum militaceum [Sorghum, millet], Oryza sativa, Oryza latifolia [rice], Zea mays [corn, maize] Triticum aestivum, Triticum durum, Triticum turgidum, 30 Triticum hybernum, Triticum macha, Triticum sativum or Triticum vulgare [wheat, bread wheat, common wheat], Proteaceae such as the genera Macadamia e.g. the species Macadamia intergrifolia [macadamia]; Rubiaceae such as the genera Coffea e.g. the species Cofea spp., Coffea arabica, Coffea canephora or Coffea liberica [cof fee]; Scrophulariaceae such as the genera Verbascum e.g. the species Verbascum 35 blattaria, Verbascum chaixii, Verbascum densiflorum, Verbascum lagurus, Verbascum longifolium, Verbascum lychnitis, Verbascum nigrum, Verbascum olympicum, Verbas cum phlomoides, Verbascum phoenicum, Verbascum pulverulentum or Verbascum thapsus [mullein, white moth mullein, nettle-leaved mullein, dense-flowered mullein, silver mullein, long-leaved mullein, white mullein, dark mullein, greek mullein, orange 40 mullein, purple mullein, hoary mullein, great mullein]; Solanaceae such as the genera Capsicum, Nicotiana, Solanum, Lycopersicon e.g. the species Capsicum annuum, WO 2008/129060 28 PCT/EP2008/054924 Capsicum annuum var. glabriusculum, Capsicum frutescens [epper], Capsicum an nuum [aprika], Nicotiana tabacum, Nicotiana alata, Nicotiana attenuata, Nicotiana glauca, Nicotiana langsdorffii, Nicotiana obtusifolia, Nicotiana quadrivalvis, Nicotiana repanda, Nicotiana rustica, Nicotiana sylvestris [tobacco], Solanum tuberosum [o 5 tato], Solanum melongena [egg-plant] (Lycopersicon esculentum, Lycopersicon ly copersicum., Lycopersicon pyriforme, Solanum integrifolium or Solanum lycopersicum [tomato]; Sterculiaceae such as the genera Theobroma e.g. the species Theobroma cacao [cacao]; Theaceae such as the genera Camellia e.g. the species Camellia sinensis) [tea]. 10 In a further embodiment of the invention the plant with the transgenic modification is derived from a monocotyledonous plant. In a further embodiment of the invention the plant with the transgenic modification is derived from a dicotyledonous plant. In a further embodiment of the invention the plant with the transgenic modification is 15 derived from a gymnosperm plant, preferably selected from the group of spruce, pine and fir. In a further embodiment the process of the invention comprises treating the plant with an effective amount of a chemical composition comprising at least one active ingredi ent. 20 In a further embodiment of the invention the active ingredient (B) is an active com pound selected from the group consisting of B1) an active compound that inhibits the mitochondrial respiration (breath ing) chain at the level of the b/c 1 complex: famoxadone and strobilurins se 25 lected from the group consisting of pyraclostrobin, kresoxim-methyl, dimox ystrobin, picoxystrobin, ZJ 0712, trifloxystrobin, enestroburin, orysastrobin, metominostrobin, azoxystrobin, fluoxastrobin, metominostrobin, orysastrobin, pyribencarb, trifloxystrobin, 2-(2-(6-(3-chloro-2-methyl-phenoxy)-5-fluoro pyrimidin-4-yloxy)-phenyl)-2-methoxyimino-N-methyl-acetamide, 3-methoxy-2 30 (2-(N-(4-methoxy-phenyt)-cyclopropane-carboximidoylsulfanylmethyl) phenyl)-acrylic acid methyl ester, methyl (2-chloro-5-[1-(3-methylbenzyloxy imino)ethyl]benzyl)carbamate and 2-(2-(3-(2,6-dichlorophenyl)-1-methyl allylideneaminooxymethyl)-phenyl)-2-methoxyimino-N-methyl preferably famoxadone, pyraclostrobin, kresoxim-methyl, dimoxystrobin, 35 picoxystrobin, ZJ 0712, trifloxystrobin, orysastrobin, azoxystrobin, fluox astrobin WO 2008/129060 29 PCT/EP2008/054924 B2) carboxylic amides selected from benalaxyl, benodanil, boscalid, carboxin, mepronil, fenfuram, fenhexamid, futolanil, furametpyr, metalaxyl, ofurace, oxadixyl, oxycarboxin, penthiopyrad, thifluzamid, tiadinil, 4-difluoromethyl 2-methyl-thiazol-5-carboxylic acid-(4'-bromo-biphenyl-2-yl)-amide, 4 5 difluoromethyl-2-methyl-thiazol-5-carboxylic acid-(4'-trifluoromethyl biphenyl-2-yl)-amide, 4-difluoromethyl-2-methyl-thiazol-5-carboxylic acid (4'-chloro-3'-fluoro-biphenyl-2-yl)-amide, 3-difluoromethyl-1-methyl-pyrazol 4-carboxylic acid-(3',4'-dichloro-4-fluoro-biphenyl-2-yl)-amide, 3,4-dichloro isothiazol-5-carboxylic acid-(2-cyano-phenyl)-amide, dimethomorph, flu 10 morph, flumetover, fluopicolide (picobenzamid), zoxamide, carpropamide, diclocymet, mandipropamid, N-(2-(4-[3-(4-chloro-phenyl)-prop-2-inyloxy]-3 methoxy-phenyl)-ethyl)-2-methanesulfonylamino-3-methyl-butyramid and N-(2-(4-[3-(4-chloro-phenyl)-prop-2-inyloxy]-3-methoxy-phenyl)-ethyl)-2 ethanesulfonylamino-3-methyl-butyramide; 15 preferably benalaxyl, benodanil, boscalid, carboxin, mepronil, fenfuram, fenhexamid, futolanil, furametpyr, metalaxyl, ofurace, oxadixyl, oxy carboxin, penthiopyrad, thifluzamid, tiadinil, (picobenzamid), diclocymet B3) azoles selected from bitertanole, bromuconazole, cyproconazole, difeno conazole, diniconazole, enilconazole, epoxiconazole, fenbuconazole, flusi 20 lazole, fluquinconazole, flutriafol, hexaconazole, imibenconazole, ipcona zole, metconazole, myclobutanil, penconazole, propiconazole, prothio conazole, simeconazole, tebuconazole, tetraconazole, triadimenol, triadi mefon, triticonazole, cyazofamid, imazalil, pefurazoate, prochloraz, triflumizol, benomyl, carbendazim, fuberidazole, thiabendazole, eth 25 aboxam, etridiazole and hymexazole; paclobutrazol, uniconazole-P; preferably cyproconazole, epoxiconazole, fenbuconazole, fluquincon azole, flutriafol, hexaconazole, ipconazole, metconazole, propiconazole, prothioconazole, ebuconazole, tetraconazole, triadimenol, triadimefon, triticonazole, cyazofamid, imazalil, prochloraz, triflumizol, benomyl, car 30 bendazim, thiabendazole, ethaboxam, hymexazole B4) nitrogen-containing heterocyclic compounds selected from fluazinam, pyrifenox, 3-[5-(4-chloro-phenyl)-2,3-dimethyl-isoxazolidin-3-yl]-pyridine, bupirimat, cyprodinil, ferimzon, fenarimol, mepanipyrim, nuarimol, pyrimethanil, triforin, fludioxonil, fenpiclonil, aldimorph, dodemorph, fen 35 propimorph, tridemorph, iprodion, procymidon, vinclozolin, acibenzolar-S methyl, anilazin, captan, captafol, dazomet, diclomezine, fenoxanil, folpet, fenpropidin, famoxadone, fenamidone, octhilinon, probenazol, proquina zid, pyroquilon, quinoxyfen, tricyclazol, 2-butoxy-6-iodo-3-propyl-chromen 4-one, 3-(3-bromo-6-fluoro-2-methyl-indole-1 -sulfonyl)-[1,2,4]triazole-1 - WO 2008/129060 30 PCT/EP2008/054924 sulfonic acid dimethylamide, ancymidol, flurprimidol, inabenfide, tetcy clacis; preferably pyrimethanil, fludioxonil, fenpiclonil, aldimorph, dodemorph, fen propimorph, tridemorph, iprodion, procymidon, captan, captafol, dazomet, 5 diclomezine, fenoxanil, probenazol, proquinazid, pyroquilon, quinoxyfen, tricyclazol, B5) carbamates and dithiocarbamates selected from ferbam, mancozeb, meti ram, metam, propineb, thiram, zineb, ziram, diethofencarb, flubenthiavali carb, iprovalicarb, propamocarb, 3-(4-chloro-phenyl)-3-(2 10 isopropoxycarbonylamino-3-methyl-butyrylamino)-propionic acid methyles ter and N-(1 -(1 -(4-cyanophenyl)ethanesulfonyl)-but-2-yl) carbamic acid -(4 fluorophenyl)ester; preferably erbam, mancozeb, metiram, metam, propineb, thiram, zineb, ziram, diethofencarb, iprovalicarb, propamocarb, 15 B6) guanidines selected from dodin, iminoctadine and guazatin; preferably guazatin B7) antibiotics selected from kasugamycin, polyoxine, streptomycin, oxytetra cyclin and validamycin A; preferably streptomycin, oxytetracyclin and validamycin A 20 B8) fentin salts; preferably fentin salts; B9) sulfur-containing heterocyclic compounds selected from isoprothiolan and dithianon; preferably sulfur-containing heterocyclic compounds selected from iso prothiolan and dithianon; 25 B10) organophosphorous compounds selected from edifenphos, fosetyl, fo setyl-aluminium, iprobenfos, pyrazophos, tolclofos-methyl, phosphoric acid and the salts thereof; preferably edifenphos, fosetyl, iprobenfos, pyrazopho, phosphoric acid and the salts thereof; 30 B11) organo-chloro compounds selected from thiophanate methyl, chlorothalo nil, dichlofluanid, tolylfluanid, flusulfamid, phthalide, hexachlorbenzene, pencycuron, quintozen; preferably thiophanate methyl, chlorothalonil, dichlofluanid, flusulfamid, phthalide, quintozen; WO 2008/129060 31 PCT/EP2008/054924 B12) nitrophenyl derivatives selected from binapacryl, dinocap and dinobuton; preferably binapacryl, dinocap and dinobuton B13) inorganic active ingredients selected from Bordeaux composition, copper acetate, copper hydroxide, copper oxychloride, basic copper sulfate and 5 sulfur; preferably copper acetate, copper hydroxide, copper oxychloride, basic copper sulfate and sulfur; B14) spiroxamine; B15) cyflufenamide; 10 B16) cymoxanil; B17) metrafenone; B18) organo(thio)phosphates selected from acephate, azamethiphos, azinphos methyl, chlorpyrifos, chlorpyrifos-methyl, chlorfenvinphos, diazinon, di chlorvos, dicrotophos, dimethoate, disulfoton, ethion, fenitrothion, fen 15 thion, isoxathion, malathion, methamidophos, methidathion, methyl parathion, mevinphos, monocrotophos, oxydemeton-methyl, paraoxon, parathion, phenthoate, phosalone, phosmet, phosphamidon, phorate, phoxim, pirimiphos-methyl, profenofos, prothiofos, sulprophos, tetra chlorvinphos, terbufos, triazophos and trichlorfon; 20 preferably metrafenone, chlorpyrifos, chlorpyrifos-methyl, chlorfenvin phos, diazinon, dichlorvos, dimethoate, disulfoton, ethion, methidathion, methyl-parathion, paraoxon, parathion, phenthoate, phosalone, phosmet, phosphamidon, phorate, phoxim, profenofos, prothiofos, sulprophos, tet rachlorvinphos, terbufos, triazophos and trichlorfon; 25 B19) carbamates selected from alanycarb, aldicarb, bendiocarb, benfuracarb, carbaryl, carbofuran, carbosulfan, fenoxycarb, furathiocarb, methiocarb, methomyl, oxamyl, pirimicarb, propoxur, thiodicar and triazamate; preferably aldicarb, bendiocarb, benfuracarb, carbaryl, carbofuran, carbo sulfan, fenoxycarb, furathiocarb, methiocarb, methomyl, oxamyl, pirimi 30 carb, propoxur, thiodicar and triazamate; B20) pyrethroids selected from allethrin, bifenthrin, cyfluthrin, cyhalothrin, cy phenothrin, cypermethrin, alpha-cypermethrin, beta-cypermethrin, zeta cypermethrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fen valerate, imiprothrin, lambda-cyhalothrin, permethrin, prallethrin, pyrethrin I WO 2008/129060 32 PCT/EP2008/054924 and II, resmethrin, silafluofen, tau-fluvalinate, tefluthrin, tetramethrin, tralomethrin, transfluthrin and profluthrin, dimefluthrin; preferably bifenthrin, cyfluthrin, cyphenothrin, cypermethrin, alpha cypermethrin, beta-cypermethrin, zeta-cypermethrin, deltamethrin, eto 5 fenprox, fenpropathrin, fenvalerate, imiprothrin, lambda-cyhalothrin, per methrin, prallethrin, pyrethrin I and II, resmethrin, tefluthrin, tetramethrin, tralomethrin, transfluthrin and profluthrin, dimefluthrin; B21) growth regulators selected from a) chitin synthesis inhibitors that are se lected from the benzoylureas chlorfluazuron, diflubenzuron, flucycloxuron, 10 flufenoxuron, hexaflumuron, lufenuron, novaluron, teflubenzuron, triflu muron; buprofezin, diofenolan, hexythiazox, etoxazole and clofentazine; b) ecdysone antagonists that are selceted from halofenozide, methoxy fenozide, tebufenozide and azadirachtin; c) juvenoids that are selected from pyriproxyfen, methoprene and fenoxycarb and d) lipid biosynthesis 15 inhibitors that are selected from spirodiclofen, spiromesifen and spiro tetramat; preferably flufenoxuron, hexaflumuron, teflubenzuron, triflumuron; azadirachtin, methoprene and fenoxycarb, spirodiclofen, spiromesifen and spirotetramat; 20 B22) nicotinic receptor agonists/antagonists compounds selected from clothianidin, dinotefuran, imidacloprid, thiamethoxam, nitenpyram, acetami prid, thiacloprid, AKD1022, bensultap, cartap hydrochloride; preferably clothianidin, dinotefuran, imidacloprid, thiamethoxam, niten pyram, acetamiprid, thiacloprid, AKD1022B23)GABA antagonist com 25 poundsselected from acetoprole, endosulfan, ethiprole, fipronil, vaniliprole, pyrafluprole, pyriprole and the phenylpyrazole compound of formula 0 S CF-S NH 2 3 N 2 N H2N N
F
1 Cl Cl
CF
3 preferably acetoprole, endosulfan, ethiprole, fipronil, vaniliprole, pyraflu 30 prole, pyriprole and the phenylpyrazole WO 2008/129060 33 PCT/EP2008/054924 B24) METI I compounds selected from fenazaquin, pyridaben, tebufenpyrad, tolfenpyrad and flufenerim; preferably fenazaquin, pyridaben, tebufenpyrad, tolfenpyrad and flufene rim; 5 B25) METI || and Ill compounds selected from acequinocyl, fluacyprim and hy dramethylnon; preferably acequinocyl, fluacyprim and hydramethylnon; B26) chlorfenapyr;; B27) oxidative phosphorylation inhibitor compounds selected from cyhexatin, 10 diafenthiuron, fenbutatin oxide and propargite; preferably diafenthiuron, fenbutatin oxid B28) cyromazine; B29) piperonyl butoxide B30) indoxacarb 15 B31) a compound selected from benclothiaz, bifenazate, cartap, flonicamid, pyridalyl, pymetrozine, sulfur, thiocyclam, flubendiamide, cyenopyrafen, flupyrazofos, cyflumetofen, amidoflumet, pyrifluquinazon; preferably benclothiaz, bifenazate, cartap, flonicamid, pyridalyl, pymetro zine, sulfur, thiocyclam, flubendiamide, cyenopyrafen, flupyrazofos, cyflu 20 metofen, amidoflumet B.32) Anthranilamides: chloranthraniliprole, the compound of formula 2 CH 3 O Br NC N N _ H Cl (F 2 ) H3C-N H B33) Acibenzolar-S-methyl; 25 WO 2008/129060 34 PCT/EP2008/054924 B34) Plant bioregulators: trinexapac-ethyl, prohexadione-calcium, chlormequat chloride, mepiquat chloride, 16,17-dihydro gibberellin A 5 1-methylcyclopropene, 2,5-norbornadiene, 3-amino-1,2,4-triazole; preferably trinexapac-ethyl, prohexadione-calcium, chlormequat chloride, mepi 5 quat chloride, 1-methylcyclopropene, B35) neonicotinoid. In a further embodiment of the invention the active ingredient (B) is an active com pound that inhibits the mitochondrial respiration (breathing) chain at the level of the 10 b/c 1 complex. In a further embodiment of the invention the active ingredient (B) is a strobilurin se lected from pyraclostrobin, kresoxim-methyl, dimoxystrobin, 2-(ortho-((2,5 Dimethylphenyl-oxymethylene)phenyl)-3-methoxy-acrylic acid methyl ester, picox ystrobin, trifloxystrobin, enestroburin, orysastrobin, metominostrobin, azoxystrobin and 15 fluoxastrobin. In a further embodiment of the invention the active ingredient (B) is selected from (EZ)-3-(2-chloro-1,3-thiazol-5-ylmethyl)-5-methyl-1,3,5-oxadiazinan-4 ylidene(nitro)amine (thiamethoxam), 5-amino-1-(2,6-dichloro-a,a,a-trifluoro-p-tolyl)-4 trifluoromethylsulfinylpyrazole-3-carbonitrile (fipronil) and (EZ)-1-(6-chloro-3 20 pyridylmethyl)-N-nitroimidazolidin-2-ylideneamine (imidacloprid). In a further embodiment of the invention the active ingredient (B) is a plant bioregula tor. In one embodiment of the invention the plant bioregulator is selected from the group consisting of: 25 i) Plant bioregulators of the acylcyclohexanedione-type known to induce defence mechanisms against bacterial and fungal pathogens and against insect pests are: prohexadione and trinexapac, as free acids, esters (C1-C3) or salts (in particular: trinexapac-ethyl and prohexadione-calcium). ii) Plant bioregulators known to reduce shoot length and leaf surface and 30 to increase root growth, thereby diminishing the vulnerability of plants to abiotic stress (e.g. lodging as a result of wind and severe rainfall; dehydration as a re sult of water shortage and high evaporative demand; cell, tissue or whole-plant death as a result of too high or too low temperatures; root anoxia as a result of intense rainfall or flooding) are: (i) Quaternary ammonium compounds, in par 35 ticular chlormequat and mepiquat as chlorides, borates, sulfates, phosphates or WO 2008/129060 35 PCT/EP2008/054924 other agriculturally useful salts; (ii) compounds with a nitrogen-containing het erocycle, in particular paclobutrazol, uniconazole-P, metconazole, tebuconazole, ancym idol, flurprimidol, inabenfide, tetcyclacis; (iii) acylcyclohexanediones, in particular prohexadione and trinexapac, as free acids, esters (C1-C3) or salts (in 5 particular: trinexapac-ethyl and prohexadione-calcium) (iiii) derivatives of 16, 17 dihydro gibberellin A 5 . iii) Plant bioregulators diminishing the responsiveness of plants to abiotic and biotic stresses (thereby avoiding yield-reducing over-reactions), in particular ethylene modulators are: 10 ethylene biosynthesis inhibitors which inhibit the conversion of S-adenosyl-L methionine into 1-aminocyclopropane-1-carboxylic acid (ACC), such as deriva tives of vinylglycine, hydroxylamines, oxime ether derivatives; ethylene biosynthesis inhibitors which block the conversion of ACC into ethyl ene, selected from the group consisting of: Co** or Ni** ions in plant-available 15 form; phenolic radical scavengers such as n-propyl gallate; polyamines, such as putrescine, spermine or spermidine; structural analogs of ACC, such as a aminoisobutyric acid or L-aminocyclopropene-1-carboxylic acid; salicylic acid or acibenzolar-S-methyl; structural analogs of ascorbic acid which act as inhibitors of ACC oxidase, such as prohexadione-Ca or trinexapac-ethyl; and triazolyl 20 compounds such as paclobutrazole or uniconazole as inhibitors of cytochrome P-450-dependent monooxygenases whose main action is to block the metabo lism of gibberellins; inhibitors of the action of ethylene selected from the group consisting of: struc tural analogs of ethylene such as 1-methylcyclopropene or 2,5-norbornadiene 25 and 3-amino-1,2,4-triazole or Ag** ions in a weight ratio of I to II of from 20 : 1 to 0.05 : 1 Plant bioregulators can also be involved in endogenous defense mechanisms against biotic (e.g. jasmonic acid and methyl jasmonate) and abiotic stress (e.g. abscisic acid and also its synthetic analogs). 30 In a further embodiment of the invention the chemical composition comprises at least one active ingredient (B) and a component (A) which is a glucan or a glucan deriva tive. Component (A) according to the present invention is a glucan or a glucan derivative. "Glucans" are a class of homopolysaccharides which contain glucose units as mono 35 mer building blocks, wherein the glucose molecule may be linked by alpha- or beta glycosidic bonds and may be branched or straight chain. Specific examples for suit able glucans according to the present invention are beta-glucans, more specifically WO 2008/129060 36 PCT/EP2008/054924 beta -1,3-glucans such as, for example, laminarin and curdlan. Beta-1-3 glucans, for example, have various origins. They can be extracted from bacteria (for example Al caligenes faecalis which leads to curdlan), fungi, yeasts and from various plants, par ticularly from algae and cereals. 5 "Glucan derivatives" according to the present invention are glucans that are modified, for example by sulfatation or by hydrolysis. Specific examples for suitable glucan de rivatives are sulfated glucans, particularly sulfated beta -glucans, more specifically beta -1,3-glucans such as sulfated laminarin or sulfated curdlan. Furthermore, also laminaribiose, cellobiose, nigerose, laminaritriose, laminaritetrose and laminaripentose 10 are suitable glucan derivatives according to the present invention. Further derivates of glucans are described in US 6,979,665, Alban S. et al., Synthesis of laminarin sulfates with anticoagulant activity, Arzneim. Forsch. (1992) 42; 1005 1008; US 6,979,665; US 6,387,847; .US 6,303,587; US 6,303,587; Black et al., AppL. Chem. (1951), volume 1, pages 505 to 517; US 5,750,472 and references cited 15 therein), US 5,750,472, FR 92 08387; which are included by reference. According to one preferred embodiment of the present invention, component (A) is a beta -glucan, in particular a beta -1,3-glucan. Specifically, component (A) is laminarin or curdlan. According to another preferred embodiment, component (A) is selected from sulfated 20 glucan, Laminaribiose, Cellobiose, Nigerose, Laminaritriose, Laminaritetrose and Laminaripentose. The active compounds of groups B1) to B17) that can be used as the active ingredi ent (B), their preparation and their action against harmful fungi are generally known; they are commercially available. In most of the cases, they can also be found in The 25 Pesticide Manual, 13 1h Edition, British Crop Protection Council (2003) among other publications. - benalaxyl, methyl N-(phenylacetyl)-N-(2,6-xylyl)-DL-alaninate (DE 29 03 612), - boscalid, 2-chloro-N-(4'-chlorbiphenyl-2-yl)nicotinamide (EP-A 545 099); - carboxin, 5,6-dihydro-2-methyl-N-phenyl-1,4-oxathiin-3-carboxamide (US 3 249 499), 30 - mepronil, 3'-isopropoxy-o-toluanilide (US 3 937 840), - fenhexamid, N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide (Proc. Br. Crop Prot. Conf. - Pests Dis., 1998, Vol. 2, p. 327); - flutolanil, a,a,a-trifluoro-3'-isopropoxy-o-toluanilide (JP 1104514), - furametpyr, 5-chloro-N-(1,3-dihydro-1,1,3-trimethyl-4-isobenzofuranyl)-1,3-dimethyl 35 1H-pyrazole-4-carboxamide [CAS RN 123572-88-31, - metalaxyl, methyl N-(methoxyacetyl)-N-(2,6-xylyl)-DL-alaninate (GB 15 00 581); - ofurace, (RS)-a-(2-ch loro-N-2,6-xylylacetamido)-y-butyrolactone [CAS RN 58810-48 31; WO 2008/129060 37 PCT/EP2008/054924 - oxadixyl; N-(2,6-d imethylphenyl)-2-methoxy-N-(2-oxo-3-oxazol id inyl)acetam ide (GB 20 58 059), - oxycarboxin, 5,6-dihydro-2-methyl-1,4-oxathiin-3-carboxanilide 4,4-dioxide (US 3399214), 5 - penthiopyrad, N-[2-(1,3-dimethylbutyl)-3-thienyl]-1-methyl-3-(trifluoromethyl)-1H pyrazole-4-carboxamide (JP 10130268), - thifluzamide, N-[2,6-dibromo-4-(trifluoromethoxy)phenyl]-2-methyl-4-(trifluoromethyl) 5-thiazolecarboxamide; - tiadinil, 3'-chloro-4,4'-dimethyl-1,2,3-thiadiazole-5-carboxanilide [CAS RN 223580 10 51-6], - dimethomorph, 3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-morpholin-4-yl propenone (EP-A 120 321); - flumorph, 3-(4-fluorophenyl)-3-(3,4-dimethoxyphenyl)-1 -morpholin-4-ylpropenone (EP-A 860 438); 15 - flumetover, 2-(3,4-dimethoxyphenyl)-N-ethyl-a, a, a-trifluoro-N-methyl-p-toluamide [AGROW No. 243, 22 (1995)], - fluopicolide (picobenzamid), 2,6-dichloro-N-(3-chloro-5-trifluoromethylpyridin-2 ylmethyl)benzamide (WO 99/42447); - zoxamide, (RS)-3,5-dichloro-N-(3-chloro-1 -ethyl-1 -methyl-2-oxopropyl)-p-toluamide 20 [CAS RN 156052-68-5]; - carpropamid, 2,2-dichloro-N-[1 -(4-chlorophenyl)ethyl]-1 -ethyl-3-methylcyclopropane carboxamide [CAS RN 104030-54-8], - diclocymet, 2-cyano-N-[(1 R)-1 -(2,4-dichlorophenyl)ethyl]-3,3-dimethyl butanamide; - mandipropamid, (RS)-2-(4-chlorophenyl)-N-[3-methoxy-4-(prop-2-ynyloxy)phenethyl] 25 2-(prop-2-ynyloxy)acetamide [CAS RN 374726-62-2]; - bitertanole, prop-2-'-biphenyl]-4-yloxy)-2-ynyloxy)phenethyl]-2-H-1,2,4-triazole-1 ethanol (DE 23 24 020), - bromuconazole, 1 -[[4-bromo-2-(2,4-dichlorophenyl)tetrahydro-2-fu ranyl]methyl]-1H 1,2,4-triazole (Proc. 1990 Br. Crop. Prot. Conf. - Pests Dis. Vol. 1, p. 459); 30 - cyproconazole, 2-(4-chlorophenyl)-3-cyclopropyl-1-[1,2,4]triazol-1-ylbutan-2-ol (US 4 664 696); - difenoconazole, 1-{2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-[1,3]dioxolan-2 ylmethyl}-1 H-[1,2,4]triazole (GB-A 2 098 607); - diniconazole, (P E)-P-[(2,4-dichlorophenyl)methylene]-a-(1, 1 -dimethylethyl)-1H-1,2,4 35 triazole-1-ethanol (Noyaku Kagaku, 1983, Vol. 8, p. 575); - enilconazole (imazalil), 1-[2-(2,4-dichlorphenyl)-2-(2-propenyloxy)ethyl]-1 H-imidazole (Fruits, 1973, Vol. 28, p. 545); - epoxiconazole, (2RS,3SR)-1-[3-(2-chlorophenyl)-2,3-epoxy-2-(4 fluorophenyl)propyl]-1H-1,2,4-triazole (EP-A 196 038); 40 - fenbuconazole, a-[2-(4-chlorophenyl)ethyl]-a-phenyl-1 H-1,2,4-triazole-1 propanenitrile (Proc. 1988 Br. Crop Prot. Conf. - Pests Dis. Vol. 1, p. 33); WO 2008/129060 38 PCT/EP2008/054924 - flusilazole, 1 -{[bis-(4-fluorophenyl)methylsilanyl]methyl}-1 H-[1,2,4]triazole (Proc. Br. Crop Prot. Conf.-Pests Dis., 1, 413 (1984)); - fluquinconazole, 3-(2,4-dichlorophenyl)-6-fluoro-2-[1,2,4]-triazol-1 -yl-3H-quinazolin 4-one (Proc. Br. Crop Prot. Conf.-Pests Dis., 5-3, 411 (1992)); 5 - flutriafol, a-(2-fluorophenyl)-a-(4-fluorophenyl)-1 H-1,2,4-triazole-1 -ethanol (EP 15 756); - hexaconazole, 2-(2,4-dichlorophenyl)-1-[1,2,4]triazol-1-ylhexan-2-ol (CAS RN 79983-71-4); - imibenconazole, (4-chlorophenyl)methyl N-(2,4-dichlorophenyl)-1H-1,2,4-triazole-1 10 ethanimidothioate ((Proc. 1988 Br. Crop Prot. Conf. - Pests Dis. Vol. 2, p. 519), - ipconazole, 2-[(4-chlorophenyl)methyll-5-(1 -methylethyl)-1 -(1 H-1,2,4-triazol-1 -yl methyl)cyclopentanol (EP 267 778), - metconazole, 5-(4-chlorobenzyl)-2,2-dimethyl-1 -[1,2,4]triazol-1 -ylmethylcyclo pentanol (GB 857 383); 15 - myclobutanil, 2-(4-chlorophenyl)-2-[1,2,4]triazol-1-ylmethylpentanenitrile (CAS RN 88671-89-0); - penconazole, 1-[2-(2,4-dichlorophenyl)pentyl]-1 H-[1,2,4]triazole (Pesticide Manual, 12th Ed. (2000), p.712); - propiconazole, 1 -[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1 H-1,2,4 20 triazole (BE 835 579); - prothioconazole, 2-[2-(1-ch lorocyclopropyl)-3-(2-ch lorophenyl)-2-hyd roxypropyl]-2,4 dihydro-[1,2,4]triazole-3-thione (WO 96/16048); - simeconazole, a-(4-fluorophenyl)-a-[(trimethylsilyl)methyl]-1 H-1,2,4-triazole-I -ethanol [CAS RN 149508-90-7], 25 - tebuconazole, 1-(4-chlorophenyl)-4,4-dimethyl-3-[1,2,4]triazol-1 -ylmethylpentan-3-ol (EP-A 40 345); - tetraconazole, 1-[2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1 H 1,2,4-triazole (EP 234 242); - triadimenol, P-(4-chlorophenoxy)-a-(1, 1 -dimethylethyl)-1 H-1,2,4-triazole-1 -ethanol; 30 - triadimefon, 1 -(4-chlorophenoxy)-3,3-dimethyl-1 -(1 H-1,2,4-triazol-1 -yl)-2-butanone; - triticonazole, (5E)-5-[(4-chlorophenyl)methylene]-2,2-dimethyl-1 -(1 H-1,2,4-triazol-1 ylmethyl)cyclopentanol (FR 26 41 277); - cyazofamid, 4-chloro-2-cyano-NN-dimethyl-5-(4-methylphenyl)-1H-imidazole-1 sulfonamide (CAS RN 120116-88-3], 35 - pefurazoate, 4-pentenyl 2-[(2-furanylmethyl)(1H-imidazol-1 ylcarbonyl)amino]butanoate [CAS RN 101903-30-4], - prochloraz, N-{propyl-[2-(2,4,6-trichlorophenoxy)ethyl]}imidazole-1 -carboxamide (US 3 991 071); - triflumizole, (4-chloro-2-trifluoromethylphenyl)-(2-propoxy-1-[1,2,4]triazol-1-ylethyli 40 dene)amine (JP-A 79/119 462) - benomyl, N-butyl-2-acetylaminobenzoimidazol-1-carboxamide (US 3 631 176); - carbendazim, methyl (1 H-benzoimidazol-2-yl)-carbamate (US 3 657 443); WO 2008/129060 39 PCT/EP2008/054924 - fuberidazole, 2-(2-furanyl)-1H-benzimidazole (DE 12 09 799), - thiabendazole, 2-(1,3-thiazol-4-yl)benzimidazole (US 3 017 415), - ethaboxam, N-(cyano-2-thienylmethyl)-4-ethyl-2-(ethylamino)-5-thiazolcarboxamide (EP-A 639 574), 5 - etridiazole, - hymexazole, 5-methyl-1,2-oxazol-3-ol (JP 518249, JP 532202), - fluazinam, 3-chloro-N-[3-chloro-2,6-dinitro-4-(trifluoromethyl)phenyl]-5-(trifluor omethyl)-2-pyridinamine (The Pesticide Manual, publ. The British Crop Protection Council, 10th ed. (1995), p. 474); 10 - pyrifenox, 1-(2,4-dichlorophenyl)-2-(3-pyridinyl)ethanone 0-methyloxime (EP-A 49 854); - bupirimate, 5-butyl-2-ethylamino-6-methylpyrimidin-4-yldimethylsulfamate [CAS RN 41483-43-6]; - cyprodinil, (4-cyclopropyl-6-methylpyrimidin-2-yl)phenylamine (EP-A 310 550); 15 - ferimzone, (Z)-2'-methylacetophenone 4,6-dimethylpyrimidin-2-ylhydrazone [CAS RN 89269-64-7]; - fenarimol, (4-chlorophenyl) (2-chlorophenyl) pyrimidin-5-ylmethanol (GB 12 18 623); - mepanipyrim, (4-methyl-6-prop-1-ynylpyrimidin-2-yl)phenylamine (EP-A 224 339); - nuarimol, alpha-(2-chlorophenyl)-alpha-(4-fluorophenyl)-5-pyrimidinemethano (GB 20 12 18 623); - pyrimethanil, 4,6-dimethylpyrimidin-2-ylphenylamine (DD-A 151 404); - triforine, N,N'-{piperazine-1,4-diylbis[(trichloromethyl)methylene]}diformamide (DE 19 01 421); - fludioxonil, 4-(2,2-difluorobenzo[1,3]dioxol-4-yl)-1 H-pyrrole-3-carbonitrile (The Pesti 25 cide Manual, publ. The British Crop Protection Council, 10th ed. (1995), p. 482); - fenpiclonil, 4-(2,3-dichlorophenyl)-1 H-pyrrole-3-carbonitrile (Proc. 1988 Br. Crop Prot. Conf. - Pests Dis., Vol. 1, p. 65); - aldimorph, 4-alkyl-2,5(or 2,6)-dimethylmorpholine, comprising 65-75% of 2,6 dimethylmorpholine and 25-35% of 2,5-dimethylmorpholine, comprising more than 30 85% of 4-dodecyl-2,5(or 2,6)-dimethylmorpholine, where "alkyl" may also include octyl, decyl, tetradecyl or hexadecyl and where the cis/trans ratio is 1:1; - dodemorph, 4-cyclododecyl-2,6-dimethylmorpholine (DE 1198125); - fenpropimorph, (RS)-cis-4-[3-(4-tert-butylphenyl)-2-methylpropyl]-2,6-dimethyl morpholine (DE 27 52 096); 35 - tridemorph, 2,6-dimethyl-4-tridecylmorpholine (DE 11 64 152); - iprodione, N-isopropyl-3-(3,5-dichlorophenyl)-2,4-dioxoimidazolidine-1-carboxamide (GB 13 12 536); - procymidone, N-(3,5-dichlorophenyl)-1,2-dimethylcyclopropane-1,2-dicarboximide (US 3 903 090); 40 - vinclozolin, 3-(3,5-dichlorophenyl)-5-methyl-5-vinyloxazolidine-2,4-dione (DE-OS 22 07 576); - acibenzolar-S-methyl, methyl benzo[1,2,3]thiadiazole-7-carbothionate; WO 2008/129060 40 PCT/EP2008/054924 - anilazine, 4,6-dichloro-N-(2-chlorophenyl)-1,3,5-triazine-2-amine (US 2 720 480); - captan, 2-trichloromethylsulfanyl-3a,4,7,7a-tetrahydroisoindole-1 ,3-dione (US 2 553 770); - captafol, N-(1,1,2,2-tetrachloroethylthio)cyclohex-4-ene-1,2-dicarboximide (Phytopa 5 thology 52, S. 754 (1962)); - dazomet, 3,5-dimethyl-1,3,5-thiadiazinane-2-thione (Bull. Soc. Chim. Fr. Vol. 15, p. 891 (1897)); - diclomezine, 6-(3,5-dichlorophenyl)-p-tolyl)pyridazin-3(2H)-one (US 4,052,395); - fenoxanil, N-(1-cyano-1,2-dimethylpropyl)-2-(2,4-dichlorophenoxy) propanamide (EP 10 A 262 393); - folpet, 2-trichloromethylsulfanylisoindole-1,3-dione (US 2 553 770); - fenpropidin, (RS)-1-[3-(4-tert-butylphenyl)-2-methylpropyl]piperidine (DE 27 52 096); - famoxadone, (RS)-3-anilino-5-methyl-5-(4-phenoxyphenyl)-1,3-oxazolidine-2,4-dione [CAS RN 131807-57-3]; 15 - fenamidone, (S)-1 -anilino-4-methyl-2-methylthio-4-phenylimidazolin-5-one [CAS RN 161326-34-7]; - octhilinone, - probenazole, 3-allyloxy-1,2-benzothiazole 1,1-dioxide; - proquinazid, 6-iodo-2-propoxy-3-propylquinazolin-4(3H)-one (WO 97/48684); 20 - pyroquilon, 1,2,5,6-tetrahydropyrrolo[3,2,1-i]quinolin-4-on (GB 139 43 373) - quinoxyfen, 5,7-dichloro-4-(4-fluorophenoxy)quinoline (US 5 240 940); - tricyclazole, 5-methyl-1,2,4-triazolo[3,4-b]benzothiazole (GB 14 19 121); - ferbam, iron(3+) dimethyldithiocarbamate (US 1 972 961); - mancozeb, manganese ethylenebis(dithiocarbanate) zinc complex (US 3 379 610); 25 - maneb, manganese ethylenebis(dithiocarbamate) (US 2 504 404); - metiram, zinc ammoniate ethylenebis(dithiocarbamate) (US 3 248 400); - metam, methyldithiocarbaminic acid (US 2 791 605); - propineb, zinc propylenebis(dithiocarbamate) polymer (BE 611 960); - thiram, bis(dimethylthiocarbamoyl) disulfide (DE 642 532); 30 - zineb, zinc ethylenebis(dithiocarbamate) (US 2 457 674); - ziram, dimethyldithiocarbamate [CAS RN 137-30-4]; - diethofencarb, isopropyl 3,4-diethoxycarbanilate (EP-A 78 663); - flubenthiavalicarb (benthiavalicarb), isopropyl {(S)-1-[(1 R)-1-(6-fluorobenzothiazol-2 yl)ethylcarbamoyl]-2-methylpropyl}carbamate (JP-A 09/323 984); 35 - iprovalicarb, isopropyl [(1 S)-2-methyl-1-(1-p-tolylethylcarbamoyl)propyl]carbamate (EP-A 472 996); - propamocarb, propyl 3-(dimethylamino)propylcarbamate (DE 16 43 040); - dodine, (2,4-dichlorophenoxy)acetic acid (US 2 867 562); - iminoctadine, bis(8-guanidinooctyl)amine (GB 11 14 155); 40 - guazatine, mixture of products from the amidation of iminodi(octamethylene)diamine, mainly iminoctadine [CAS RN 108173-90-6]; - kasugamycin, 1 L-1,3,4/2,5,6-1 -deoxy-2,3,4,5,6-pentahydroxycyclohexyl 2-amino- WO 2008/129060 41 PCT/EP2008/054924 2,3,4,6-tetradeoxy-4-(alpha-iminoglycino)-alpha-D-arabino-hexopyranoside [CAS RN 6980-18-3]; - polyoxine, 5-(2-amino-5-O-carbamoyl-2-deoxy-L-xylonamido)-1-(5-carboxy-1,2,3,4 tetrahydro-2,4-dioxopyrimidin-1-yl)-1,5-dideoxy-beta-D-allofuranuronic acid and the 5 salts thereof [CAS RN 22976-86-9]; - streptomycin, 0-2-deoxy-2-methylamino-alpha-L-glucopyranosyl-(1-92)-O-5-deoxy 3-C-formyl-alpha-L-lyxofuranosyl-(1--4)N,N 3 -diamidino-D-streptamine (J. Am. Chem. Soc. 69, S.1234 (1947)); - validamycin A,- fentin acetate, triphenyltin acetate (US 3 499 086); 10 - isoprothiolan, diisopropyl 1,3-dithiolan-2-ylidenemalonat (Proc. Insectic. Fungic. Conf. 8. Bd. 2, S. 715 (1975)); - dithianon, 5,1 O-Dioxo-5,1 0-dihydronaphtho[2,3-b][1,4]dithiin-2,3-dicarbonitril (GB 857 383); - edifenphos, 0-ethyl S,S-diphenyl phosphorodithioate (DE-A 14 93 736); 15 - fosetyl, fosetyl-aluminum, (aluminum) ethylphosphonate (FR 22 54 276); - iprobenfos, S-benzyl O,O-diisopropyl phosphorothioate (Jpn. Pesticide Inf., No. 2, S. 11 (1970)); - pyrazophos, ethyl 2-diethoxyphosphinothioyloxy-5-methylpyrazolo[1,5-a]pyrimidine 6-carboxylate (DE 15 45 790); 20 - tolclofos-methyl, O-2,6-dichloro-p-tolyl 0,0-dimethyl phosphorothioate (GB 14 67 561); - thiophanate-methyl, 1,2-phenylenebis(iminocarbonothioyl)bis(dimethylcarbamate) (DE-OS 19 30 540); - chlorothalonil, 2,4,5,6-tetrachloroisophthalonitrile (US 3 290 353); 25 - dichlofluanid, N-dichlorofluoromethylthio-N',N'-dimethyl-N-phenylsulfamide (DE 11 93 498); - tolylfluanid, N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide (DE 11 93 498); - flusulfamide, 2',4-dichloro-a,a,a-trifluoro-4'-nitro-m-toluenesulfanilide (EP-A 199 30 433); - phthalide (DE 16 43 347); - hexachlorobenzene (C. R. Seances Acad. Agric. Fr., Vol. 31, p. 24 (1945)); - pencycuron, 1-(4-chlorobenzyl)-1-cyclopentyl-3-phenylurea (DE 27 32 257); - quintozene, pentachloronitrobenzene (DE 682 048); 35 - binapacryl, (RS)-2-sec-Butyl-4,6-dinitrophenyl 3-methylcrotonat [CAS RN 485-31-4]; - dinocap, mixture of 2,6-dinitro-4-octylphenylcrotonate and 2,4-dinitro-6-octyl phenylcrotonate, wherein "octyl" is a mixture of 1-methylheptyl, 1-ethylhexyl and 1 propylpentyl (US 2,526,660); - dinobuton, (RS)-2-sec-Butyl-4,6-dinitropheny isopropyl carbonat [CAS RN 973-21 40 7]; - Bordeaux composition, mixture of CuSO 4 x 3Cu(OH) 2 x 3CaSO 4 [CAS RN 8011-63 0] WO 2008/129060 42 PCT/EP2008/054924 - copper acetate, Cu(OCOCH 3
)
2 [CAS RN 8011-63-0]; - copper oxychloride, Cu 2
CI(OH)
3 [CAS RN 1332-40-7]; - basic copper sulfate, CuSO4 [CAS RN 1344-73-6]; - spiroxamine, (8-tert-butyl-1,4-dioxaspiro[4.5]dec-2-yl)diethylamine (EP-A 281 842). 5 - cyflufenamid, (Z)-N-[a-(cyclopropylmethoxyimino)-2,3-difluoro-6-(trifluoromethyl)ben zyl]-2-phenylacetamide (WO 96/19442); - cymoxanil, 1-(2-cyano-2-methoxyiminoacetyl)-3-ethylurea (US 3 957 847); - metrafenone, 3'-bromo-2,3,4,6'-tetramethoxy-2',6-dimethylbenzophenone (US 5 945 567); 10 The compounds are named according to IUPAC, their preparation and their fungicidal actions are likewise known: N-(4'-bromobiphenyl-2-yl)-4-difluoromethyl-2-methylthiazole-5-carboxamide, N-(4' trifluoromethylbiphenyl-2-yl)-4-difluoromethyl-2-methylthiazole-5-carboxamide, N-(4' chloro-3'-fluorobiphenyl-2-yl)-4-difluoromethyl-2-methylthiazole-5-carboxamide, N 15 (3',4'-dichloro-4-fluorobiphenyl-2-yl)-3-difluoromethyl-1 -methylpyrazole-4-carboxamide (WO 03/066609), 3,4-dichloro-isothiazol-5-carboxylic acid (2-cyanophenyl) amide (WO 99/24413); N-(2-(4-[3-(4-Chlor-phenyl)-prop-2-ynyloxy]-3-methoxy-phenyl)-ethyl)-2-methan sulfonylamino-3-methyl-butyramid, N-(2-(4-{3-(4-Chlor-phenyl)-prop-2-ynyloxy)-3 20 methoxy-phenyl)-ethyl)-2-ethanesulfonylamino-3-methyl-butyramid (WO 04/49804); 3-[5-(4-chlorophenyl)-2,3-dimethylisoxazolidin-3-yl]pyridine (EP-A 10 35 122); 2-butoxy-6-iodo-3-propylchromen-4-one (WO 03/14103), methyl 3-(4-chlorophenyl)-3-(2-isopropoxycarbonylamino-3-methylbutyrylamino) propanoate (EP-A 1028125) 25 Furthermore, the commercially available compounds of groups B1 8) to B32) of the active ingredient (B) may be found in The Pesticide Manual, 13 h Edition, British Crop Protection Council (2003) among other publications. Thiamides of formula F (gamma)' and their preparation have been described in WO199828279. 30 Lepimection is known from Agro Project, PJB Publications Ltd, November 2004. Ben clothiaz and its preparation have been described in EP-Al 454621. Methidathion and Paraoxon and their preparation have been described in Farm Chemicals Handbook, Volume 88, Meister Publishing Company, 2001. Acetoprole and its preparation have been described in W0199828277. Flupyrazofos has been described in Pesticide Sci 35 ence 54, 1988, p. 237-243 and in US 4822779. Pyrafluprole and its preparation have WO 2008/129060 43 PCT/EP2008/054924 been described in JP 2002193709 and in W0200100614. Pyriprole and its prepara tion have been described in W0199845274 and in US 6335357. Amidoflumet and its preparation have been described in US 6221890 and in JP 21010907. Flufenerim and its preparation have been described in W02003007717 and in W02003007718. Cy 5 flumetofen and its preparation have been described in W02004080180. Anthranila mides of formula F (gamma) 5 and their preparation have been described in W0200170671; W0200248137; W0200324222, W0200315518, W0200467528; W0200433468; and W02005118552. According to one embodiment of the invention, the active ingredient (B) is an active 10 compound that inhibits the mitochondrial breathing chain at the level of the b/c 1 com plex. Active compounds that inhibit the mitochondrial breathing chain at the level of the b/c 1 complex are known as fungicides from the literature [see for example Dechema Monographien Bd. 129, 27-38, VCH Verlagsgemeinschaft Weinheim 1993; Natural 15 Product Reports 1993, 565-574; Biochem. Soc. Trans. 22, 63S (1993)]. A particularly important class of active compounds that inhibit the mitochondrial breathing chain at the level of the b/c 1 complex are strobilurins. Strobilurins are gen erally known as fungicides since a long time and have, in some cases, also been de scribed as insecticides (EP-A 178 826; EP-A 253 213; WO 93/15046; WO 95/18789; 20 WO 95/21153; WO 95/21154; WO 95/24396; WO 96/01256; WO 97/15552; WO 97/27189). A further example of an active compound hat inhibits the mitochondrial breathing chain at the level of the b/c 1 complex is famoxadone (5-methyl-5-(4 phenoxyphenyl)-3-(phenylamino)-2,4-oxazolidinedione). In a further preferred embodiment of the present invention, strobilurins are used as 25 the active ingredient (B). According to the present invention, strobilurins which have proven particularly suitable are selected from 1) compounds of formula I Xm Q in which 30 X is halogen, C-C 4 -alkyl or trifluoromethyl; m is 0 or 1; WO 2008/129060 44 PCT/EP2008/054924 Q is C(=CH-CH 3
)-COOCH
3 , C(=CH-OCH 3
)-COOCH
3 ,
C(=N-OCH
3
)-CONHCH
3 , C(=N-OCH 3
)-COOCH
3 , N(-OCH 3
)-COOCH
3 , or a group Q1 O N-OCH 3 Q1 5 wherein # denotes the bond to the phenyl ring; A is -0-B, -CH 2 0-B, -OCH 2 -B, -CH 2 S-B, -CH=CH-B, -C=C-B,
-CH
2 0-N=C(R)-B, -CH 2 S-N=C(R)-B, -CH 2 0-N=C(R')-CH=CH-B, or
-CH
2 0-N=C(R)-C(R 2
)=N-OR
3 , where 10 B is phenyl, naphthyl, 5-membered or 6-membered heteroaryl or 5-membered or 6-membered heterocyclyl, containing one, two or three N atoms and/or one 0 or S atom or one or two 0 and/or S atoms, the ring systems being unsubstituted or substituted by one, two or three radicals Ra: Ra is independently cyano, nitro, amino, aminocarbonyl, aminothiocarbonyl, 15 halogen, C-C 6 -alkyl, 0 1
-C
6 -haloalkyl, C-C 6 -alkylcarbonyl, C-C 6 -alkyl sulfonyl, C-C 6 -alkylsulfinyl, C 3
-C
6 -cycloalkyl, C-C 6 -alkoxy, C-C 6 -halo alkoxy, C-C 6 -alkyloxycarbonyl, 0 1
-C
6 -alkylthio, Cr 1
C
6 -alkylamino, di-Cr 1
C
6 alkylamino, C-C 6 -alkylaminocarbonyl, di-0 1
-C
6 -alkylaminocarbonyl, CrC-6 alkylaminothiocarbonyl, di-C-C 6 -alkylaminothiocarbonyl, C 2
-C
6 -alkenyl, C2 20 C 6 -alkenyloxy, phenyl, phenoxy, benzyl, benzyloxy, 5- or 6-membered het erocyclyl, 5- or 6-membered heteroaryl, 5- or 6-membered heteroaryloxy, C(=NOR")-Rb or OC(R") 2 -C(Rb)=NOR , the cyclic radicals, in turn, being unsubstituted or substituted by one, two or three radicals Rb: R is independently cyano, nitro, halogen, amino, aminocarbonyl, 25 aminothiocarbonyl, C-C 6 -alkyl, C-C 6 -haloalkyl, C-C 6 -alkylsulfonyl, Cl-C 6 -alkylsulfinyl, C 3
-C
6 -cycloalkyl, C-C 6 -alkoxy, 0 1
-C
6 -haloalkoxy,
C-C
6 -alkoxycarbonyl, C-C 6 -alkylthio, Cr-C 6 -alkylamino, di-Cr-C 6 alkylamino, C-C 6 -alkylaminocarbonyl, di-C-C 6 -alkylaminocarbonyl, Cl-C 6 -alkylaminothiocarbonyl, di-C-C 6 -alkyl-aminothiocarbonyl, C2 30 C 6 -alkenyl, C 2
-C
6 -alkenyloxy, C 3
-C
6 -cycloalkyl, C 3
-C
6 -cycloalkenyl, phenyl, phenoxy, phenylthio, benzyl, benzyloxy, 5- or 6-membered heterocyclyl, 5- or 6-membered heteroaryl, 5- or 6-membered het eroaryloxy or C(=NORA)_RB WO 2008/129060 45 PCT/EP2008/054924 RA , RB are independently hydrogen or C 1
-C
6 -alkyl; R1 is hydrogen, cyano, C-C 4 -alkyl, C-C 4 -haloalkyl, C 3
-C
6 -cycloalkyl, C1-C4 alkoxy, or C-C 4 -alkylthio;
R
2 is phenyl, phenylcarbonyl, phenylsulfonyl, 5- or 6-membered heteroaryl, 5 5 or 6-membered heteroarylcarbonyl or 5- or 6-membered heteroarylsulfonyl, the ring systems being unsubstituted or substituted by one, two or three radi cals Ra,
C
1 -0 1 o-alkyl, C 3
-C
6 -cycloalkyl, C 2
-C
10 -alkenyl, C 2
-C
10 -alkynyl, C-C1O alkylcarbonyl, C 2
-C
1 o-alkenylcarbonyl, C 3
-C
1 0 -alkynylcarbonyl, CrC-10 10 alkylsulfonyl, or C(=NORa)-R , the hydrocarbon radicals of these groups being unsubstituted or substituted by one, two or three radi cals Rc: Rc is independently cyano, nitro, amino, aminocarbonyl, aminothio carbonyl, halogen, 0 1
-C
6 -alkyl, Cr 1
C
6 -haloalkyl, Cr 1
C
6 -alkylsulfonyl, 15 C-C 6 -alkylsulfinyl, C-C 6 -alkoxy, C-C 6 -haloalkoxy, C-C 6 -alkoxy carbonyl, Cr 1
C
6 -alkylthio, 0 1
-C
6 -alkylamino, di-0 1
-C
6 -alkylamino, C
C
6 -alkylaminocarbonyl, di-C-C 6 -alkylaminocarbonyl, Cr-C 6 -alkyl aminothiocarbonyl, di-C-C 6 -alkylaminothiocarbonyl, C 2
-C
6 -alkenyl,
C
2
-C
6 -alkenyloxy, 20 C 3
-C
6 -cycloalkyl, C 3
-C
6 -cycloalkyloxy, 5- or 6-membered heterocyclyl, 5- or 6-membered heterocyclyloxy, benzyl, benzyloxy, phenyl, phenoxy, phenylthio, 5- or 6-membered heteroaryl, 5- or 6 membered heteroaryloxy and heteroarylthio, it being possible for the cyclic groups, in turn, to be partially or fully halogenated or to have 25 attached to them one, two or three radicals Ra; and
R
3 is hydrogen, C-C 6 -alkyl, C 2
-C
6 -alkenyl, C 2
-C
6 -alkynyl, the hydrocarbon radicals of these groups being unsubstituted or substituted by one, two or three radicals Rc; and 30 2) the strobilurins (2-chloro-5-[1-(3-methyl-benzyloxyimino)-ethyl]-benzyl)-carbamic acid methyl ester, (2-chloro-5-[1-(6-methyl-pyridine-2-ylmethoxyimino)-ethyl]-benzyl) carbamic acid methyl ester and 2-(ortho-((2,5-dimethyl phenyl-oxymethylene)phenyl) 3-methoxy-acrylic acid methyl ester. 35 Compounds of formula I are generally known as fungicides since a long time (see references above).
WO 2008/129060 46 PCT/EP2008/054924 The publications cited above describe synthesis routes for the preparation of stro bilurins used in the method according to the invention, the disclosure of which is hereby incorporated. Especially preferred according to the invention are strobilurins with the following 5 meanings of the substituents, in each case alone or in combination, the disclosure of the publications cited being hereby incorporated. In one preferred embodiment of the present invention, preferred strobilurins of for mula I wherein Q is N(-OCH 3
)-COOCH
3 are the compounds described in the publica tions WO 93/15046 and WO 96/01256. 10 In another preferred embodiment of the present invention, preferred strobilurins of formula I, wherein Q is C(=CH-OCH 3
)-COOCH
3 are the compounds described in the publications EP-A 178 826 and EP-A 278 595. In another preferred embodiment of the present invention, preferred strobilurins of formula I, wherein Q is C(=N-OCH 3
)-COOCH
3 are the compounds described in the 15 publications EP-A 253 213 and EP-A 254 426. In another preferred embodiment of the present invention, preferred strobilurins of formula I, wherein Q is C(=N-OCH 3
)-CONHCH
3 are the compounds described in the publications EP-A 398 692, EP-A 477 631 and EP-A 628 540. In another preferred embodiment of the present invention, preferred strobilurins of 20 formula I, wherein Q is C(=CH-CH 3
)-COOCH
3 are the compounds described in the publications EP-A 280 185 and EP-A 350 691. In another preferred embodiment of the present invention, preferred strobilurins of formula I, wherein Q is -CH 2 0-N=C(R)-B are the compounds described in the publica tions EP-A 460 575 and EP-A 463 488. 25 In another preferred embodiment of the present invention, preferred strobilurins of formula I, wherein A is -0-B are the compounds described in the publications EP-A 382 375 and EP-A 398 692. In another preferred embodiment of the present invention, preferred strobilurins of formula I, wherein A is -CH 2 0-N=C(R 1
)-C(R
2
)=N-OR
3 are the compounds described in 30 the publications WO 95/18789, WO 95/21153, WO 95/21154, WO 97/05103 and WO 97/06133. Especially preferred are the strobilurins of the formula I in which Q is N(-OCH 3
)-COOCH
3 , A is CH 2 -0- and WO 2008/129060 47 PCT/EP2008/054924 B is 3-pyrazolyl or 1,2,4-triazolyl, where B has attached to it one or two substituents selected from the group of - halogen, methyl and trifluoromethyl and - phenyl and pyridyl, in particular 2-pyridyl, substituted by 1 to 3 radicals Rb. 5 These active ingredients are described by formula ll, O N (Ra.), O0 T - Il y'OCH 3 | (Rb)
OCH
3 in which T is a carbon or a nitrogen atom, Ra is independently selected from halogen, methyl and trifluoromethyl, y is zero, 1 or 2, R is as defined for formula I, x is zero, 1, 10 2, 3 or 4. More preferred active ingredients are those of formula II': 0 N (R b) ' ,OCH 3
OCH
3 in which R is as defined for formula 1. According to another embodiment of the present invention, the active ingredient (B) is 15 a carboxylic amide selected from the group B2). According to another embodiment of the present invention, the active ingredient (B) is an azole selected from the group B3). According to another embodiment of the present invention, the active ingredient (B) is a nitrogen-containing heterocyclic compound selected from the group B4). 20 According to another embodiment of the present invention, the active ingredient (B) is a carbamate or thiocarbamate selected from the group B5). According to another embodiment of the present invention, the active ingredient (B) is a guanidine selected from the group B6).
WO 2008/129060 48 PCT/EP2008/054924 According to another embodiment of the present invention, the active ingredient (B) is an antibiotic selected from the group B7). According to another embodiment of the present invention, the active ingredient (B) is a fentin salt. 5 According to another embodiment of the present invention, the active ingredient (B) is isoprothiolan or dithianon. According to another embodiment of the present invention, the active ingredient (B) is an organophosphorous compound selected from the group B10). According to another embodiment of the present invention, the active ingredient (B) is 10 an organo-chloro compound selected from the group B11). According to another embodiment of the present invention, the active ingredient (B) is a nitrophenyl derivative selected from the group B12). According to another embodiment of the present invention, the active ingredient (B) is an inorganic ingredient selected from the group B13). 15 According to another embodiment of the present invention, the active ingredient (B) is spiroxamine. According to another embodiment of the present invention, the active ingredient (B) is cyflufenamide. According to another embodiment of the present invention, the active ingredient (B) is 20 cymoxanil. According to another embodiment of the present invention, the active ingredient (B) is metrafenone. According to still another preferred embodiment of the present ivention, the active ingredient (B) is (EZ)-3-(2-chloro-1,3-thiazol-5-ylmethyl)-5-methyl-1,3,5-oxadiazinan-4 25 ylidene(nitro)amine (thiamethoxam). According to still another preferred embodiment of the present ivention, the active ingredient (B) is 5-amino-1-(2,6-dichloro-a,a,a-trifluoro-p-tolyl)-4 trifluoromethylsulfinylpyrazole-3-carbonitrile (fipronil). According to still another preferred embodiment of the present ivnention, the active 30 ingredient (B) is(EZ)- 1 -(6-chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-ylideneamine (imidacloprit). According to still another preferred embodiment of the present ivnention, the active ingredient (B) is selected from the group consisting of: WO 2008/129060 49 PCT/EP2008/054924 Fungicide: Anilide, preferably Isopyrazam, N-(2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-l methyl-I H-pyrazole-4-carboxylic , acid amide N-(trans-2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-I -methyl-i H-pyrazole-4 5 carboxylic acid amide N-(cis-2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid amide N-(2-(1,3-dimethyl-butyl)-phenyl)-1,3-dimethyl-5-fluoro-1 H-pyrazole-4-carboxylic acid amide 10 3-Difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid (2',4'-difluorobiphenyl-2-yi)-amide 3-Difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid (2',4'-dichlorobiphenyl-2-yl)-amide 3-Difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid 15 (3',4'-difluorobiphenyl-2-yl)-amide 3-Difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid (3',4'-dichlorobiphenyl-2-yl)-amide 3-Difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid (3',5'-difluorobiphenyl-2-yl)-amide 20 3-Difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid (3',5'-dichlorobiphenyl-2-yl)-amide 3-Difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid (3',4',5'-trifluorobiphenyl-2-yl)-amide 25 Fluopyram, 5-Amino-2-isopropyl-3-oxo-4-ortho-tolyl-2,3-dihydro-pyrazole-1-carbothioic acid S-allyl ester N'-(4-(4-chloro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methy formamidine N'-(4-(4-fluoro-3-trifluoromethyl-phenoxy)-2,5-dimethyl-phenyl)-N-ethyl-N-methyl 30 formamidine N'-(2-methyl-5-trifluormethyl-4-(3-trimethylsilanyl-propoxy)-phenyl)-N-ethyl-N-methy formamidine N'-(5-difluormethyl-2-methyl-4-(3-trimethylsilanyl-propoxy)-phenyl)-N-ethyl-N-methy formamidine, 35 According to still another preferred embodiment of the present ivnention, the active ingredient (B) is selected from the group consisting of: PGR's: abscisic acid, Amido chlor, Ancymidol, 6-Benzylaminopurine, Brassinolide, Butralin, Choline chloride, Cy clanilide, Daminozide, Dikegulac, Dimethipin, 2,6-Dimethylpuridine, Ethephon, Flu 40 metralin, Flurprimidol, Fluthiacet, Forchlorfenuron, Gibberellic acid, Inabenfide, indole 3-acetic acid, Maleic hydrazide, Mefluidide, naphthaleneacetic acid, N-6 benzy- WO 2008/129060 50 PCT/EP2008/054924 ladenine, Paclobutrazol, Prohydrojasmon, Thidiazuron, Triapenthenol, Tributyl phos phorotrithioate, 2,3,5-tri-iodobenzoic acid, Uniconazole, According to still another preferred embodiment of the present ivnention, the active ingredient (B) is selected from the group consisting of: insecticides:acephate, chlor 5 pyrifos, diazinon, dichlorvos, dimethoate, fenitrothion, methamidophos, methidathion, methyl-parathion, monocrotophos, phorate, profenofos, terbufos, aldicarb, carbaryl, carbofuran, carbosulfan, methomyl, thiodicarb, bifenthrin, cyfluthrin, cypermethrin, alpha-cypermethrin, zeta-cypermethrin, deltamethrin, esfenvalerate, lambda cyhalothrin, permethrin, tefluthrin, diflubenzuron, flufenoxuron, lufenuron, te 10 flubenzuron, spirotetramat; clothianidin, dinotefuran, imidacloprid, thiamethoxam, acetamiprid, thiacloprid; endosulfan, fipronil, abamectin, emamectin, spinosad, spine toram, hydramethylnon; chlorfenapyr; fenbutatin oxide, indoxacarb, metaflumizone, flonicamid, flubendiamide, chlorantraniliprole, cyazypyr (HGW86), cyflumetofenmost preferred: acephate, chlorpyrifos, dimethoate, methamidophos, terbufos, aldicarb, 15 carbofuran, bifenthrin, cypermethrin, alpha-cypermethrin, deltamethrin, lambda cyhalothrin, tefluthrin, flufenoxuron, teflubenzuron, spirotetramat; clothianidin, imida cloprid, thiamethoxam, endosulfan, fipronil, abamectin, spinosad, spinetoram, hy dramethylnon; chlorfenapyr; indoxacarb, metaflumizone, flubendiamide, chloran traniliprole, cyazypyr (HGW86), cyflumetofen. 20 According to still another preferred embodiment of the present ivnention, the active ingredient (B) is selected from the group consisting of: fungicides: azoxystrobin, Dimoxystrobin, Kresoxim-methyl, Orysastrobin, Pyraclostrobin, Triflox ystrobin, Bixafen, Boscalid, Isopyrazam, Metalaxyl, Penthiopyrad, 3-Difluoromethyl-1 methyl-1 H-pyrazole-4-carboxylic acid (2',4',5'-trifluorobiphenyl-2-yl)-amide , N-(2 25 bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid amide, Dimethomorph, Fluopicolide, Difenoconazole, Epoxiconazole, Fluquincona zole, Flusilazole, Flutriafol, Metconazol, Myclobutanil, Propiconazole, Prothioconazole, Tebuconazole, Tetraconazole, Triticonazole, Prochloraz, Carbendazim , Fluazinam, Cyprodinil, Pyrimethanil, Fludioxonil, Dodemorph, Fenpropimorph, Tridemorph, Fen 30 propidin, lprodione, Vinclozolin, Famoxadone, Probenazole, Captan, Folpet, 5-ethyl-6 octyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-ylamine, Mancozeb, Maneb, Metiram, Thiram, Dithianon, Fosetyl, Fosetyl-aluminium, Chlorothalonil, Thiophanate Methyl, Cymoxanil, Metrafenone, Spiroxamine,most preferred: Azoxystrobin, Dimoxystrobin, Kresoxim methyl, Orysastrobin, Pyraclostrobin, Trifloxystrobin, Bixafen, Boscalid, Isopyrazam, 35 Metalaxyl, Penthiopyrad, 3-Difluoromethyl-1 -methyl-i H-pyrazole-4-carboxylic acid (2',4',5'-trifluorobiphenyl-2-yl)-amide , Dimethomorph, Difenoconazole, Epoxiconazole, Fluquinconazole, Metconazol, Propiconazole, Prothioconazole, Tebuconazole, Triti conazole, Prochloraz, Carbendazim, Cyprodinil, Pyrimethanil, Fenpropimorph, Tride morph, lprodione, 5-ethyl-6-octyl-[1,2,4]triazolo[ 1, 5-a]pyrimidine-7-ylamine, Mancozeb, 40 Maneb, Metiram, Dithianon, Chlorothalonil, Thiophanate Methyl, Cymoxanil, WO 2008/129060 51 PCT/EP2008/054924 Metrafenone.According to still another preferred embodiment of the present ivnention, the active ingredient (B) is selected from the group consisting of: N-(3',4',5' trifluorobiphenyl-2-yl)- 3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxamide, N-[2-(4'-trifluoromethylthio)-biphenyll-3-difluoromethyl-I -methyl-I H-pyrazole-4 5 carboxamide, N-[2-(1,3-dimethylbutyl)-phenyl]-1,3-dimethyl-5-fluoro-1 H-pyrazole-4-carboxamide, N-(2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1-methyl-1 H-pyrazole-4-carboxamide, N-(cis-2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1 -methyl-1 H-pyrazole-4 carboxamide, 10 N-(trans-2-bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1 -methyl-1 H-pyrazole-4 carboxamide, N-[1,2,3,4-tetrahydro-9-(1 -methylethyl)-1,4-methanonaphthalen-5-yl]-3 (difluoromethyl)-1-methyl-I H-pyrazole-4-carboxamide. According to still another preferred embodiment of the present invention, the active 15 ingredient (B) is selected from the group consisting of herbicides: Acetochlor, Dimethenamid, Metolachlor, Metazachlor, Glyphosate, Glufosinate, Sul fosate, Clodinafop, Fenoxaprop, Fluazifop, Haloxyfop, Paraquat, Phenmedipham, Clethodim, Cycloxydim, Profoxydim, Sethoxydim, Tepraloxydim, Pendimethalin, Triflu ralin, Acifluorfen, Bromoxynil, Imazamethabenz, Imazamox, Imazapic, Imazapyr, Ima 20 zaquin, Imazethapyr, 2,4-D, Chloridazon, Clopyralid, Fluroxypyr, Picloram, Picoli nafen, Bensulfuron, Chlorimuron ethyl, Cyclosulfamuron, lodosulfuron, Mesosulfuron, Metsulfuron-methyl, Nicosulfuron, Rimsulfuron, Triflusulfuron, Atrazine, Hexazinone, Diuron, Florasulam, Pyroxasulfone, Bentazone, Cinidon-ethly, Cinmethylin, Dicamba, Diflufenzopyr, Quinclorac, Quinmerac, Mesotrione, Saflufenacil, Topramezone; 25 most preferred: Acetochlor, Dimethenamid, Metolachlor, Metazachlor, Glyphosate, Glufosinate, Sul fosate, Fenoxaprop, Paraquat, Cycloxydim, Profoxydim, Sethoxydim, Tepraloxydim, Pendimethalin, Acifluorfen, Imazamethabenz, Imazamox, Imazapic, Imazapyr, Ima zaquin, Imazethapyr, 2,4-D, Chloridazon, Picloram, Picolinafen, Cyclosulfamuron, 30 Triflusulfuron, Atrazine, Pyroxasulfone, Bentazone, Cinidon-ethly, Cinmethylin, Dicamba, Diflufenzopyr, Quinclorac, Quinmerac, Mesotrione, Saflufenacil, Toprame zone In one embodiment a plant selected from the group of transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant with an 35 increased or generated activities of a polypeptide with an activity as indicated in table B, column 5, line No 1, 5, 7,10, 11, 12, 16, 19, 20, 21, 23, 25, 27, 28, 30, 31, 33, 37, 39,40,42,43,91,105,107,112,150,159,164,165,166,167,168,169,170,171, 172, 173, 174, 175, 176, 177, 178,182, 186, 187, 188, 189, 190, 194, 196, 203, 204, 205, 206, 207, 209, 210, 211, 213, respectively plants with an increased or generated WO 2008/129060 52 PCT/EP2008/054924 activities of a polypeptide according to the sequence number as depicted in table B, column 3, line No 1, 5, 7,10, 11, 12, 16, 19, 20, 21, 23, 25, 27, 28, 30, 31, 33, 37, 39, 40,42,43,91,105,107,112,150,159,164,165,166,167,168,169,170,171,172, 173, 174, 175, 176, 177, 178,182, 186, 187, 188, 189, 190, 194, 196, 203, 204, 205, 5 206, 207, 209, 210, 211, 213, respectively plants with an increased or generated ex pression of the gene as idepicted in table B, column 1, line No 1, 5, 7,10, 11, 12, 16, 19,20,21,23,25,27,28,30,31,33,37,39,40,42,43,91,105,107,112, 150,159, 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178,182, 186, 187,188,189,190,194,196,203,204,205,206,207,209,210,211,213; 10 in combination with the treatment with an effective amount of any of the active ingre dients selected from the group consisting of acephate, chlorpyrifos, diazinon, dichlorvos, dimethoate, fenitrothion, methamidophos, methidathion, methyl-parathion, monocrotophos, phorate, profenofos, terbufos, aldi carb, carbaryl, carbofuran, carbosulfan, methomyl, thiodicarb, bifenthrin, cyfluthrin, 15 cypermethrin, alpha-cypermethrin, zeta-cypermethrin, deltamethrin, esfenvalerate, lambda-cyhalothrin, permethrin, tefluthrin, diflubenzuron, flufenoxuron, lufenuron, te flubenzuron, spirotetramat; clothianidin, dinotefuran, imidacloprid, thiamethoxam, acetamiprid, thiacloprid; endosulfan, fipronil, abamectin, emamectin, spinosad, spine toram, hydramethylnon; chlorfenapyr; fenbutatin oxide, indoxacarb, metaflumizone, 20 flonicamid, flubendiamide, chlorantraniliprole, cyazypyr (HGW86), cyflumetofen, Azoxystrobin, Dimoxystrobin, Kresoxim-methyl, Orysastrobin, Pyraclostrobin, Triflox ystrobin, Bixafen, Boscalid, Isopyrazam, Metalaxyl, Penthiopyrad, 3-Difluoromethyl-1 methyl-1 H-pyrazole-4-carboxylic acid (2',4',5'-trifluorobiphenyl-2-yl)-amide , N-(2 bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxylic acid 25 amide, Dimethomorph, Fluopicolide, Difenoconazole, Epoxiconazole, Fluquinconazo le, Flusilazole, Flutriafol, Metconazol, Myclobutanil, Propiconazole, Prothioconazole, Tebuconazole, Tetraconazole, Triticonazole, Prochloraz, Carbendazim , Fluazinam, Cyprodinil, Pyrimethanil, Fludioxonil, Dodemorph, Fenpropimorph, Tridemorph, Fen propidin, Iprodione, Vinclozolin, Famoxadone, Probenazole, Captan, Folpet, 5-ethyl-6 30 octyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-ylamine, Mancozeb, Maneb, Metiram, Thiram, Dithianon, Fosetyl, Fosetyl-aluminium, Chlorothalonil, Thiophanate Methyl, Cymoxanil, Metrafenone and Spiroxamine, as depicted detailed in Table C. In one embodiment of the invention the combination of the transgenic modification, 35 e.g. the increased or generated activity in the plant and the active ingredient is de picted in table C. In one embodiment 2, 3, 4, 5, 6, 7, 8, 9, 10 ore more of the above mentioned active ingredients are used simultaneously for the treatment.
WO 2008/129060 53 PCT/EP2008/054924 In one embodiment a plant selected from the group of transgenic plants with at least one transgenic modification as compared to a corresponding wild-type plant with an increased or generated activities of a polypeptide with an activity as indicated in table B, column 5, line No 1, 5, 7,10, 11, 12, 16, 19, 20, 21, 23, 25, 27, 28, 30, 31, 33, 37, 5 39,40,42,43,91,105,107,112,150,159,164,165,166,167,168,169,170,171, 172, 173, 174, 175, 176, 177, 178,182, 186, 187, 188, 189, 190, 194, 196, 203, 204, 205, 206, 207, 209, 210, 211, 213, respectively plants with an increased or generated activities of a polypeptide according to the sequence number as depicted in table B, column 3, line No 1, 5, 7,10, 11, 12, 16, 19, 20, 21, 23, 25, 27, 28, 30, 31, 33, 37, 39, 10 40,42,43,91,105,107,112,150,159,164,165,166,167,168,169,170,171,172, 173, 174, 175, 176, 177, 178,182, 186, 187, 188, 189, 190, 194, 196, 203, 204, 205, 206, 207, 209, 210, 211, 213, respectively plants with an increased or generated ex pression of the gene as idepicted in table B, column 1, line No 1, 5, 7,10, 11, 12, 16, 19,20,21,23,25,27,28,30,31,33,37,39,40,42,43,91,105,107,112, 150,159, 15 164, 165, 166, 167, 168, 169, 170, 171, 172, 173, 174, 175, 176, 177, 178,182, 186, 187,188,189,190,194,196,203,204,205,206,207,209,210,211,213; in combination with the treatment with an effective amount of any of the active ingre dients selected from the group consisting of fipronil and pyraclostrobin. If the component (A) is a sulfated glucan as defined above, the active ingredient (B) 20 can also be the active ingredient maneb. In another aspect, the present invention relates to a composition comprising an ex tract from seaweed and a pesticide. The seaweed extract is preferably obtained ac cording to the methods as described in WO 93/06730, which is hereby incorporated by reference. Particularly, the extract is obtained from brown algae, wherein the brown 25 algae is specifically from the Phaeophyceae type (in particular Fucales or Laminaria les). In general, the extraction can be accomplished by basic hydrolysis of the respec tive seaweed in the presence of a reducing agent such as an alkali metal borhydride. Then, the resulting hydrolysate is neutralised to a pH of about 6 to 8, e.g. by the addi tion of a strong acid. The product is filtrated and optionally diafiltrated or an electrodi 30 alysis may be carried out (cf. WO 93/06730). The following list M of pesticides together with one or more of the above mentioned active ingredients (B) according to the invention can be used and potential synergistic effects might be produced, whereby the list is intended to illustrate the possible combinations, but not to impose any limitation: 35 M.1. Organo(thio)phosphates: acephate, azamethiphos, azinphos-ethyl, azinphos methyl, chlorethoxyfos, chlorfenvinphos, chlormephos, chlorpyrifos, chlorpyrifos methyl, coumaphos, cyanophos, demeton-S-methyl, diazinon, dichlorvos/ DDVP, di crotophos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, fam phur, fenamiphos, fenitrothion, fenthion, flupyrazophos, fosthiazate, heptenophos, WO 2008/129060 54 PCT/EP2008/054924 isoxathion, malathion, mecarbam, methamidophos, methidathion, mevinphos, monocrotophos, naled, omethoate, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosmet, phosphamidon, phoxim, pirimiphos-methyl, profenofos, propetamphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos, sulfo 5 tep, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, triazophos, tri chlorfon, vamidothion; M.2. Carbamates: aldicarb, alanycarb, bendiocarb, benfuracarb, butocarboxim, bu toxycarboxim, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetan ate, furathiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, 10 propoxur, thiodicarb, thiofanox, trimethacarb, XMC, xylylcarb, triazamate; M.3. Pyrethroids: acrinathrin, allethrin, d-cis-trans allethrin, d-trans allethrin, bifenthrin, bioallethrin, bioallethrin S-cylclopentenyl, bioresmethrin, cycloprothrin, cyfluthrin, beta , yfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin, cyphe 15 nothrin, deltamethrin, empenthrin, esfenvalerate, etofenprox, fenpropathrin, fenvaler ate, flucythrinate, flumethrin, tau-fluvalinate, halfenprox, imiprothrin, permethrin, phe nothrin, prallethrin, resmethrin, RU 15525, silafluofen, tefluthrin, tetramethrin, tralome thrin, transfluthrin, ZXI 8901; M.4. Juvenile hormone mimics: hydroprene, kinoprene, methoprene, fenoxycarb, 20 pyriproxyfen; M.5. Nicotinic receptor agonists/antagonists compounds: acetamiprid, bensultap, car tap hydrochloride, clothianidin, dinotefuran, imidacloprid, thiamethoxam, nitenpyram, nicotine, spinosad (allosteric agonist), thiacloprid, thiocyclam, thiosultap-sodium and AKD1022. 25 M.6. GABA gated chloride channel antagonist compounds: chlordane, endosulfan, gamma-HCH (lindane); acetoprole, ethiprole, fipronil, pyrafluprole, pyriprole, vaniliprole, the phenylpyrazole compound of formula M 6
,
1 o S CFIS
NH
2 H NN 2 N (M 6 1) Cl Cl
CF
3 M.7. Chloride channel activators: abamectin, emamectin benzoate, milbemectin, le 30 pimectin; WO 2008/129060 55 PCT/EP2008/054924 M.8. METI I compounds: fenazaquin, fenpyroximate, pyrimidifen, pyridaben, tebufen pyrad, tolfenpyrad, flufenerim, rotenone; M.9. METI || and Ill compounds: acequinocyl, fluacyprim, hydramethylnon; M.10. Uncouplers of oxidative phosphorylation: chlorfenapyr, DNOC; 5 M.1 1. Inhibitors of oxidative phosphorylation: azocyclotin, cyhexatin, diafenthiuron, fenbutatin oxide, propargite, tetradifon; M.12. Moulting disruptors: cyromazine, chromafenozide, halofenozide, methoxy fenozide, tebufenozide; M. 13. Synergists: piperonyl butoxide, tribufos; 10 M.14. Sodium channel blocker compounds: indoxacarb, metaflumizone; M.15. Fumigants: methyl bromide, chloropicrin sulfuryl fluoride; M.16. Selective feeding blockers: crylotie, pymetrozine, flonicamid; M.17. Mite growth inhibitors: clofentezine, hexythiazox, etoxazole; M.18. Chitin synthesis inhibitors: buprofezin, bistrifluron, chlorfluazuron, diflubenzuron, 15 flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, te flubenzuron, triflumuron; M.19. Lipid biosynthesis inhibitors: spirodiclofen, spiromesifen, spirotetramat; M.20. octapaminergic agonsits: amitraz; M.21. ryanodine receptor modulators: flubendiamide; 20 M.22. Various: aluminium phosphide, amidoflumet, benclothiaz, benzoximate, bifenazate, borax, bromopropylate, cyanide, cyenopyrafen, cyflumetofen, chinome thionate, dicofol, fluoroacetate, phosphine, pyridalyl, pyrifluquinazon, sulfur, organic sulfur compounds, tartar emetic; pyrimidinyl alkynylether compounds M2 or thiadia zolyl alkynylether compounds M 2 22 : 25 N N N-S 2 Het* M N Het* R M-2,- F R M2," WO 2008/129060 56 PCT/EP2008/054924 wherein R M-22 is methyl or ethyl and Het* is 3,3-dimethylpyrrolidin-1-yl, 3 methylpiperidin-1-yl, 3,5-dimethylpiperidin-1-yl, 3-trifluormethylpiperidin-1-yl, hexahy droazepin-1 -yl, 2,6-dimethylhexahydroazepin-1 -yl or 2,6-dimethylmorpholin-4-yl. M.23. N-R'-2,2-dihalo-1-R"cyclo-propanecarboxamide-2-(2,6-dichloro- alpha, alpha, 5 alpha -tri-fluoro-p-tolyl)hydrazone or N-R'-2,2-di(R' ")propionamide-2-(2,6-dichloro alpha, alpha, alpha -trifluoro-p-tolyl)-hydrazone, wherein R' is methyl or ethyl, halo is chloro or bromo, R" is hydrogen or methyl and R.' is methyl or ethyl; M.24. Anthranilamides: chloranthraniliprole, the compound of formula M 2 4 1
CH
3 O Br NC N N-N H Cl (M 24 )
H
3 C-N H 10 M.25. Malononitrile compounds: CF 2
HCF
2
CF
2
CF
2
CH
2
C(CN)
2
CH
2
CH
2
CF
3 (2 (2,2,3,3,4,4,5,5-octafluoropentyl)-2-(3,3,3-trifluoro-propyl)malononitrile),
CF
3
(CH
2
)
2
C(CN)
2
CH
2
(CF
2
)
5
CF
2 H, (2-(2,2,3,3,4,4,5,5,6,6,7,7-Dodecafluoro-heptyl)-2 (3,3,3-trifluoro-propyl)-malononitrile), CF 3
(CH
2
)
2
C(CN)
2
(CH
2
)
2
C(CF
3
)
2 F (2-(3,4,4,4 15 Tetrafl uoro-3-trifluoromethyl-butyl)-2-(3,3,3-trifluoro-propyl)-malonon itri le),
CF
3
(CH
2
)
2
C(CN)
2
(CH
2
)
2
(CF
2
)
3
CF
3 (2-(3,3,4,4,5,5,6,6,6-Nonafluoro-hexyl)-2-(3,3,3 trifluoro-propyl)-malononitrile), CF 2
H(CF
2
)
3
CH
2
C(CN)
2
CH
2
(CF
2
)
3
CF
2 H (2,2-Bis (2,2,3,3,4,4,5,5-octafluoro-pentyl)-malononitrile), CF 3
(CH
2
)
2
C(CN)
2
CH
2
(CF
2
)
3
CF
3 (2 (2,2,3,3,4,4,5,5,5-Nonafluoro-pentyl)-2-(3,3,3-trifluoro-propyl)-maononitrile), 20 CF 3
(CF
2
)
2
CH
2
C(CN)
2
CH
2
(CF
2
)
3
CF
2 H (2-(2,2,3,3,4,4,4-Heptafluoro-butyl)-2 (2,2,3,3,4,4,5,5-octafluoro-pentyl)-malononitrile), CF 3
CF
2
CH
2
C(CN)
2
CH
2
(CF
2
)
3
CF
2 H (2 (2,2,3,3,4,4,5,5-Octafluoro-pentyl)-2-(2,2,3,3,3-pentafluoro-propyl)-maononitrile),
CF
2
HCF
2
CF
2
CF
2
CH
2 C(CN) 2
CH
2
CH
2
CF
2
CF
3 (2-(2,2,3,3,4,4,5,5-octafluoropentyl)-2 (3,3,4,4,4-pentafluorobutyl)-maonodinitrile), CF 3
(CH
2
)
2
C(CN)
2
CH
2
(CF
2
)
3
CF
2 H (2 25 (2,2,3,3,4,4,5,5-octafluoropentyl)-2-(3,3,3-trifluoro-butyl)-maononitrile); M.26. Microbial disruptors: Bacillus thuringiensis subsp. /sraeensi, Bacillus sphaeri cus, Bacillus thuringiensis subsp. Aizawai, Bacillus thuringiensis subsp. Kurstaki, Ba cillus thuringiensis subsp. Tenebrionis; The commercially available compounds of the group M may be found in The Pesticide 30 Manual, 13 Edition, British Crop Protection Council (2003) among other publications.
WO 2008/129060 57 PCT/EP2008/054924 Thioamides of formula M 61 and their preparation have been described in WO 98/28279. Lepimectin is known from Agro Project, PJB Publications Ltd, November 2004. Benclothiaz and its preparation have been described in EP-Al 454621. Methi dathion and Paraoxon and their preparation have been described in Farm Chemicals 5 Handbook, Volume 88, Meister Publishing Company, 2001. Acetoprole and its prepa ration have been described in WO 98/28277. Metaflumizone and its preparation have been described in EP-Al 462 456. Flupyrazofos has been described in Pesticide Sci ence 54, 1988, p.237-243 and in US 4822779. Pyrafluprole and its preparation have been described in JP 2002193709 and in WO 01/00614. Pyriprole and its preparation 10 have been described in WO 98/45274 and in US 6335357. Amidoflumet and its preparation have been described in US 6221890 and in JP 21010907. Flufenerim and its preparation have been described in WO 03/007717 and in WO 03/007718. AKD 1022 and its preparation have been described in US 6300348. Chloranthraniliprole has been described in WO 01/70671, WO 03/015519 and WO 05/118552. An 15 thranilamide derivatives of formula M2 have been described in WO 01/70671, WO 04/067528 and WO 05/118552. Cyflumetofen and its preparation have been de scribed in WO 04/080180. The aminoquinazolinone compound pyrifluquinazon has been described in EP A 109 7932. The alkynylether compounds M 221 and M 2 2
,
2 are described e.g. in JP 2006131529. Organic sulfur compounds have been described in 20 WO 2007060839. The malononitrile compounds have been described in WO 02/089579, WO 02/090320, WO 02/090321, WO 04/006677, WO 05/068423, WO 05/068432 and WO 05/063694. The pesticide that can be used according to this aspect of the invention may be se lected from fungicides, herbices and insecticides. Also maneb is a suitable pesticide. 25 Particularly, the pesticide is selected from the active ingredient (B) and preferred the active ingredients (B) as indicated above. Thus, it was surprisingly found within the framework of the present invention that the combination of chemical agents, e.g. at least one active ingredient, and at least one trangenic modification, which does not confer a resistance against the active ingredi 30 ent, leads to a synergistic effect, i.e. the effectiveness of the combination is higher compared to the use of the individual components. Thereby, synergistic effects con fering plant productivity enhancement and/or plant health enhancement and/or pest control can be obtained. Consequently, according to another aspect, the present invention provides the use of 35 a composition as defined according to the present invention for increasing the health, the productivity, the yield and/or improving the vigor of a transgenic plant of the inven tion, preferably an agricultural transgenic plant. The present invention further provides a method for increasing productivity of a trans genic plant, which comprises treating the location where the plant is growing or is ex- WO 2008/129060 58 PCT/EP2008/054924 pected to grow, and/or the seeds from which the plant grows with an effective amount of the active ingredient (B) as defined herein. According to a further embodiment, the present invention provides a method for in creasing the productivity of a transgenic plant, which comprises treating the plant, the 5 location where the plant is growing or is expected to grow, and/or the seeds from which the plant grows with an effective amount of the active ingredient (B) as defined herein. According to the present invention, "increased yield" of an agricultural plant means that the yield of a product of the respective plant is increased by a measurable 10 amount over the yield of the same product of the plant produced under the same con ditions, but without the application of the present invention. According to the present invention, it is preferred that the yield be increased by at least 0,5 %, more preferred at least 1 %, even more preferred at least 2 %, still more preferred at least 4 %, pref erably 5% or even more. 15 According to the present invention, "improved plant vigor" means that certain crop characteristics are increased or improved by a measurable or noticeable amount over the same factor of the plant produced under the same conditions, but without the ap plication of the present invention, such as: delay of senescence, root growth, longer panicles, increased or improved plant stand, the plant weight, plant height, emer 20 gence, improved visual appearance, improved protein content, more developed root system, tillering increase, increase in plant height, bigger leaf blade, less dead basal leaves, stronger tillers, greener leaf color, pigment content, photosynthetic activity, less fertilizers needed, less seeds needed, more productive tillers, earlier flowering, early grain maturity, less plant verse (lodging), increased shoot growth, early and im 25 proved germination, improved vitality of the plant, improved quality of the plant, im proved quality of the fruits or vegetables (or other products produced by the plant), improved self defence mechanism of the plant such as induced tolerance against fungi, bacteria, viruses and/or insects. The improvement of the plant vigor according to the present invention particularly 30 means that the improvement of any one or several or all of the above mentioned plant characteristics are improved independently of the pesticidal action of the composition or active ingredients. According to one embodiment of the present invention, the inventive compositions are used for yield increase of an agricultural transgenic plant. 35 According to a further embodiment of the present invention, the inventive composi tions are used for stimulating the natural defensive reactions of a plant against a pathogen and/or a pest. Thereby, the plant can be protected against unwanted micro organisms such as phytopathogenic fungi, bacteria, viruses and insects and it has WO 2008/129060 59 PCT/EP2008/054924 been found that the inventive compositions result in plant strengthening effects. Therefore, they are useful for mobilizing the plant's defense mechanisms against the attack of unwanted microorganisms. Consequently, the plant becomes tolerant or re sistant towards these microorganisms. Unwanted microorganisms in this context are 5 phytopathogenic fungi and/or bacteria and/or viruses and/or insects, preferably phy topathogenic fungi, bacteria and/or viruses, wherein, according to the present inven tion, the treated plant may develop increased defense mechanism against one of these pathogens/pests or against two, three or all of these pathogens/pests. According to one embodiment of the described methods of the invention the treatment 10 is made to transgenic vegetables and transgenic field crops. According to a further embodiment of the described methods of the invention the treatment is made to trans genic cereals such as for example wheat, barley or rye. In one specific embodiment, the method of the invention can be applied to transgenic field crops, such as soy beans, corn, cotton, wheat, barley, rye, rice, sugar beets, sugar cane, sunflower 15 and/or oilseed rape/canola, in particular soybeans, corn, cotton, sugar cane, oilseed rape/canola, tobacco, common beans, wheat, barley, rye, peas, and others. In relation to these crops the method is preferably applied by treating the seeds or the plants. In this embodiment it may be preferred that the plants are treated with two to three ap plications per season. 20 According to another embodiment of the described methods of the invention the treat ment is made to transgenic potatoes, tomatoes, cucurbits, cucumbers, melons, wa termelons, garlic, onions, bananas, peanuts, carrots, cabage, peppers, common beans, peas, lentils and/or lettuce, in particular potatoes, tomatoes, cucurbits, cucum bers, melons, watermelons, garlic, onions, and/or lettuce. 25 According to another embodiment of the described methods of the invention the treat ment is made to transgenic apples, pears, stone fruits, or citrus, in particular apples, stone fruits, citrus, pines, snip grass. According to another embodiment of the described methods of the invention, the treatment is made to transgenic strawberries, cherries, almonds, mango, papaya, 30 blueberries and/or grapes in particular strawberries and/or cherries. According to another embodiment of the described methods of the invention, the treatment is made to transgenic turf and/or ornamentals. According to another embodiment of the described methods of the invention, the treatment is made to transgenic tea, tobacco and/or coffee. 35 According to one embodiment of the described methods of the invention, two to ten, three to eight or four to six treatments with the compounds are made during a season.
WO 2008/129060 60 PCT/EP2008/054924 According to one embodiment of the invention, the inventive composition is applied via the leaves or to the soil. According to another embodiment of the described meth ods of the invention, the treatment(s) are carried out as foliar application. In one pre ferred embodiment of the present invention the method according to the invention is 5 carried out as foliar application or spray application, respectively. Preferably, one, two, three, four, five and up to ten applications during one season are carried out, specifi cally more than two applications, and up to 10 applications. Also preferred more than two applications, and up to 5 applications during a season are carried out. The inventive compositions are also suitable for dressing applications on plant propa 10 gation material. The latter term embraces seeds of all kinds (fruit, tubers, grains), cut tings, cut shoots and the like. One particular field of application is the treatment of all kinds of seeds. The method according to the invention is preferably carried out as foliar application when applied to transgenic fruit and vegetables, such as potatoes, tomatoes, cucur 15 bits, preferably cucumbers, melons, watermelons, garlic, onions, and lettuce. Prefera bly more than two applications and up to 5 or up to 10 applications during a season are carried out. The application rates are usually between 0.01 and 2.0 kg, preferably up to 1.0 kg of active ingredient per hectare. 20 In one embodiment the application rates are usually between 0.0001 and 2.0 kg, pref erably between 0.0001 and 1.0 kg of active ingredient per hectare. According to a further aspect, the present invention relates to seed, comprising one of the inventive copositions as defined herein in an amount of from 0.1 g to 1 kg per 100 kg of seeds. 25 Furthermore, it has been found that the inventive compositions achieve markedly en hanced action against plant pathogens (insects and harmful fungi). In general, if laminarin is used, it can be preferred to use it in doses of between 0.005 g and 100 g per liter for treating the leaves, and of between 1 g and 100 g per 100 kg for treating the seeds. 30 The active ingredient mixtures of the invention can be used in the form of premix for mulations or the active ingredients can be applied to the area, plant or seed to be treated simultaneously or in immediate succession, if desired together with further carriers, surfactants or other application-promoting adjuvants customarily employed in formulation technology. Besides an effective amount of the active ingredients, the 35 inventive composition can contain an agriculturally acceptable carrier and/or vehicle. The composition may be in solid form, for example in the form of a powder or gran ules, or in liquid form, for example in the form of an aqueous solution.
WO 2008/129060 61 PCT/EP2008/054924 The active ingredients or compositions used according to the present invention can be converted into the formulations conventionally used for pesticides, for example solu tions, emulsions, suspensions, dusts, powders, pastes and granules. The use form depends on the particular purpose; in any case, it should ensure fine and uniform dis 5 tribution of the compound according to the invention. The present invention furthermore provides a composition as described above with at least one one solid or liquid carrier. Best results are obtained when a formulation is used which supports the transport of the active compounds into the plants, and the distribution within the entire plant. 10 The compositions generally comprise between 0.1 and 95%, preferably between 0.5 and 90%, by weight of active ingredient. When employed in plant protection, the amounts applied are, depending on the kind of effect desired, between 0.01 and 2.0 kg, preferably between 0.1 and 1 kg of active ingredient per ha. 15 In one embodiment the application the amounts applied are, depending on the kind of effect desired, between 0.0001 and 2.0 kg, preferably between 0.1 and 1kg of active ingredient per ha. Seed can be treated by methods known to the person skilled in the art, such as, for example, seed dressing, seed coating, seed dusting, seed soaking and seed pellet 20 ing. In the treatment of seed, the amounts of active ingredient employed are generally from 1 to 1000 g/1 00 kg of seed, preferably from 1 to 200 g/1 00 kg, in particular from 1 to 100 g/100 kg. When used in the protection of materials or stored products, the amount of active in 25 gredient applied depends on the kind of application area and on the desired effect. Amounts customarily applied in the protection of materials are, for example, 0.001 g to 2 kg, preferably 0.005 g to 1 kg, of active compound per cubic meter of treated ma terial. The formulations are prepared in a known manner, for example by extending the ac 30 tive compound with solvents and/or carriers, if desired using emulsifiers and dispers ants. Solvents/auxiliaries which are suitable are essentially: - water, aromatic solvents (for example Solvesso products, xylene), paraffins (for example mineral oil fractions), alcohols (for example methanol, butanol, pentanol, benzyl alcohol), ketones (for example cyclohexanone, gamma 35 butyrolactone), pyrrolidones (NMP, NOP), acetates (glycol diacetate), glycols, WO 2008/129060 62 PCT/EP2008/054924 fatty acid dimethylamides, fatty acids and fatty acid esters. In principle, solvent mixtures may also be used, - carriers such as ground natural minerals (for example kaolins, clays, talc, chalk) and ground synthetic minerals (for example finely divided silica, 5 silicates); emulsifiers such as nonionic and anionic emulsifiers (for example polyoxyethylene fatty alcohol ethers, alkylsulfonates and arylsulfonates) and dispersants such as lignosulfite waste liquors and methylcellulose. Suitable surfactants are alkali metal, alkaline earth metal and ammonium salts of lignosulfonic acid, naphthalenesulfonic acid, phenolsulfonic acid, dibutylnaphthalene 10 sulfonic acid, alkylarylsulfonates, alkyl sulfates, alkylsulfonates, fatty alcohol sulfates, fatty acids and sulfated fatty alcohol glycol ethers, furthermore condensates of sulfonated naphthalene and naphthalene derivatives with formaldehyde, condensates of naphthalene or of naphthalenesulfonic acid with phenol and formaldehyde, polyoxyethylene octylphenol ether, ethoxylated isooctylphenol, octylphenol, 15 nonylphenol, alkylphenol polyglycol ethers, tributylphenyl polyglycol ether, tristearyl phenyl polyglycol ether, alkylaryl polyether alcohols, alcohol and fatty alcohol/ethylene oxide condensates, ethoxylated castor oil, polyoxyethylene alkyl ethers, ethoxylated polyoxypropylene, lauryl alcohol polyglycol ether acetal, sorbitol esters, lignosulfite waste liquors and methylcellulose. 20 Suitable for the preparation of directly sprayable solutions, emulsions, pastes or oil dispersions are mineral oil fractions of medium to high boiling point, such as kerosene or diesel oil, furthermore coal tar oils and oils of vegetable or animal origin, aliphatic, cyclic and aromatic hydrocarbons, for example toluene, xylene, paraffin, tetrahy dronaphthalene, alkylated naphthalenes or their derivatives, methanol, ethanol, pro 25 panol, butanol, cyclohexanol, cyclohexanone, isophorone, strongly polar solvents, for example dimethyl sulfoxide, N-methylpyrrolidone and water. Powders, materials for spreading and dustable products can be prepared by mixing or concomitantly grinding the active substances with a solid carrier. Granules, for example coated granules, impregnated granules and homogeneous 30 granules, can be prepared by binding the active compounds to solid carriers. Examples of solid carriers are mineral earths such as silica gels, silicates, talc, kaolin, attaclay, limestone, lime, chalk, bole, less, clay, dolomite, diatomaceous earth, calcium sulfate, magnesium sulfate, magnesium oxide, ground synthetic materials, fertilizers, such as, for example, ammonium sulfate, ammonium phosphate, 35 ammonium nitrate, ureas, and products of vegetable origin, such as cereal meal, tree bark meal, wood meal and nutshell meal, cellulose powders and other solid carriers. Formulations for seed treatment may further comprise binders and/or gelants and if appropriate dyes.
WO 2008/129060 63 PCT/EP2008/054924 Binders can be added to increase the adhesion of the active compounds to the seed after the treatment. Suitable binders are for example EO/PO block copolymer surfac tants, but also polyvinyl alcohols, polyvinylpyrrolidones, polyacrylates, polymethacry lates, polybutenes, polyisobutylenes, polystyrenes, polyethyleneamines, polyethyl 5 eneamides, polyethyleneimines (Lupasol@, Polymin@), polyethers, polyurethanes, polyvinyl acetates, Tylose and copolymers of these polymers. A suitable gelant is for example carrageen (Satiagel@). In general, the formulations comprise from 0.01 to 95% by weight, preferably from 0.1 to 90% by weight, of the active compound. The active compounds are employed in a 10 purity of from 90% to 100%, preferably 95% to 100% (according to NMR spectrum). The concentrations of active compound in the ready-to-use preparations can be var ied within relatively wide ranges. In general, they are between 0.0001 and 10%, pref erably between 0.01 and 1%. The active compounds can also be used with great success in the ultra-low-volume 15 (ULV) process, it being possible to apply formulations with more than 95% by weight of active compound or even the active compound without additives. For the treatment of seed, the formulations in question give, after two-to-tenfold dilu tion, active compound concentrations of from 0.01 to 60% by weight, preferably from 0.1 to 40% by weight, in the ready-to-use preparations. 20 The following are examples of formulations according to the invention: Products for dilution with water A Water-soluble concentrates (SL, LS) 10 parts by weight of active ingredient are dissolved with 90 parts by weight of water or with a water-soluble solvent. As an alternative, wetters or other auxiliaries are 25 added. The active compound dissolves upon dilution with water. This gives a formula tion having an active compound content of 10% by weight. B Dispersible concentrates (DC) 20 parts by weight of active ingredient are dissolved in 70 parts by weight of cyclo hexanone with addition of 10 parts by weight of a dispersant, for example polyvi 30 nylpyrrolidone. Dilution with water gives a dispersion. The active compound content is 20% by weight. C Emulsifiable concentrates (EC) 15 parts by weight of active ingredient are dissolved in 75 parts by weight of xylene with addition of calcium dodecylbenzenesulfonate and castor oil ethoxylate (in each 35 case 5 parts by weight). Dilution with water gives an emulsion. The formulation has an active compound content of 15% by weight.
WO 2008/129060 64 PCT/EP2008/054924 D Emulsions (EW, EO, ES) 25 parts by weight of active ingredient are dissolved in 35 parts by weight of xylene with addition of calcium dodecylbenzenesulfonate and castor oil ethoxylate (in each case 5 parts by weight). This mixture is added to 30 parts by weight of water by 5 means of an emulsifying machine (e.g. Ultraturrax) and made into a homogeneous emulsion. Dilution with water gives an emulsion. The formulation has an active com pound content of 25% by weight. E Suspensions (SC, OD, FS) In an agitated ball mill, 20 parts by weight of active ingredient are comminuted with 10 addition of 10 parts by weight of dispersants and wetters and 70 parts by weight of water or an organic solvent to give a fine active compound suspension. Dilution with water gives a stable suspension of the active compound. The active compound con tent in the formulation is 20% by weight. F Water-dispersible granules and water-soluble granules (WG, SG) 15 50 parts by weight of active ingredient are ground finely with addition of 50 parts by weight of dispersants and wetters and made into water-dispersible or water-soluble granules by means of technical appliances (for example extrusion, spray tower, fluid ized bed). Dilution with water gives a stable dispersion or solution of the active com pound. The formulation has an active compound content of 50% by weight. 20 G Water-dispersible powders and water-soluble powders (WP, SP, SS, WS) 75 parts by weight of active ingredient are ground in a rotor-stator mill with addition of 25 parts by weight of dispersants, wetters and silica gel. Dilution with water gives a stable dispersion or solution of the active compound. The active compound content of the formulation is 75% by weight. 25 Products to be applied undiluted H Dustable powders (DP, DS) 5 parts by weight of active ingredient are ground finely and mixed intimately with 95 parts by weight of finely divided kaolin. This gives a dustable product with an active 30 compound content of 5% by weight. I Granules (GR, FG, GG, MG) 0.5 part by weight of active ingredient is ground finely and associated with 99.5 parts by weight of carriers. Current methods are extrusion, spray-drying or the fluidized bed. This gives granules with an active compound content of 0.5% by weight to be applied 35 undiluted. J ULV solutions (UL) 10 parts by weight of active ingredient are dissolved in 90 parts by weight of an or- WO 2008/129060 65 PCT/EP2008/054924 ganic solvent, for example xylene. This gives a product with an active compound con tent of 10% by weight to be applied undiluted. Seed treatment typically utilizes water-soluble concentrates (LS), suspensions (FS), dusts (DS), water-dispersible and water-soluble powders (WS, SS), emulsions (ES), 5 emulsifiable concentrates (EC) and gel formulations (GF). These formulations can be applied neat or preferably diluted to the seed. The application can take place prior to sowing. Preference is given to using FS formulations for seed treatment. Such formulations typically comprise from 1 to 800 g/I of active compound, from 1 to 200 g/I of surfac 10 tants, from 0 to 200 g/l of antifreeze, from 0 to 400 g/l of binder, from 0 to 200 g/l of dyes and solvent, preferably water. The active compounds can be used as such, in the form of their formulations or the use forms prepared therefrom, for example in the form of directly sprayable solutions, powders, suspensions or dispersions, emulsions, oil dispersions, pastes, dustable 15 products, materials for spreading, or granules, by means of spraying, atomizing, dust ing, spreading or pouring. The use forms depend entirely on the intended purposes; the intention is to ensure in each case the finest possible distribution of the active compounds used according to the invention. Aqueous use forms can be prepared from emulsion concentrates, pastes or wettable 20 powders (sprayable powders, oil dispersions) by adding water. To prepare emulsions, pastes or oil dispersions, the substances, as such or dissolved in an oil or solvent, can be homogenized in water by means of a wetting agent, tackifier, dispersant or emulsifier. Alternatively, it is also possible to prepare concentrates composed of active substance, wetter, tackifier, dispersant or emulsifier and, if appropriate, solvent or oil, 25 and such concentrates are suitable for dilution with water. The active compound concentrations in the ready-to-use preparations can be varied within relatively wide ranges. In general, they are from 0.0001 to 10%, preferably from 0.01 to 1%. If not otherwise specified, the solutions are prepared as follow: 30 The active ingredient is dissolved at the desired concentration in a mixture of 1:1 (vol/vol) distilled water : acteon. The test solution is prepared at the day of use. Test solutions are prepared in general at concentrations of 1000 ppm, 500 ppm, 300 ppm,100 ppm and 30 ppm (wt/vol). The active compounds may also be used successfully in the ultra-low-volume process 35 (ULV), by which it is possible to apply formulations comprising over 95% by weight of active compound, or even to apply the active compound without additives.
WO 2008/129060 66 PCT/EP2008/054924 Various types of oils, wetters, adjuvants, may be added to the active compounds, if appropriate not until immediately prior to use (tank mix). These agents can be admixed with the agents according to the invention in a weight ratio of 1:100 to 100:1, preferably 1:10 to 10:1. 5 Suitable adjuvants in this sense are in particular: organically modified polysiloxanes, for example Break Thru S 240*; alcohol alkoxylates, for example Atplus 245*, Atplus MBA 1303*, Plurafac LF 300* and Lutensol ON 30*; EO/PO block polymers, for ex ample Pluronic RPE 2035* and Genapol B®; alcohol ethoxylates, for example Luten sol XP 80*; and sodium dioctylsulfosuccinate, for example Leophen RA*. 10 In one embodiment, the method of the invention is directed to the transgenic plant according to table A, preferably Al by increasing or generating the activity as depicted in table B, column 5, preferably a polypeptide as depicted in SEQ ID NO:1 to 270, preferably a polypeptide encoded by a nucleic acid molecule as depicted in table B, column 1 or 3 and the active ingredient (B) is selected from the group consisting of 15 the groups B1, B2, B3, B4, B5, B6, B7, B8, B9, B10, B11, B12, B13, B14, B15, B16, B17, B18, B19, B20, B21, B22, B23, B24, B25, B26, B27, B28, B29, B30, B31, B32, B33, B34 and B35. The present examples illustrate the basic invention without being intended as limiting the subject of the invention. The content of all of the references, patent applications, patents and published patent 20 applications cited in the present patent application is herewith incorporated by refer ence. Examples Materials and Methods 25 Engineering Productivity-Enhanced Corn Plants by Expressing EST163 Genes Transformation of maize (Zea Mays L.) was performed using the construct NC027 (Figure 1). Immature embryos were co-cultivated with Agrobacterium tumefaciens that carry "super binary" vectors, and transgenic plants were recovered through organo 30 genesis (Ishida et al., 1996, Nature Biotech 14745-50). This procedure provided a transformation efficiency of between 2.5% and 20%. The transgenic plants were then screened for improved plant biomass demonstrating that transgene expression con fers productivity performance.
WO 2008/129060 67 PCT/EP2008/054924 Figure 1. Map of the construct NC027 of the gene of interest, EST163. The expres sion was driven by the promoter, ScBv, and AHAS was chosen as the selectable marker. Agrobacterium cells harboring the genes and the maize ahas gene on the same plas 5 mid were grown in YP medium supplemented with appropriate antibiotics for 1-3 days. A loop of Agrobacterium cells was collected and suspended in 2 ml M-LS-002 medium (LS-inf), and the tube containing Agrobactium cells was kept on a shaker for 1-3 hrs at 1,200 rpm. Corncobs [genotype J553x (HIIIAxA188)] were harvested at 7-12 days after pollina 10 tion. The cobs were sterilized in a 20% Clorox solution for 15 min followed by a thor ough rinse with sterile water. Immature embryos between 0.8 and 2.0 mm in size were dissected into the tube containing Agrobacterium cells in LS-inf solution. Agro-infection was carried out by keeping the tube horizontally in the laminar hood at room temperature for 30 min. Mixture of the agro infection was poured onto a plate 15 containing the co-cultivation medium (M-LS-011). After the liquid agro-solution was piped out, the embryos were plated on the co-cultivation medium with scutellum side up and cultured in the dark at 22C for 2-4 days. Embryos were transferred to M-MS-101 medium without selection. Seven to ten days later, the embryos were transferred to M-LS-401 medium containing 0.75 uM 20 imazethapyr where they were grown for 4 weeks to select for transformed callus cells. Plant regeneration was initiated by transferring resistant calli to M-LS-504 medium supplemented with 0.75 pM imazethapyr and grown under light at 26'C for 2 to 3 weeks. Regenerated shoots were then transferred to a rooting box with M-MS-607 medium (0.5 pM imazethapyr). 25 Plantlets with roots were transferred to potting mixture and grown in a growth cham ber for 1 week, then transplanted to larger pots and maintained in greenhouse until maturity. The seed was harvested, and the presence of the transgene was deter mined by resistance to imi herbicide or by the Taqman molecular analysis technique. 30 Seed Treatments J553x(HIIIAxA188) null and transgenic corn seeds of the T2 generation were treated with deionized water (Blank), 200 grams fipronil, 10 grams pyraclostrobin (F500), and 200 grams fipronil + 10 grams pyraclostrobin; all formulation rates were grams /100 kg 35 seed. Every formulation was applied to approximately 80 seeds. The formulation was WO 2008/129060 68 PCT/EP2008/054924 pipetted into a 125 ml flask along the sides and bottom of the flask before adding the seeds and shaking the flask for 30 seconds. The coated seeds were then removed from the flask and placed in a plastic dish for drying. 5 Plant Management - WUE Study of Plants with the NC027 Construct Transgene positive and negative corn seedlings for the transformation events, SDM 23881, SDM-23885, SDM-23889, SDM-23890, and SDM-23891 were transplanted into a pot 5-L pots. The pots were covered with lids that permit the seedlings to grow through but minimize water loss. Each pot was weighed periodically and water added 10 to maintain the initial water content (50% full water capacity). At the end of the ex periment, the fresh and dry weights of each plant were measured, the water con sumed by each plant was determined, and WUE of each plant was computed. Plant growth and physiological traits such as WUE, height, fresh weight, and dry weight were measured during the experiment. A comparison was made for every phenotype 15 between the transgene positive and negative plants. Plant Management - fipronil/pyraclostrobin Study Seventy-five 3-L pots per treatment (Blank, fipronil, pyraclostrobin, and fipronil + pyra clostrobin) were filled with potting media, labeled with colored stakes, and given a 20 unique barcode. One seed per pot was planted at a depth of approximately 2 cm and covered with media. The media was lightly watered to imbibe the seeds, while allow ing for ample oxygen exchange and so that the chemical coatings on the seeds re mained intact. After planting, the pots were randomly distributed into three replicate blocks (1 bench = 1 block), each with 25 plants of every treatment. 25 The plants were maintained in a greenhouse under optimal, well-watered conditions (80-90% field capacity) upon emergence. Supplemental nutrients were administered every third day during watering. The greenhouse temperature was maintained at 30'C, relative humidity at 75%, and light at 350 pmol m- 2 8 1 , in a 15-hour day / 9-hour night photoperiod. Supplemental lighting was provided using metal-halide lights. 30 Once per week, the pots were randomly mixed within each block. On day 21, the plants were imaged to collect the phenotypic data as described in the Imaging Procedures section. Leaves were sampled for transgene copy number on day 25 to identify the null and transgenic plants. On day 28, the plants were imaged 35 and then harvested to collect fresh weight. The presence of the transgene was de termined by the Taqman molecular analysis technique. Differences in the phenotypic WO 2008/129060 69 PCT/EP2008/054924 data collected during the imaging process and in fresh weight among the four treat ments and between the null and transgenic plants were assessed. The chemical by transgenic interactions were determined. 5 Imaging Procedures Imaging of the plants was facilitated using a LemnaTec Scanalyzer (WOrselen, Ger many), which includes a conveyor belt, an imaging station, a watering station, and computers for collecting, processing, and storing the image data. The cameras have a resolution of 1280 X 960 pixels and operate in 24-bit color. 10 The plants were manually transferred by block onto the conveyor system of the sca nalyzer. Each plant was then moved through the imager automatically. At the imaging station, cameras collected the top view image and two side view images. The side view images were the transverse view and the view parallel with the plane of the plant. 15 As described in the formula (see Appendix A), the scanalyzer calculates plant volume as a number of pixels. To assign a physiologically meaningful value to the volume measurements, a separate experiment was conducted. The plants were scanned with the scanalyzer then harvested. The plant material was placed into a graduated cylin der filled to a known volume with water. The difference between the water plus plant 20 material and water alone provided a known plant volume in mL. The number of Lem naTec calculated volume pixels divided by the number of mL per plant indicated that about 36,000 pixels is equivalent to 1 mL of plant volume. Using the LemnaTec scanalyzer, we collected stem width; stalk volume; top, trans verse, and parallel view plant areas; top, transverse, and parallel view green and yel 25 low pixel counts; stem length; leaf angles and internode lengths through leaf 5; plant width and height; total leaf length; and total plant length. Results (format of the following text needs to be corrected) 30 Testing Enhancement of NC027 As shown in Table 1, the transgenic plants exhibited significant improvements in fresh weight (FW), dry weight, and plant volume. On average, fresh weight increased 6.5%, dry weight increased 7%, and plant volume increased 10.7%. All three were signifi 35 cant at 95% level of probability according to Analysis of Variance. Table 1. Average percent change in growth between transgenic plants and their null siblings for 5 NC027 events in two experiments. Asterisks (*) indicate significance at 95%.
WO 2008/129060 70 PCT/EP2008/054924 Lemnatec Lemnatec Lemnatec Measured Measured Plant Vol- Plant Experiment Event FW ume Length FW Dry Wt 1 SDM-23881 8.5 18.2 -5.7* 6.3 8.1 1 SDM-23885 0.3 -0.2 -10.5* 2.2 2.1 1 SDM-23889 -2.0 -1.3 1.7 1.2 4.0 1 SDM-23890 0.1 9.2 1.3 3.2 3.0 1 SDM-23891 11.8* 8.1 3.5 7.3 8.5* 1 Average 5.2* 10.7* -2.0 6.5* 7.0* Testing Enhancement of Chemical Amendments to Trangenic Plants In an initial trial, the phenotypes that showed treatment by genotype interactions at 5 95% significance included internode length and green vs. yellow plant material (Ta bles 2-5). At 80% significance, leaf angle and plant area were also included (Tables 6 7). fipronil enhanced greenness, internode length, leaf angle, and plant area relative to all other treatments. Other phenotypes showing significance for transgenic and treatment effects included fresh weight, plant and volume, number of fully expanded 10 leaves, stem length, and View 3 size (Tables 8-10). Table 2. Values for internode length in all treatments, measured in cm. The single asterisk (*) indicates a significant treatment by geno type effect at 95%. Small letters indicate significant differences 15 between treatments at 95% confidence, and capital letters indi cate differences at 99%. Internodel* Internode2 lnternode3 Null Trans Avg Test Null Trans Avg Test Null Trans Avg Test Blank 34.1 35.0 34.6 a 40.3 36.8 38.5 a 35.4 40.0 37.8 a F500 32.5 35.9 34.3 ac 36.0 40.4 38.4 ac 38.8 42.1 40.7 ac Fipronil 35.3 36.6 35.9 ac 45.9 42.5 44.2 BD 42.4 37.7 40.0 ac Fipronil + F500 33.4 27.6 30.7 BDE 38.1 36.6 37.4 acE 32.6 32.7 32.6 bDE Average 33.8 33.9 33.9 40.1 39.2 39.7 37.2 38.3 37.8 Test a a a a a a Table 3. Values for yellow, medium green, and dark green pixels 20 counts in all treatments in the parallel view. The single asterisk (*) indicates a significant treatment by genotype effect at 95%. Small letters indicate significant differences between treatments at 95% confidence, and capital letters indicate differences at 99%. 25 Yellow Count* Medium Green Count Dark Green Count* Null Trans Avg Test Null Trans Avg Test Null Trans Avg Test Blank 1777.7 1956.1 1866.9 A 5648.8 5876.9 5762.8 a 16259.9 15850.4 16055.2 a F500 2006.6 2088.1 2051.9 A 5691.8 6522.1 6153.1 a 14727.7 15010.4 14884.7 B WO 2008/129060 71 PCT/EP2008/054924 Fipronil 1609.1 1806.0 1708.9 Ac 5470.9 5848.7 5662.4 ac 15955.0 16812.3 16389.5 aC Fipronil + F500 2496.2 3486.3 2970.9 BCD 6605.8 7106.0 6845.6 BCD 13381.2 11886.3 12664.5 BCD Average 1981.7 2321.1 2154.9 5872.6 6341.2 6111.8 15049.9 14913.7 14980.4 Test a b a b a a 5 Table 4. Values for yellow and medium green pixels counts in all treat ments in the transverse view. Small letters indicate significant differences between treatments at 95% confidence, and capital letters indicate differences at 99%. Medium Green Count Yellow Count Null Trans Avg Test Null Trans Avg Test Blank 8861.5 9198.8 9030.2 a 3625.4 3837.4 3731.4 a F500 9303.7 9809.2 9584.5 bc 4081.7 4343.5 4227.2 b Fipronil 9132.8 9046.4 9089.0 ade 3268.7 3455.9 3363.6 aC Fipronil + F500 9591.0 9251.6 9428.3 ace 4959.3 5865.9 5394.0 BCD Average 9230.4 9340.1 9286.4 4000.0 4365.7 4186.7 Test a a a b 10 Table 5. Values for medium green pixels counts in all treatments in the top view. Small letters indicate significant differences between treatments at 95% confidence, and capital letters indicate dif 15 ferences at 99%. Medium Green Count Null Trans Avg Test Blank 17563 17866 17715 a F500 17893 19062 18542 a Fipronil 17038 17881 17465 ac Fipronil + F500 19152 19720 19424 Bd Average 17935 18642 18296 Test a a 20 Table 6. Values for leaf angle in all treatments, measured in degrees. This phenotype was significant at 80% confidence. Small let ters indicate significant differences between treatments at 95% confidence, and capital letters indicate differences at 99%. 25 Leaf Angle 0 Leaf Angle 1 Null Trans Avg Test Null Trans Avg Test Blank 62.7 69.6 66.2 a 51.3 33.6 42.4 a F500 39.2 52.5 46.6 bc 36.5 38.2 37.4 ab Fipronil 57.5 68.7 63.2 acd 63.6 54.4 58.9 acd WO 2008/129060 72 PCT/EP2008/054924 Fipronil + F500 43.9 36.6 40.5 BcE 47.8 16.8 33.2 abE Average 50.8 56.9 53.9 50.1 36.2 43.0 Test a a a b Table 7. Values for plant area in the parallel view in all treatments, measured in pixels. This phenotype was significant at 80% con 5 fidence. Small letters indicate significant differences between treatments at 95% confidence, and capital letters indicate dif ferences at 99%. Plant Area Null Trans Avg Test Blank 23686.4 23683.3 23684.8 a F500 22426.2 23620.6 23089.7 a Fipronil 23035.0 24467.0 23760.8 ac Fipronil + F500 22483.1 22478.7 22481.0 Bd Average 22904.2 23576.0 23247.1 Test a b 10 Table 8. Values for whole plant phenotypes in all treatments. Fresh weight was hand-collected and measured in grams. Plant height was LemnaTec calculated and measured in cm. Plant volume was measured in pixels. Small letters indicate significant differ ences between treatments at 95% confidence, and capital let 15 ters indicate differences at 99%. Fresh Weight Plant Height Plant Volume Null Trans Avg Test Null Trans Avg Test Null Trans Avg Test Blank 162.9 155.2 159.0 a 477.4 479.4 478.4 a 6.58E+06 6.60E+06 6.59E+06 a F500 155.7 155.0 155.3 ac 469.9 481.7 476.5 a 6.18E+06 6.63E+06 6.43E+06 a Fipronil 160.9 164.7 162.8 ace 478.7 486.1 482.5 a 6.53E+06 6.86E+06 6.70E+06 ac Fipronil + F500 144.0 152.8 148.2 BdF 478.3 481.1 479.7 a 6.19E+06 6.10E+06 6.15E+06 BD Average 155.6 157.0 156.3 476.3 482.2 479.3 6.37E+06 6.55E+06 6.46E+06 Test a a a b a a Table 9. Values for leaf number and stem length in all treatments. 20 Stem length was measured in cm. Small letters indicate signifi cant differences between treatments at 95% confidence, and capital letters indicate differences at 99%. # Fully Expanded Leaves Stem Length Null Trans Avg Test Null Trans Avg Test Blank 3.2 3.4 3.3 a 107.3 117.6 112.5 a F500 2.9 3.1 3.0 a 97.2 110.2 104.4 ac Fipronil 3.1 3.0 3.0 a 110.4 107.1 108.8 ac Fipronil + F500 2.9 2.5 2.7 B 86.7 77.4 82.2 BD WO 2008/129060 73 PCT/EP2008/054924 Average 3.0 3.0 3.0 100.2 103.3 101.8 Test a a a a Table 10. Values for stalk area from the transverse view. Small letters indicate significant differences between treatments at 95% con 5 fidence, and capital letters indicate differences at 99%. Pixel Count Null Trans Avg Test Blank 4881 5138 5010 a F500 4725 4723 4724 ac Fipronil 5081 4744 4910 ac Fipronil + F500 4375 4196 4289 BdE Average 4760 4699 4729 Test a a Longer internode length may have represented better plant growth. A higher 10 percentage of green pixels per plant area implies that the plant had greater photosynthetic capacity. Similarly, when the preponderance of yellow pixels may have indicated that the plant was experiencing some measure of stress causing chlorosis. Larger leaf angles implies that leaves were laying flatter and thus received 15 more photosynthetic radiation, and larger plant area suggests that there was more leaf surface area for photosynthesis. In general, fipronil enhanced fresh mass, plant volume, plant height, and plant width as well. The effect of chemical amendments was enhanced when applied to transgenic 20 plants indicating a significant chemical by trangene interaction, as exemplified by the effects on internode length and changes in leaf angle. Variable Interaction SS MS FValue ProbF Internode treatment*CopyCall 1805.79 601.9298 3.56 0.0142 Sideview-yellow treatment*CopyCall 13579567 4526522 2.81 0.0389 Sideview-darkgreen_ treatment*CopyCall 96292593 32097531 2.6 0.0516 In a second trial, the phenotypes that showed treatment by genotype interac 25 tions at 95% significance included plant volume, calculated fresh weight, side plant area, and dark green pixel count (Table 11). Plant volume and dark green pixel count were significant at 99% for the pyraclostrobin treatment. In WO 2008/129060 74 PCT/EP2008/054924 general, pyraclostrobin enhanced plant size and photosynthetic health. The effect of chemical amendments was enhanced when applied to transgenic plants indicating a significant chemical by trangene interaction. Increases in plant volume, fresh weight, and plant area show an enhancement 5 of plant growth. A higher percentage of green pixels per plant area may imply increased photosynthetic capacity. Similarly, a preponderance of yellow pixels indicates some measure of stress, causing chlorosis. A larger plant area suggests that more leaf surface area is available for photo synthesis. 10 Results from both days 21 and 28 followed the same trends. Table 11. Values for plant volume, fresh weight, and plant greenness. Small letters indicate significant differences be tween treatments at 95% confidence, and capital letters indi cate differences at 99%. 15 Plant Volume (M pixels) CalcFreshWeight (g) Broad Side Plnt Area (pixels) Treatment Null Trans Avg Test Null Trans Avg Test Null Trans Avg Test Blank 7_26 9.43 8.36 a 83,26 101.45 92.37 a 2 34714.96 32248.57 a Control 8.42 8.65 8.53 ac 99.33 94,37 96.85 ac 32106.05 31843.49 31974.77 ac F500 9.90 11.04 10.47 Bde 100.53 110.41 105.47 bcd 36740.30 39599.17 38169.74 bde Fip + F500 9.56 9.94 9.75 acef 99.33 105.42 102.38 acde 37117.46 37053.24 37085.35 adef Fipronil 8.89 9.50 9.19 acef 99.88 101.65 100.77 acde 36398.18 34428.06 35413.12 acef Average 8.82 9.68 9.25 96.22 102.41 99.31 34443.87 35397.68 34920.78 Test a a a a a a Top Drk Grn (pixels) Broad Side Drk Grn (pixels) Narrow Side Drk Gm (pix) Treatment Null Trans Avg Test Null Trans Avg Test Null Trans Avg Test Blank S C,35 55954.94 53075.14 a 2 23051.09 21896.48 a 21603A 25317.00 23460.24 a Control 58874.73 56391.61 57633.17 ac 22733.68 21788.39 22261.04 ac 26482.95 25010.75 25746.85 ac F500 57676.78 62307.07 59991.92 Bcd 26088.87 27881.04 26984.96 Bde 26394.93 28392.28 27393.61 bcd Fip + F500 56384.17 56031.02 56207.60 acde 26769.63 26003.90 26386.77 bdef 26203.26 27419.26 26811.26 acde Fipronil 56608.71 57655.69 57132.20 acde 26176.97 23958.33 25067.65 acef 24703.55 27235.14 25969.34 acde Average 55800.19 57661.27 56730.73 24512.31 24435.34 24473.82 25053.73 26633.30 25843.52 Test a a a a a a Variable Interaction SS MS FValue ProbF Internode treatment*CopyCall 1805.79 601.9298 3.56 0.0142 Sideview-yellow treatment*CopyCall 13579567 4526522 2.81 0.0389 Sideview-darkgreen_ treatment*CopyCall 96292593 32097531 2.6 0.0516 Conclusions 20 WO 2008/129060 75 PCT/EP2008/054924 Chemical amendments enhance plant performance of transgenic and non-transgenic plants through manipulation of whole plant architecture and size, leaf color, and leaf morphology, among others. Administering combinations of chemical amendments carefully with transgenic plants may stimulate an even greater effect. The benefits will 5 include greater plant performance in stress conditions, whether biotic or abiotic in na ture, leading to increased yield and economic benefit. Appendix A Dry Weight - A measurement of the dry weight of the plant in grams. After harvest, the plants are placed into a drying oven set at 650C, dried for a minimum of 72 hours, 10 then weighed. Fresh Weight - A measurement of the fresh weight of the plant in grams. Hand collected fresh weight is measured by harvesting the plant and weighing it on a bal ance. LemnaTec fresh weight is calculated by the scanalyzer based on plant volume and plant age. The zoom angles of the camera lenses are normalized using a calibra 15 tion table. Internode length - Internode length is measured from leaf collar to leaf collar up the stem. Internode 1, for example, is measured from Leaf 0 to Leaf 1. Reported in cm. Leaf Angle - A measurement of the angle of the leaf. The vectors for the angle are from the base of the leaf horizontally to the leaf tip and vertically up the plant stalk. 20 The measured angle is from the stalk above the leaf to the leaf tip, reported in de grees. Number of Fully Expanded Leaves - A count of the number of leaves with a recog nizable leaf collar. Parallel View Plant Area - A count of the total number of pixels of the plant as imaged 25 from the parallel side. Parallel View Dark Green Pixels - A count of the total number of user-defined dark green pixels as imaged from the parallel side. Indicates photosynthetic health of the plant. Parallel View Medium Green Pixels - A count of the total number of user-defined dark 30 green pixels as imaged from the parallel side. Indicates initial onset of chlorosis in the plant. Parallel View Yellow Pixels - A count of the total number of user-defined yellow pix els as imaged from the parallel side. Indicates chlorosis in the plant.
WO 2008/129060 76 PCT/EP2008/054924 Plant Height - A measurement from the base of the stem to the collar of the last fully expanded leaf, reported in cm. Plant Volume - Calculated from the pixel counts of the three images and reported in pixels according to the formula: 5 Volume = (top view x transverse view x parallel view pixels)0 Plant Width - A measurement of the breadth of the plant from left-most leaf tip to right-most leaf tip. Stalk Volume - Measured from the base of the plant to the last expanded leaf. Incor porates the pixel counts from the transverse and parallel view images, reported in 10 pixels. Stem Length - A measurement of the stem length from the base of the plant to the last fully expanded leaf, reported in cm. Stem Width - A measurement of the stem at the base of the plant in the transverse view, reported in mm. 15 Top View Plant Area - A count of the total number of pixels of the plant as imaged from above. Top View Dark Green Pixels - A count of the total number of user-defined dark green pixels as imaged from above. Indicates photosynthetic health of the plant. Top View Medium Green Pixels - A count of the total number of user-defined dark 20 green pixels as imaged from the parallel side. Indicates initial onset of chlorosis in the plant. Top View Yellow Pixels - A count of the total number of user-defined yellow pixels as imaged from above. Indicates chlorosis in the plant. Total Leaf Length - A sum of all leaves as measured from the base to the tip of each 25 leaf, reported in cm. Total Plant Length - A measurement from the base of the stem to the tip of the high est most leaf, reported in cm. Transverse View Plant Area - A count of the total number of pixels of the plant as imaged from the transverse side. 30 Transverse View Dark Green Pixels - A count of the total number of user-defined dark green pixels as imaged from the transverse side. Indicates photosynthetic health of the plant.
WO 2008/129060 77 PCT/EP2008/054924 Transverse View Medium Green Pixels - A count of the total number of user-defined dark green pixels as imaged from the parallel side. Indicates initial onset of chlorosis in the plant. Transverse View Yellow Pixels - A count of the total number of user-defined yellow 5 pixels as imaged from the transverse side. Indicates chlorosis in the plant. Transverse View Stalk Area - A count of the total number of pixels of the stalk from the transverse view. Those of ordinary skill in the art will recognize, or will be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of 10 the invention described herein. Such equivalents are intended to be encompassed by the following claims.
WO 2008/129060 78 PCT/EP2008/054924 Table B Li- 1 2 3 4 5 ne/ Co lum n Gene Publicati- SEQ Source organ- Gene Annotation/Function/Activity Name/ on No ID ism Locus ID NO. in the resp. publi cation 1. ATACCD W02007 2 Arabidopsis ATACCD 011625 thaliana 2. ATAGR1 W02007 2 Arabidopsis ATAGR1 011771 thaliana 3. ATHLS W02007 2,6 Arabidopsis N-ACETYL TRANSFERASE 011681 thaliana PROTEIN FROM ARABIDOPSIS THALIANA 4. ATSHMT US2006/ 2 Arabidopsis GLYCINE HYDROXYMETHYL 4 027384 thaliana TRANSFERASE 5. ATSTE24 W020021 3,4 Arabidopsis ARABIDOPSIS THALIANA PRE 16625 thaliana NYLPEPTIDASE 6. b2699 W02007 159 E. coli (0/1061)DNA STRAND EX 020198 CHANGE, RENATURATION 7. b2965 W02006 797, E. coli ORNITHINE DECARBOXYLASE 069610 9163 6 8. BN45412 W02004/ 517 Brassica napus RHO1PS HOMOLOG/RAC-LIKE 825 092398 PROTEIN 9. BN51473 W02004/ Brassica napus ASPARTYLAMINO PEPTIDASE 779 092398 10. B0730 W02006/ 3422 E. coli TRANSCRIPTION REGULATOR 069610 9,291 63,24 084,4 465,1 7105, 2261 0,197 85,41 8, 2049 11. b1830 W02004/ 259, E. coli CARBOXY-TERMINALPROTEASE 092398 260 FOR PENICILLIN-BINDING PRO TEIN3 WO 2008/129060 79 PCT/EP2008/054924 12. b2664 W02004/ 263, E. coli PUTATIVE TRANSCRIPTIONAL 092398 264 REGULATOR 13. b2082 W02004/ 253, E. coli PROPHAGE P2OGR PROTEIN 092398 254 14. b2799 W02004/ 265, E. coli L-1 092398 266 15. b2148 W02004/ 249, E. coli METHYL-GALACTOSIDE TRANS 092398 250 PORT, GALACTOSETAXIS 16. b2796 W02004/ 251, E. coli PROBABLE SERINE TRANSPOR 092398 252 TER 17. b3116 W02006 258 E. coli ANAEROBICALLY INDUCIBLE L 069610 THREONINE 18. b0124 W02004/ 255, E. coli GLUCOSE DEHYDROGENASE 092398 256 19. EST102 US20070 016, Physcomitrella 028333 5, 6 patens 20. EST12 US20070 883, Physcomitrella 157343 11, patens 18 21. EST134 US20070 688, Physcomitrella 261131 5,8 patens 22. PpPK_E US7,176, 176, ST142 026 026, 5, 6 23. PpAPS_ US20070 282, Physcomitrella TRANSCRIPTION FACTOR EST163 192908 9, 17 patens 24. PpGBP- US20041 6,11 Physcomitrella SMALL GTP-BINDING PROTEIN 1_EST20 0194163 patens SAR1BNT 3 25. EST217 US20070 246, Physcomitrella 157344 8,13 patens 26. EST255 US6,677, 677, 504 504, 10, 18 27. EST266 US7,166, 166, 767 767, 6,11 28. EST268 W02006 8, 133983 477, 7,12 29. PpCK- W02006 105, 3_EST28 020717 723, 9 11, 12 30. EST293 US20070 902, Physcomitrella 157334 20, patens WO 2008/129060 80 PCT/EP2008/054924 33 31. EST295 W02003 12 Physcomitrella- LEUCINE-RICH REPEAT TRANS 040171 patents MEMBRANE PROTEIN KINASE 32. PpZFES US2004/ 12, Physcomitrella ZINO-FINGERPROTEIN T307 0107463 20 patents 33. EST335 US2004/ 5,8 Physcomitrella PUTATIVE CDC21 PROTEIN 0128721 patents 34. PpSCLE W02006/ 1,2 Physcomitrella SCARE CROW-LIKE TRAN ST386 044912 patents SCRIPTION FACTOR 14(S0L14) 35. PpCBF_ US7,164, 164, EST39 057 057, 10, 17 36. EST391 US20070 646, Physcomitrella 079400 129, patents 130 37. EST4 US7,091, 091, 402 402, 2,3 38. pPP2A- W02002 8,13 Physcomitrella TYPE 2A PROTEIN PHOSPHA 4 EST43 46442 TASE-1 0 39. EST443 US20070 353, Physcomitrella 157345 8,9 patents 40. EST46 US7,125, 125, 719 719, 5,6 41. EST472 US20040 750, Physcomitrella 148658 1,2 patents 42. EST512 W02006/ 5,6 Physcomitrella PHYTOCHROME ASIGNAL 044912 patents TRANSOUCTIONi(PATI) 43. PpVTP_E W02006/ 1,2 Physcomitrella RA3C ST513 050038 patens 44. PpLLPK_ W02006 2. Physcomitrella PUTATIVE LECTIN-LIKE PRO EST557 134162 patens TEIN KINASE 45. EST65 US2003/ 11, Physcomitrella TRANSCRIPTIONAL REGULATOR 0172408 12 patens 46. GM52570 W02006 968 Glycine max VESICLE TRANSPORT V-SNARE 278 032708 PROTEIN 47. GM59556 W02006/ 7,8 Glycine max (124/2079)SCARE CROW-LIKE 757 044912 TRANSCRIPTION FAC TOR8(SCL8) 48. GM59587 W02006 834 Glycine max PUTATIVE PROTEINKINASE 863 032708 49. GM59594 W02003 18,20 Glycine max (1861106)TYPE2APROTEINPHO 1 1319 020914 ,22 p SPHATASE-1 WO 2008/129060 81 PCT/EP2008/054924 50. GM59629 W02006 914 Glycine max PUTATIVE CASEINKINASEI 961 032708 51. At3g2457 W02004 2 Arabidopsis ARABIDOPSIS THALIANA 0 074440 thaliana AT3G24570 PROTEIN 52. YDR071 W02004/ 289, Sacoharomyces POLYAMINE ACETYL TRANSFE C 092398 290 cerevisiae RASE 53. YGL239c W02004/ 7,8 Sacharomyces HYPOTHETICAL PROTEIN 092398 cerevisiae 54. YBR288C W02004/ 59, Saccharomyces MU3-LIKE SUBUNIT OF THE 092398 60 cerevisiae CLATHRIN ASSOCIATED PRO TEIN COMPLEX(AP-3) 55. YBR258C W02004/ 61, Saccharomyces SUBUNIT OF THE COM 092398 62 cerevisiae PASS(SET1C)COMPLEX 56. YCL001w US2004/ 63, Saccharomyces D0M34 PROTEIN HOMOLOG -a 011888 64 cerevisiae 57. YBR274w W02004/ 65, Sacoharomyces DNA DAMAGE CHECKPOINT EF 092398 66 cerevisiae FECTORKINASE 58. YCLO27w W02004/ 273, Saccharomyces CELL FUSION PROTEIN 092398 274 cerevisiae 59. YBL6Ow W02004/ 9, 10 Saccharomyces HYPOTHETICAL PROTEIN 092398 cerevisiae 60. YHR090c W02004/ 67, Saccharomyces SUBUNIT OF THE NUA4 HIS 092398 68 cerevisiae TONE ACETYLTRANSFERASE COMPLEX THAT ACETYLATES HISTONE H4, H2A; HAS SIMILAR ITY TO THE HUMAN TUMOR SUPPRESSORING 61. YGR121c W02004/ 69, Saccharomyces AMMONIUM TRANSPOR TPRO 092398 70 cerevisiae TEINMEPI 62. YGR127 W02004/ 71, Saccharomyces HYPOTHETICAL PROTEIN w 092398 72 cerevisiae 63. YGR16Lc W02004/ 287, Saccharomyces PROTEIN PHOSPHATASE TY 092398 288 cerevisiae PE2A 64. YKL051w W02004/ 77, Saccharomyces PLASMA MEMBRANE PROTEIN 092398 78 cerevisiae THAT MAY ACT TO GET HER WITH OR UPSTREAM OF STT4P TO GENERATE NORMAL LEVEL SOFTHE ESSENTIAL PHOS PHOLIPID P14P 65. YKL103C W02004/ 283, Saccharomy AMINOPEPTIDASE YSCI 092398 284 ces cerevisiae 66. YKLO17c W02004/ 83, Saccharomyces DNA HELICASEl; H S P 092398 84 cerevisiae 67. YKL132c W02004/ 87, Saccharomyces SIMILAR TO FOLYL 092398 88 cerevisiae POLYGLUTAMATE SYNTHASE RMA1P 68. YGR126 W02004/ 89, Saccharomyces PUTATIVE PROTEIN OF UN- WO 2008/129060 82 PCT/EP2008/054924 w 092398 90 cerevisiae KNOWN FUNCTION 69. YKL058w W02004/ 93, Saccharomyces TOA2TFIIA SUBUNIT (TRAN 092398 94 cerevisiae SCRIPTION INITIATION FACTOR) 70. YIL023c W02004/ 243, Saccharomyces YEAST KE4 092398 244 cerevisiae 71. YHR195 W02004/ 99, Saccharomyces NUCLEAR ENVELOPEP ROTEIN w 092398 100 cerevisiae THAT INTERACTS WITH THE VACUOLARMEMBRANE PRO TEIN VAC8P TO PROMOTE FORMATION OF NUCLEUS VACUOLE JUNCTIONS DURING PIECEMEAL MICRO AUTO PHAGYOFTHENUCLEUS 72. YIR022w W02004/ 101, Saccharomyces SIGNAL PEPTIDASE SUBUNIT 092398 102 cerevisiae SEC11P 73. YJL172w W02004/ 105, Saccharomyces VACUOLAR CARBOXYPEPTIDA 092398 106 cerevisiae SE YSCS 74. YHR113 W02004/ 107, Saccharomyces CYTOPLASMIC ASPARTYLAMI W 092398 108 cerevisiae NOPEPTIDASE] 75. YGR141 W02006 84 Saccharomyces VACUOLAR PROTEIN SORTING w 032708 cerevisiae (VPS) PROTEIN REQUIRED FOR CYTOPLASM TO VACUOLE TARGETING OF PROTEINS 76. YHR175 W02004/ 109, Saccharomyces PUTATIVE LOW-AFFINITY COP w 092398 110 cerevisiae PERTRANSPORTER OF THE VACUOLARMEMBRANE 77. YGR212 W02004/ 111, Saccharomyces N-ACETYLTRANSFERASE w 092398 112 cerevisiae 78. YGR180c W02004/ 115, Saccharomyces RNR4 RIBONUCLEOTIDERE 092398 116 cerevisiae DUCTASE 79. YJL179W W02004/ 117, Saccharomyces PREFOLDIN SUBUNIT1; PUTA 092398 118 cerevisiae TIVE HOMOLOG OF SUBUNIT 1 OF BOVINE PREFOLDIN 80. YJL001W W02004/ 119, Saccharomyces 20S PROTEASOME BETA-TYPE 092398 120 cerevisiae SUBUNIT 81. YJL208c W02004/ 121, Saccharomyces NUC1_YEAST MITOCHONDRIAL 092398 122 cerevisiae NUCLEASE 82. YJL152W W02004/ 123, Saccharomyces HYPOTHETICALPROTEIN 092398 124 cerevisiae 83. YGL166w W02004/ 11, Saccharomyces CUP2 COPPER-DEPENDENT 092398 12 cerevisiae TRANSCRIPTION FACTOR 84. YJL151c W02004/ 127, Saccharomyces SNA3 INTEGRAL MEMBRANE 092398 128 cerevisiae PROTEIN LOCALIZED TO VACUOLAR INTRALUMENAL VESICLE 85. YLR441c W02004/ 129, Saccharomyces RPS1A RIBOSOMALPROTEIN 092398 130 S3A.E WO 2008/129060 83 PCT/EP2008/054924 86. YLR029C W02004/ 135, Saccharomyces PROTEIN COMPONENT OF THE 092398 136 cerevisiae LARGE(60S) RIBOSOMAL SUB UNIT 87. YFR042 W02004/ 279, Saccharomyces PUTATIVE PROTEIN OF UN W 092398 280 cerevisiae KNOWN FUNCTION 88. YLR210w W02006 Saccharomyces B-TYPE CYCLIN INVOLVED IN 032708 cerevisiae CELLCYCLE PROGRESSION 89. YLR173w W02006 Saccharomyces HYPOTHETICAL PROTEIN 032708 cerevisiae 90. YLLO41c W02004/ 137, Saccharomyces IRON-SULFUR PROTEIN SUB 092398 138 cerevisiae UNIT OF SUCCINATE DEHY DROGENASE (SDH1P 91. YKL150w W02006 Saccharomyces MCR1 CYTOCHROME-B5 RE 032708 cerevisiae DUCTASE 92. YLR105c W02004/ 139, Saccharomyces SUBUNIT OF THE TRNASPLIC 092398 140 cerevisiae ING ENDONUCLEASE 93. YIL136w W02004/ 141, Saccharomyces OM45 PROTEIN OF THE OUTER 092398 142 cerevisiae MITOCHONDRIAL MEMBRANE 94. YLR224 W02004/ 223, Saccharomyces F-BOX PROTEIN, COMPONENT W 092398 224 cerevisiae OF SCF UBIQUITIN LIGASECOM PLEXES INVOLVED INUBIQUIT IN DEPENDENT PROTEINCATABO LISM; READILY MONO UBIQUITIN ATED INVITRO BY SCF-UBC4 COMPLEXES 95. YGL106 W02004/ 239, Saccharomyces ESSENTIAL LIGHT CHAINFOR W 092398 240 cerevisiae MYOSIN MYO2P; MAY STABILIZE MYO2P BY BINDING TO THE NECK REGION; MAY INTERACT WITH MYO1P 96. YLR215c W02004/ 143, Saccharomyces PROTEIN INVOLVED IN NUTRI 092398 144 cerevisiae TIONAL CONTROL OF THE CELLCYCLE; REGULATES ABUNDANCE OF THE TRANSLA TION INITIATION FACTOR EIF2; ORTHOLOG OF HUMAN D123 PROTEIN 97. YLR274w W02006 Saccharomyces COMPONENT OF THE 032708 cerevisiae HEXAMERIC MCM COMPLEX 98. YMR260 W02004/ 147, Saccharomyces TRANSLATION INITIATION FAC C 092398 148 cerevisiae TOR EIF1A 99. YNL120C W02004/ 149, Saccharomyces DUBIOUS OPEN READINGFRAME 092398 150 cerevisiae UNLIKELY TO ENCODE A PRO TEIN 100. YMR154c W02004/ 227, Saccharomyces CALPAIN-LIKE PROTEASE IN 092398 228 cerevisiae VOLVED IN PROTEOLYTIC ACTI VATION OF RIM101P IN RE SPONSE TO ALKALINE PH WO 2008/129060 84 PCT/EP2008/054924 101. YNL090 W02004/ 285, Saccharomyces NON-ESSENTIAL SMALL W 092398 286 cerevisiae GTPASE OF THE RHO/RAC SUB FAMILY OF RAS-LIKE PROTEINS 102. YNL108c W02006 Saccharomyces PROTEIN OF UNKNOWN FUNC 032708 cerevisiae TION LOCALISED TO CYTO PLASM, NUCLEUS 103. YNL141w W02006 Saccharomyces AAH1 ADENOSINE DEAMINASE 032708 cerevisiae 104. YLR407 W02004/ 151, Saccharomyces PUTATIVE PROTEIN OF UN W 092398 152 cerevisiae KNOWN FUNCTION 105. YNL079C W02004/ 277, Saccharomyces TPM1TROPOMYOSIN1 092398 278 cerevisiae 106. YMR197c W02004/ 154 Saccharomyces PROTEIN INVOLVED IN CIS 092398 cerevisiae GOLGI MEMBRANE TRAFFIC; V SNARE THAT INTERACTS WITHT WOT-SNARES 107. YMR100 W02004/ 155, Saccharomyces PROTEIN OF UNKNOWN FUNC W 092398 156 cerevisiae TION 108. YMR210 W02004/ 157, Saccharomyces PUTATIVE ACYLTRANSFERASE w 092398 158 cerevisiae WITH SIMILARITY TO EEB1PANDEHT1P 109. YMR069 W02004/ 161, Saccharomyces NAT4N-ALPHAACETYL w 092398 162 cerevisiae TRANSFERASE (N-TERMINAL RESIDUES OF HISTONE SH4, H2A) 110. YMR118c W02004/ 219, Saccharomyces PROTEIN OF UNKNOWN FUNC 092398 220 cerevisiae TION WITH SIMILARITY TO SUC CINATE DEHYDROGENASE CY TOCHROMEB SUB UNIT;YMR118C IS NOT AN ES SENTIAL GENE 111. YNL076w W02004/ 163, Saccharomyces Gill 3019651EMBICAA95950.1 |OR 092398 164 cerevisiae FYNL076W 112. YNL024c W02004/ 165, Saccharomyces PUTATIVE PROTEIN OF UN 092398 166 cerevisiae KNOWN FUNCTION WITH SEVEN BETA-STRAND METHYL TRANSFERASE MOTIF 113. YNL125c W02004/ 167, Saccharomyces PROTEIN WITH SIMILARITY TO 092398 168 cerevisiae MONOCARBOXYLATE PER MEASES 114. YNL029c W02004/ 169, Saccharomyces PUTATIVE MANNOSYL TRANS 092398 170 cerevisiae FERASE INVOLVED IN PROTE INGLYCOSYLATION; MEMBER OF THE KRE2/MNT1 MANNO SYLTRANSFERASE FAMILY 115. YMR115 W02004/ 171, Saccharomyces HYPOTHETICAL ORF w 092398 172 cerevisiae 116. YNL282 W02006 166 Saccharomyces SUBUNIT OF BOTH RNASE MRP WO 2008/129060 85 PCT/EP2008/054924 W 032708 cerevisiae 117. YALO46c W02004/ 15, Saccharomyces HYPOTHETICAL PROTEIN 092398 16 cerevisiae 118. YNL244c W02004/ 173, Saccharomyces TRANSLATION INITIATION FAC 092398 174 cerevisiae TOR EIF1; COMPONENT OF A COMPLEX INVOLVED IN REC OGNITION OF THE INITIATOR CODON; MODULATES TRANS LATION ACCURACY AT THE INI TIATION PHASE 119. YNL334c W02004/ 175, Saccharomyces SNO2 PROTEIN IS RELATED 092398 176 cerevisiae WITH B(1)BIOSYNTHESIS DUR ING THE EXPONENTIAL PHASE 120. YNR029c W02006 Saccharomyces HYPOTHETICAL PROTEIN 032708 cerevisiae 121. YNRO18 W02004/ 177, Saccharomyces PROTEIN OF UNKNOWN FUNC w 092398 178 cerevisiae TION LOCALISED TO MITO CHONDRIA 122. YNL277w W02004/ 179, Saccharomyces L-HOMOSERINE-O 092398 180 cerevisiae ACETYLTRANSFERASE 123. YOL118c W02004/ 181, Saccharomyces HYPOTHETICAL PROTEIN 092398 182 cerevisiae 124. YOL123w W02004/ 183, Saccharomyces SUBUNIT OF CLEAVAGE FAC 092398 184 cerevisiae TORI 125. YOR020c W02004/ 185, Saccharomyces 10KDA HEAT SHOCK PROTEIN 092398 186 cerevisiae 126. Y- W02006 Saccharomyces HYPOTHETICAL PROTEIN OR154w 032708 cerevisiae 127. YOL1 16w W02004/ 187, Saccharomyces TRANSCRIPTIONAL ACTIVATOR 092398 188 cerevisiae 128. Y- W02006 Saccharomyces MITOCHONDRIAL INNER MEM OR266W 032708 cerevisiae BRANE PROTEIN INVOLVED IN EXPORT OF PROTEINS FROM THE MITOCHONDRIAL MATRIX 129. YPL103c W02006 Saccharomyces UNCHARACTERIZED ORF 032708 cerevisiae 130. W02004/ 21, Saccharomyces HYPOTHETICAL PROTEIN 092398 22 cerevisiae 131. Y- W02004/ 189, Saccharomyces PROTEIN OF UNKNOWN FUNC OR305w 092398 190 cerevisiae TION 132. YKL057c W02006 Saccharomyces SUBUNIT OF THE NUP84P SUB 032708 cerevisiae COMPLEX OF THE NUCLEAR PORECOMPLEX(NPC) 133. YDR205 W02004/ 229, Saccharomyces MEMBER OF THE CATION DIF w 092398 230 cerevisiae FUSION FACILITATOR FAMILY 134. YPL267w W02004/ 191, Saccharomyces PUTATIVE TRANSCRIPTION 092398 192 cerevisiae FACTOR WO 2008/129060 86 PCT/EP2008/054924 135. YPL229w W02004/ 193, Saccharomyces PUTATIVEP ROTEIN OF UN 092398 194 cerevisiae KNOWN FUNCTION 136. YPLO38w W02004/ 195, Saccharomyces ZINC-FINGERDNA 092398 196 cerevisiae BINDINGPROTEIN 137. YPR047w W02004/ 197, Saccharomyces ALPHASUBUNIT OF YEAST MI 092398 198 cerevisiae TOCHONDRIAL PHENYL
ALANYL
TRNASYNTHETASE;MSF1 P 138. YPR052C W02004/ 221, Saccharomyces HOMOLOGOUS TO MAMMALIA 092398 222 cerevisiae NHIGHMOBILITY GROUP PRO TEINS1 AND2; FUNCTIONS RE DUNDANTLY WITH THE HIGHLY HOMOLOGOUS GENE 139. YNRO08 W02004/ 233, Saccharomyces ACYLTRANSFERASE THAT w 092398 234 cerevisiae CATALYZES DIACYLGLYCEROL ESTERIFICATION 140. YOL103w W02004/ 203, Saccharomyces MYO-INOSITOLTRANSPORTER 092398 204 cerevisiae WITH STRONG SIMILARITY TO THE MAJOR MYO-INOSITOL TRANSPORTER ITR1P 141. Y- W02004/ 209, Saccharomyces GAMMA SUBUNIT OF THE OR260w 092398 210 cerevisiae TRANSLATION INITIATION FAC TOREIF 2B 142. YOR360c W02004/ 211, Saccharomyces HIGH-AFFINITY CYCLIC AMP 092398 212 cerevisiae PHOSPHODIESTERASE 143. Y- W02004/ 235, Saccharomyces PUTATIVE LIPASE OF THE PER OR084w 092398 236 cerevisiae OXISOMALMATRIX 144. YPLO30w W02006 Saccharomyces HYPOTHETICAL PROTEIN 032708 cerevisiae 145. YGL263 W02004/ 1,2 Saccharomyces PUTATIVE MEMBRANE TRAF W 092398 cerevisiae FICKING PROTEIN 146. YDL057w W02006 129 Saccharomyces WEAK SIMILARITY TO HYPO 013010 cerevisiae THETICAL PROTEIN A.THALIANA 147. YGR054 W02004/ 237, Saccharomyces EUKARYOTIC INITIATION FAC W 092398 238 cerevisiae TOR (EIF)2A 148. YBR064w W02004/ 245, Saccharomyces PROBABLE MEMBRANE PROTE 092398 246 cerevisiae IN 149. YAL067C W02004/ 241, Saccharomyces PUTATIVE PERMEASE 092398 242 cerevisiae 150. YER174c W02004/ 33, Saccharomyces HYDROPEROXIDE, SUPEROX 092398 34 cerevisiae IDE-RADICAL RESPONSIVE GLUTATHIONE-DEPEN DENT
OXIDOREDUC
TASE;MONOTHIOLGLUTAREDOX IN SUBFAMILY MEMBER ALONG WITH GRX3P, GRX5P; PRO TECTS CELLS FROMOXIDATIVE
DAMAGE
WO 2008/129060 87 PCT/EP2008/054924 151. YBR051w W02004/ 35, Saccharomyces PROBABLE MEMBRANE PROTE 092398 36 cerevisiae IN 152. YER175c WO2004/ 37, Saccharomyces TRANS-ACONITATE METHYL 092398 38 cerevisiae TRANSFERASE 153. YDR521 W02004/ 39, Saccharomyces HYPOTHETICAL PROTEIN w 092398 40 cerevisiae 154. YER123w W02004/ 41 Saccharomyces CASEIN KINASEI 092398 cerevisiae 155. YER137C W02004/ 281, Saccharomyces HYPOTHETICAL PROTEIN 092398 282 cerevisiae 156. YELO52w W02004/ 47, Saccharomyces PUTATIVEATPASE OF THE 092398 48 cerevisiae CDC48/PAS1/SEC18(AAA) FAM ILY 157. YDR536 W02004/ 49, Saccharomyces STL1P:PLASMA MEMBRANE w 092398 50 cerevisiae SUGAR TRANSPORTER 158. YDR513 W02004/ 51, Saccharomyces TTR1P:GLUTAREDOXIN w 092398 52 cerevisiae 159. YGR060 W02006 Saccharomyces ERG25C w 032708 cerevisiae 4STEROLMETHYLOXIDASE 160. YELO41w W02004/ 55, Saccharomyces ATP-NADH 092398 56 cerevisiae KINASE;PHOSOPHORYLATES BOTH NAD, NADH 161. YEL001C W02006 54 Saccharomyces PUTATIVE PROTEIN OF UN 032708 cerevisiae KNOWN FUNCTION 162. YDR415c W02004/ 45, Saccharomyces STRONG SIMILARITY TO BAC 092398 46 cerevisiae TERIAL LEUCYL AMINOPEPTI DASE 163. YDL238c W02004/ 57, Saccharomyces GUANINEDEAMINASE 092398 58 cerevisiae 164. ROB5 US2006/ 1,2 BI LATE EMBRYOGENESIS ABUN 0122375 DANT TYPE PROTEIN ROB5 165. GOICDS W092/09 Claim Arabidopsis CYCLIN-DEPENDENT PROTEIN CDS001 685 3 thaliana KINASE 2 166. GOICDS W02005/ 4 Arabidopsis CYCLIN-DEPENDENT PROTEIN CDS004 024029 thaliana KINASECCDC2B2);CELLCYCLE 5 REGULATION NOTE:THIS IS A TRUNCATED PROTEIN 167. GOICDS W02007 167 Arabidopsis PUTATIVE TRANSCRIPTION _CDS018 064724 thaliana FACTOR 5 168. W02005 2 Arabidopsis PUTATIVE PP2A INHIBITOR; IN 094562 thaliana VOLVED IN NUCLEOSOME AS SEMBLY 169. W02004 Claim Arabidopsis CYTOKININOXIDASE; DEGRA 038027 8 thaliana DATION OF CYTOKININ WO 2008/129060 88 PCT/EP2008/054924 170. GOICDS W02005 2 Arabidopsis CYCLIN-DEPEN DENT PRO CDS064 083094 thaliana TEINKINASE; D-TYPE 7 (SER/THRPROTEINKINASE); CELLCYCLE REGULATION 171. W02006/ 2 Arabidopsis TYROSINEKINASE 008271 thaliana 172. GOICDS WO01/96 2,4,6, Arabidopsis CYTOKININOXIDASE; DEGRA CDS149 580 8,10, thaliana DATION OF CYTOKININ 9_2 12,32 or35 173. GOICDS W02006 2 Arabidopsis SODIUMTRANSPORTER CDS153 045829 thaliana 2 174. GOICDS W02007 199 Arabidopsis TRANSCRIPTION FACTOR CDS332 064724 thaliana 5 175. GOICDS W02007 2 Arabidopsis CATALYZES THE DECARBOXY CDSO21 113237 thaliana LATION OF 4 8 PHOSPHOPANTOTHENOYL CYSTEINETO 4 PHOSPHOPANTETHEINE 176. GOICDS W02004/ 2 Arabidopsis SALT INDUCIBLE TRANSCRIP _CDS153 058980 thaliana TIONAL REGULATOR (CYS 6 2/HIS-2-TYPE ZINC FINGER) 177. W02004/ 27 Arabidopsis TRANSCRIPTION FAC 058980 thaliana TOR;CYS2/HIS2-TYPE ZINC FIN GER PROTEIN 178. GOICDS W02006/ 8 Arabidopsis SYTprotein CDS307 079655 thaliana 4 179. DPpro- W020051 2 Arabidopsis TRANSCRIPTION FACTOR;CELL tein 117568 thaliana CYCLEREGULATION 180. GOICDS W02006 2 Arabidopsis RNA BINDING;CELLP ROLIFERA CDS007 018432 thaliana TION 8 181. GOICDS W02006 2 Arabidopsis SERINE/THREONINE CDS082 005771 thaliana PROTEINKINASE 7 182. W02004/ 2 Arabidopsis METAL-BINDING;RESISTANCE 090142 thaliana TO METALS;DETOXIFICATION OF HYDROXYL RADICALS 183. GOICDS W02006/ 2 Arabidopsis PUTATIVE ZINC BINDINGPROTE _CDS152 005751 thaliana IN 2 184. GOICDS W02004 2 Arabidopsis NON-SYMBIOTIC HEMOGLOBIN2 _CDS259 087755 thaliana 1 185. GOICDS W02006/ 14 Arabidopsis RECEPTOR-LIKE WO 2008/129060 89 PCT/EP2008/054924 CDS314 131547 thaliana KINASE;SERINE/THREONINE 2 PROTEINKINASE;LEUCINE-RICH REPEAT(LRR)CONTAINING KINASE 186. W02006/ 804 Arabidopsis 079655 thaliana 187. W02007/ 14 138070 188. W02007 132 Arabidopsis CELLCYCLE REGULATION 064724 thaliana 189. CDS3298 W02007/ 602 Arabidopsis 113237 thaliana 190. W02004/ 10 BV PUTATIVE UBIQUITIN 090141 PROTEINLIGASE 191. GOICDS W02004 2 BV NON-SYMBIOTIC HEMOGLOBIN2 CDS276 087755 7 192. YIL076w W02006 98 Saccharomyces EPSILON-COP SUBUNIT OF THE 032708 cerevisiae COATOMER;REGULATES RET ROGRADEGOLGI-TO-ER PRO TEIN TRAFFIC;STABILIZE SCOP1P 193. YIL156W W02006 Saccharomyces UBIQUITIN-SPECIFIC PROTEASE 032708 cerevisiae THAT CLEAVE SUBIQUITIN PROTEIN FUSIONS 194. YIL172C W02007 225 Saccharomyces PUTATIVE PROTEIN OF UN 020198 cerevisiae KNOWN FUNCTION WITH SIMI LARITY TO GLUCOSIDASES 195. YMR095 W02006 2 Saccharomyces PUTATIVE GLUTAMINE AMIDO C 013010 cerevisiae TRANSFERASE 196. YMR217 W02007 244 Saccharomyces GMP SYNTHASE W 020198 cerevisiae 197. GOICDS W02005 2 Nicotianataba- UNKNOWN (UNDEFINED ROLEIN CDS068 049646 cum CELLCYCLE) 9 198. GOICDS W02006 15 Nicotianataba- RNA BINDING;PROBABLY IN CDS070 018432 cum VOLVED IN RNA PRCESS 1 ING(I.E.SPLICING) 199. EF-Tu W02006/ 2 Nicotianataba- TRANSLATION ELONGATION 067232 cum FACTOR;TRNA BINDING 200. GOICDS W02005 2 Nicotianataba- FUNCTION UNKNOWN (HYPO CDS066 059147 cum THETICALLY GROWTH RE 9 LATED) 201. GOICDS W02004 2 Nicotianataba- AAA-ATPASE;THIS IS A TRUN _CDS067 087927 cum CATED PROTEIN THAT CON 1 TAINS ONLY THE ATPASE DO MAIN OFATOB3-LIKEPROTEIN WO 2008/129060 90 PCT/EP2008/054924 202. GOICDS W02007/ 042 Oryza sativa 0647249 203. GOICDS W02004/ 2 Oryza sativa VACUOLAR(NA CDS160 106528 8 204. W02006 2 Oryza sativa TRANSCRIPTION FACTOR;MAY 056590 PROMOTE FLORAL TRANSITION PAHSE, DIFFERENTIATION PROGRAM OF THE VEGETATIVE SHOOT 205. GOICDS W02006 2 Oryza sativa CDKA CDS064 058897 4 7 206. W02007 2 Oryza sativa DNA BINDING PRO 099096 TEIN;INVOLVED IN SEEDMATU RATION (PUTATIVE) 207. GOICDS W02007/ 2 Oryza sativa TRANSCRIPTION FACTOR;HOME CDS244 051866 0 DOMAIN LEUCINE ZIPPER 7 PROTEIN 208. GOICDS W02007/ 2 Oryza sativa CDS302 113237 7 209. GOISCD W02007/ 042 Oryza sativa S_CDS3 0647249 159 210. GOISCD W02006/ 2 Oryza sativa TRANSCRIPTION FACTOR S 008271 211. GOICDS W02006 2 Oryza sativa CYCLIN-DEPENDENT KINASE CDS064 058897 4 7 212. GOICDS W02006/ 2 Oryza sativa CO-CHAPERONE;PROTECTION CDS187 067236 OF CELLS AGAINST STRESS 7 213. W02007/ 2 Oryza sativa TRANSCRIPTIONAL REGULATOR 003409 (GASIGNALLING REPRES SORINKERNELS) 214. YPL211w W02006 218 Saccharomyces NUCLEOLAR PROTEIN RE 032708 cerevisiae QUIRED FOR 60SRIBOSOME SUBUNIT BIOGENESIS 215. YIL121w W02006 106 Saccharomyces MULTIDRUG TRANSPORTER 032708 cerevisiae REQUIRED FOR RESISTANCE TO QUINIDINE WO 2008/129060 91 PCT/EP2008/054924 Table C Line Gene Active ingredientB Line Gene Active ingredientB in Name/ Lo- in Name/ Lo Table cusiD Table cusID B B I ATACCD acephate 112 YNL024c Cyprodinil 1 ATACCD chlorpyrifos 112 YNL024c Pyrimethanil 1 ATACCD dimethoate 112 YNL024c Fenpropimorph I ATACCD methamidophos 112 YNL024c Tridemorph 1 ATACCD terbufos 112 YNL024c lprodione 1 ATACCD aldicarb 112 YNL024c 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 1 ATACCD carbofuran 112 YNL024c Mancozeb 1 ATACCD bifenthrin 112 YNL024c Maneb 1 ATACCD cypermethrin 112 YNL024c Metiram 1 ATACCD alpha-cypermethrin 112 YNL024c Dithianon 1 ATACCD deltamethrin 112 YNL024c Chlorothalonil 1 ATACCD lambda-cyhalothrin 112 YNL024c ThiophanateMethyl 1 ATACCD tefluthrin 112 YNL024c Cymoxanil 1 ATACCD flufenoxuron 112 YNL024c Metrafenone 1 ATACCD teflubenzuron 112 YNL024c Acetochlor I ATACCD spirotetramat; 112 YNL024c Dimethenamid 1 ATACCD clothianidin 112 YNL024c Metolachlor 1 ATACCD imidacloprid 112 YNL024c Metazachlor 1 ATACCD thiamethoxam 112 YNL024c Glyphosate 1 ATACCD endosulfan 112 YNL024c Glufosinate 1 ATACCD fipronil 112 YNL024c Sulfosate I ATACCD abamectin 112 YNL024c Fenoxaprop 1 ATACCD spinosad 112 YNL024c Paraquat 1 ATACCD spinetoram 112 YNL024c Cycloxydim 1 ATACCD hydramethylnon; 112 YNL024c Profoxydim 1 ATACCD chlorfenapyr; 112 YNL024c Sethoxydim 1 ATACCD indoxacarb 112 YNL024c Tepraloxydim I ATACCD metaflumizone 112 YNL024c Pendimethalin I ATACCD flubendiamide 112 YNL024c Acifluorfen 1 ATACCD chlorantraniliprole 112 YNL024c Imazamethabenz 1 ATACCD cyazypyr(HGW86) 112 YNL024c Imazamox WO 2008/129060 92 PCT/EP2008/054924 1 ATACCD Azoxystrobin 112 YNL024c Imazapic I ATACCD Dimoxystrobin 112 YNL024c Imazapyr I ATACCD Kresoxim-methyl 112 YNL024c Imazaquin 1 ATACCD Orysastrobin 112 YNL024c Imazethapyr I ATACCD Pyraclostrobin 112 YNL024c 2,4-D 1 ATACCD Trifloxystrobin 112 YNL024c Chloridazon 1 ATACCD Bixafen 112 YNL024c Picloram 1 ATACCD Boscalid 112 YNL024c Picolinafen 1 ATACCD Isopyrazam 112 YNL024c Cyclosulfamuron I ATACCD Metalaxyl 112 YNL024c Triflusulfuron 1 ATACCD Penthiopyrad 112 YNL024c Atrazine 1 ATACCD 3-Difluoromethyl-1- 112 YNL024c Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid(2',4',5' trifluorobiphenyl-2-yl) amide I ATACCD Dimethomorph 112 YNL024c Bentazone 1 ATACCD Difenoconazole 112 YNL024c Cinidon-ethly 1 ATACCD Epoxiconazole 112 YNL024c Cinmethylin I ATACCD Fluquinconazole 112 YNL024c Dicamba 1 ATACCD Metconazol 112 YNL024c Diflufenzopyr I ATACCD Propiconazole 112 YNL024c Quinclorac 1 ATACCD Prothioconazole 112 YNL024c Quinmerac 1 ATACCD Tebuconazole 112 YNL024c Mesotrione I ATACCD Triticonazole 112 YNL024c Saflufenacil 1 ATACCD Prochloraz 112 YNL024c Topramezone; 1 ATACCD Carbendazim 150 YER174c acephate I ATACCD Cyprodinil 150 YER174c chlorpyrifos 1 ATACCD Pyrimethanil 150 YER174c dimethoate 1 ATACCD Fenpropimorph 150 YER174c methamidophos 1 ATACCD Tridemorph 150 YER174c terbufos 1 ATACCD Iprodione 150 YER174c aldicarb I ATACCD 5-ethyl-6-octyl-[1,2,4] 150 YER174c carbofuran triazolo[1,5-a]pyri midine-7-ylamine 1 ATACCD Mancozeb 150 YER174c bifenthrin 1 ATACCD Maneb 150 YER174c cypermethrin 1 ATACCD Metiram 150 YER174c alpha-cypermethrin I ATACCD Dithianon 150 YER174c deltamethrin 1 ATACCD Chlorothalonil 150 YER174c lambda-cyhalothrin WO 2008/129060 93 PCT/EP2008/054924 1 ATACCD ThiophanateMethyl 150 YER174c tefluthrin I ATACCD Cymoxanil 150 YER174c flufenoxuron I ATACCD Metrafenone 150 YER174c teflubenzuron 1 ATACCD Acetochlor 150 YER174c spirotetramat; I ATACCD Dimethenamid 150 YER174c clothianidin 1 ATACCD Metolachlor 150 YER174c imidacloprid 1 ATACCD Metazachlor 150 YER174c thiamethoxam 1 ATACCD Glyphosate 150 YER174c endosulfan 1 ATACCD Glufosinate 150 YER174c fipronil I ATACCD Sulfosate 150 YER174c abamectin 1 ATACCD Fenoxaprop 150 YER174c spinosad 1 ATACCD Paraquat 150 YER174c spinetoram 1 ATACCD Cycloxydim 150 YER174c hydramethylnon; 1 ATACCD Profoxydim 150 YER174c chlorfenapyr; 1 ATACCD Sethoxydim 150 YER174c indoxacarb I ATACCD Tepraloxydim 150 YER174c metaflumizone 1 ATACCD Pendimethalin 150 YER174c flubendiamide 1 ATACCD Acifluorfen 150 YER174c chlorantraniliprole 1 ATACCD Imazamethabenz 150 YER174c cyazypyr(HGW86) 1 ATACCD Imazamox 150 YER174c Azoxystrobin 1 ATACCD Imazapic 150 YER174c Dimoxystrobin I ATACCD Imazapyr 150 YER174c Kresoxim-methyl 1 ATACCD Imazaquin 150 YER174c Orysastrobin 1 ATACCD Imazethapyr 150 YER174c Pyraclostrobin 1 ATACCD 2,4-D 150 YER174c Trifloxystrobin I ATACCD Chloridazon 150 YER174c Bixafen 1 ATACCD Picloram 150 YER174c Boscalid 1 ATACCD Picolinafen 150 YER174c Isopyrazam I ATACCD Cyclosulfamuron 150 YER174c Metalaxyl 1 ATACCD Triflusulfuron 150 YER174c Penthiopyrad 1 ATACCD Atrazine 150 YER174c 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 1 ATACCD Pyroxasulfone 150 YER174c Dimethomorph 1 ATACCD Bentazone 150 YER174c Difenoconazole 1 ATACCD Cinidon-ethly 150 YER174c Epoxiconazole 1 ATACCD Cinmethylin 150 YER174c Fluquinconazole 1 ATACCD Dicamba 150 YER174c Metconazol WO 2008/129060 94 PCT/EP2008/054924 1 ATACCD Diflufenzopyr 150 YER174c Propiconazole I ATACCD Quinclorac 150 YER174c Prothioconazole 1 ATACCD Quinmerac 150 YER174c Tebuconazole 1 ATACCD Mesotrione 150 YER174c Triticonazole I ATACCD Saflufenacil 150 YER174c Prochloraz 1 ATACCD Topramezone; 150 YER174c Carbendazim 5 ATSTE24 acephate 150 YER174c Cyprodinil 5 ATSTE24 chlorpyrifos 150 YER174c Pyrimethanil 5 ATSTE24 dimethoate 150 YER174c Fenpropimorph 5 ATSTE24 methamidophos 150 YER174c Tridemorph 5 ATSTE24 terbufos 150 YER174c lprodione 5 ATSTE24 aldicarb 150 YER174c 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 5 ATSTE24 carbofuran 150 YER174c Mancozeb 5 ATSTE24 bifenthrin 150 YER174c Maneb 5 ATSTE24 cypermethrin 150 YER174c Metiram 5 ATSTE24 alpha-cypermethrin 150 YER174c Dithianon 5 ATSTE24 deltamethrin 150 YER174c Chlorothalonil 5 ATSTE24 lambda-cyhalothrin 150 YER174c ThiophanateMethyl 5 ATSTE24 tefluthrin 150 YER174c Cymoxanil 5 ATSTE24 flufenoxuron 150 YER174c Metrafenone 5 ATSTE24 teflubenzuron 150 YER174c Acetochlor 5 ATSTE24 spirotetramat; 150 YER174c Dimethenamid 5 ATSTE24 clothianidin 150 YER174c Metolachlor 5 ATSTE24 imidacloprid 150 YER174c Metazachlor 5 ATSTE24 thiamethoxam 150 YER174c Glyphosate 5 ATSTE24 endosulfan 150 YER174c Glufosinate 5 ATSTE24 fipronil 150 YER174c Sulfosate 5 ATSTE24 abamectin 150 YER174c Fenoxaprop 5 ATSTE24 spinosad 150 YER174c Paraquat 5 ATSTE24 spinetoram 150 YER174c Cycloxydim 5 ATSTE24 hydramethylnon; 150 YER174c Profoxydim 5 ATSTE24 chlorfenapyr; 150 YER174c Sethoxydim 5 ATSTE24 indoxacarb 150 YER174c Tepraloxydim 5 ATSTE24 metaflumizone 150 YER174c Pendimethalin 5 ATSTE24 flubendiamide 150 YER174c Acifluorfen 5 ATSTE24 chlorantraniliprole 150 YER174c Imazamethabenz 5 ATSTE24 cyazypyr(HGW86) 150 YER174c Imazamox WO 2008/129060 95 PCT/EP2008/054924 5 ATSTE24 Azoxystrobin 150 YER174c Imazapic 5 ATSTE24 Dimoxystrobin 150 YER174c Imazapyr 5 ATSTE24 Kresoxim-methyl 150 YER174c Imazaquin 5 ATSTE24 Orysastrobin 150 YER174c Imazethapyr 5 ATSTE24 Pyraclostrobin 150 YER1 74c 2,4-D 5 ATSTE24 Trifloxystrobin 150 YER174c Chloridazon 5 ATSTE24 Bixafen 150 YER174c Picloram 5 ATSTE24 Boscalid 150 YER174c Picolinafen 5 ATSTE24 Isopyrazam 150 YER174c Cyclosulfamuron 5 ATSTE24 Metalaxyl 150 YER174c Triflusulfuron 5 ATSTE24 Penthiopyrad 150 YER174c Atrazine 5 ATSTE24 3-Difluoromethyl-1- 150 YER174c Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 5 ATSTE24 Dimethomorph 150 YER174c Bentazone 5 ATSTE24 Difenoconazole 150 YER174c Cinidon-ethly 5 ATSTE24 Epoxiconazole 150 YER174c Cinmethylin 5 ATSTE24 Fluquinconazole 150 YER174c Dicamba 5 ATSTE24 Metconazol 150 YER174c Diflufenzopyr 5 ATSTE24 Propiconazole 150 YER174c Quinclorac 5 ATSTE24 Prothioconazole 150 YER174c Quinmerac 5 ATSTE24 Tebuconazole 150 YER174c Mesotrione 5 ATSTE24 Triticonazole 150 YER174c Saflufenacil 5 ATSTE24 Prochloraz 150 YER174c Topramezone; 5 ATSTE24 Carbendazim 159 YGR060w acephate 5 ATSTE24 Cyprodinil 159 YGR060w chlorpyrifos 5 ATSTE24 Pyrimethanil 159 YGR060w dimethoate 5 ATSTE24 Fenpropimorph 159 YGR060w methamidophos 5 ATSTE24 Tridemorph 159 YGR060w terbufos 5 ATSTE24 Iprodione 159 YGR060w aldicarb 5 ATSTE24 5-ethyl-6-octyl-[1,2,4] 159 YGR060w carbofuran triazolo[1,5-a]pyri midine-7-ylamine 5 ATSTE24 Mancozeb 159 YGR060w bifenthrin 5 ATSTE24 Maneb 159 YGR060w cypermethrin 5 ATSTE24 Metiram 159 YGR060w alpha-cypermethrin 5 ATSTE24 Dithianon 159 YGR060w deltamethrin 5 ATSTE24 Chlorothalonil 159 YGR060w lambda-cyhalothrin WO 2008/129060 96 PCT/EP2008/054924 5 ATSTE24 ThiophanateMethyl 159 YGR060w tefluthrin 5 ATSTE24 Cymoxanil 159 YGR060w flufenoxuron 5 ATSTE24 Metrafenone 159 YGR060w teflubenzuron 5 ATSTE24 Acetochlor 159 YGR060w spirotetramat; 5 ATSTE24 Dimethenamid 159 YGR060w clothianidin 5 ATSTE24 Metolachlor 159 YGR060w imidacloprid 5 ATSTE24 Metazachlor 159 YGR060w thiamethoxam 5 ATSTE24 Glyphosate 159 YGR060w endosulfan 5 ATSTE24 Glufosinate 159 YGR060w fipronil 5 ATSTE24 Sulfosate 159 YGR060w abamectin 5 ATSTE24 Fenoxaprop 159 YGR060w spinosad 5 ATSTE24 Paraquat 159 YGR060w spinetoram 5 ATSTE24 Cycloxydim 159 YGR060w hydramethylnon; 5 ATSTE24 Profoxydim 159 YGR060w chlorfenapyr; 5 ATSTE24 Sethoxydim 159 YGR060w indoxacarb 5 ATSTE24 Tepraloxydim 159 YGR060w metaflumizone 5 ATSTE24 Pendimethalin 159 YGR060w flubendiamide 5 ATSTE24 Acifluorfen 159 YGR060w chlorantraniliprole 5 ATSTE24 Imazamethabenz 159 YGR060w cyazypyr(HGW86) 5 ATSTE24 Imazamox 159 YGR060w Azoxystrobin 5 ATSTE24 Imazapic 159 YGR060w Dimoxystrobin 5 ATSTE24 Imazapyr 159 YGR060w Kresoxim-methyl 5 ATSTE24 Imazaquin 159 YGR060w Orysastrobin 5 ATSTE24 Imazethapyr 159 YGR060w Pyraclostrobin 5 ATSTE24 2,4-D 159 YGR060w Trifloxystrobin 5 ATSTE24 Chloridazon 159 YGR060w Bixafen 5 ATSTE24 Picloram 159 YGR060w Boscalid 5 ATSTE24 Picolinafen 159 YGR060w Isopyrazam 5 ATSTE24 Cyclosulfamuron 159 YGR060w Metalaxyl 5 ATSTE24 Triflusulfuron 159 YGR060w Penthiopyrad 5 ATSTE24 Atrazine 159 YGR060w 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 5 ATSTE24 Pyroxasulfone 159 YGR060w Dimethomorph 5 ATSTE24 Bentazone 159 YGR060w Difenoconazole 5 ATSTE24 Cinidon-ethly 159 YGR060w Epoxiconazole 5 ATSTE24 Cinmethylin 159 YGR060w Fluquinconazole 5 ATSTE24 Dicamba 159 YGR060w Metconazol WO 2008/129060 97 PCT/EP2008/054924 5 ATSTE24 Diflufenzopyr 159 YGR060w Propiconazole 5 ATSTE24 Quinclorac 159 YGR060w Prothioconazole 5 ATSTE24 Quinmerac 159 YGR060w Tebuconazole 5 ATSTE24 Mesotrione 159 YGR060w Triticonazole 5 ATSTE24 Saflufenacil 159 YGR060w Prochloraz 5 ATSTE24 Topramezone; 159 YGR060w Carbendazim 7 b2965 acephate 159 YGR060w Cyprodinil 7 b2965 chlorpyrifos 159 YGR060w Pyrimethanil 7 b2965 dimethoate 159 YGR060w Fenpropimorph 7 b2965 methamidophos 159 YGR060w Tridemorph 7 b2965 terbufos 159 YGR060w lprodione 7 b2965 aldicarb 159 YGR060w 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 7 b2965 carbofuran 159 YGR060w Mancozeb 7 b2965 bifenthrin 159 YGR060w Maneb 7 b2965 cypermethrin 159 YGR060w Metiram 7 b2965 alpha-cypermethrin 159 YGR060w Dithianon 7 b2965 deltamethrin 159 YGR060w Chlorothalonil 7 b2965 lambda-cyhalothrin 159 YGR060w ThiophanateMethyl 7 b2965 tefluthrin 159 YGR060w Cymoxanil 7 b2965 flufenoxuron 159 YGR060w Metrafenone 7 b2965 teflubenzuron 159 YGR060w Acetochlor 7 b2965 spirotetramat; 159 YGR060w Dimethenamid 7 b2965 clothianidin 159 YGR060w Metolachlor 7 b2965 imidacloprid 159 YGR060w Metazachlor 7 b2965 thiamethoxam 159 YGR060w Glyphosate 7 b2965 endosulfan 159 YGR060w Glufosinate 7 b2965 fipronil 159 YGR060w Sulfosate 7 b2965 abamectin 159 YGR060w Fenoxaprop 7 b2965 spinosad 159 YGR060w Paraquat 7 b2965 spinetoram 159 YGR060w Cycloxydim 7 b2965 hydramethylnon; 159 YGR060w Profoxydim 7 b2965 chlorfenapyr; 159 YGR060w Sethoxydim 7 b2965 indoxacarb 159 YGR060w Tepraloxydim 7 b2965 metaflumizone 159 YGR060w Pendimethalin 7 b2965 flubendiamide 159 YGR060w Acifluorfen 7 b2965 chlorantraniliprole 159 YGR060w Imazamethabenz 7 b2965 cyazypyr(HGW86) 159 YGR060w Imazamox WO 2008/129060 98 PCT/EP2008/054924 7 b2965 Azoxystrobin 159 YGR060w Imazapic 7 b2965 Dimoxystrobin 159 YGR060w Imazapyr 7 b2965 Kresoxim-methyl 159 YGR060w Imazaquin 7 b2965 Orysastrobin 159 YGR060w Imazethapyr 7 b2965 Pyraclostrobin 159 YGR060w 2,4-D 7 b2965 Trifloxystrobin 159 YGR060w Chloridazon 7 b2965 Bixafen 159 YGR060w Picloram 7 b2965 Boscalid 159 YGR060w Picolinafen 7 b2965 Isopyrazam 159 YGR060w Cyclosulfamuron 7 b2965 Metalaxyl 159 YGR060w Triflusulfuron 7 b2965 Penthiopyrad 159 YGR060w Atrazine 7 b2965 3-Difluoromethyl-1- 159 YGR060w Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 7 b2965 Dimethomorph 159 YGR060w Bentazone 7 b2965 Difenoconazole 159 YGR060w Cinidon-ethly 7 b2965 Epoxiconazole 159 YGR060w Cinmethylin 7 b2965 Fluquinconazole 159 YGR060w Dicamba 7 b2965 Metconazol 159 YGRO60w Difiufenzopyr 7 b2965 Propiconazole 159 YGR060w Quinclorac 7 b2965 Prothioconazole 159 YGR060w Quinmerac 7 b2965 Tebuconazole 159 YGR060w Mesotrione 7 b2965 Triticonazole 159 YGR060w Saflufenacil 7 b2965 Prochloraz 159 YGR060w Topramezone; 7 b2965 Carbendazim 164 ROB5 acephate 7 b2965 Cyprodinil 164 ROB5 chlorpyrifos 7 b2965 Pyrimethanil 164 ROB5 dimethoate 7 b2965 Fenpropimorph 164 ROB5 methamidophos 7 b2965 Tridemorph 164 ROB5 terbufos 7 b2965 Iprodione 164 ROB5 aldicarb 7 b2965 5-ethyl-6-octyl-[1,2,4] 164 ROB5 carbofuran triazolo[1,5-a]pyri midine-7-ylamine 7 b2965 Mancozeb 164 ROB5 bifenthrin 7 b2965 Maneb 164 ROB5 cypermethrin 7 b2965 Metiram 164 ROB5 alpha-cypermethrin 7 b2965 Dithianon 164 ROB5 deltamethrin 7 b2965 Chlorothalonil 164 ROB5 lambda-cyhalothrin WO 2008/129060 99 PCT/EP2008/054924 7 b2965 ThiophanateMethyl 164 ROB5 tefluthrin 7 b2965 Cymoxanil 164 ROB5 flufenoxuron 7 b2965 Metrafenone 164 ROB5 teflubenzuron 7 b2965 Acetochlor 164 ROB5 spirotetramat; 7 b2965 Dimethenamid 164 ROB5 clothianidin 7 b2965 Metolachlor 164 ROB5 imidacloprid 7 b2965 Metazachlor 164 ROB5 thiamethoxam 7 b2965 Glyphosate 164 ROB5 endosulfan 7 b2965 Glufosinate 164 ROB5 fipronil 7 b2965 Sulfosate 164 ROB5 abamectin 7 b2965 Fenoxaprop 164 ROB5 spinosad 7 b2965 Paraquat 164 ROB5 spinetoram 7 b2965 Cycloxydim 164 ROB5 hydramethylnon; 7 b2965 Profoxydim 164 ROB5 chlorfenapyr; 7 b2965 Sethoxydim 164 ROB5 indoxacarb 7 b2965 Tepraloxydim 164 ROB5 metaflumizone 7 b2965 Pendimethalin 164 ROB5 flubendiamide 7 b2965 Acifluorfen 164 ROB5 chlorantraniliprole 7 b2965 Imazamethabenz 164 ROB5 cyazypyr(HGW86) 7 b2965 Imazamox 164 ROB5 Azoxystrobin 7 b2965 Imazapic 164 ROB5 Dimoxystrobin 7 b2965 Imazapyr 164 ROB5 Kresoxim-methyl 7 b2965 Imazaquin 164 ROB5 Orysastrobin 7 b2965 Imazethapyr 164 ROB5 Pyraclostrobin 7 b2965 2,4-D 164 ROB5 Trifloxystrobin 7 b2965 Chloridazon 164 ROB5 Bixafen 7 b2965 Picloram 164 ROB5 Boscalid 7 b2965 Picolinafen 164 ROB5 Isopyrazam 7 b2965 Cyclosulfamuron 164 ROB5 Metalaxyl 7 b2965 Triflusulfuron 164 ROB5 Penthiopyrad 7 b2965 Atrazine 164 ROB5 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 7 b2965 Pyroxasulfone 164 ROB5 Dimethomorph 7 b2965 Bentazone 164 ROB5 Difenoconazole 7 b2965 Cinidon-ethly 164 ROB5 Epoxiconazole 7 b2965 Cinmethylin 164 ROB5 Fluquinconazole 7 b2965 Dicamba 164 ROB5 Metconazol WO 2008/129060 100 PCT/EP2008/054924 7 b2965 Diflufenzopyr 164 ROB5 Propiconazole 7 b2965 Quinclorac 164 ROB5 Prothioconazole 7 b2965 Quinmerac 164 ROB5 Tebuconazole 7 b2965 Mesotrione 164 ROB5 Triticonazole 7 b2965 Saflufenacil 164 ROB5 Prochloraz 7 b2965 Topramezone; 164 ROB5 Carbendazim 10 B0730 acephate 164 ROB5 Cyprodinil 10 B0730 chlorpyrifos 164 ROB5 Pyrimethanil 10 B0730 dimethoate 164 ROB5 Fenpropimorph 10 B0730 methamidophos 164 ROB5 Tridemorph 10 B0730 terbufos 164 ROB5 lprodione 10 B0730 aldicarb 164 ROB5 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 10 B0730 carbofuran 164 ROB5 Mancozeb 10 B0730 bifenthrin 164 ROB5 Maneb 10 B0730 cypermethrin 164 ROB5 Metiram 10 B0730 alpha-cypermethrin 164 ROB5 Dithianon 10 B0730 deltamethrin 164 ROB5 Chlorothalonil 10 B0730 lambda-cyhalothrin 164 ROB5 ThiophanateMethyl 10 B0730 tefluthrin 164 ROB5 Cymoxanil 10 B0730 flufenoxuron 164 ROB5 Metrafenone 10 B0730 teflubenzuron 164 ROB5 Acetochlor 10 B0730 spirotetramat; 164 ROB5 Dimethenamid 10 B0730 clothianidin 164 ROB5 Metolachlor 10 B0730 imidacloprid 164 ROB5 Metazachlor 10 B0730 thiamethoxam 164 ROB5 Glyphosate 10 B0730 endosulfan 164 ROB5 Glufosinate 10 B0730 fipronil 164 ROB5 Sulfosate 10 B0730 abamectin 164 ROB5 Fenoxaprop 10 B0730 spinosad 164 ROB5 Paraquat 10 B0730 spinetoram 164 ROB5 Cycloxydim 10 B0730 hydramethylnon; 164 ROB5 Profoxydim 10 B0730 chlorfenapyr; 164 ROB5 Sethoxydim 10 B0730 indoxacarb 164 ROB5 Tepraloxydim 10 B0730 metaflumizone 164 ROB5 Pendimethalin 10 B0730 flubendiamide 164 ROB5 Acifluorfen 10 B0730 chlorantraniliprole 164 ROB5 Imazamethabenz 10 B0730 cyazypyr(HGW86) 164 ROB5 Imazamox WO 2008/129060 101 PCT/EP2008/054924 10 B0730 Azoxystrobin 164 ROB5 Imazapic 10 B0730 Dimoxystrobin 164 ROB5 Imazapyr 10 B0730 Kresoxim-methyl 164 ROB5 Imazaquin 10 B0730 Orysastrobin 164 ROB5 Imazethapyr 10 B0730 Pyraclostrobin 164 ROB5 2,4-D 10 B0730 Trifloxystrobin 164 ROB5 Chloridazon 10 B0730 Bixafen 164 ROB5 Picloram 10 B0730 Boscalid 164 ROB5 Picolinafen 10 B0730 Isopyrazam 164 ROB5 Cyclosulfamuron 10 B0730 Metalaxyl 164 ROB5 Triflusulfuron 10 B0730 Penthiopyrad 164 ROB5 Atrazine 10 B0730 3-Difluoromethyl-1- 164 ROB5 Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 10 B0730 Dimethomorph 164 ROB5 Bentazone 10 B0730 Difenoconazole 164 ROB5 Cinidon-ethly 10 B0730 Epoxiconazole 164 ROB5 Cinmethylin 10 B0730 Fluquinconazole 164 ROB5 Dicamba 10 B0730 Metconazol 164 ROB5 Diflufenzopyr 10 B0730 Propiconazole 164 ROB5 Quinclorac 10 B0730 Prothioconazole 164 ROB5 Quinmerac 10 B0730 Tebuconazole 164 ROB5 Mesotrione 10 B0730 Triticonazole 164 ROB5 Saflufenacil 10 B0730 Prochloraz 164 ROB5 Topramezone; 10 B0730 Carbendazim 165 GOICDSC acephate DS0012 10 B0730 Cyprodinil 165 GOICDSC chlorpyrifos DS0012 10 B0730 Pyrimethanil 165 GOICDS C dimethoate DS0012 10 B0730 Fenpropimorph 165 GOICDS C methamidophos DS0012 10 B0730 Tridemorph 165 GOICDS C terbufos DS0012 10 B0730 lprodione 165 GOICDS C aldicarb DS0012 10 B0730 5-ethyl-6-octyl-[1,2,4] 165 GOICDS C carbofuran triazolo[1,5-a]pyri- DS0012 midine-7-ylamine 10 B0730 Mancozeb 165 GOICDSC bifenthrin WO 2008/129060 102 PCT/EP2008/054924 DS0012 10 B0730 Maneb 165 GOICDS_C cypermethrin DS0012 10 B0730 Metiram 165 GOICDS_C alpha-cypermethrin DS0012 10 B0730 Dithianon 165 GOICDS C deltamethrin DS0012 10 B0730 Chlorothalonil 165 GOICDSC lambda-cyhalothrin DS0012 10 B0730 ThiophanateMethyl 165 GOICDS_C tefluthrin DS0012 10 B0730 Cymoxanil 165 GOICDS C flufenoxuron DS0012 10 B0730 Metrafenone 165 GOICDS C teflubenzuron DS0012 10 B0730 Acetochlor 165 GOICDSC spirotetramat; DS0012 10 B0730 Dimethenamid 165 GOICDS C clothianidin DS0012 10 B0730 Metolachlor 165 GOICDSC imidacloprid DS0012 10 B0730 Metazachlor 165 GOICDS C thiamethoxam DS0012 10 B0730 Glyphosate 165 GOICDS_C endosulfan DS0012 10 B0730 Glufosinate 165 GOICDS_C fipronil DS0012 10 B0730 Sulfosate 165 GOICDS C abamectin DS0012 10 B0730 Fenoxaprop 165 GOICDSC spinosad DS0012 10 B0730 Paraquat 165 GOICDS_C spinetoram DS0012 10 B0730 Cycloxydim 165 GOICDS_C hydramethylnon; DS0012 10 B0730 Profoxydim 165 GOICDS_C chlorfenapyr; DS0012 10 B0730 Sethoxydim 165 GOICDS C indoxacarb DS0012 10 B0730 Tepraloxydim 165 GOICDS C metaflumizone DS0012 10 B0730 Pendimethalin 165 GOICDS C flubendiamide DS0012 10 B0730 Acifluorfen 165 GOICDSC chlorantraniliprole DS0012 WO 2008/129060 103 PCT/EP2008/054924 10 B0730 Imazamethabenz 165 GOICDS_C cyazypyr(HGW86) DS0012 10 B0730 Imazamox 165 GOICDSC Azoxystrobin DS0012 10 B0730 Imazapic 165 GOICDS_C Dimoxystrobin DS0012 10 B0730 Imazapyr 165 GOICDS_C Kresoxim-methyl DS0012 10 B0730 Imazaquin 165 GOICDS_C Orysastrobin DS0012 10 B0730 Imazethapyr 165 GOICDS_C Pyraclostrobin DS0012 10 B0730 2,4-D 165 GOICDS_C Trifloxystrobin DS0012 10 B0730 Chloridazon 165 GOICDS C Bixafen DS0012 10 B0730 Picloram 165 GOICDS C Boscalid DS0012 10 B0730 Picolinafen 165 GOICDS_C Isopyrazam DS0012 10 B0730 Cyclosulfamuron 165 GOICDS_C Metalaxyl DS0012 10 B0730 Triflusulfuron 165 GOICDS_C Penthiopyrad DS0012 10 B0730 Atrazine 165 GOICDS_C 3-Difluoromethyl-1 DS0012 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 10 B0730 Pyroxasulfone 165 GOICDS_C Dimethomorph DS0012 10 B0730 Bentazone 165 GOICDS C Difenoconazole DS0012 10 B0730 Cinidon-ethly 165 GOICDS_C Epoxiconazole DS0012 10 B0730 Cinmethylin 165 GOICDSC Fluquinconazole DS0012 10 B0730 Dicamba 165 GOICDS C Metconazol DS0012 10 B0730 Diflufenzopyr 165 GOICDS_C Propiconazole DS0012 10 B0730 Quinclorac 165 GOICDS C Prothioconazole DS0012 10 B0730 Quinmerac 165 GOICDS C Tebuconazole DS0012 10 B0730 Mesotrione 165 GOlCDSC Triticonazole WO 2008/129060 1 04 PCT/EP2008/054924 DS0012 10 B0730 Saflufenacil 165 GOICDS C Prochloraz DS0012 10 B0730 Topramezone; 165 GOICDS C Carbendazim DS0012 11 b1830 acephate 165 GOICDS_C Cyprodinil DS0012 11 b1830 chlorpyrifos 165 GOICDS_C Pyrimethanil DS0012 11 b1830 dimethoate 165 GOICDS_C Fenpropimorph DS0012 11 b1830 methamidophos 165 GOICDS_C Tridemorph DS0012 11 b1830 terbufos 165 GOICDS_C lprodione DS0012 11 b1830 aldicarb 165 GOICDSC 5-ethyl-6-octyl-[1,2,4] DS0012 triazolo[1,5-alpyri midine-7-ylamine 11 b1830 carbofuran 165 GOICDS C Mancozeb DS0012 11 b1830 bifenthrin 165 GOICDS C Maneb DS0012 11 b1830 cypermethrin 165 GOICDS_C Metiram DS0012 11 b1830 alpha-cypermethrin 165 GOICDS_C Dithianon DS0012 11 b1830 deltamethrin 165 GOICDS C Chlorothalonil DS0012 11 b1830 |ambda-cyhalothrin 165 GOICDS_C ThiophanateMethyl DS0012 11 b1830 tefluthrin 165 GOICDS_C Cymoxanil DS0012 11 b1830 flufenoxuron 165 GOICDS C Metrafenone DS0012 11 b1830 teflubenzuron 165 GOICDS C Acetochlor DS0012 11 b1830 spirotetramat; 165 GOICDS C Dimethenamid DS0012 11 b1830 clothianidin 165 GOICDS C Metolachlor DS0012 11 b1830 imidacloprid 165 GOICDS C Metazachlor DS0012 11 b1830 thiamethoxam 165 GOICDS_C Glyphosate DS0012 11 b1830 endosulfan 165 GOICDSC Glufosinate WO 2008/129060 105 PCT/EP2008/054924 DS0012 11 b1830 fipronil 165 GOICDS_C Sulfosate DS0012 11 b1830 abamectin 165 GOICDS_C Fenoxaprop DS0012 11 b1830 spinosad 165 GOICDS_C Paraquat DS0012 11 b1830 spinetoram 165 GOICDS_C Cycloxydim DS0012 11 b1830 hydramethylnon; 165 GOICDS_C Profoxydim DS0012 11 b1830 chlorfenapyr; 165 GOICDS_C Sethoxydim DS0012 11 b1830 indoxacarb 165 GOICDS_C Tepraloxydim DS0012 11 b1830 metaflumizone 165 GOICDS C Pendimethalin DS0012 11 b1830 flubendiamide 165 GOICDS C Acifluorfen DS0012 11 b1830 chlorantraniliprole 165 GOICDSC Imazamethabenz DS0012 11 b1830 cyazypyr(HGW86) 165 GOICDS_C Imazamox DS0012 11 b1830 Azoxystrobin 165 GOICDS_C Imazapic DS0012 11 b1830 Dimoxystrobin 165 GOICDS_C Imazapyr DS0012 11 b1830 Kresoxim-methyl 165 GOICDS_C Imazaquin DS0012 11 b1830 Orysastrobin 165 GOICDSC Imazethapyr DS0012 11 b1830 Pyraclostrobin 165 GOICDS C 2,4-D DS0012 11 b1830 Trifloxystrobin 165 GOICDS C Chloridazon DS0012 11 b1830 Bixafen 165 GOICDS C Picloram DS0012 11 b1830 Boscalid 165 GOICDS C Picolinafen DS0012 11 b1830 Isopyrazam 165 GOICDS_C Cyclosulfamuron DS0012 11 b1830 Metalaxyl 165 GOICDS C Triflusulfuron DS0012 11 b1830 Penthiopyrad 165 GOICDS C Atrazine DS0012 WO 2008/129060 106 PCT/EP2008/054924 11 b1830 3-Difluoromethyl-1- 165 GOICDS_C Pyroxasulfone methyl-1 H-pyrazole- DS0012 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 11 b1830 Dimethomorph 165 GOICDS C Bentazone DS0012 11 b1830 Difenoconazole 165 GOICDS_C Cinidon-ethly DS0012 11 b1830 Epoxiconazole 165 GOICDS_C Cinmethylin DS0012 11 b1830 Fluquinconazole 165 GOICDSC Dicamba DS0012 11 b1830 Metconazol 165 GOICDSC Diflufenzopyr DS0012 11 b1830 Propiconazole 165 GOICDS C Quinclorac DS0012 11 b1830 Prothioconazole 165 GOICDS C Quinmerac DS0012 11 b1830 Tebuconazole 165 GOICDS C Mesotrione DS0012 11 b1830 Triticonazole 165 GOICDS C Saflufenacil DS0012 11 b1830 Prochloraz 165 GOICDS_C Topramezone; DS0012 11 b1830 Carbendazim 166 GOICDS_C acephate DS0045 11 b1830 Cyprodinil 166 GOICDS_C chlorpyrifos DS0045 11 b1830 Pyrimethanil 166 GOICDS C dimethoate DS0045 11 b1830 Fenpropimorph 166 GOICDSC methamidophos DS0045 11 b1830 Tridemorph 166 GOICDS_ C terbufos DS0045 11 b1830 lprodione 166 GOICDSC aldicarb DS0045 11 b1830 5-ethyl-6-octyl-[1,2,4] 166 GOICDS C carbofuran triazolo[1,5-a]pyri- DS0045 midine-7-ylamine 11 b1830 Mancozeb 166 GOICDS C bifenthrin DS0045 11 b1830 Maneb 166 GOICDSC cypermethrin DS0045 11 b1830 Metiram 166 GOICDS C alpha-cypermethrin DS0045 WO 2008/129060 107 PCT/EP2008/054924 11 b1830 Dithianon 166 GOICDS C deltamethrin DS0045 11 b1830 Chlorothalonil 166 GOICDSC lambda-cyhalothrin DS0045 11 b1830 ThiophanateMethyl 166 GOICDS_C tefluthrin DS0045 11 b1830 Cymoxanil 166 GOICDS C flufenoxuron DS0045 11 b1830 Metrafenone 166 GOICDS C teflubenzuron DS0045 11 b1830 Acetochlor 166 GOICDS_C spirotetramat; DS0045 11 b1830 Dimethenamid 166 GOICDS C clothianidin DS0045 11 b1830 Metolachlor 166 GOICDS_C imidacloprid DS0045 11 b1830 Metazachlor 166 GOICDS C thiamethoxam DS0045 11 b1830 Glyphosate 166 GOICDS_C endosulfan DS0045 11 b1830 Glufosinate 166 GOICDS_C fipronil DS0045 11 b1830 Sulfosate 166 GOICDS C abamectin DS0045 11 b1830 Fenoxaprop 166 GOICDSC spinosad DS0045 11 b1830 Paraquat 166 GOICDS C spinetoram DS0045 11 b1830 Cycloxydim 166 GOICDS C hydramethylnon; DS0045 11 b1830 Profoxydim 166 GOICDS C chlorfenapyr; DS0045 11 b1830 Sethoxydim 166 GOICDS C indoxacarb DS0045 11 b1830 Tepraloxydim 166 GOICDS C metaflumizone DS0045 11 b1830 Pendimethalin 166 GOICDS C flubendiamide DS0045 11 b1830 Acifluorfen 166 GOICDS_C chlorantraniliprole DS0045 11 b1830 lmazamethabenz 166 GOICDS_C cyazypyr(HGW86) DS0045 11 b1830 Imazamox 166 GOICDS_C Azoxystrobin DS0045 11 b1830 Imazapic 166 GOICDSC Dimoxystrobin WO 2008/129060 108 PCT/EP2008/054924 DS0045 11 b1830 Imazapyr 166 GOICDS_C Kresoxim-methyl DS0045 11 b1830 Imazaquin 166 GOICDS_C Orysastrobin DS0045 11 b1830 Imazethapyr 166 GOICDS_C Pyraclostrobin DS0045 11 b1830 2,4-D 166 GOICDSC Trifloxystrobin DS0045 11 b1830 Chloridazon 166 GOICDS C Bixafen DS0045 11 b1830 Picloram 166 GOICDS C Boscalid DS0045 11 b1830 Picolinafen 166 GOICDS_C Isopyrazam DS0045 11 b1830 Cyclosulfamuron 166 GOICDSC Metalaxyl DS0045 11 b1830 Triflusulfuron 166 GOICDS_C Penthiopyrad DS0045 11 b1830 Atrazine 166 GOICDSC 3-Difluoromethyl-1 DS0045 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 11 b1830 Pyroxasulfone 166 GOICDS_C Dimethomorph DS0045 11 b1830 Bentazone 166 GOICDS C Difenoconazole DS0045 11 b1830 Cinidon-ethly 166 GOICDSC Epoxiconazole DS0045 11 b1830 Cinmethylin 166 GOICDS_C Fluquinconazole DS0045 11 b1830 Dicamba 166 GOICDS C Metconazol DS0045 11 b1830 Diflufenzopyr 166 GOICDS_C Propiconazole DS0045 11 b1830 Quinclorac 166 GOICDS C Prothioconazole DS0045 11 b1830 Quinmerac 166 GOICDS C Tebuconazole DS0045 11 b1830 Mesotrione 166 GOICDS C Triticonazole DS0045 11 b1830 Saflufenacil 166 GOICDS_C Prochloraz DS0045 11 b1830 Topramezone; 166 GOICDS_C Carbendazim DS0045 WO 2008/129060 109 PCT/EP2008/054924 12 b2664 acephate 166 GOICDS_C Cyprodinil DS0045 12 b2664 chlorpyrifos 166 GOICDSC Pyrimethanil DS0045 12 b2664 dimethoate 166 GOICDS_C Fenpropimorph DS0045 12 b2664 methamidophos 166 GOICDS_C Tridemorph DS0045 12 b2664 terbufos 166 GOICDS_C lprodione DS0045 12 b2664 aldicarb 166 GOICDS_C 5-ethyl-6-octyl-[1,2,4] DS0045 triazolo[1,5-a]pyri midine-7-ylamine 12 b2664 carbofuran 166 GOICDS C Mancozeb DS0045 12 b2664 bifenthrin 166 GOICDS C Maneb DS0045 12 b2664 cypermethrin 166 GOICDS C Metiram DS0045 12 b2664 alpha-cypermethrin 166 GOICDS_C Dithianon DS0045 12 b2664 deltamethrin 166 GOICDS C Chlorothalonil DS0045 12 b2664 lambda-cyhalothrin 166 GOICDS_C ThiophanateMethyl DS0045 12 b2664 tefluthrin 166 GOICDS_C Cymoxanil DS0045 12 b2664 flufenoxuron 166 GOICDS C Metrafenone DS0045 12 b2664 teflubenzuron 166 GOICDS C Acetochlor DS0045 12 b2664 spirotetramat; 166 GOICDS C Dimethenamid DS0045 12 b2664 clothianidin 166 GOICDS C Metolachlor DS0045 12 b2664 imidacloprid 166 GOICDS C Metazachlor DS0045 12 b2664 thiamethoxam 166 GOICDS_C Glyphosate DS0045 12 b2664 endosulfan 166 GOICDS C Glufosinate DS0045 12 b2664 fipronil 166 GOICDS_C Sulfosate DS0045 12 b2664 abamectin 166 GOICDS_C Fenoxaprop DS0045 WO 2008/129060 110 PCT/EP2008/054924 12 b2664 spinosad 166 GOICDS_C Paraquat DS0045 12 b2664 spinetoram 166 GOICDSC Cycloxydim DS0045 12 b2664 hydramethylnon; 166 GOICDS_C Profoxydim DS0045 12 b2664 chlorfenapyr; 166 GOICDS_C Sethoxydim DS0045 12 b2664 indoxacarb 166 GOICDS_C Tepraloxydim DS0045 12 b2664 metaflumizone 166 GOICDS C Pendimethalin DS0045 12 b2664 flubendiamide 166 GOICDS C Acifluorfen DS0045 12 b2664 chlorantraniliprole 166 GOICDS_C Imazamethabenz DS0045 12 b2664 cyazypyr(HGW86) 166 GOICDS_C Imazamox DS0045 12 b2664 Azoxystrobin 166 GOICDS_C Imazapic DS0045 12 b2664 Dimoxystrobin 166 GOICDS_C Imazapyr DS0045 12 b2664 Kresoxim-methyl 166 GOICDSC Imazaquin DS0045 12 b2664 Orysastrobin 166 GOICDS_C Imazethapyr DS0045 12 b2664 Pyraclostrobin 166 GOICDS C 2,4-D DS0045 12 b2664 Trifloxystrobin 166 GOICDS C Chloridazon DS0045 12 b2664 Bixafen 166 GOICDS C Picloram DS0045 12 b2664 Boscalid 166 GOICDS C Picolinafen DS0045 12 b2664 Isopyrazam 166 GOICDS_C Cyclosulfamuron DS0045 12 b2664 Metalaxyl 166 GOICDS C Triflusulfuron DS0045 12 b2664 Penthiopyrad 166 GOICDS C Atrazine DS0045 12 b2664 3-Difluoromethyl-1- 166 GOICDS_C Pyroxasulfone methyl-1 H-pyrazole- DS0045 4-carboxylic a cid(2',4',5'-trifluoro biphenyl-2-yl)-amide 12 b2664 Dimethomorph 166 GOICDS_C Bentazone WO 2008/129060 111 PCT/EP2008/054924 DS0045 12 b2664 Difenoconazole 166 GOICDS_C Cinidon-ethly DS0045 12 b2664 Epoxiconazole 166 GOICDS_C Cinmethylin DS0045 12 b2664 Fluquinconazole 166 GOICDS_C Dicamba DS0045 12 b2664 Metconazol 166 GOICDSC Diflufenzopyr DS0045 12 b2664 Propiconazole 166 GOICDS C Quinclorac DS0045 12 b2664 Prothioconazole 166 GOICDS C Quinmerac DS0045 12 b2664 Tebuconazole 166 GOICDS C Mesotrione DS0045 12 b2664 Triticonazole 166 GOICDS C Saflufenacil DS0045 12 b2664 Prochloraz 166 GOICDS_C Topramezone; DS0045 12 b2664 Carbendazim 167 GOICDS_C acephate DS0185 12 b2664 Cyprodinil 167 GOICDS_C chlorpyrifos DS0185 12 b2664 Pyrimethanil 167 GOICDS C dimethoate DS0185 12 b2664 Fenpropimorph 167 GOICDS__C methamidophos DS0185 12 b2664 Tridemorph 167 GOICDS_C terbufos DS0185 12 b2664 Iprodione 167 GOICDSC aldicarb DS0185 12 b2664 5-ethyl-6-octyl-[1,2,4] 167 GOICDS_C carbofuran triazolo[1,5-a]pyri- DS0185 midine-7-ylamine 12 b2664 Mancozeb 167 GOICDS C bifenthrin DS0185 12 b2664 Maneb 167 GOICDS_C cypermethrin DS0185 12 b2664 Metiram 167 GOICDS_C alpha-cypermethrin DSO185 12 b2664 Dithianon 167 GOICDS C deltamethrin DS0185 12 b2664 Chlorothalonil 167 GOICDSC lambda-cyhalothrin DS0185 12 b2664 ThiophanateMethyl 167 GOICDSC tefluthrin WO 2008/129060 112 PCT/EP2008/054924 DS0185 12 b2664 Cymoxanil 167 GOICDS C flufenoxuron DS0185 12 b2664 Metrafenone 167 GOICDS C teflubenzuron DS0185 12 b2664 Acetochlor 167 GOICDS_C spirotetramat; DS0185 12 b2664 Dimethenamid 167 GOICDS C clothianidin DSO185 12 b2664 Metolachlor 167 GOICDS_C imidacloprid DSO185 12 b2664 Metazachlor 167 GOICDS C thiamethoxam DS0185 12 b2664 Glyphosate 167 GOICDSC endosulfan DS0185 12 b2664 Glufosinate 167 GOICDSC fipronil DS0185 12 b2664 Sulfosate 167 GOICDS C abamectin DS0185 12 b2664 Fenoxaprop 167 GOICDS_C spinosad DS0185 12 b2664 Paraquat 167 GOICDS_C spinetoram DS0185 12 b2664 Cycloxydim 167 GOICDS_C hydramethylnon; DS0185 12 b2664 Profoxydim 167 GOICDS__C chlorfenapyr; DS0185 12 b2664 Sethoxydim 167 GOICDS C indoxacarb DS0185 12 b2664 Tepraloxydim 167 GOICDS C metaflumizone DS0185 12 b2664 Pendimethalin 167 GOICDS C flubendiamide DS0185 12 b2664 Acifluorfen 167 GOICDS_C chlorantraniliprole DS0185 12 b2664 Imazamethabenz 167 GOICDS_C cyazypyr(HGW86) DSO 185 12 b2664 Imazamox 167 GOICDS_C Azoxystrobin DS0185 12 b2664 Imazapic 167 GOICDSC Dimoxystrobin DS0185 12 b2664 Imazapyr 167 GOICDSC Kresoxim-methyl DS0185 12 b2664 Imazaquin 167 GOICDSC Orysastrobin DS0185 WO 2008/129060 113 PCT/EP2008/054924 12 b2664 Imazethapyr 167 GOICDS_C Pyraclostrobin DSO185 12 b2664 2,4-D 167 GOICDSC Trifloxystrobin DS0185 12 b2664 Chloridazon 167 GOICDS C Bixafen DS0185 12 b2664 Picloram 167 GOICDS C Boscalid DS0185 12 b2664 Picolinafen 167 GOICDS_C Isopyrazam DS0185 12 b2664 Cyclosulfamuron 167 GOICDS_C Metalaxyl DS0185 12 b2664 Triflusulfuron 167 GOICDS_C Penthiopyrad DS0185 12 b2664 Atrazine 167 GOICDS_C 3-Difluoromethyl-1 DS0185 methyl-1 H-pyrazole 4-carboxylic acid (2',4',5'-trifluoro biphenyl-2-yl)-amide 12 b2664 Pyroxasulfone 167 GOICDS_C Dimethomorph DS0185 12 b2664 Bentazone 167 GOICDS C Difenoconazole DS0185 12 b2664 Cinidon-ethly 167 GOICDS_C Epoxiconazole DS0185 12 b2664 Cinmethylin 167 GOICDS_C Fluquinconazole DS0185 12 b2664 Dicamba 167 GOICDS C Metconazol DS0185 12 b2664 Diflufenzopyr 167 GOICDS_C Propiconazole DS0185 12 b2664 Quinclorac 167 GOICDS C Prothioconazole DS0185 12 b2664 Quinmerac 167 GOICDS C Tebuconazole DS0185 12 b2664 Mesotrione 167 GOICDS C Triticonazole DS0185 12 b2664 Saflufenacil 167 GOICDS C Prochloraz DS0185 12 b2664 Topramezone; 167 GOICDS C Carbendazim DS0185 16 b2796 acephate 167 GOICDS_C Cyprodinil DS0185 16 b2796 chlorpyrifos 167 GOICDS_C Pyrimethanil DS0185 16 b2796 dimethoate 167 GOICDS_C Fenpropimorph WO 2008/129060 114 PCT/EP2008/054924 DSO185 16 b2796 methamidophos 167 GOICDS_C Tridemorph DS0185 16 b2796 terbufos 167 GOICDS_C lprodione DS0185 16 b2796 aldicarb 167 GOICDS_C 5-ethyl-6-octyl-[1,2,4] DS0185 triazolo[1,5-a]pyri midine-7-ylamine 16 b2796 carbofuran 167 GOICDS C Mancozeb DS0185 16 b2796 bifenthrin 167 GOICDS C Maneb DS0185 16 b2796 cypermethrin 167 GOICDS C Metiram DS0185 16 b2796 alpha-cypermethrin 167 GOICDS_C Dithianon DS0185 16 b2796 deltamethrin 167 GOICDS C Chlorothalonil DS0185 16 b2796 lambda-cyhalothrin 167 GOICDS_C ThiophanateMethyl DS0185 16 b2796 tefluthrin 167 GOICDS_C Cymoxanil DS0185 16 b2796 flufenoxuron 167 GOICDS C Metrafenone DS0185 16 b2796 teflubenzuron 167 GOICDS C Acetochlor DS0185 16 b2796 spirotetramat; 167 GOICDS C Dimethenamid DS0185 16 b2796 clothianidin 167 GOICDS C Metolachlor DS0185 16 b2796 imidacloprid 167 GOICDS C Metazachlor DS0185 16 b2796 thiamethoxam 167 GOICDSC Glyphosate DS0185 16 b2796 endosulfan 167 GOICDS C Glufosinate DS0185 16 b2796 fipronil 167 GOICDS C Sulfosate DS0185 16 b2796 abamectin 167 GOICDS_C Fenoxaprop DSO185 16 b2796 spinosad 167 GOICDS_C Paraquat DS0185 16 b2796 spinetoram 167 GOICDS_C Cycloxydim DS0185 16 b2796 hydramethylnon; 167 GOICDSC Profoxydim WO 2008/129060 115 PCT/EP2008/054924 DSO185 16 b2796 chlorfenapyr; 167 GOICDS_C Sethoxydim DS0185 16 b2796 indoxacarb 167 GOICDS_C Tepraloxydim DS0185 16 b2796 metaflumizone 167 GOICDS C Pendimethalin DS0185 16 b2796 flubendiamide 167 GOICDS C Acifluorfen DS0185 16 b2796 chlorantraniliprole 167 GOICDS_C Imazamethabenz DS0185 16 b2796 cyazypyr(HGW86) 167 GOICDS_C Imazamox DS0185 16 b2796 Azoxystrobin 167 GOICDSC Imazapic DS0185 16 b2796 Dimoxystrobin 167 GOICDSC Imazapyr DS0185 16 b2796 Kresoxim-methyl 167 GOICDS_C Imazaquin DS0185 16 b2796 Orysastrobin 167 GOICDSC Imazethapyr DS0185 16 b2796 Pyraclostrobin 167 GOICDS_C 2,4-D DS0185 16 b2796 Trifloxystrobin 167 GOICDS C Chloridazon DS0185 16 b2796 Bixafen 167 GOICDS C Picloram DS0185 16 b2796 Boscalid 167 GOICDS C Picolinafen DS0185 16 b2796 Isopyrazam 167 GOICDSC Cyclosulfamuron DS0185 16 b2796 Metalaxyl 167 GOICDS C Triflusulfuron DS0185 16 b2796 Penthiopyrad 167 GOICDS C Atrazine DS0185 16 b2796 3-Difluoromethyl-1- 167 GOICDS_C Pyroxasulfone methyl-1 H-pyrazole- DS0185 4-carboxylic a cid(2',4',5'-trifluoro biphenyl-2-yl)-amide 16 b2796 Dimethomorph 167 GOICDS C Bentazone DS0185 16 b2796 Difenoconazole 167 GOICDS_C Cinidon-ethly DS0185 16 b2796 Epoxiconazole 167 GOICDS_C Cinmethylin DS0185 WO 2008/129060 116 PCT/EP2008/054924 16 b2796 Fluquinconazole 167 GOICDS_C Dicamba DS0185 16 b2796 Metconazol 167 GOICDSC Diflufenzopyr DS0185 16 b2796 Propiconazole 167 GOICDS C Quinclorac DS0185 16 b2796 Prothioconazole 167 GOICDS C Quinmerac DS0185 16 b2796 Tebuconazole 167 GOICDS C Mesotrione DS0185 16 b2796 Triticonazole 167 GOICDS C Saflufenacil DS0185 16 b2796 Prochloraz 167 GOICDS_C Topramezone; DS0185 16 b2796 Carbendazim 168 acephate 16 b2796 Cyprodinil 168 chlorpyrifos 16 b2796 Pyrimethanil 168 dimethoate 16 b2796 Fenpropimorph 168 methamidophos 16 b2796 Tridemorph 168 terbufos 16 b2796 Iprodione 168 aldicarb 16 b2796 5-ethyl-6-octyl-[1,2,4] 168 carbofuran triazolo{1,5-alpyri midine-7-ylamine 16 b2796 Mancozeb 168 bifenthrin 16 b2796 Maneb 168 cypermethrin 16 b2796 Metiram 168 alpha-cypermethrin 16 b2796 Dithianon 168 deltamethrin 16 b2796 Chlorothalonil 168 lambda-cyhalothrin 16 b2796 ThiophanateMethyl 168 tefluthrin 16 b2796 Cymoxanil 168 flufenoxuron 16 b2796 Metrafenone 168 teflubenzuron 16 b2796 Acetochlor 168 spirotetramat; 16 b2796 Dimethenamid 168 clothianidin 16 b2796 Metolachlor 168 imidacloprid 16 b2796 Metazachlor 168 thiamethoxam 16 b2796 Glyphosate 168 endosulfan 16 b2796 Glufosinate 168 fipronil 16 b2796 Sulfosate 168 abamectin 16 b2796 Fenoxaprop 168 spinosad 16 b2796 Paraquat 168 spinetoram 16 b2796 Cycloxydim 168 hydramethyinon; WO 2008/129060 117 PCT/EP2008/054924 16 b2796 Profoxydim 168 chlorfenapyr; 16 b2796 Sethoxydim 168 indoxacarb 16 b2796 Tepraloxydim 168 metaflumizone 16 b2796 Pendimethalin 168 flubendiamide 16 b2796 Acifluorfen 168 chlorantraniliprole 16 b2796 Imazamethabenz 168 cyazypyr(HGW86) 16 b2796 Imazamox 168 Azoxystrobin 16 b2796 Imazapic 168 Dimoxystrobin 16 b2796 Imazapyr 168 Kresoxim-methyl 16 b2796 Imazaquin 168 Orysastrobin 16 b2796 Imazethapyr 168 Pyraclostrobin 16 b2796 2,4-D 168 Trifloxystrobin 16 b2796 Chloridazon 168 Bixafen 16 b2796 Picloram 168 Boscalid 16 b2796 Picolinafen 168 Isopyrazam 16 b2796 Cyclosulfamuron 168 Metalaxyl 16 b2796 Triflusulfuron 168 Penthiopyrad 16 b2796 Atrazine 168 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 16 b2796 Pyroxasulfone 168 Dimethomorph 16 b2796 Bentazone 168 Difenoconazole 16 b2796 Cinidon-ethly 168 Epoxiconazole 16 b2796 Cinmethylin 168 Fluquinconazole 16 b2796 Dicamba 168 Metconazol 16 b2796 Diflufenzopyr 168 Propiconazole 16 b2796 Quinclorac 168 Prothioconazole 16 b2796 Quinmerac 168 Tebuconazole 16 b2796 Mesotrione 168 Triticonazole 16 b2796 Saflufenacil 168 Prochloraz 16 b2796 Topramezone; 168 Carbendazim 19 EST102 acephate 168 Cyprodinil 19 EST102 chlorpyrifos 168 Pyrimethanil 19 EST102 dimethoate 168 Fenpropimorph 19 EST102 methamidophos 168 Tridemorph 19 EST102 terbufos 168 lprodione 19 EST1 02 aldicarb 168 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri- WO 2008/129060 118 PCT/EP2008/054924 midine-7-ylamine 19 EST102 carbofuran 168 Mancozeb 19 EST102 bifenthrin 168 Maneb 19 EST102 cypermethrin 168 Metiram 19 EST102 alpha-cypermethrin 168 Dithianon 19 EST102 deltamethrin 168 Chlorothalonil 19 EST102 lambda-cyhalothrin 168 ThiophanateMethyl 19 EST102 tefluthrin 168 Cymoxanil 19 EST102 flufenoxuron 168 Metrafenone 19 EST102 teflubenzuron 168 Acetochlor 19 EST102 spirotetramat; 168 Dimethenamid 19 EST102 clothianidin 168 Metolachlor 19 EST102 imidacloprid 168 Metazachlor 19 EST102 thiamethoxam 168 Glyphosate 19 EST102 endosulfan 168 Glufosinate 19 EST102 fipronil 168 Sulfosate 19 EST102 abamectin 168 Fenoxaprop 19 EST102 spinosad 168 Paraquat 19 EST102 spinetoram 168 Cycloxydim 19 EST102 hydramethylnon; 168 Profoxydim 19 EST102 chlorfenapyr; 168 Sethoxydim 19 EST102 indoxacarb 168 Tepraloxydim 19 EST102 metaflumizone 168 Pendimethalin 19 EST102 flubendiamide 168 Acifluorfen 19 EST1 02 chlorantraniliprole 168 Imazamethabenz 19 EST102 cyazypyr(HGW86) 168 Imazamox 19 EST102 Azoxystrobin 168 Imazapic 19 EST102 Dimoxystrobin 168 Imazapyr 19 EST102 Kresoxim-methyl 168 Imazaquin 19 EST102 Orysastrobin 168 Imazethapyr 19 EST102 Pyraclostrobin 168 2,4-D 19 EST102 Trifloxystrobin 168 Chloridazon 19 EST102 Bixafen 168 Picloram 19 EST102 Boscalid 168 Picolinafen 19 EST102 Isopyrazam 168 Cyclosulfamuron 19 EST102 Metalaxyl 168 Triflusulfuron 19 EST102 Penthiopyrad 168 Atrazine 19 EST102 3-DifluoromethyI-1- 168 Pyroxasulfone methyl-1 H-pyrazole- WO 2008/129060 119 PCT/EP2008/054924 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 19 EST102 Dimethomorph 168 Bentazone 19 EST102 Difenoconazole 168 Cinidon-ethly 19 EST102 Epoxiconazole 168 Cinmethylin 19 EST102 Fluquinconazole 168 Dicamba 19 EST102 Metconazol 168 Diflufenzopyr 19 EST102 Propiconazole 168 Quinclorac 19 EST102 Prothioconazole 168 Quinmerac 19 EST102 Tebuconazole 168 Mesotrione 19 EST102 Triticonazole 168 Saflufenacil 19 EST102 Prochloraz 168 Topramezone; 19 EST102 Carbendazim 169 acephate 19 EST102 Cyprodinil 169 chlorpyrifos 19 EST102 Pyrimethanil 169 dimethoate 19 EST102 Fenpropimorph 169 methamidophos 19 EST102 Tridemorph 169 terbufos 19 EST102 lprodione 169 aldicarb 19 EST1 02 5-ethyl-6-octyl-[1,2,4] 169 carbofuran triazolo[1,5-a]pyri midine-7-ylamine 19 EST102 Mancozeb 169 bifenthrin 19 EST102 Maneb 169 cypermethrin 19 EST102 Metiram 169 alpha-cypermethrin 19 EST102 Dithianon 169 deltamethrin 19 EST102 Chlorothalonil 169 lambda-cyhalothrin 19 EST102 ThiophanateMethyl 169 tefluthrin 19 EST102 Cymoxanil 169 flufenoxuron 19 EST102 Metrafenone 169 teflubenzuron 19 EST102 Acetochlor 169 spirotetramat; 19 EST102 Dimethenamid 169 clothianidin 19 EST102 Metolachlor 169 imidacloprid 19 EST102 Metazachlor 169 thiamethoxam 19 EST102 Glyphosate 169 endosulfan 19 EST102 Glufosinate 169 fipronil 19 EST102 Sulfosate 169 abamectin 19 EST102 Fenoxaprop 169 spinosad 19 EST102 Paraquat 169 spinetoram 19 EST102 Cycloxydim 169 hydramethylnon; WO 2008/129060 120 PCT/EP2008/054924 19 EST102 Profoxydim 169 chlorfenapyr; 19 EST102 Sethoxydim 169 indoxacarb 19 EST102 Tepraloxydim 169 metaflumizone 19 EST102 Pendimethalin 169 flubendiamide 19 EST102 Acifluorfen 169 chlorantraniliprole 19 EST102 Imazamethabenz 169 cyazypyr(HGW86) 19 EST102 Imazamox 169 Azoxystrobin 19 EST102 Imazapic 169 Dimoxystrobin 19 EST102 Imazapyr 169 Kresoxim-methyl 19 EST102 Imazaquin 169 Orysastrobin 19 EST102 Imazethapyr 169 Pyraclostrobin 19 EST102 2,4-D 169 Trifloxystrobin 19 EST102 Chloridazon 169 Bixafen 19 EST102 Picloram 169 Boscalid 19 EST102 Picolinafen 169 Isopyrazam 19 EST102 Cyclosulfamuron 169 Metalaxyl 19 EST102 Triflusulfuron 169 Penthiopyrad 19 EST102 Atrazine 169 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 19 EST102 Pyroxasulfone 169 Dimethomorph 19 EST102 Bentazone 169 Difenoconazole 19 EST102 Cinidon-ethly 169 Epoxiconazole 19 EST102 Cinmethylin 169 Fluquinconazole 19 EST102 Dicamba 169 Metconazol 19 EST1 02 Diflufenzopyr 169 Propiconazole 19 EST102 Quinclorac 169 Prothioconazole 19 EST102 Quinmerac 169 Tebuconazole 19 EST102 Mesotrione 169 Triticonazole 19 EST102 Saflufenacil 169 Prochloraz 19 EST102 Topramezone; 169 Carbendazim 20 EST12 acephate 169 Cyprodinil 20 EST12 chlorpyrifos 169 Pyrimethanil 20 EST12 dimethoate 169 Fenpropimorph 20 EST12 methamidophos 169 Tridemorph 20 EST12 terbufos 169 lprodione 20 EST12 aldicarb 169 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri- WO 2008/129060 121 PCT/EP2008/054924 midine-7-ylamine 20 EST12 carbofuran 169 Mancozeb 20 EST12 bifenthrin 169 Maneb 20 EST12 cypermethrin 169 Metiram 20 EST12 alpha-cypermethrin 169 Dithianon 20 EST12 deltamethrin 169 Chlorothalonil 20 EST12 lambda-cyhalothrin 169 ThiophanateMethyl 20 EST12 tefluthrin 169 Cymoxanil 20 EST12 flufenoxuron 169 Metrafenone 20 EST12 teflubenzuron 169 Acetochlor 20 EST12 spirotetramat; 169 Dimethenamid 20 EST12 clothianidin 169 Metolachlor 20 EST12 imidacloprid 169 Metazachlor 20 EST12 thiamethoxam 169 Glyphosate 20 EST12 endosulfan 169 Glufosinate 20 EST12 fipronil 169 Sulfosate 20 EST12 abamectin 169 Fenoxaprop 20 EST12 spinosad 169 Paraquat 20 EST12 spinetoram 169 Cycloxydim 20 EST12 hydramethylnon; 169 Profoxydim 20 EST12 chlorfenapyr; 169 Sethoxydim 20 EST12 indoxacarb 169 Tepraloxydim 20 EST12 metaflumizone 169 Pendimethalin 20 EST12 flubendiamide 169 Acifluorfen 20 EST12 chlorantraniliprole 169 Imazamethabenz 20 EST12 cyazypyr(HGW86) 169 Imazamox 20 EST12 Azoxystrobin 169 Imazapic 20 EST12 Dimoxystrobin 169 Imazapyr 20 EST12 Kresoxim-methyl 169 Imazaquin 20 EST12 Orysastrobin 169 Imazethapyr 20 EST12 Pyraclostrobin 169 2,4-D 20 EST12 Trifloxystrobin 169 Chloridazon 20 EST12 Bixafen 169 Picloram 20 EST12 Boscalid 169 Picolinafen 20 EST12 Isopyrazam 169 Cyclosulfamuron 20 EST12 Metalaxyl 169 Triflusulfuron 20 EST12 Penthiopyrad 169 Atrazine 20 EST12 3-Difluoromethyl-1- 169 Pyroxasulfone methyl-1 H-pyrazole- WO 2008/129060 122 PCT/EP2008/054924 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 20 EST12 Dimethomorph 169 Bentazone 20 EST12 Difenoconazole 169 Cinidon-ethly 20 EST12 Epoxiconazole 169 Cinmethylin 20 EST12 Fluquinconazole 169 Dicamba 20 EST12 Metconazol 169 Diflufenzopyr 20 EST12 Propiconazole 169 Quinclorac 20 EST12 Prothioconazole 169 Quinmerac 20 EST12 Tebuconazole 169 Mesotrione 20 EST12 Triticonazole 169 Saflufenacil 20 EST12 Prochloraz 169 Topramezone; 20 EST12 Carbendazim 170 GOICDS_C acephate DS0647 20 EST12 Cyprodinil 170 GOICDS_C chlorpyrifos DS0647 20 EST12 Pyrimethanil 170 GOICDS C dimethoate DS0647 20 EST12 Fenpropimorph 170 GOICDS_C methamidophos DS0647 20 EST12 Tridemorph 170 GOICDS_C terbufos DS0647 20 EST12 lprodione 170 GOICDS_C aldicarb DS0647 20 EST12 5-ethyl-6-octyl-[1,2,4] 170 GOICDS_C carbofuran triazolo[1,5-a]pyri- DS0647 midine-7-ylamine 20 EST12 Mancozeb 170 GOICDS C bifenthrin DS0647 20 EST12 Maneb 170 GOICDS_C cypermethrin DS0647 20 EST12 Metiram 170 GOICDS_C alpha-cypermethrin DS0647 20 EST12 Dithianon 170 GOICDS C deltamethrin DS0647 20 EST12 Chlorothalonil 170 GOICDS_C lambda-cyhalothrin DS0647 20 EST12 ThiophanateMethyl 170 GOICDS_C tefluthrin DS0647 20 EST12 Cymoxanil 170 GOICDS C flufenoxuron DS0647 20 EST12 Metrafenone 170 GOICDS C teflubenzuron DS0647 WO 2008/129060 123 PCT/EP2008/054924 20 EST12 Acetochlor 170 GOICDS_C spirotetramat; DS0647 20 EST12 Dimethenamid 170 GOICDS C clothianidin DS0647 20 EST12 Metolachlor 170 GOICDS_C imidacloprid DS0647 20 EST12 Metazachlor 170 GOICDS C thiamethoxam DS0647 20 EST12 Glyphosate 170 GOICDS_C endosulfan DS0647 20 EST12 Glufosinate 170 GOICDS_C fipronil DS0647 20 EST12 Sulfosate 170 GOICDS C abamectin DS0647 20 EST12 Fenoxaprop 170 GOICDS_C spinosad DS0647 20 EST12 Paraquat 170 GOICDS_C spinetoram DS0647 20 EST12 Cycloxydim 170 GOICDS_C hydramethylnon; DS0647 20 EST12 Profoxydim 170 GOICDS_C chlorfenapyr; DS0647 20 EST12 Sethoxydim 170 GOICDS C'indoxacarb DS0647 20 EST12 Tepraloxydim 170 GOICDS C metaflumizone DS0647 20 EST12 Pendimethalin 170 GOICDS C flubendiamide DS0647 20 EST12 Acifluorfen 170 GOICDS C chlorantraniliprole DS0647 20 EST12 Imazamethabenz 170 GOICDS C cyazypyr(HGW86) DS0647 20 EST12 Imazamox 170 GOICDSC Azoxystrobin DS0647 20 EST12 Imazapic 170 GOICDS C Dimoxystrobin DS0647 20 EST12 Imazapyr 170 GOICDS C Kresoxim-methyl DS0647 20 EST12 Imazaquin 170 GOICDSC Orysastrobin DS0647 20 EST12 Imazethapyr 170 GOICDSC Pyraclostrobin DS0647 20 EST12 2,4-D 170 GOICDS C Trifloxystrobin DS0647 20 EST12 Chloridazon 170 GOICDSC Bixafen WO 2008/129060 124 PCT/EP2008/054924 DS0647 20 EST12 Picloram 170 GOICDS C Boscalid DS0647 20 EST12 Picolinafen 170 GOICDS_C Isopyrazam DS0647 20 EST12 Cyclosulfamuron 170 GOICDS_C Metalaxyl DS0647 20 EST12 Triflusulfuron 170 GOICDSC Penthiopyrad DS0647 20 EST12 Atrazine 170 GOICDS_C 3-Difluoromethyl-1 DS0647 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 20 EST12 Pyroxasulfone 170 GOICDS_C Dimethomorph DS0647 20 EST12 Bentazone 170 GOICDS C Difenoconazole DS0647 20 EST12 Cinidon-ethly 170 GOICDS_C Epoxiconazole DS0647 20 EST12 Cinmethylin 170 GOICDS_C Fluquinconazole DS0647 20 EST12 Dicamba 170 GOICDS C Metconazol DS0647 20 EST12 Diflufenzopyr 170 GOICDS_C Propiconazole DS0647 20 EST12 Quinclorac 170 GOICDS C Prothioconazole DS0647 20 EST12 Quinmerac 170 GOICDS C Tebuconazole DS0647 20 EST12 Mesotrione 170 GOICDS C Triticonazole DS0647 20 EST12 Saflufenacil 170 GOICDS C Prochloraz DS0647 20 EST12 Topramezone; 170 GOICDS_C Carbendazim DS0647 21 EST134 acephate 170 GOICDS_C Cyprodinil DS0647 21 EST134 chlorpyrifos 170 GOICDS_C Pyrimethanil DS0647 21 EST134 dimethoate 170 GOICDS_C Fenpropimorph DS0647 21 EST134 methamidophos 170 GOICDS_C Tridemorph DS0647 21 EST134 terbufos 170 GOICDS_C Iprodione DS0647 WO 2008/129060 125 PCT/EP2008/054924 21 EST134 aldicarb 170 GOICDS_C 5-ethyl-6-octyl-[1,2,4] DS0647 triazolo[1,5-a]pyri midine-7-ylamine 21 EST134 carbofuran 170 GOICDS C Mancozeb DS0647 21 EST134 bifenthrin 170 GOICDS C Maneb DS0647 21 EST134 cypermethrin 170 GOICDS_C Metiram DS0647 21 EST134 alpha-cypermethrin 170 GOICDSC Dithianon DS0647 21 EST134 deltamethrin 170 GOICDS C Chlorothalonil DS0647 21 EST134 lambda-cyhalothrin 170 GOICDS_C ThiophanateMethyl DS0647 21 EST134 tefluthrin 170 GOICDS_C Cymoxanil DS0647 21 EST134 flufenoxuron 170 GOICDS C Metrafenone DS0647 21 EST134 teflubenzuron 170 GOICDS C Acetochlor DS0647 21 EST134 spirotetramat; 170 GOICDS_C Dimethenamid DS0647 21 EST134 clothianidin 170 GOICDS C Metolachlor DS0647 21 EST134 imidacloprid 170 GOICDS C Metazachlor DS0647 21 EST134 thiamethoxam 170 GOICDS_C Glyphosate DS0647 21 EST134 endosulfan 170 GOICDS C Glufosinate DS0647 21 EST134 fipronil 170 GOICDS_C Sulfosate DS0647 21 EST134 abamectin 170 GOICDSC Fenoxaprop DS0647 21 EST134 spinosad 170 GOICDS_C Paraquat DS0647 21 EST134 spinetoram 170 GOICDSC Cycloxydim DS0647 21 EST134 hydramethylnon; 170 GOICDS_C Profoxydim DS0647 21 EST134 chlorfenapyr; 170 GOICDS_C Sethoxydim DS0647 21 EST134 indoxacarb 170 GOICDS_C Tepraloxydim DS0647 WO 2008/129060 126 PCT/EP2008/054924 21 EST134 metaflumizone 170 GOICDS C Pendimethalin DS0647 21 EST134 flubendiamide 170 GOICDS C Acifluorfen DS0647 21 EST134 chlorantraniliprole 170 GOICDS_C Imazamethabenz DS0647 21 EST134 cyazypyr(HGW86) 170 GOICDS_C Imazamox DS0647 21 EST134 Azoxystrobin 170 GOICDS_C Imazapic DS0647 21 EST134 Dimoxystrobin 170 GOICDS_C Imazapyr DS0647 21 EST134 Kresoxim-methyl 170 GOICDS_C Imazaquin DS0647 21 EST134 Orysastrobin 170 GOICDS_C Imazethapyr DS0647 21 EST134 Pyraclostrobin 170 GOICDS C 2,4-D DS0647 21 EST134 Trifloxystrobin 170 GOICDS C Chloridazon DS0647 21 EST134 Bixafen 170 GOICDS C Picloram DS0647 21 EST134 Boscalid 170 GOICDS C Picolinafen DS0647 21 EST134 Isopyrazam 170 GOICDSC Cyclosulfamuron DS0647 21 EST134 Metalaxyl 170 GOICDS C Triflusulfuron DS0647 21 EST134 Penthiopyrad 170 GOICDS C Atrazine DS0647 21 EST134 3-Difluoromethyl-1- 170 GOICDS C Pyroxasulfone methyl-1 H-pyrazole- DS0647 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 21 EST134 Dimethomorph 170 GOICDS C Bentazone DS0647 21 EST134 Difenoconazole 170 GOICDS C Cinidon-ethly DS0647 21 EST134 Epoxiconazole 170 GOICDS C Cinmethylin DS0647 21 EST134 Fluquinconazole 170 GOICDS C Dicamba DS0647 21 EST134 Metconazol 170 GOICDS C Diflufenzopyr DS0647 21 EST134 Propiconazole 170 GOlCDSC Quinclorac WO 2008/129060 127 PCT/EP2008/054924 DS0647 21 EST134 Prothioconazole 170 GOICDS C Quinmerac DS0647 21 EST134 Tebuconazole 170 GOICDS C Mesotrione DS0647 21 EST134 Triticonazole 170 GOICDS C Saflufenacil DS0647 21 EST134 Prochloraz 170 GOICDS_C Topramezone; DS0647 21 EST134 Carbendazim 171 acephate 21 EST134 Cyprodinil 171 chlorpyrifos 21 EST134 Pyrimethanil 171 dimethoate 21 EST134 Fenpropimorph 171 methamidophos 21 EST134 Tridemorph 171 terbufos 21 EST134 lprodione 171 aldicarb 21 EST134 5-ethyl-6-octyl-[1,2,4] 171 carbofuran triazolo[1,5-a]pyri midine-7-ylamine 21 EST134 Mancozeb 171 bifenthrin 21 EST134 Maneb 171 cypermethrin 21 EST134 Metiram 171 alpha-cypermethrin 21 EST134 Dithianon 171 deltamethrin 21 EST1 34 Chlorothalonil 171 lambda-cyhalothrin 21 EST134 ThiophanateMethyl 171 tefluthrin 21 EST134 Cymoxanil 171 flufenoxuron 21 EST134 Metrafenone 171 teflubenzuron 21 EST134 Acetochlor 171 spirotetramat; 21 EST134 Dimethenamid 171 clothianidin 21 EST134 Metolachlor 171 imidacloprid 21 EST134 Metazachlor 171 thiamethoxam 21 EST134 Glyphosate 171 endosulfan 21 EST134 Glufosinate 171 fipronil 21 EST134 Sulfosate 171 abamectin 21 EST134 Fenoxaprop 171 spinosad 21 EST134 Paraquat 171 spinetoram 21 EST134 Cycloxydim 171 hydramethylnon; 21 EST134 Profoxydim 171 chlorfenapyr; 21 EST134 Sethoxydim 171 indoxacarb 21 EST134 Tepraloxydim 171 metaflumizone 21 EST134 Pendimethalin 171 flubendiamide WO 2008/129060 128 PCT/EP2008/054924 21 EST134 Acifluorfen 171 chlorantraniliprole 21 EST1 34 Imazamethabenz 171 cyazypyr(HGW86) 21 EST134 Imazamox 171 Azoxystrobin 21 EST134 Imazapic 171 Dimoxystrobin 21 EST1 34 Imazapyr 171 Kresoxim-methyl 21 EST134 Imazaquin 171 Orysastrobin 21 EST134 Imazethapyr 171 Pyraclostrobin 21 EST134 2,4-D 171 Trifloxystrobin 21 EST134 Chloridazon 171 Bixafen 21 EST134 Picloram 171 Boscalid 21 EST134 Picolinafen 171 Isopyrazam 21 EST134 Cyclosulfamuron 171 Metalaxyl 21 EST134 Triflusulfuron 171 Penthiopyrad 21 EST134 Atrazine 171 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 21 EST134 Pyroxasulfone 171 Dimethomorph 21 EST134 Bentazone 171 Difenoconazole 21 EST134 Cinidon-ethly 171 Epoxiconazole 21 EST134 Cinmethylin 171 Fluquinconazole 21 EST134 Dicamba 171 Metconazol 21 EST134 Diflufenzopyr 171 Propiconazole 21 EST134 Quinclorac 171 Prothioconazole 21 EST134 Quinmerac 171 Tebuconazole 21 EST134 Mesotrione 171 Triticonazole 21 EST134 Saflufenacil 171 Prochloraz 21 EST134 Topramezone; 171 Carbendazim 23 EST163 acephate 171 Cyprodinil 23 EST163 chlorpyrifos 171 Pyrimethanil 23 EST163 dimethoate 171 Fenpropimorph 23 EST163 methamidophos 171 Tridemorph 23 EST163 terbufos 171 lprodione 23 EST163 aldicarb 171 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 23 EST163 carbofuran 171 Mancozeb 23 EST163 bifenthrin 171 Maneb 23 EST163 cypermethrin 171 Metiram WO 2008/129060 129 PCT/EP2008/054924 23 EST163 alpha-cypermethrin 171 Dithianon 23 EST163 deltamethrin 171 Chlorothalonil 23 EST163 lambda-cyhalothrin 171 ThiophanateMethyl 23 EST163 tefluthrin 171 Cymoxanil 23 EST163 flufenoxuron 171 Metrafenone 23 EST163 teflubenzuron 171 Acetochlor 23 EST163 spirotetramat; 171 Dimethenamid 23 EST163 clothianidin 171 Metolachlor 23 EST163 imidacloprid 171 Metazachlor 23 EST163 thiamethoxam 171 Glyphosate 23 EST163 endosulfan 171 Glufosinate 23 EST163 fipronil 171 Sulfosate 23 EST163 abamectin 171 Fenoxaprop 23 EST163 spinosad 171 Paraquat 23 EST163 spinetoram 171 Cycloxydim 23 EST163 hydramethylnon; 171 Profoxydim 23 EST163 chlorfenapyr; 171 Sethoxydim 23 EST163 indoxacarb 171 Tepraloxydim 23 EST163 metaflumizone 171 Pendimethalin 23 EST163 flubendiamide 171 Acifluorfen 23 EST163 chlorantraniliprole 171 Imazamethabenz 23 EST163 cyazypyr(HGW86) 171 Imazamox 23 EST163 Azoxystrobin 171 Imazapic 23 EST163 Dimoxystrobin 171 Imazapyr 23 EST163 Kresoxim-methyl 171 Imazaquin 23 EST163 Orysastrobin 171 Imazethapyr 23 EST163 Pyraclostrobin 171 2,4-D 23 EST163 Trifloxystrobin 171 Chloridazon 23 EST163 Bixafen 171 Picloram 23 EST163 Boscalid 171 Picolinafen 23 EST163 Isopyrazam 171 Cyclosulfamuron 23 EST163 Metalaxyl 171 Triflusulfuron 23 EST163 Penthiopyrad 171 Atrazine 23 EST163 3-Difluoromethyl-1- 171 Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 23 EST163 Dimethomorph 171 Bentazone 23 EST163 Difenoconazole 171 Cinidon-ethly WO 2008/129060 130 PCT/EP2008/054924 23 EST163 Epoxiconazole 171 Cinmethylin 23 EST163 Fluquinconazole 171 Dicamba 23 EST163 Metconazol 171 Diflufenzopyr 23 EST163 Propiconazole 171 Quinclorac 23 EST163 Prothioconazole 171 Quinmerac 23 EST163 Tebuconazole 171 Mesotrione 23 EST163 Triticonazole 171 Saflufenacil 23 EST163 Prochloraz 171 Topramezone; 23 EST163 Carbendazim 172 GOICDS_C acephate DS1499_2 23 EST163 Cyprodinil 172 GOICDS_C chlorpyrifos DS1499_2 23 EST163 Pyrimethanil 172 GOICDS C dimethoate DS1499_2 23 EST163 Fenpropimorph 172 GOICDSC methamidophos DS1499_2 23 EST1 63 Tridemorph 172 GOICDSC terbufos DS1499_2 23 EST163 lprodione 172 GOICDS_C aldicarb DS1499_2 23 EST163 5-ethyl-6-octyl-[1,2,4] 172 GOICDS_C carbofuran triazolo[1,5-a]pyri- DS1499_2 midine-7-ylamine 23 EST163 Mancozeb 172 GOICDS C bifenthrin DS1499_2 23 EST163 Maneb 172 GOICDS_C cypermethrin DS1499 2 23 EST163 Metiram 172 GOICDSC alpha-cypermethrin DS1499_2 23 EST163 Dithianon 172 GOICDS C deltamethrin DS1499_2 23 EST163 Chlorothalonil 172 GOICDS_C lambda-cyhalothrin DS1499_2 23 EST163 ThiophanateMethyl 172 GOICDS_C tefluthrin DS1499_2 23 EST163 Cymoxanil 172 GOICDSC flufenoxuron DS1499_2 23 EST163 Metrafenone 172 GOICDS C teflubenzuron DS1499_2 23 EST163 Acetochlor 172 GOICDSC spirotetramat; DS1499_2 23 EST163 Dimethenamid 172 GOICDS_C clothianidin DS1499_2 23 EST163 Metolachlor 172 GOICDSC imidacloprid WO 2008/129060 1 31 PCT/EP2008/054924 DS1499_2 23 EST163 Metazachlor 172 GOICDS C thiamethoxam DS1499_2 23 EST163 Glyphosate 172 GOICDS_C endosulfan DS1499_2 23 EST163 Glufosinate 172 GOICDS_C fipronil DS1499_2 23 EST163 Sulfosate 172 GOICDS C abamectin DS1499_2 23 EST163 Fenoxaprop 172 GOICDS_C spinosad DS1499_2 23 EST163 Paraquat 172 GOICDS_C spinetoram DS1499_2 23 EST163 Cycloxydim 172 GOICDS_C hydramethylnon; DS1499_2 23 EST163 Profoxydim 172 GOICDSC chlorfenapyr; DS1499_2 23 EST163 Sethoxydim 172 GOICDS_C indoxacarb DS1499_2 23 EST163 Tepraloxydim 172 GOICDS C metaflumizone DS1499_2 23 EST163 Pendimethalin 172 GOICDS C flubendiamide DS1499_2 23 EST163 Acifluorfen 172 GOICDS_C chlorantraniliprole DS1499_2 23 EST163 Imazamethabenz 172 GOICDS_C cyazypyr(HGW86) DS1499_2 23 EST163 Imazamox 172 GOICDS_C Azoxystrobin DS1499_2 23 EST163 Imazapic 172 GOICDSC Dimoxystrobin DS1499_2 23 EST163 Imazapyr 172 GOICDS_C Kresoxim-methyl DS1499_2 23 EST163 Imazaquin 172 GOICDS_C Orysastrobin DS1499_2 23 EST163 Imazethapyr 172 GOICDS_C Pyraclostrobin DS1499_2 23 EST163 2,4-D 172 GOICDS_C Trifloxystrobin DS1499_2 23 EST163 Chloridazon 172 GOICDS C Bixafen DS1499_2 23 EST163 Picloram 172 GOICDS C Boscalid DS1499_2 23 EST163 Picolinafen 172 GOICDS C Isopyrazam DS1499 2 WO 2008/129060 132 PCT/EP2008/054924 23 EST163 Cyclosulfamuron 172 GOICDS_C Metalaxyl DS1499_2 23 EST163 Triflusulfuron 172 GOICDSC Penthiopyrad DS1499_2 23 EST163 Atrazine 172 GOICDS_C 3-Difluoromethyl-1 DS1499_2 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 23 EST163 Pyroxasulfone 172 GOICDS_C Dimethomorph DS1499_2 23 EST163 Bentazone 172 GOICDS C Difenoconazole DS1499_2 23 EST163 Cinidon-ethly 172 GOICDSC Epoxiconazole DS1499_2 23 EST163 Cinmethylin 172 GOICDS_C Fluquinconazole DS1499_2 23 EST163 Dicamba 172 GOICDS C Metconazol DS1499_2 23 EST163 Diflufenzopyr 172 GOICDS_C Propiconazole DS1499_2 23 EST163 Quinclorac 172 GOICDS C Prothioconazole DS1499_2 23 EST163 Quinmerac 172 GOICDS C Tebuconazole DS1499_2 23 EST163 Mesotrione 172 GOICDS C Triticonazole DS1499_2 23 EST163 Saflufenacil 172 GOICDS C Prochloraz DS1499_2 23 EST163 Topramezone; 172 GOICDS_C Carbendazim DS1499_2 25 EST217 acephate 172 GOICDS_C Cyprodinil DS1499_2 25 EST217 chlorpyrifos 172 GOICDS_C Pyrimethanil DS1499_2 25 EST217 dimethoate 172 GOICDSC Fenpropimorph DS1499_2 25 EST217 methamidophos 172 GOICDSC Tridemorph DS1499_2 25 EST217 terbufos 172 GOICDS_C lprodione DS1499_2 25 EST217 aldicarb 172 GOICDS_C 5-ethyl-6-octyl-[1,2,4] DS1499_2 triazolo[1,5-a]pyri midine-7-ylamine 25 EST217 carbofuran 172 GOICDS C Mancozeb DS1499 2 WO 2008/129060 133 PCT/EP2008/054924 25 EST217 bifenthrin 172 GOICDS C Maneb DS1499 2 25 EST217 cypermethrin 172 GOICDSC Metiram DS1499_2 25 EST217 alpha-cypermethrin 172 GOICDS_C Dithianon DS1499_2 25 EST217 deltamethrin 172 GOICDS C Chlorothalonil DS1499 2 25 EST217 lambda-cyhalothrin 172 GOICDS_C ThiophanateMethyl DS1499_2 25 EST217 tefluthrin 172 GOICDS_C Cymoxanil DS1499_2 25 EST217 flufenoxuron 172 GOICDS C Metrafenone DS1499_2 25 EST217 teflubenzuron 172 GOICDS C Acetochlor DS1499_2 25 EST217 spirotetramat; 172 GOICDS C Dimethenamid DS1499_2 25 EST217 clothianidin 172 GOICDS C Metolachlor DS1499_2 25 EST217 imidacloprid 172 GOICDS C Metazachlor DS1499_2 25 EST217 thiamethoxam 172 GOICDS_C Glyphosate DS1499_2 25 EST217 endosulfan 172 GOICDS C Glufosinate DS1499_2 25 EST217 fipronil 172 GOICDS C Sulfosate DS1499_2 25 EST217 abamectin 172 GOICDS C Fenoxaprop DS1499_2 25 EST217 spinosad 172 GOICDS C Paraquat DS1499_2 25 EST217 spinetoram 172 GOICDS C Cycloxydim DS1499_2 25 EST217 hydramethylnon; 172 GOICDS C Profoxydim DS1499_2 25 EST217 chlorfenapyr; 172 GOICDS C Sethoxydim DS1499_2 25 EST217 indoxacarb 172 GOICDS_C Tepraloxydim DS1499_2 25 EST217 metaflumizone 172 GOICDS C Pendimethalin DS1499_2 25 EST217 flubendiamide 172 GOICDS C Acifluorfen DS1499_2 25 EST217 chlorantraniliprole 172 GOICDSC Imazamethabenz WO 2008/129060 1 34 PCT/EP2008/054924 DS1499_2 25 EST217 cyazypyr(HGW86) 172 GOICDS_C Imazamox DS1499_2 25 EST217 Azoxystrobin 172 GOICDS_C Imazapic DS1499_2 25 EST217 Dimoxystrobin 172 GOICDS_C Imazapyr DS1499_2 25 EST217 Kresoxim-methyl 172 GOICDSC Imazaquin DS1499_2 25 EST217 Orysastrobin 172 GOICDS_C Imazethapyr DS1499_2 25 EST217 Pyraclostrobin 172 GOICDS C 2,4-D DS1499_2 25 EST217 Trifloxystrobin 172 GOICDS C Chloridazon DS1499_2 25 EST217 Bixafen 172 GOICDS C Picloram DS1499_2 25 EST217 Boscalid 172 GOICDS C Picolinafen DS1499_2 25 EST217 Isopyrazam 172 GOICDS_C Cyclosulfamuron DS1499_2 25 EST217 Metalaxyl 172 GOICDS_C Triflusulfuron DS1499_2 25 EST217 Penthiopyrad 172 GOICDS_C Atrazine DS1499_2 25 EST217 3-Difluoromethyl-1- 172 GOICDS_C Pyroxasulfone methyl-1 H-pyrazole- DS1499_2 4-carboxylic acid (2',4',5'-trifluoro biphenyl-2-yl)-amide 25 EST217 Dimethomorph 172 GOICDS_C Bentazone DS1499 2 25 EST217 Difenoconazole 172 GOICDS_C Cinidon-ethly DS1499_2 25 EST217 Epoxiconazole 172 GOICDS_C Cinmethylin DS1499_2 25 EST217 Fluquinconazole 172 GOICDS_C Dicamba DS1499_2 25 EST217 Metconazol 172 GOICDS_C Diflufenzopyr DS1499_2 25 EST217 Propiconazole 172 GOICDS C Quinclorac DS1499_2 25 EST217 Prothioconazole 172 GOICDS C Quinmerac DS1499_2 25 EST217 Tebuconazole 172 GOICDS C Mesotrione DS1499 2 WO 2008/129060 135 PCT/EP2008/054924 25 EST217 Triticonazole 172 GOICDS C Saflufenacil DS1499_2 25 EST217 Prochloraz 172 GOICDSC Topramezone; DS1499_2 25 EST217 Carbendazim 173 GOICDS_C acephate DS1532 25 EST217 Cyprodinil 173 GOICDS_C chlorpyrifos DS 1532 25 EST217 Pyrimethanil 173 GOICDS C dimethoate DS 1532 25 EST217 Fenpropimorph 173 GOICDS_C methamidophos DS1532 25 EST217 Tridemorph 173 GOICDS_C terbufos DS 1532 25 EST217 lprodione 173 GOICDS_C aldicarb DS 1532 25 EST217 5-ethyl-6-octyl-[1,2,4] 173 GOICDS_C carbofuran triazolo[1,5-a]pyri- DS 1532 midine-7-ylamine 25 EST217 Mancozeb 173 GOICDS C bifenthrin DS 1532 25 EST217 Maneb 173 GOICDS_C cypermethrin DS 1532 25 EST217 Metiram 173 GOICDS_C alpha-cypermethrin DS 1532 25 EST217 Dithianon 173 GOICDS C deltamethrin DS1532 25 EST217 Chlorothalonil 173 GOICDS_C lambda-cyhalothrin DS1532 25 EST217 ThiophanateMethyl 173 GOICDS_ C tefluthrin DS 1532 25 EST217 Cymoxanil 173 GOICDS_C flufenoxuron DS 1532 25 EST217 Metrafenone 173 GOICDS C teflubenzuron DS 1532 25 EST217 Acetochlor 173 GOICDS_C spirotetramat; DS 1532 25 EST217 Dimethenamid 173 GOICDS C clothianidin DS 1532 25 EST217 Metolachlor 173 GOICDS_C imidacloprid DS 1532 25 EST217 Metazachlor 173 GOICDS C thiamethoxam DS1532 25 EST217 Glyphosate 173 GOICDS_C endosulfan DS1532 WO 2008/129060 136 PCT/EP2008/054924 25 EST217 Glufosinate 173 GOICDS_C fipronil DS 1532 25 EST217 Sulfosate 173 GOICDS C abamectin DS 1532 25 EST217 Fenoxaprop 173 GOICDS_C spinosad DS1532 25 EST217 Paraquat 173 GOICDS_C spinetoram DS 1532 25 EST217 Cycloxydim 173 GOICDS_C hydramethylnon; DS1532 25 EST217 Profoxydim 173 GOICDS_C chlorfenapyr; DS1532 25 EST217 Sethoxydim 173 GOICDS_C indoxacarb DS 1532 25 EST217 Tepraloxydim 173 GOICDS C metaflumizone DS 1532 25 EST217 Pendimethalin 173 GOICDS C flubendiamide DS 1532 25 EST217 Acifluorfen 173 GOICDS C chlorantraniliprole DS 1532 25 EST217 Imazamethabenz 173 GOICDSC cyazypyr(HGW86) DS 1532 25 EST217 imazamox 173 GOICDSC Azoxystrobin DS 1532 25 EST217 Imazapic 173 GOICDS C Dimoxystrobin DS1532 25 EST217 Imazapyr 173 GOICDS C Kresoxim-methyl DS 1532 25 EST217 Imazaquin 173 GOICDS ClOrysastrobin DS 1532 25 EST217 Imazethapyr 173 GOICDS C Pyraclostrobin DS 1532 25 EST217 2,4-D 173 GOICDSC Trifloxystrobin DS1532 25 EST217 Chloridazon 173 GOICDS C Bixafen DS 1532 25 EST217 Picloram 173 GOICDS C Boscalid DS1532 25 EST217 Picolinafen 173 GOICDS_C Isopyrazam DS 1532 25 EST217 Cyclosulfamuron 173 GOICDS_C Metalaxyl DS 1532 25 EST217 Triflusulfuron 173 GOICDSC Penthiopyrad DS 1532 25 EST217 Atrazine 173 GOICDSC 3-Difluoromethyi-1- WO 2008/129060 137 PCT/EP2008/054924 DS1532 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 25 EST217 Pyroxasulfone 173 GOICDSC Dimethomorph DS1532 25 EST217 Bentazone 173 GOICDS C Difenoconazole DS 1532 25 EST217 Cinidon-ethly 173 GOICDS_C Epoxiconazole DS 1532 25 EST217 Cinmethylin 173 GOICDS_C Fluquinconazole DS1532 25 EST217 Dicamba 173 GOICDS C Metconazol DS 1532 25 EST217 Diflufenzopyr 173 GOICDS_C Propiconazole DS1532 25 EST217 Quinclorac 173 GOICDS C Prothioconazole DS 1532 25 EST217 Quinmerac 173 GOICDS C Tebuconazole DS 1532 25 EST217 Mesotrione 173 GOICDS C Triticonazole DS 1532 25 EST217 Saflufenacil 173 GOICDS C Prochloraz DS 1532 25 EST217 Topramezone; 173 GOICDS C Carbendazim DS 1532 27 EST266 acephate 173 GOICDS_C Cyprodinil DS 1532 27 EST266 chlorpyrifos 173 GOICDS_C Pyrimethanil DS 1532 27 EST266 dimethoate 173 GOICDS_C Fenpropimorph DS1532 27 EST266 methamidophos 173 GOICDS_C Tridemorph DS 1532 27 EST266 terbufos 173 GOICDS_C lprodione DS1532 27 EST266 aldicarb 173 GOICDS_C 5-ethyl-6-octyl-[1,2,4] DS1532 triazolo[1,5-a]pyri midine-7-ylamine 27 EST266 carbofuran 173 GOICDS C Mancozeb DS 1532 27 EST266 bifenthrin 173 GOICDS C Maneb DS 1532 27 EST266 cypermethrin 173 GOICDS_C Metiram DS 1532 27 EST266 alpha-cypermethrin 173 GOICDS_C Dithianon WO 2008/129060 1 38 PCT/EP2008/054924 DS 1532 27 EST266 deltamethrin 173 GOICDS C Chlorothalonil DS1532 27 EST266 lambda-cyhalothrin 173 GOICDS_C ThiophanateMethyl DS 1532 27 EST266 tefluthrin 173 GOICDS_C Cymoxanil DS 1532 27 EST266 flufenoxuron 173 GOICDS C Metrafenone DS 1532 27 EST266 teflubenzuron 173 GOICDS C Acetochlor DS 1532 27 EST266 spirotetramat; 173 GOICDS C Dimethenamid DS 1532 27 EST266 clothianidin 173 GOICDS C Metolachlor DS 1532 27 EST266 imidacloprid 173 GOICDS C Metazachlor DS 1532 27 EST266 thiamethoxam 173 GOICDS_C Glyphosate DS1532 27 EST266 endosulfan 173 GOICDS C Glufosinate DS 1532 27 EST266 fipronil 173 GOICDS_C Sulfosate DS1532 27 EST266 abamectin 173 GOICDS_C Fenoxaprop DS 1532 27 EST266 spinosad 173 GOICDS_C Paraquat DS1532 27 EST266 spinetoram 173 GOICDS_C Cycloxydim DS 1532 27 EST266 hydramethylnon; 173 GOICDSC Profoxydim DS 1532 27 EST266 chlorfenapyr; 173 GOICDS_C Sethoxydim DS 1532 27 EST266 indoxacarb 173 GOICDS_C Tepraloxydim DS 1532 27 EST266 metaflumizone 173 GOICDS C Pendimethalin DS1532 27 EST266 flubendiamide 173 GOICDS C Acifluorfen DS 1532 27 EST266 chlorantraniliprole 173 GOICDS_C Imazamethabenz DS1532 27 EST266 cyazypyr(HGW86) 173 GOICDSC Imazamox DS 1532 27 EST266 Azoxystrobin 173 GOICDSC Imazapic DS1532 WO 2008/129060 139 PCT/EP2008/054924 27 EST266 Dimoxystrobin 173 GOICDS_C Imazapyr DS 1532 27 EST266 Kresoxim-methyl 173 GOICDSC Imazaquin DS 1532 27 EST266 Orysastrobin 173 GOICDS_C Imazethapyr DS1532 27 EST266 Pyraclostrobin 173 GOICDS C 2,4-D DS 1532 27 EST266 Trifloxystrobin 173 GOICDS C Chloridazon DS1532 27 EST266 Bixafen 173 GOICDS C Picloram DS1532 27 EST266 Boscalid 173 GOICDS C Picolinafen DS 1532 27 EST266 Isopyrazam 173 GOICDS_C Cyclosulfamuron DS 1532 27 EST266 Metalaxyl 173 GOICDS C Triflusulfuron DS 1532 27 EST266 Penthiopyrad 173 GOICDS_C Atrazine DS 1532 27 EST266 3-Difluoromethyl-1- 173 GOICDS_C Pyroxasulfone methyl-1 H-pyrazole- DS 1532 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 27 EST266 Dimethomorph 173 GOICDS_C Bentazone DS1532 27 EST266 Difenoconazole 173 GOICDS_C Cinidon-ethly DS 1532 27 EST266 Epoxiconazole 173 GOICDS_C Cinmethylin DS1532 27 EST266 Fluquinconazole 173 GOICDSC Dicamba DS1532 27 EST266 Metconazol 173 GOICDS_.C Diflufenzopyr DS1532 27 EST266 Propiconazole 173 GOICDS C Quinclorac DS1532 27 EST266 Prothioconazole 173 GOICDSC Quinmerac DS 1532 27 EST266 Tebuconazole 173 GOICDS C Mesotrione DS 1532 27 EST266 Triticonazole 173 GOICDS_C Saflufenacil DS 1532 27 EST266 Prochloraz 173 GOICDS_C Topramezone; DS 1532 27 EST266 Carbendazim 174 _GOICDS_ acephate WO 2008/129060 140 PCT/EP2008/054924 CDS3325 27 EST266 Cyprodinil 174 _GOICDS chlorpyrifos CDS3325 27 EST266 Pyrimethanil 174 GOICDS dimethoate CDS3325 27 EST266 Fenpropimorph 174 _GOICDS_ methamidophos CDS3325 27 EST266 Tridemorph 174 _GOICDS_ terbufos CDS3325 27 EST266 lprodione 174 _GOICDS_ aldicarb CDS3325 27 EST266 5-ethyl-6-octyl-[1,2,41 174 _GOICDS carbofuran triazolo[1,5-a]pyri- CDS3325 midine-7-ylamine 27 EST266 Mancozeb 174 _GOICDS bifenthrin CDS3325 27 EST266 Maneb 174 _GOICDS_ cypermethrin CDS3325 27 EST266 Metiram 174 _GOICDS_ alpha-cypermethrin CDS3325 27 EST266 Dithianon 174 _GOICDS deltamethrin CDS3325 27 EST266 Chlorothalonil 174 _GOiCDS_ lambda-cyhalothrin CDS3325 27 EST266 ThiophanateMethyl 174 _GOICDS tefluthrin CDS3325 27 EST266 Cymoxanil 174 _GOICDS flufenoxuron CDS3325 27 EST266 Metrafenone 174 _GOICDS teflubenzuron CDS3325 27 EST266 Acetochlor 174 _GOICDS_ spirotetramat; CDS3325 27 EST266 Dimethenamid 174 _GOICDS clothianidin CDS3325 27 EST266 Metolachlor 174 _GOICDS_ imidacloprid CDS3325 27 EST266 Metazachlor 174 _GOICDS thiamethoxam CDS3325 27 EST266 Glyphosate 174 _GOICDS_ endosulfan CDS3325 27 EST266 Glufosinate 174 _GOICDS fipronil CDS3325 27 EST266 Sulfosate 174 GOICDS abamectin CDS3325 27 EST266 Fenoxaprop 174 _GOICDS_ spinosad WO 2008/129060 141 PCT/EP2008/054924 CDS3325 27 EST266 Paraquat 174 _GOICDS_ spinetoram CDS3325 27 EST266 Cycloxydim 174 _GOICDS_ hydramethylnon; CDS3325 27 EST266 Profoxydim 174 _GOICDS_ chlorfenapyr; CDS3325 27 EST266 Sethoxydim 174 _GOICDS_ indoxacarb CDS3325 27 EST266 Tepraloxydim 174 _GOICDS metaflumizone CDS3325 27 EST266 Pendimethalin 174 GOICDS flubendiamide CDS3325 27 EST266 Acifluorfen 174 _GOICDS_ chlorantraniliprole CDS3325 27 EST266 imazamethabenz 174 _GOICDS_ cyazypyr(HGW86) CDS3325 27 EST266 Imazamox 174 _GOICDS Azoxystrobin CDS3325 27 EST266 Imazapic 174 _GOICDS_ Dimoxystrobin CDS3325 27 EST266 Imazapyr 174 _GOICDS_ Kresoxim-methyl CDS3325 27 EST266 Imazaquin 174 _GOICDS Orysastrobin CDS3325 27 EST266 Imazethapyr 174 _GOICDS_ Pyraclostrobin CDS3325 27 EST266 2,4-D 174 _GOICDS Trifloxystrobin CDS3325 27 EST266 Chloridazon 174 _GOICDS Bixafen CDS3325 27 EST266 Picloram 174 _GOICDS Boscalid CDS3325 27 EST266 Picolinafen 174 _GOICDS_ Isopyrazam CDS3325 27 EST266 Cyclosulfamuron 174 _GOICDS_ Metalaxyl CDS3325 27 EST266 Triflusulfuron 174 _GOICDS_ Penthiopyrad CDS3325 27 EST266 Atrazine 174 _GOICDS 3-Difluoromethyl-1 CDS3325 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 27 EST266 Pyroxasulfone 174 _GOICDS Dimethomorph CDS3325 WO 2008/129060 142 PCT/EP2008/054924 27 EST266 Bentazone 174 GOICDS Difenoconazole CDS3325 27 EST266 Cinidon-ethly 174 _GOICDS_ Epoxiconazole CDS3325 27 EST266 Cinmethylin 174 _GOICDS_ Fluquinconazole CDS3325 27 EST266 Dicamba 174 _GOICDS Metconazol CDS3325 27 EST266 Diflufenzopyr 174 _GOICDS Propiconazole CDS3325 27 EST266 Quinclorac 174 _GOICDS Prothioconazole CDS3325 27 EST266 Quinmerac 174 GOICDS Tebuconazole CDS3325 27 EST266 Mesotrione 174 _GOICDS Triticonazole CDS3325 27 EST266 Saflufenacil 174 _GOICDS Prochloraz CDS3325 27 EST266 Topramezone; 174 _GOICDS Carbendazim CDS3325 28 EST268 acephate 174 _GOICDS_ Cyprodinil CDS3325 28 EST268 chlorpyrifos 174 _GOiCDS_ Pyrimethanil CDS3325 28 EST268 dimethoate 174 _GOICDS Fenpropimorph CDS3325 28 EST268 methamidophos 174 _GOICDS_ Tridemorph CDS3325 28 EST268 terbufos 174 _GOICDS_ lprodione CDS3325 28 EST268 aldicarb 174 _GOICDS_ 5-ethyl-6-octyl-[1,2,4] CDS3325 triazolo[1,5-a]pyri midine-7-ylamine 28 EST268 carbofuran 174 _GOICDS Mancozeb CDS3325 28 EST268 bifenthrin 174 _GOICDS Maneb CDS3325 28 EST268 cypermethrin 174 _GOICDS Metiram CDS3325 28 EST268 alpha-cypermethrin 174 _GOICDS Dithianon CDS3325 28 EST268 deltamethrin 174 _GOICDS_ Chlorothalonil CDS3325 28 EST268 lambda-cyhalothrin 174 _GOICDS ThiophanateMethyl CDS3325 WO 2008/129060 143 PCT/EP2008/054924 28 EST268 tefluthrin 174 _GOICDS Cymoxanil CDS3325 28 EST268 flufenoxuron 174 GOICDS Metrafenone CDS3325 28 EST268 teflubenzuron 174 GOICDS Acetochlor CDS3325 28 EST268 spirotetramat; 174 _GOICDS Dimethenamid CDS3325 28 EST268 clothianidin 174 GOICDS Metolachlor CDS3325 28 EST268 imidacloprid 174 _GOICDS Metazachlor CDS3325 28 EST268 thiamethoxam 174 _GOICDS Glyphosate CDS3325 28 EST268 endosulfan 174 _GOICDS Glufosinate CDS3325 28 EST268 fipronil 174 _GOICDS_ Sulfosate CDS3325 28 EST268 abamectin 174 _GOICDS_ Fenoxaprop CDS3325 28 EST268 spinosad 174 _GOICDS_ Paraquat CDS3325 28 EST268 spinetoram 174 _GOiCDS_ Cycloxydim CDS3325 28 EST268 hydramethylnon; 174 _GOICDS_ Profoxydim CDS3325 28 EST268 chlorfenapyr; 174 _GOICDS_ Sethoxydim CDS3325 28 EST268 indoxacarb 174 _GOICDS_ |Tepraloxydim CDS3325 28 EST268 metaflumizone 174 _GOICDS_ Pendimethalin CDS3325 28 EST268 flubendiamide 174 _GOICDS Acifluorfen CDS3325 28 EST268 chlorantraniliprole 174 _GOICDS Imazamethabenz CDS3325 28 EST268 cyazypyr(HGW86) 174 _GOICDS_ Imazamox CDS3325 28 EST268 Azoxystrobin 174 _GOICDS_ Imazapic CDS3325 28 EST268 Dimoxystrobin 174 _GOICDS Imazapyr CDS3325 28 EST268 Kresoxim-methyl 174 _GOICDS Imazaquin CDS3325 28 EST268 Orysastrobin 174 _GOICDS Imazethapyr WO 2008/129060 144 PCT/EP2008/054924 CDS3325 28 EST268 Pyraclostrobin 174 _GOICDS 2,4-D CDS3325 28 EST268 Trifloxystrobin 174 GOICDS_ Chloridazon CDS3325 28 EST268 Bixafen 174 GOICDS Picloram CDS3325 28 EST268 Boscalid 174 GOICDS Picolinafen CDS3325 28 EST268 Isopyrazam 174 _GOICDS_ Cyclosulfamuron CDS3325 28 EST268 Metalaxyl 174 GOICDS Triflusulfuron CDS3325 28 EST268 Penthiopyrad 174 _GOICDS_ Atrazine CDS3325 28 EST268 3-DifIuoromethyl-1- 174 _GOICDS_ Pyroxasulfone methyl-1 H-pyrazole- CDS3325 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 28 EST268 Dimethomorph 174 _GOICDS_ Bentazone CDS3325 28 EST268 Difenoconazole 174 _GOICDS Cinidon-ethly CDS3325 28 EST268 Epoxiconazole 174 _GOICDS_ Cinmethylin CDS3325 28 EST268 Fluquinconazole 174 GOICDS Dicamba CDS3325 28 EST268 Metconazol 174 _GOICDS_ Diflufenzopyr CDS3325 28 EST268 Propiconazole 174 _GOICDS Quinclorac CDS3325 28 EST268 Prothioconazole 174 _GOICDS Quinmerac CDS3325 28 EST268 Tebuconazole 174 _GOICDS Mesotrione CDS3325 28 EST268 Triticonazole 174 _GOICDS Saflufenacil CDS3325 28 EST268 Prochloraz 174 _GOICDS Topramezone; CDS3325 28 EST268 Carbendazim 175 GOICDS_C acephate DS0218 28 EST268 Cyprodinil 175 GOICDS_C chlorpyrifos DS0218 28 EST268 Pyrimethanil 175 GOICDS C dimethoate DS0218 WO 2008/129060 145 PCT/EP2008/054924 28 EST268 Fenpropimorph 175 GOICDS_C methamidophos DS0218 28 EST268 Tridemorph 175 GOICDSC terbufos DS0218 28 EST268 lprodione 175 GOICDS_C aldicarb DS0218 28 EST268 5-ethyl-6-octyl-[1,2,4] 175 GOICDS_C carbofuran triazolo[1,5-alpyri- DS0218 midine-7-ylamine 28 EST268 Mancozeb 175 GOICDS C bifenthrin DS0218 28 EST268 Maneb 175 GOICDSC cypermethrin DS0218 28 EST268 Metiram 175 GOICDS_C alpha-cypermethrin DS0218 28 EST268 Dithianon 175 GOICDS C deltamethrin DS0218 28 EST268 Chlorothalonil 175 GOICDS_C lambda-cyhalothrin DS0218 28 EST268 ThiophanateMethyl 175 GOICDS_C tefluthrin DS0218 28 EST268 Cymoxanil 175 GOICDS_C flufenoxuron DS0218 28 EST268 Metrafenone 175 GOICDS C teflubenzuron DS0218 28 EST268 Acetochlor 175 GOICDS_C spirotetramat; DS0218 28 EST268 Dimethenamid 175 GOICDS C clothianidin DS0218 28 EST268 Metolachlor 175 GOICDS_ C imidacloprid DS0218 28 EST268 Metazachlor 175 GOICDS C thiamethoxam DS0218 28 EST268 Glyphosate 175 GOICDSC endosulfan DS0218 28 EST268 Glufosinate 175 GOICDS_C fipronil DS0218 28 EST268 Sulfosate 175 GOICDS C abamectin DS0218 28 EST268 Fenoxaprop 175 GOICDS_C spinosad DS0218 28 EST268 Paraquat 175 GOICDS_C spinetoram DS0218 28 EST268 Cycloxydim 175 GOICDS_C hydramethylnon; DS0218 WO 2008/129060 146 PCT/EP2008/054924 28 EST268 Profoxydim 175 GOICDS_C chlorfenapyr; DS0218 28 EST268 Sethoxydim 175 GOICDSC indoxacarb DS0218 28 EST268 Tepraloxydim 175 GOICDS_C metaflumizone DS0218 28 EST268 Pendimethalin 175 GOICDS C flubendiamide DS0218 28 EST268 Acifluorfen 175 GOICDS_C chlorantraniliprole DS0218 28 EST268 Imazamethabenz 175 GOICDS_C cyazypyr(HGW86) DS0218 28 EST268 Imazamox 175 GOICDS_C Azoxystrobin DS0218 28 EST268 Imazapic 175 GOICDS_C Dimoxystrobin DS0218 28 EST268 Imazapyr 175 GOICDS_C Kresoxim-methyl DS0218 28 EST268 Imazaquin 175 GOICDS_C Orysastrobin DS0218 28 EST268 Imazethapyr 175 GOICDS_C Pyraclostrobin DS0218 28 EST268 2,4-D 175 GOICDSC Trifloxystrobin DS0218 28 EST268 Chloridazon 175 GOICDS C Bixafen DS0218 28 EST268 Picloram 175 GOICDS C Boscalid DS0218 28 EST268 Picolinafen 175 GOICDS_C isopyrazam DS0218 28 EST268 Cyclosulfamuron 175 GOICDS_C Metalaxyl DS0218 28 EST268 Triflusulfuron 175 GOICDS_C Penthiopyrad DS0218 28 EST268 Atrazine 175 GOICDS_C 3-Difluoromethyl-1 DS0218 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 28 EST268 Pyroxasulfone 175 GOICDS_C Dimethomorph DS0218 28 EST268 Bentazone 175 GOICDS C Difenoconazole DS0218 28 EST268 Cinidon-ethly 175 GOICDS_C Epoxiconazole DS0218 28 EST268 Cinmethylin 175 GOICDS_C Fluquinconazole WO 2008/129060 147 PCT/EP2008/054924 DS0218 28 EST268 Dicamba 175 GOICDS C Metconazol DS0218 28 EST268 Diflufenzopyr 175 GOICDS_C Propiconazole DS0218 28 EST268 Quinclorac 175 GOICDS C Prothioconazole DS0218 28 EST268 Quinmerac 175 GOICDS C Tebuconazole DS0218 28 EST268 Mesotrione 175 GOICDS C Triticonazole DS0218 28 EST268 Saflufenacil 175 GOICDS C Prochloraz DS0218 28 EST268 Topramezone; 175 GOICDS C Carbendazim DS0218 30 EST293 acephate 175 GOICDSC Cyprodinil DS0218 30 EST293 chlorpyrifos 175 GOICDS_C Pyrimethanil DS0218 30 EST293 dimethoate 175 GOICDS_C Fenpropimorph DS0218 30 EST293 methamidophos 175 GOICDS_C Tridemorph DSO218 30 EST293 terbufos 175 GOICDS_C lprodione DS0218 30 EST293 aldicarb 175 GOICDS_C 5-ethyl-6-octyl-[1,2,4] DS0218 triazolo[1,5-a]pyri midine-7-ylamine 30 EST293 carbofuran 175 GOICDS C Mancozeb DS0218 30 EST293 bifenthrin 175 GOICDS C Maneb DS0218 30 EST293 cypermethrin 175 GOICDS_C Metiram DS0218 30 EST293 alpha-cypermethrin 175 GOICDS_C Dithianon DS0218 30 EST293 deltamethrin 175 GOICDS C Chlorothalonil DS0218 30 EST293 lambda-cyhalothrin 175 GOICDS_C ThiophanateMethyl DS0218 30 EST293 tefluthrin 175 GOICDS_C Cymoxanil DS0218 30 EST293 flufenoxuron 175 GOICDSC Metrafenone DS0218 30 EST293 teflubenzuron 175 GOICDS _C Acetochlor WO 2008/129060 148 PCT/EP2008/054924 DS0218 30 EST293 spirotetramat; 175 GOICDS C Dimethenamid DS0218 30 EST293 clothianidin 175 GOICDS C Metolachlor DS0218 30 EST293 imidacloprid 175 GOICDS C Metazachlor DS0218 30 EST293 thiamethoxam 175 GOICDS_C Glyphosate DS0218 30 EST293 endosulfan 175 GOICDS C Glufosinate DS0218 30 EST293 fipronil 175 GOICDS_C Sulfosate DS0218 30 EST293 abamectin 175 GOICDSC Fenoxaprop DS0218 30 EST293 spinosad 175 GOICDSC Paraquat DS0218 30 EST293 spinetoram 175 GOICDS_C Cycloxydim DS0218 30 EST293 hydramethylnon; 175 GOICDSC Profoxydim DS0218 30 EST293 chlorfenapyr; 175 GOICDS_C Sethoxydim DSO218 30 EST293 indoxacarb 175 GOICDS_C Tepraloxydim DS0218 30 EST293 metaflumizone 175 GOICDS C Pendimethalin DS0218 30 EST293 flubendiamide 175 GOICDS C Acifluorfen DS0218 30 EST293 chlorantraniliprole 175 GOICDSC Imazamethabenz DS0218 30 EST293 cyazypyr(HGW86) 175 GOICDS_C Imazamox DS0218 30 EST293 Azoxystrobin 175 GOICDS_C Imazapic DS0218 30 EST293 Dimoxystrobin 175 GOICDS_C Imazapyr DS0218 30 EST293 Kresoxim-methyl 175 GOICDS_C Imazaquin DS0218 30 EST293 Orysastrobin 175 GOICDSC Imazethapyr DS0218 30 EST293 Pyraclostrobin 175 GOICDSC 2,4-D DS0218 30 EST293 Trifloxystrobin 175 GOICDS C Chloridazon DS0218 WO 2008/129060 149 PCT/EP2008/054924 30 EST293 Bixafen 175 GOICDS C Picloram DS0218 30 EST293 Boscalid 175 GOICDS C Picolinafen DS0218 30 EST293 Isopyrazam 175 GOICDS_C Cyclosulfamuron DS0218 30 EST293 Metalaxyl 175 GOICDS_C Triflusulfuron DS0218 30 EST293 Penthiopyrad 175 GOICDS_C Atrazine DS0218 30 EST293 3-Difluoromethyl-1- 175 GOICDS_C Pyroxasulfone methyl-1 H-pyrazole- DSO218 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 30 EST293 Dimethomorph 175 GOICDSC Bentazone DS0218 30 EST293 Difenoconazole 175 GOICDS_C Cinidon-ethly DS0218 30 EST293 Epoxiconazole 175 GOICDS_C Cinmethylin DS0218 30 EST293 Fluquinconazole 175 GOICDS_C Dicamba DS0218 30 EST293 Metconazol 175 GOICDS_C Diflufenzopyr DS0218 30 EST293 Propiconazole 175 GOICDS_C Quinclorac DS0218 30 EST293 Prothioconazole 175 GOICDS C Quinmerac DS0218 30 EST293 Tebuconazole 175 GOICDS C Mesotrione DS0218 30 EST293 Triticonazole 175 GOICDS C Saflufenacil DS0218 30 EST293 Prochloraz 175 GOICDS_C Topramezone; DS0218 30 EST293 Carbendazim 176 GOICDSC acephate DS1536 30 EST293 Cyprodinil 176 GOICDS_C chlorpyrifos DS1536 30 EST293 Pyrimethanil 176 GOICDS_C dimethoate DS1536 30 EST293 Fenpropimorph 176 GOICDS_C methamidophos DS1536 30 EST293 Tridemorph 176 GOICDS_C terbufos DS1536 30 EST293 lprodione 176 GOICDS_C aldicarb WO 2008/129060 150 PCT/EP2008/054924 DS1536 30 EST293 5-ethyl-6-octyl-[1,2,4] 176 GOICDS_C carbofuran triazolo[1,5-a]pyri- DS1536 midine-7-ylamine 30 EST293 Mancozeb 176 GOICDS C bifenthrin DS1536 30 EST293 Maneb 176 GOICDS_C cypermethrin DS1536 30 EST293 Metiram 176 GOICDS_C alpha-cypermethrin DS1536 30 EST293 Dithianon 176 GOICDS C deltamethrin DS1536 30 EST293 Chlorothalonil 176 GOICDS_C lambda-cyhalothrin DS1536 30 EST293 ThiophanateMethyl 176 GOICDS_C tefluthrin DS1536 30 EST293 Cymoxanil 176 GOICDS_C flufenoxuron DS1536 30 EST293 Metrafenone 176 GOICDS C teflubenzuron DS1536 30 EST293 Acetochlor 176 GOICDS_C spirotetramat; DS1536 30 EST293 Dimethenamid 176 GOICDS C clothianidin DS1536 30 EST293 Metolachlor 176 GOICDS_C imidacloprid DS1536 30 EST293 Metazachlor 176 GOICDS C thiamethoxam DS1536 30 EST293 Glyphosate 176 GOICDS_C endosulfan DS1536 30 EST293 Glufosinate 176 GOICDS_C fipronil DS1536 30 EST293 Sulfosate 176 GOICDS C abamectin DS1536 30 EST293 Fenoxaprop 176 GOICDS_C spinosad DS1536 30 EST293 Paraquat 176 GOICDS_C spinetoram DS1536 30 EST293 Cycloxydim 176 GOICDS_C hydramethylnon; DS1536 30 EST293 Profoxydim 176 GOICDS_C chlorfenapyr; DS1536 30 EST293 Sethoxydim 176 GOICDSC indoxacarb DS1536 30 EST293 Tepraloxydim 176 GOICDSC metaflumizone WO 2008/129060 151 PCT/EP2008/054924 DS1536 30 EST293 Pendimethalin 176 GOICDS C flubendiamide DS1536 30 EST293 Acifluorfen 176 GOICDS_C chlorantraniliprole DS1536 30 EST293 Imazamethabenz 176 GOICDS_C cyazypyr(HGW86) DS1536 30 EST293 Imazamox 176 GOICDS_C Azoxystrobin DS1536 30 EST293 Imazapic 176 GOICDS_C Dimoxystrobin DS1536 30 EST293 Imazapyr 176 GOICDS_C Kresoxim-methyl DS1536 30 EST293 Imazaquin 176 GOICDS_C Orysastrobin DS1536 30 EST293 imazethapyr 176 GOICDSC Pyraclostrobin DS1536 30 EST293 2,4-D 176 GOICDS_C Trifloxystrobin DS1536 30 EST293 Chloridazon 176 GOICDS C Bixafen DS1536 30 EST293 Picloram 176 GOICDS C Boscalid DS1536 30 EST293 Picolinafen 176 GOICDS_C Isopyrazam DS1536 30 EST293 Cyclosulfamuron 176 GOICDS_C Metalaxyl DS1536 30 EST293 Triflusulfuron 176 GOICDS_C Penthiopyrad DS1536 30 EST293 Atrazine 176 GOICDSC 3-Difluoromethyl-1 DS1536 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 30 EST293 Pyroxasulfone 176 GOICDS_C Dimethomorph DS1536 30 EST293 Bentazone 176 GOICDS C Difenoconazole DS1536 30 EST293 Cinidon-ethly 176 GOICDS_C Epoxiconazole DS1536 30 EST293 Cinmethylin 176 GOICDS_C Fluquinconazole DS1536 30 EST293 Dicamba 176 GOICDS_C Metconazol DS1536 30 EST293 Diflufenzopyr 176 GOICDS_C Propiconazole DS1536 WO 2008/129060 152 PCT/EP2008/054924 30 EST293 Quinclorac 176 GOICDS C Prothioconazole DS1536 30 EST293 Quinmerac 176 GOICDS C Tebuconazole DS1536 30 EST293 Mesotrione 176 GOICDS C Triticonazole DS1536 30 EST293 Saflufenacil 176 GOICDS C Prochloraz DS1536 30 EST293 Topramezone; 176 GOICDS C Carbendazim DS1536 31 EST295 acephate 176 GOICDS_C Cyprodinil DS1536 31 EST295 chlorpyrifos 176 GOICDS_C Pyrimethanil DS1536 31 EST295 dimethoate 176 GOICDS_C Fenpropimorph DS1536 31 EST295 methamidophos 176 GOICDS_C Tridemorph DS1536 31 EST295 terbufos 176 GOICDS_C lprodione DS1536 31 EST295 aldicarb 176 GOICDS_C 5-ethyl-6-octyl-[1,2,4] DS1536 triazolo[1,5-a]pyri midine-7-ylamine 31 EST295 carbofuran 176 GOICDS C Mancozeb DS1536 31 EST295 bifenthrin 176 GOICDS C Maneb DS1536 31 EST295 cypermethrin 176 GOICDS_C Metiram DS1536 31 EST295 alpha-cypermethrin 176 GOICDS_ C Dithianon DS1536 31 EST295 deltamethrin 176 GOICDS C Chlorothalonil DS1536 31 EST295 lambda-cyhalothrin 176 GOICDSC ThiophanateMethyl DS1536 31 EST295 tefluthrin 176 GOICDS_C Cymoxanil DS1536 31 EST295 flufenoxuron 176 GOICDS C Metrafenone DS1536 31 EST295 teflubenzuron 176 GOICDS C Acetochlor DS1536 31 EST295 spirotetramat; 176 GOICDS_C Dimethenamid DS1536 31 EST295 clothianidin 176 GOICDS C Metolachlor DS1536 WO 2008/129060 153 PCT/EP2008/054924 31 EST295 imidacloprid 176 GOICDS C Metazachlor DS1536 31 EST295 thiamethoxam 176 GOICDS_C Glyphosate DS1536 31 EST295 endosulfan 176 GOICDS C Glufosinate DS1536 31 EST295 fipronil 176 GOICDS_C Sulfosate DS1536 31 EST295 abamectin 176 GOICDS_C Fenoxaprop DS1536 31 EST295 spinosad 176 GOICDS_C Paraquat DS1536 31 EST295 spinetoram 176 GOICDS_C Cycloxydim DS1536 31 EST295 hydramethylnon; 176 GOICDS_C Profoxydim DS1536 31 EST295 chlorfenapyr; 176 GOICDS_C Sethoxydim DS1536 31 EST295 indoxacarb 176 GOICDS_C Tepraloxydim DS1536 31 EST295 metaflumizone 176 GOICDS C Pendimethalin DS1536 31 EST295 flubendiamide 176 GOICDS C Acifluorfen DS1536 31 EST295 chlorantraniliprole 176 GOICDS C Imazamethabenz DS1536 31 EST295 cyazypyr(HGW86) 176 GOICDS C Imazamox DS1536 31 EST295 Azoxystrobin 176 GOICDS C imazapic DS1536 31 EST295 Dimoxystrobin 176 GOICDS C Imazapyr DS1536 31 EST295 Kresoxim-methyl 176 GOICDS C Imazaquin DS1536 31 EST295 Orysastrobin 176 GOICDS C Imazethapyr DS1536 31 EST295 Pyraciostrobin 176 GOICDS C 2,4-D DS1536 31 EST295 Trifloxystrobin 176 GOICDS C Chloridazon DS1536 31 EST295 Bixafen 176 GOICDS C Picloram DS1536 31 EST295 Boscalid 176 GOICDS C Picolinafen DS1536 31 EST295 isopyrazam 176 GOICDSC Cyclosulfamuron WO 2008/129060 154 PCT/EP2008/054924 DS1536 31 EST295 Metalaxyl 176 GOICDS C Triflusulfuron DS1536 31 EST295 Penthiopyrad 176 GOICDS_C Atrazine DS1536 31 EST295 3-Difluoromethyl-l- 176 GOICDS_C Pyroxasulfone methyl-1 H-pyrazole- DS1536 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 31 EST295 Dimethomorph 176 GOICDS_C Bentazone DS1536 31 EST295 Difenoconazole 176 GOICDS_C Cinidon-ethly DS1536 31 EST295 Epoxiconazole 176 GOICDS_C Cinmethylin DS1536 31 EST295 Fluquinconazole 176 GOICDS_C Dicamba DS1536 31 EST295 Metconazol 176 GOICDS_C Diflufenzopyr DS1536 31 EST295 Propiconazole 176 GOICDS C Quinclorac DS1536 31 EST295 Prothioconazole 176 GOICDS C Quinmerac DS1536 31 EST295 Tebuconazole 176 GOICDS C Mesotrione DS1536 31 EST295 Triticonazole 176 GOICDSC Saflufenacil DS1536 31 EST295 Prochloraz 176 GOICDS_C Topramezone; DS1536 31 EST295 Carbendazim 177 acephate 31 EST295 Cyprodinil 177 chlorpyrifos 31 EST295 Pyrimethanil 177 dimethoate 31 EST295 Fenpropimorph 177 methamidophos 31 EST295 Tridemorph 177 terbufos 31 EST295 lprodione 177 aldicarb 31 EST295 5-ethyl-6-octyl-[1,2,4] 177 carbofuran triazolo[1,5-a]pyri midine-7-ylamine 31 EST295 Mancozeb 177 bifenthrin 31 EST295 Maneb 177 cypermethrin 31 EST295 Metiram 177 alpha-cypermethrin 31 EST295 Dithianon 177 deltamethrin 31 EST295 Chlorothalonil 177 lambda-cyhalothrin WO 2008/129060 155 PCT/EP2008/054924 31 EST295 ThiophanateMethyl 177 tefluthrin 31 EST295 Cymoxanil 177 flufenoxuron 31 EST295 Metrafenone 177 teflubenzuron 31 EST295 Acetochlor 177 spirotetramat; 31 EST295 Dimethenamid 177 clothianidin 31 EST295 Metolachlor 177 imidacloprid 31 EST295 Metazachlor 177 thiamethoxam 31 EST295 Glyphosate 177 endosulfan 31 EST295 Glufosinate 177 fipronil 31 EST295 Sulfosate 177 abamectin 31 EST295 Fenoxaprop 177 spinosad 31 EST295 Paraquat 177 spinetoram 31 EST295 Cycloxydim 177 hydramethylnon; 31 EST295 Profoxydim 177 chlorfenapyr; 31 EST295 Sethoxydim 177 indoxacarb 31 EST295 Tepraloxydim 177 metaflumizone 31 EST295 Pendimethalin 177 flubendiamide 31 EST295 Acifluorfen 177 chlorantraniliprole 31 EST295 Imazamethabenz 177 cyazypyr(HGW86) 31 EST295 Imazamox 177 Azoxystrobin 31 EST295 Imazapic 177 Dimoxystrobin 31 EST295 Imazapyr 177 Kresoxim-methyl 31 EST295 Imazaquin 177 Orysastrobin 31 EST295 Imazethapyr 177 Pyraclostrobin 31 EST295 2,4-D 177 Trifloxystrobin 31 EST295 Chloridazon 177 Bixafen 31 EST295 Picloram 177 Boscalid 31 EST295 Picolinafen 177 Isopyrazam 31 EST295 Cyclosulfamuron 177 Metalaxyl 31 EST295 Triflusulfuron 177 Penthiopyrad 31 EST295 Atrazine 177 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 31 EST295 Pyroxasulfone 177 Dimethomorph 31 EST295 Bentazone 177 Difenoconazole 31 EST295 Cinidon-ethly 177 Epoxiconazole 31 EST295 Cinmethylin 177 Fluquinconazole 31 EST295 Dicamba 177 Metconazol WO 2008/129060 156 PCT/EP2008/054924 31 EST295 Diflufenzopyr 177 Propiconazole 31 EST295 Quinclorac 177 Prothioconazole 31 EST295 Quinmerac 177 Tebuconazole 31 EST295 Mesotrione 177 Triticonazole 31 EST295 Saflufenacil 177 Prochloraz 31 EST295 Topramezone; 177 Carbendazim 33 EST335 acephate 177 Cyprodinil 33 EST335 chlorpyrifos 177 Pyrimethanil 33 EST335 dimethoate 177 Fenpropimorph 33 EST335 methamidophos 177 Tridemorph 33 EST335 terbufos 177 lprodione 33 EST335 aldicarb 177 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 33 EST335 carbofuran 177 Mancozeb 33 EST335 bifenthrin 177 Maneb 33 EST335 cypermethrin 177 Metiram 33 EST335 alpha-cypermethrin 177 Dithianon 33 EST335 deltamethrin 177 Chlorothalonil 33 EST335 lambda-cyhalothrin 177 ThiophanateMethyl 33 EST335 tefluthrin 177 Cymoxanil 33 EST335 flufenoxuron 177 Metrafenone 33 EST335 teflubenzuron 177 Acetochlor 33 EST335 spirotetramat; 177 Dimethenamid 33 EST335 clothianidin 177 Metolachlor 33 EST335 imidacloprid 177 Metazachlor 33 EST335 thiamethoxam 177 Glyphosate 33 EST335 endosulfan 177 Glufosinate 33 EST335 fipronil 177 Sulfosate 33 EST335 abamectin 177 Fenoxaprop 33 EST335 spinosad 177 Paraquat 33 EST335 spinetoram 177 Cycloxydim 33 EST335 hydramethylnon; 177 Profoxydim 33 EST335 chlorfenapyr; 177 Sethoxydim 33 EST335 indoxacarb 177 Tepraloxydim 33 EST335 metaflumizone 177 Pendimethalin 33 EST335 flubendiamide 177 Acifluorfen 33 EST335 chlorantraniliprole 177 Imazamethabenz 33 EST335 cyazypyr(HGW86) 177 Imazamox WO 2008/129060 157 PCT/EP2008/054924 33 EST335 Azoxystrobin 177 Imazapic 33 EST335 Dimoxystrobin 177 Imazapyr 33 EST335 Kresoxim-methyl 177 Imazaquin 33 EST335 Orysastrobin 177 Imazethapyr 33 EST335 Pyraclostrobin 177 2,4-D 33 EST335 Trifloxystrobin 177 Chloridazon 33 EST335 Bixafen 177 Picloram 33 EST335 Boscalid 177 Picolinafen 33 EST335 Isopyrazam 177 Cyclosulfamuron 33 EST335 Metalaxyl 177 Triflusulfuron 33 EST335 Penthiopyrad 177 Atrazine 33 EST335 3-Difluoromethyl-1- 177 Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 33 EST335 Dimethomorph 177 Bentazone 33 EST335 Difenoconazole 177 Cinidon-ethly 33 EST335 Epoxiconazole 177 Cinmethylin 33 EST335 Fluquinconazole 177 Dicamba 33 EST335 Metconazol 177 Diflufenzopyr 33 EST335 Propiconazole 177 Quinclorac 33 EST335 Prothioconazole 177 Quinmerac 33 EST335 Tebuconazole 177 Mesotrione 33 EST335 Triticonazole 177 Saflufenacil 33 EST335 Prochloraz 177 Topramezone; 33 EST335 Carbendazim 178 GOICDSC acephate DS3074 33 EST335 Cyprodinil 178 GOICDSC chlorpyrifos DS3074 33 EST335 Pyrimethanil 178 GOICDS C dimethoate DS3074 33 EST335 Fenpropimorph 178 GOICDS C methamidophos DS3074 33 EST335 Tridemorph 178 GOICDS C terbufos DS3074 33 EST335 lprodione 178 GOICDS C aldicarb DS3074 33 EST335 5-ethyl-6-octyl-[1,2,4] 178 GOICDS C carbofuran triazolo[1,5-a]pyri- DS3074 midine-7-ylamine 33 EST335 Mancozeb 178 GOICDSC bifenthrin WO 2008/129060 158 PCT/EP2008/054924 DS3074 33 EST335 Maneb 178 GOICDS_C cypermethrin DS3074 33 EST335 Metiram 178 GOICDS_C alpha-cypermethrin DS3074 33 EST335 Dithianon 178 GOICDS C deltamethrin DS3074 33 EST335 Chlorothalonil 178 GOICDSC lambda-cyhalothrin DS3074 33 EST335 ThiophanateMethyl 178 GOICDS_C tefluthrin DS3074 33 EST335 Cymoxanil 178 GOICDS_C flufenoxuron DS3074 33 EST335 Metrafenone 178 GOICDS C teflubenzuron DS3074 33 EST335 Acetochlor 178 GOICDSC spirotetramat; DS3074 33 EST335 Dimethenamid 178 GOICDS C clothianidin DS3074 33 EST335 Metolachlor 178 GOICDSC imidacloprid DS3074 33 EST335 Metazachlor 178 GOICDS C thiamethoxam DS3074 33 EST335 Glyphosate 178 GOICDS_C endosulfan DS3074 33 EST335 Glufosinate 178 GOICDS_C fipronil DS3074 33 EST335 Sulfosate 178 GOICDS C abamectin DS3074 33 EST335 Fenoxaprop 178 GOICDSC spinosad DS3074 33 EST335 Paraquat 178 GOICDS_C spinetoram DS3074 33 EST335 Cycloxydim 178 GOICDS_C hydramethylnon; DS3074 33 EST335 Profoxydim 178 GOICDS_C chlorfenapyr; DS3074 33 EST335 Sethoxydim 178 GOICDS_C indoxacarb DS3074 33 EST335 Tepraloxydim 178 GOICDS C metaflumizone DS3074 33 EST335 Pendimethalin 178 GOICDS C flubendiamide DS3074 33 EST335 Acifluorfen 178 GOICDSC chlorantraniliprole DS3074 WO 2008/129060 159 PCT/EP2008/054924 33 EST335 Imazamethabenz 178 GOICDS_C cyazypyr(HGW86) DS3074 33 EST335 Imazamox 178 GOICDSC Azoxystrobin DS3074 33 EST335 Imazapic 178 GOICDS_C Dimoxystrobin DS3074 33 EST335 Imazapyr 178 GOICDS_C Kresoxim-methyl DS3074 33 EST335 Imazaquin 178 GOICDS_C Orysastrobin DS3074 33 EST335 Imazethapyr 178 GOICDS_C Pyraclostrobin DS3074 33 EST335 2,4-D 178 GOICDS_C Trifloxystrobin DS3074 33 EST335 Chloridazon 178 GOICDS C Bixafen DS3074 33 EST335 Picloram 178 GOICDS C Boscalid DS3074 33 EST335 Picolinafen 178 GOICDS_C Isopyrazam DS3074 33 EST335 Cyclosulfamuron 178 GOICDS_C Metalaxyl DS3074 33 EST335 Triflusulfuron 178 GOICDSC Penthiopyrad DS3074 33 EST335 Atrazine 178 GOICDS_C 3-Difluoromethyl-1 DS3074 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 33 EST335 Pyroxasulfone 178 GOICDS_C Dimethomorph DS3074 33 EST335 Bentazone 178 GOICDS C Difenoconazole DS3074 33 EST335 Cinidon-ethly 178 GOICDSC Epoxiconazole DS3074 33 EST335 Cinmethylin 178 GOICDS_C Fluquinconazole DS3074 33 EST335 Dicamba 178 GOICDS C Metconazol DS3074 33 EST335 Diflufenzopyr 178 GOICDS_C Propiconazole DS3074 33 EST335 Quinclorac 178 GOICDS C Prothioconazole DS3074 33 EST335 Quinmerac 178 GOICDS C Tebuconazole DS3074 33 EST335 Mesotrione 178 GOlCDSC Triticonazole WO 2008/129060 160 PCT/EP2008/054924 DS3074 33 EST335 Saflufenacil 178 GOICDS C Prochloraz DS3074 33 EST335 Topramezone; 178 GOICDS C Carbendazim DS3074 37 EST4 acephate 178 GOICDS_C Cyprodinil DS3074 37 EST4 chlorpyrifos 178 GOICDS_C Pyrimethanil DS3074 37 EST4 dimethoate 178 GOICDS_C Fenpropimorph DS3074 37 EST4 methamidophos 178 GOICDS_C Tridemorph DS3074 37 EST4 terbufos 178 GOICDS_C lprodione DS3074 37 EST4 aldicarb 178 GOICDSC 5-ethyl-6-octyl-[1,2,4] DS3074 triazolo[1,5-alpyri midine-7-ylamine 37 EST4 carbofuran 178 GOICDS C Mancozeb DS3074 37 EST4 bifenthrin 178 GOICDS C Maneb DS3074 37 EST4 cypermethrin 178 GOICDS C Metiram DS3074 37 EST4 alpha-cypermethrin 178 GOICDS_C Dithianon DS3074 37 EST4 deltamethrin 178 GOICDS C Chlorothalonil DS3074 37 EST4 |ambda-cyhalothrin 178 GOICDS_C ThiophanateMethyl DS3074 37 EST4 tefluthrin 178 GOICDS_C Cymoxanil DS3074 37 EST4 flufenoxuron 178 GOICDS C Metrafenone DS3074 37 EST4 teflubenzuron 178 GOICDS C Acetochlor DS3074 37 EST4 spirotetramat; 178 GOICDS C Dimethenamid DS3074 37 EST4 clothianidin 178 GOICDS C Metolachlor DS3074 37 EST4 imidacloprid 178 GOICDS C Metazachlor DS3074 37 EST4 thiamethoxam 178 GOICDS_C Glyphosate DS3074 37 EST4 endosulfan 178 GOICDSC Glufosinate WO 2008/129060 161 PCT/EP2008/054924 DS3074 37 EST4 fipronil 178 GOICDS_C Sulfosate DS3074 37 EST4 abamectin 178 GOICDS_C Fenoxaprop DS3074 37 EST4 spinosad 178 GOICDS_C Paraquat DS3074 37 EST4 spinetoram 178 GOICDS_C Cycloxydim DS3074 37 EST4 hydramethylnon; 178 GOICDS_C Profoxydim DS3074 37 EST4 chlorfenapyr; 178 GOICDS_C Sethoxydim DS3074 37 EST4 indoxacarb 178 GOICDS_C Tepraloxydim DS3074 37 EST4 metaflumizone 178 GOICDS C Pendimethalin DS3074 37 EST4 flubendiamide 178 GOICDS C Acifluorfen DS3074 37 EST4 chlorantraniliprole 178 GOICDSC Imazamethabenz DS3074 37 EST4 cyazypyr(HGW86) 178 GOICDS_C Imazamox DS3074 37 EST4 Azoxystrobin 178 GOICDS_C Imazapic DS3074 37 EST4 Dimoxystrobin 178 GOICDS_C Imazapyr DS3074 37 EST4 Kresoxim-methyl 178 GOICDS_C Imazaquin DS3074 37 EST4 Orysastrobin 178 GOICDSC Imazethapyr DS3074 37 EST4 Pyraclostrobin 178 GOICDS C 2,4-D DS3074 37 EST4 Trifloxystrobin 178 GOICDS C Chloridazon DS3074 37 EST4 Bixafen 178 GOICDS C Picloram DS3074 37 EST4 Boscalid 178 GOICDS C Picolinafen DS3074 37 EST4 Isopyrazam 178 GOICDS_C Cyclosulfamuron DS3074 37 EST4 Metalaxyl 178 GOICDS C Triflusulfuron DS3074 37 EST4 Penthiopyrad 178 GOICDS C Atrazine DS3074 WO 2008/129060 162 PCT/EP2008/054924 37 EST4 3-Difluoromethyl-1- 178 GOICDS_C Pyroxasulfone methyl-1 H-pyrazole- DS3074 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 37 EST4 Dimethomorph 178 GOICDS C Bentazone DS3074 37 EST4 Difenoconazole 178 GOICDS_C Cinidon-ethly DS3074 37 EST4 Epoxiconazole 178 GOICDS_C Cinmethylin DS3074 37 EST4 Fluquinconazole 178 GOICDSC Dicamba DS3074 37 EST4 Metconazol 178 GOICDSC Diflufenzopyr DS3074 37 EST4 Propiconazole 178 GOICDS C Quinclorac DS3074 37 EST4 Prothioconazole 178 GOICDS C Quinmerac DS3074 37 EST4 Tebuconazole 178 GOICDS C Mesotrione DS3074 37 EST4 Triticonazole 178 GOICDS C Saflufenacil DS3074 37 EST4 Prochloraz 178 GOICDS_C Topramezone; DS3074 37 EST4 Carbendazim 182 acephate 37 EST4 Cyprodinil 182 chlorpyrifos 37 EST4 Pyrimethanil 182 dimethoate 37 EST4 Fenpropimorph 182 methamidophos 37 EST4 Tridemorph 182 terbufos 37 EST4 lprodione 182 aldicarb 37 EST4 5-ethyl-6-octyl-[1,2,4] 182 carbofuran triazolo[1,5-a]pyri midine-7-ylamine 37 EST4 Mancozeb 182 bifenthrin 37 EST4 Maneb 182 cypermethrin 37 EST4 Metiram 182 alpha-cypermethrin 37 EST4 Dithianon 182 deltamethrin 37 EST4 Chlorothalonil 182 lambda-cyhalothrin 37 EST4 ThiophanateMethyl 182 tefluthrin 37 EST4 Cymoxanil 182 flufenoxuron 37 EST4 Metrafenone 182 teflubenzuron 37 EST4 Acetochlor 182 spirotetramat; WO 2008/129060 163 PCT/EP2008/054924 37 EST4 Dimethenamid 182 clothianidin 37 EST4 Metolachlor 182 imidacloprid 37 EST4 Metazachlor 182 thiamethoxam 37 EST4 Glyphosate 182 endosulfan 37 EST4 Glufosinate 182 fipronil 37 EST4 Sulfosate 182 abamectin 37 EST4 Fenoxaprop 182 spinosad 37 EST4 Paraquat 182 spinetoram 37 EST4 Cycloxydim 182 hydramethylnon; 37 EST4 Profoxydim 182 chlorfenapyr; 37 EST4 Sethoxydim 182 indoxacarb 37 EST4 Tepraloxydim 182 metaflumizone 37 EST4 Pendimethalin 182 flubendiamide 37 EST4 Acifluorfen 182 chlorantraniliprole 37 EST4 Imazamethabenz 182 cyazypyr(HGW86) 37 EST4 Imazamox 182 Azoxystrobin 37 EST4 Imazapic 182 Dimoxystrobin 37 EST4 Imazapyr 182 Kresoxim-methyl 37 EST4 Imazaquin 182 Orysastrobin 37 EST4 Imazethapyr 182 Pyraclostrobin 37 EST4 2,4-D 182 Trifloxystrobin 37 EST4 Chloridazon 182 Bixafen 37 EST4 Picloram 182 Boscalid 37 EST4 Picolinafen 182 Isopyrazam 37 EST4 Cyclosulfamuron 182 Metalaxyl 37 EST4 Triflusulfuron 182 Penthiopyrad 37 EST4 Atrazine 182 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid (2',4',5'-trifluoro biphenyl-2-yl)-amide 37 EST4 Pyroxasulfone 182 Dimethomorph 37 EST4 Bentazone 182 Difenoconazole 37 EST4 Cinidon-ethly 182 Epoxiconazole 37 EST4 Cinmethylin 182 Fluquinconazole 37 EST4 Dicamba 182 Metconazol 37 EST4 Diflufenzopyr 182 Propiconazole 37 EST4 Quinclorac 182 Prothioconazole 37 EST4 Quinmerac 182 Tebuconazole 37 EST4 Mesotrione 182 Triticonazole WO 2008/129060 164 PCT/EP2008/054924 37 EST4 Saflufenacil 182 Prochloraz 37 EST4 Topramezone; 182 Carbendazim 39 EST443 acephate 182 Cyprodinil 39 EST443 chlorpyrifos 182 Pyrimethanil 39 EST443 dimethoate 182 Fenpropimorph 39 EST443 methamidophos 182 Tridemorph 39 EST443 terbufos 182 lprodione 39 EST443 aldicarb 182 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-ajpyri midine-7-ylamine 39 EST443 carbofuran 182 Mancozeb 39 EST443 bifenthrin 182 Maneb 39 EST443 cypermethrin 182 Metiram 39 EST443 alpha-cypermethrin 182 Dithianon 39 EST443 deltamethrin 182 Chlorothalonil 39 EST443 lambda-cyhalothrin 182 ThiophanateMethyl 39 EST443 tefluthrin 182 Cymoxanil 39 EST443 flufenoxuron 182 Metrafenone 39 EST443 teflubenzuron 182 Acetochlor 39 EST443 spirotetramat; 182 Dimethenamid 39 EST443 clothianidin 182 Metolachlor 39 EST443 imidacloprid 182 Metazachlor 39 EST443 thiamethoxam 182 Glyphosate 39 EST443 endosulfan 182 Glufosinate 39 EST443 fipronil 182 Sulfosate 39 EST443 abamectin 182 Fenoxaprop 39 EST443 spinosad 182 Paraquat 39 EST443 spinetoram 182 Cycloxydim 39 EST443 hydramethylnon; 182 Profoxydim 39 EST443 chlorfenapyr; 182 Sethoxydim 39 EST443 indoxacarb 182 Tepraloxydim 39 EST443 metaflumizone 182 Pendimethalin 39 EST443 flubendiamide 182 Acifluorfen 39 EST443 chlorantraniliprole 182 Imazamethabenz 39 EST443 cyazypyr(HGW86) 182 Imazamox 39 EST443 Azoxystrobin 182 Imazapic 39 EST443 Dimoxystrobin 182 Imazapyr 39 EST443 Kresoxim-methyl 182 Imazaquin 39 EST443 Orysastrobin 182 Imazethapyr WO 2008/129060 165 PCT/EP2008/054924 39 EST443 Pyraclostrobin 182 2,4-D 39 EST443 Trifloxystrobin 182 Chloridazon 39 EST443 Bixafen 182 Picloram 39 EST443 Boscalid 182 Picolinafen 39 EST443 Isopyrazam 182 Cyclosulfamuron 39 EST443 Metalaxyl 182 Triflusulfuron 39 EST443 Penthiopyrad 182 Atrazine 39 EST443 3-Difluoromethyl-1- 182 Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 39 EST443 Dimethomorph 182 Bentazone 39 EST443 Difenoconazole 182 Cinidon-ethly 39 EST443 Epoxiconazole 182 Cinmethylin 39 EST443 Fluquinconazole 182 Dicamba 39 EST443 Metconazol 182 Diflufenzopyr 39 EST443 Propiconazole 182 Quinclorac 39 EST443 Prothioconazole 182 Quinmerac 39 EST443 Tebuconazole 182 Mesotrione 39 EST443 Triticonazole 182 Saflufenacil 39 EST443 Prochloraz 182 Topramezone; 39 EST443 Carbendazim 186 acephate 39 EST443 Cyprodinil 186 chlorpyrifos 39 EST443 Pyrimethanil 186 dimethoate 39 EST443 Fenpropimorph 186 methamidophos 39 EST443 Tridemorph 186 terbufos 39 EST443 lprodione 186 aldicarb 39 EST443 5-ethyl-6-octyl-[1,2,4] 186 carbofuran triazolo[1,5-a]pyri midine-7-ylamine 39 EST443 Mancozeb 186 bifenthrin 39 EST443 Maneb 186 cypermethrin 39 EST443 Metiram 186 alpha-cypermethrin 39 EST443 Dithianon 186 deltamethrin 39 EST443 Chlorothalonil 186 lambda-cyhalothrin 39 EST443 ThiophanateMethyl 186 tefluthrin 39 EST443 Cymoxanil 186 flufenoxuron 39 EST443 Metrafenone 186 teflubenzuron 39 EST443 Acetochlor 186 spirotetramat; WO 2008/129060 166 PCT/EP2008/054924 39 EST443 Dimethenamid 186 clothianidin 39 EST443 Metolachlor 186 imidacloprid 39 EST443 Metazachlor 186 thiamethoxam 39 EST443 Glyphosate 186 endosulfan 39 EST443 Glufosinate 186 fipronil 39 EST443 Sulfosate 186 abamectin 39 EST443 Fenoxaprop 186 spinosad 39 EST443 Paraquat 186 spinetoram 39 EST443 Cycloxydim 186 hydramethylnon; 39 EST443 Profoxydim 186 chlorfenapyr; 39 EST443 Sethoxydim 186 indoxacarb 39 EST443 Tepraloxydim 186 metaflumizone 39 EST443 Pendimethalin 186 flubendiamide 39 EST443 Acifluorfen 186 chlorantraniliprole 39 EST443 Imazamethabenz 186 cyazypyr(HGW86) 39 EST443 Imazamox 186 Azoxystrobin 39 EST443 Imazapic 186 Dimoxystrobin 39 EST443 Imazapyr 186 Kresoxim-methyl 39 EST443 Imazaquin 186 Orysastrobin 39 EST443 Imazethapyr 186 Pyraclostrobin 39 EST443 2,4-D 186 Trifloxystrobin 39 EST443 Chloridazon 186 Bixafen 39 EST443 Picloram 186 Boscalid 39 EST443 Picolinafen 186 Isopyrazam 39 EST443 Cyclosulfamuron 186 Metalaxyl 39 EST443 Triflusulfuron 186 Penthiopyrad 39 EST443 Atrazine 186 3-Difluoromethyl-1 methyl-1 H-pyrazole 4 carboxylica cid(2',4',5'-trifluoro biphenyl-2-yl)-amide 39 EST443 Pyroxasulfone 186 Dimethomorph 39 EST443 Bentazone 186 Difenoconazole 39 EST443 Cinidon-ethly 186 Epoxiconazole 39 EST443 Cinmethylin 186 Fluquinconazole 39 EST443 Dicamba 186 Metconazol 39 EST443 Diflufenzopyr 186 Propiconazole 39 EST443 Quinclorac 186 Prothioconazole 39 EST443 Quinmerac 186 Tebuconazole WO 2008/129060 167 PCT/EP2008/054924 39 EST443 Mesotrione 186 Triticonazole 39 EST443 Saflufenacil 186 Prochloraz 39 EST443 Topramezone; 186 Carbendazim 40 EST46 acephate 186 Cyprodinil 40 EST46 chlorpyrifos 186 Pyrimethanil 40 EST46 dimethoate 186 Fenpropimorph 40 EST46 methamidophos 186 Tridemorph 40 EST46 terbufos 186 lprodione 40 EST46 aldicarb 186 5-ethyl-6-octyl [1,2,4]triazolo[1,5 a]pyrimidine-7 ylamine 40 EST46 carbofuran 186 Mancozeb 40 EST46 bifenthrin 186 Maneb 40 EST46 cypermethrin 186 Metiram 40 EST46 alpha-cypermethrin 186 Dithianon 40 EST46 deltamethrin 186 Chlorothalonil 40 EST46 lambda-cyhalothrin 186 ThiophanateMethyl 40 EST46 tefluthrin 186 Cymoxanil 40 EST46 flufenoxuron 186 Metrafenone 40 EST46 teflubenzuron 186 Acetochlor 40 EST46 spirotetramat; 186 Dimethenamid 40 EST46 clothianidin 186 Metolachlor 40 EST46 imidacloprid 186 Metazachlor 40 EST46 thiamethoxam 186 Glyphosate 40 EST46 endosulfan 186 Glufosinate 40 EST46 fipronil 186 Sulfosate 40 EST46 abamectin 186 Fenoxaprop 40 EST46 spinosad 186 Paraquat 40 EST46 spinetoram 186 Cycloxydim 40 EST46 hydramethylnon; 186 Profoxydim 40 EST46 chlorfenapyr; 186 Sethoxydim 40 EST46 indoxacarb 186 Tepraloxydim 40 EST46 metaflumizone 186 Pendimethalin 40 EST46 flubendiamide 186 Acifluorfen 40 EST46 chlorantraniliprole 186 Imazamethabenz 40 EST46 cyazypyr(HGW86) 186 Imazamox 40 EST46 Azoxystrobin 186 Imazapic 40 EST46 Dimoxystrobin 186 Imazapyr 40 EST46 Kresoxim-methyl 186 Imazaquin WO 2008/129060 168 PCT/EP2008/054924 40 EST46 Orysastrobin 186 Imazethapyr 40 EST46 Pyraclostrobin 186 2,4-D 40 EST46 Trifloxystrobin 186 Chloridazon 40 EST46 Bixafen 186 Picloram 40 EST46 Boscalid 186 Picolinafen 40 EST46 Isopyrazam 186 Cyclosulfamuron 40 EST46 Metalaxyl 186 Triflusulfuron 40 EST46 Penthiopyrad 186 Atrazine 40 EST46 3-Difluoromethyl-1- 186 Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 40 EST46 Dimethomorph 186 Bentazone 40 EST46 Difenoconazole 186 Cinidon-ethly 40 EST46 Epoxiconazole 186 Cinmethylin 40 EST46 Fluquinconazole 186 Dicamba 40 EST46 Metconazol 186 Diflufenzopyr 40 EST46 Propiconazole 186 Quinclorac 40 EST46 Prothioconazole 186 Quinmerac 40 EST46 Tebuconazole 186 Mesotrione 40 EST46 Triticonazole 186 Saflufenacil 40 EST46 Prochloraz 186 Topramezone; 40 EST46 Carbendazim 187 acephate 40 EST46 Cyprodinil 187 chlorpyrifos 40 EST46 Pyrimethanil 187 dimethoate 40 EST46 Fenpropimorph 187 methamidophos 40 EST46 Tridemorph 187 terbufos 40 EST46 lprodione 187 aldicarb 40 EST46 5-ethyl-6-octyl-[1,2,4] 187 carbofuran triazolo[1,5-a]pyri midine-7-ylamine 40 EST46 Mancozeb 187 bifenthrin 40 EST46 Maneb 187 cypermethrin 40 EST46 Metiram 187 alpha-cypermethrin 40 EST46 Dithianon 187 deltamethrin 40 EST46 Chlorothalonil 187 lambda-cyhalothrin 40 EST46 ThiophanateMethyl 187 tefluthrin 40 EST46 Cymoxanil 187 flufenoxuron 40 EST46 Metrafenone 187 teflubenzuron WO 2008/129060 169 PCT/EP2008/054924 40 EST46 Acetochlor 187 spirotetramat; 40 EST46 Dimethenamid 187 clothianidin 40 EST46 Metolachlor 187 imidacloprid 40 EST46 Metazachlor 187 thiamethoxam 40 EST46 Glyphosate 187 endosulfan 40 EST46 Glufosinate 187 fipronil 40 EST46 Sulfosate 187 abamectin 40 EST46 Fenoxaprop 187 spinosad 40 EST46 Paraquat 187 spinetoram 40 EST46 Cycloxydim 187 hydramethylnon; 40 EST46 Profoxydim 187 chlorfenapyr; 40 EST46 Sethoxydim 187 indoxacarb 40 EST46 Tepraloxydim 187 metaflumizone 40 EST46 Pendimethalin 187 flubendiamide 40 EST46 Acifluorfen 187 chlorantraniliprole 40 EST46 Imazamethabenz 187 cyazypyr(HGW86) 40 EST46 Imazamox 187 Azoxystrobin 40 EST46 Imazapic 187 Dimoxystrobin 40 EST46 Imazapyr 187 Kresoxim-methyl 40 EST46 Imazaquin 187 Orysastrobin 40 EST46 Imazethapyr 187 Pyraclostrobin 40 EST46 2,4-D 187 Trifloxystrobin 40 EST46 Chloridazon 187 Bixafen 40 EST46 Picloram 187 Boscalid 40 EST46 Picolinafen 187 Isopyrazam 40 EST46 Cyclosulfamuron 187 Metalaxyl 40 EST46 Triflusulfuron 187 Penthiopyrad 40 EST46 Atrazine 187 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 40 EST46 Pyroxasulfone 187 Dimethomorph 40 EST46 Bentazone 187 Difenoconazole 40 EST46 Cinidon-ethly 187 Epoxiconazole 40 EST46 Cinmethylin 187 Fluquinconazole 40 EST46 Dicamba 187 Metconazol 40 EST46 Diflufenzopyr 187 Propiconazole 40 EST46 Quinclorac 187 Prothioconazole 40 EST46 Quinmerac 187 Tebuconazole WO 2008/129060 170 PCT/EP2008/054924 40 EST46 Mesotrione 187 Triticonazole 40 EST46 Saflufenacil 187 Prochloraz 40 EST46 Topramezone; 187 Carbendazim 42 EST512 acephate 187 Cyprodinil 42 EST512 chlorpyrifos 187 Pyrimethanil 42 EST512 dimethoate 187 Fenpropimorph 42 EST512 methamidophos 187 Tridemorph 42 EST512 terbufos 187 lprodione 42 EST512 aldicarb 187 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 42 EST512 carbofuran 187 Mancozeb 42 EST512 bifenthrin 187 Maneb 42 EST512 cypermethrin 187 Metiram 42 EST512 alpha-cypermethrin 187 Dithianon 42 EST512 deltamethrin 187 Chlorothalonil 42 EST512 lambda-cyhalothrin 187 ThiophanateMethyl 42 EST512 tefluthrin 187 Cymoxanil 42 EST512 flufenoxuron 187 Metrafenone 42 EST512 teflubenzuron 187 Acetochlor 42 EST512 spirotetramat; 187 Dimethenamid 42 EST512 clothianidin 187 Metolachlor 42 EST512 imidacloprid 187 Metazachlor 42 EST512 thiamethoxam 187 Glyphosate 42 EST512 endosulfan 187 Glufosinate 42 EST512 fipronil 187 Sulfosate 42 EST512 abamectin 187 Fenoxaprop 42 EST512 spinosad 187 Paraquat 42 EST512 spinetoram 187 Cycloxydim 42 EST512 hydramethylnon; 187 Profoxydim 42 EST512 chlorfenapyr; 187 Sethoxydim 42 EST512 indoxacarb 187 Tepraloxydim 42 EST512 metaflumizone 187 Pendimethalin 42 EST512 flubendiamide 187 Acifluorfen 42 EST512 chlorantraniliprole 187 Imazamethabenz 42 EST512 cyazypyr(HGW86) 187 Imazamox 42 EST512 Azoxystrobin 187 Imazapic 42 EST512 Dimoxystrobin 187 Imazapyr 42 EST512 Kresoxim-methyl 187 Imazaquin WO 2008/129060 171 PCT/EP2008/054924 42 EST512 Orysastrobin 187 Imazethapyr 42 EST512 Pyraclostrobin 187 2,4-D 42 EST512 Trifloxystrobin 187 Chloridazon 42 EST512 Bixafen 187 Picloram 42 EST512 Boscalid 187 Picolinafen 42 EST512 Isopyrazam 187 Cyclosulfamuron 42 EST512 Metalaxyl 187 Triflusulfuron 42 EST512 Penthiopyrad 187 Atrazine 42 EST512 3-Difluoromethyl-1- 187 Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 42 EST512 Dimethomorph 187 Bentazone 42 EST512 Difenoconazole 187 Cinidon-ethly 42 EST512 Epoxiconazole 187 Cinmethylin 42 EST512 Fluquinconazole 187 Dicamba 42 EST512 Metconazol 187 Diflufenzopyr 42 EST512 Propiconazole 187 Quinclorac 42 EST512 Prothioconazole 187 Quinmerac 42 EST512 Tebuconazole 187 Mesotrione 42 EST512 Triticonazole 187 Saflufenacil 42 EST512 Prochloraz 187 Topramezone; 42 EST512 Carbendazim 188 acephate 42 EST512 Cyprodinil 188 chlorpyrifos 42 EST512 Pyrimethanil 188 dimethoate 42 EST512 Fenpropimorph 188 methamidophos 42 EST512 Tridemorph 188 terbufos 42 EST512 lprodione 188 aldicarb 42 EST512 5-ethyl-6-octyl-[1,2,4] 188 carbofuran triazolo[1,5-a]pyri midine-7-ylamine 42 EST512 Mancozeb 188 bifenthrin 42 EST512 Maneb 188 cypermethrin 42 EST512 Metiram 188 alpha-cypermethrin 42 EST512 Dithianon 188 deltamethrin 42 EST512 Chlorothalonil 188 lambda-cyhalothrin 42 EST512 ThiophanateMethyl 188 tefluthrin 42 EST512 Cymoxanil 188 flufenoxuron 42 EST512 Metrafenone 188 teflubenzuron WO 2008/129060 172 PCT/EP2008/054924 42 EST512 Acetochlor 188 spirotetramat; 42 EST512 Dimethenamid 188 clothianidin 42 EST512 Metolachlor 188 imidacloprid 42 EST512 Metazachlor 188 thiamethoxam 42 EST512 Glyphosate 188 endosulfan 42 EST512 Glufosinate 188 fipronil 42 EST512 Sulfosate 188 abamectin 42 EST512 Fenoxaprop 188 spinosad 42 EST512 Paraquat 188 spinetoram 42 EST512 Cycloxydim 188 hydramethylnon; 42 EST512 Profoxydim 188 chlorfenapyr; 42 EST512 Sethoxydim 188 indoxacarb 42 EST512 Tepraloxydim 188 metaflumizone 42 EST512 Pendimethalin 188 flubendiamide 42 EST512 Acifluorfen 188 chlorantraniliprole 42 EST512 Imazamethabenz 188 cyazypyr(HGW86) 42 EST512 Imazamox 188 Azoxystrobin 42 EST512 Imazapic 188 Dimoxystrobin 42 EST512 Imazapyr 188 Kresoxim-methyl 42 EST512 Imazaquin 188 Orysastrobin 42 EST512 Imazethapyr 188 Pyraclostrobin 42 EST512 2,4-D 188 Trifloxystrobin 42 EST512 Chloridazon 188 Bixafen 42 EST512 Picloram 188 Boscalid 42 EST512 Picolinafen 188 Isopyrazam 42 EST512 Cyclosulfamuron 188 Metalaxyl 42 EST512 Triflusulfuron 188 Penthiopyrad 42 EST512 Atrazine 188 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 42 EST512 Pyroxasulfone 188 Dimethomorph 42 EST512 Bentazone 188 Difenoconazole 42 EST512 Cinidon-ethly 188 Epoxiconazole 42 EST512 Cinmethylin 188 Fluquinconazole 42 EST512 Dicamba 188 Metconazol 42 EST512 Diflufenzopyr 188 Propiconazole 42 EST512 Quinclorac 188 Prothioconazole 42 EST512 Quinmerac 188 Tebuconazole WO 2008/129060 173 PCT/EP2008/054924 42 EST512 Mesotrione 188 Triticonazole 42 EST512 Saflufenacil 188 Prochloraz 42 EST512 Topramezone; 188 Carbendazim 43 PpVTPES acephate 188 Cyprodinil T513 43 PpVTPES chlorpyrifos 188 Pyrimethanil T513 43 PpVTP_ES dimethoate 188 Fenpropimorph T513 43 PpVTPES methamidophos 188 Tridemorph T513 43 PpVTPES terbufos 188 lprodione T513 43 PpVTPES aldicarb 188 5-ethyl-6-octyl-[1,2,4) T513 triazolo[1,5-a]pyri midine-7-ylamine 43 PpVTPES carbofuran 188 Mancozeb T513 43 PpVTPES bifenthrin 188 Maneb T513 43 PpVTP_ES cypermethrin 188 Metiram T513 43 PpVTP_ES alpha-cypermethrin 188 Dithianon T513 43 PpVTPES deltamethrin 188 Chlorothalonil T513 43 PpVTPES lambda-cyhalothrin 188 ThiophanateMethyl T513 43 PpVTPES tefluthrin 188 Cymoxanil T513 43 PpVTP_ES flufenoxuron 188 Metrafenone T513 43 PpVTPES teflubenzuron 188 Acetochlor T513 43 PpVTP_ES spirotetramat; 188 Dimethenamid T513 43 PpVTPES clothianidin 188 Metolachlor T513 43 PpVTPES imidacloprid 188 Metazachlor T513 43 PpVTPES thiamethoxam 188 Glyphosate T513 43 PpVTPES endosulfan 188 Glufosinate T513 43 PpVTP_ES fipronil 188 Sulfosate WO 2008/129060 174 PCT/EP2008/054924 T513 43 PpVTP_ES abamectin 188 Fenoxaprop T513 43 PpVTP_ES spinosad 188 Paraquat T513 43 PpVTP_ES spinetoram 188 Cycloxydim T513 43 PpVTP_ES hydramethylnon; 188 Profoxydim T513 43 PpVTP_ES chlorfenapyr; 188 Sethoxydim T513 43 PpVTPES indoxacarb 188 Tepraloxydim T513 43 PpVTP_ES metaflumizone 188 Pendimethalin T513 43 PpVTPES flubendiamide 188 Acifluorfen T513 43 PpVTP_ES chlorantraniliprole 188 Imazamethabenz T513 43 PpVTP_ES cyazypyr(HGW86) 188 Imazamox T513 43 PpVTPES Azoxystrobin 188 Imazapic T513 43 PpVTPES Dimoxystrobin 188 Imazapyr T513 43 PpVTPES Kresoxim-methyl 188 Imazaquin T513 43 PpVTP_ES Orysastrobin 188 Imazethapyr T513 43 PpVTP_ES Pyraclostrobin 188 2,4-D T513 43 PpVTPES Trifloxystrobin 188 Chloridazon T513 43 PpVTPES Bixafen 188 Picloram T513 43 PpVTPES Boscalid 188 Picolinafen T513 43 PpVTP_ES Isopyrazam 188 Cyclosulfamuron T513 43 PpVTPES Metalaxyl 188 Triflusulfuron T513 43 PpVTPES Penthiopyrad 188 Atrazine T513 43 PpVTPES 3-Difluoromethyl-1- 188 Pyroxasulfone T513 methyl-1 H-pyrazole- WO 2008/129060 175 PCT/EP2008/054924 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 43 PpVTPES Dimethomorph 188 Bentazone T513 43 PpVTPES Difenoconazole 188 Cinidon-ethly T513 43 PpVTP_ES Epoxiconazole 188 Cinmethylin T513 43 PpVTPES Fluquinconazole 188 Dicamba T513 43 PpVTP_ES Metconazol 188 Diflufenzopyr T513 43 PpVTPES Propiconazole 188 Quinclorac T513 43 PpVTPES Prothioconazole 188 Quinmerac T513 43 PpVTPES Tebuconazole 188 Mesotrione T513 43 PpVTP_ES Triticonazole 188 Saflufenacil T513 43 PpVTPES Prochloraz 188 Topramezone; T513 43 PpVTP_ES Carbendazim 189 _CDS3298 acephate T513 43 PpVTP_ES Cyprodinil 189 _CDS3298 chlorpyrifos T513 43 PpVTPES Pyrimethanil 189 _CDS3298 dimethoate T513 43 PpVTPES Fenpropimorph 189 _CDS3298 methamidophos T513 43 PpVTPES Tridemorph 189 _CDS3298 terbufos T513 43 PpVTPES lprodione 189 _CDS3298 aldicarb T513 43 PpVTPES 5-ethyl-6-octyl-[1,2,4] 189 _CDS3298 carbofuran T513 triazolo[1,5-a]pyri midine-7-ylamine 43 PpVTPES Mancozeb 189 _CDS3298 bifenthrin T513 43 PpVTPES Maneb 189 _CDS3298 cypermethrin T513 43 PpVTPES Metiram 189 _CDS3298 alpha-cypermethrin T513 43 PpVTPES Dithianon 189 _CDS3298 deltamethrin T513 WO 2008/129060 176 PCT/EP2008/054924 43 PpVTP_ES Chlorothalonil 189 _CDS3298 lambda-cyhalothrin T513 43 PpVTPES ThiophanateMethyl 189 _CDS3298 tefluthrin T513 43 PpVTP_ES Cymoxanil 189 _CDS3298 flufenoxuron T513 43 PpVTP_ES Metrafenone 189 _CDS3298 teflubenzuron T513 43 PpVTPES Acetochlor 189 _CDS3298 spirotetramat; T513 43 PpVTP_ES Dimethenamid 189 _CDS3298 clothianidin T513 43 PpVTPES Metolachlor 189 _CDS3298 imidacloprid T513 43 PpVTP_ES Metazachlor 189 _CDS3298 thiamethoxam T513 43 PpVTPES Glyphosate 189 _CDS3298 endosulfan T513 43 PpVTP_ES Glufosinate 189 _CDS3298 fipronil T513 43 PpVTPES Sulfosate 189 _CDS3298 abamectin T513 43 PpVTP_ES Fenoxaprop 189 _CDS3298 spinosad T513 43 PpVTPES Paraquat 189 _CDS3298 spinetoram T513 43 PpVTP_ES Cycloxydim 189 _CDS3298 hydramethylnon; T513 43 PpVTPES Profoxydim 189 _CDS3298 chlorfenapyr; T513 43 PpVTP_ES Sethoxydim 189 _CDS3298 indoxacarb T513 43 PpVTPES Tepraloxydim 189 _CDS3298 metaflumizone T513 43 PpVTPES Pendimethalin 189 _CDS3298 flubendiamide T513 43 PpVTPES Acifluorfen 189 _CDS3298 chlorantraniliprole T513 43 PpVTPES Imazamethabenz 189 _CDS3298 cyazypyr(HGW86) T513 43 PpVTPES Imazamox 189 _CDS3298 Azoxystrobin T513 43 PpVTPES Imazapic 189 _CDS3298 Dimoxystrobin T513 43 PpVTPES Imazapyr 189 _DS3298 Kresoxim-methyl WO 2008/129060 1 77 PCT/EP2008/054924 T513 43 PpVTP_ES Imazaquin 189 _CDS3298 Orysastrobin T513 43 PpVTPES Imazethapyr 189 _CDS3298 Pyraclostrobin T513 43 PpVTP_ES 2,4-D 189 _CDS3298 Trifloxystrobin T513 43 PpVTPES Chloridazon 189 _CDS3298 Bixafen T513 43 PpVTP_ES Picloram 189 _CDS3298 Boscalid T513 43 PpVTPES Picolinafen 189 _CDS3298 Isopyrazam T513 43 PpVTP_ES Cyclosulfamuron 189 _CDS3298 Metalaxyl T513 43 PpVTPES Triflusulfuron 189 _CDS3298 Penthiopyrad T513 43 PpVTP_ES Atrazine 189 _CDS3298 3-Difluoromethyl-1 T513 methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 43 PpVTP_ES Pyroxasulfone 189 _CDS3298 Dimethomorph T513 43 PpVTPES Bentazone 189 _CDS3298 Difenoconazole T513 43 PpVTPES Cinidon-ethly 189 _CDS3298 Epoxiconazole T513 43 PpVTPES Cinmethylin 189 _CDS3298 Fluquinconazole T513 43 PpVTPES Dicamba 189 _CDS3298 Metconazol T513 43 PpVTPES Diflufenzopyr 189 _CDS3298 Propiconazole T513 43 PpVTPES Quinclorac 189 _CDS3298 Prothioconazole T513 43 PpVTPES Quinmerac 189 _CDS3298 Tebuconazole T513 43 PpVTPES Mesotrione 189 _CDS3298 Triticonazole T513 43 PpVTPES Saflufenacil 189 _CDS3298 Prochloraz T513 43 PpVTPES Topramezone; 189 _CDS3298 Carbendazim T513 91 YKL150w acephate 189 _CDS3298 Cyprodinil WO 2008/129060 178 PCT/EP2008/054924 91 YKL150w chlorpyrifos 189 _CDS3298 Pyrimethanil 91 YKL150w dimethoate 189 _CDS3298 Fenpropimorph 91 YKL150w methamidophos 189 _CDS3298 Tridemorph 91 YKL150w terbufos 189 _CDS3298 lprodione 91 YKL150w aldicarb 189 _CDS3298 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 91 YKL150w carbofuran 189 CDS3298 Mancozeb 91 YKL150w bifenthrin 189 _CDS3298 Maneb 91 YKL150w cypermethrin 189 _CDS3298 Metiram 91 YKL150w alpha-cypermethrin 189 _CDS3298 Dithianon 91 YKL150w deltamethrin 189 _CDS3298 Chlorothalonil 91 YKL150w lambda-cyhalothrin 189 _CDS3298 ThiophanateMethyl 91 YKL150w tefluthrin 189 _CDS3298 Cymoxanil 91 YKL150w flufenoxuron 189 _CDS3298 Metrafenone 91 YKL150w teflubenzuron 189 _CDS3298 Acetochlor 91 YKL150w spirotetramat; 189 _CDS3298 Dimethenamid 91 YKL150w clothianidin 189 CDS3298 Metolachlor 91 YKL150w imidacloprid 189 _CDS3298 Metazachlor 91 YKL150w thiamethoxam 189 _CDS3298 Glyphosate 91 YKL150w endosulfan 189 _CDS3298 Glufosinate 91 YKL150w fipronil 189 _CDS3298 Sulfosate 91 YKL150w abamectin 189 _CDS3298 Fenoxaprop 91 YKL150w spinosad 189 _CDS3298 Paraquat 91 YKL150w spinetoram 189 _CDS3298 Cycloxydim 91 YKL150w hydramethylnon; 189 _CDS3298 Profoxydim 91 YKL150w chlorfenapyr; 189 _CDS3298 Sethoxydim 91 YKL150w indoxacarb 189 _CDS3298 Tepraloxydim 91 YKL150w metaflumizone 189 CDS3298 Pendimethalin 91 YKL150w flubendiamide 189 _CDS3298 Acifluorfen 91 YKL150w chlorantraniliprole 189 _CDS3298 Imazamethabenz 91 YKL150w cyazypyr(HGW86) 189 _CDS3298 Imazamox 91 YKL150w Azoxystrobin 189 _CDS3298 Imazapic 91 YKL150w Dimoxystrobin 189 _CDS3298 Imazapyr 91 YKL150w Kresoxim-methyl 189 _CDS3298 Imazaquin 91 YKL150w Orysastrobin 189 _CDS3298 Imazethapyr 91 YKL150w Pyraclostrobin 189 _CDS3298 2,4-D 91 YKL150w Trifloxystrobin 189 _CDS3298 Chloridazon 91 YKL150w Bixafen 189 _CDS3298 Picloram WO 2008/129060 179 PCT/EP2008/054924 91 YKL150w Boscalid 189 CDS3298 Picolinafen 91 YKL150w Isopyrazam 189 _CDS3298 Cyclosulfamuron 91 YKL150w Metalaxyl 189 _CDS3298 Triflusulfuron 91 YKL150w Penthiopyrad 189 _CDS3298 Atrazine 91 YKL150w 3-Difluoromethyl-1- 189 _CDS3298 Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid (2',4',5'-trifluoro biphenyl-2-yl)-amide 91 YKL150w Dimethomorph 189 _CDS3298 Bentazone 91 YKL150w Difenoconazole 189 _CDS3298 Cinidon-ethly 91 YKL150w Epoxiconazole 189 _CDS3298 Cinmethylin 91 YKL150w Fluquinconazole 189 _CDS3298 Dicamba 91 YKL150w Metconazol 189 _CDS3298 Diflufenzopyr 91 YKL150w Propiconazole 189 _CDS3298 Quinclorac 91 YKL150w Prothioconazole 189 _CDS3298 Quinmerac 91 YKL150w Tebuconazole 189 _CDS3298 Mesotrione 91 YKL150w Triticonazole 189 _CDS3298 Saflufenacil 91 YKL150w Prochloraz 189 _CDS3298 Topramezone; 91 YKL150w Carbendazim 190 acephate 91 YKL150w Cyprodinil 190 chlorpyrifos 91 YKL150w Pyrimethanil 190 dimethoate 91 YKL150w Fenpropimorph 190 methamidophos 91 YKL150w Tridemorph 190 terbufos 91 YKL150w lprodione 190 aldicarb 91 YKL150w 5-ethyl-6-octyl-[1,2,4] 190 carbofuran triazolo[1,5-a]pyri midine-7-ylamine 91 YKL150w Mancozeb 190 bifenthrin 91 YKL150w Maneb 190 cypermethrin 91 YKL150w Metiram 190 alpha-cypermethrin 91 YKL150w Dithianon 190 deltamethrin 91 YKL150w Chlorothalonil 190 lambda-cyhalothrin 91 YKL150w ThiophanateMethyl 190 tefluthrin 91 YKL150w Cymoxanil 190 flufenoxuron 91 YKL150w Metrafenone 190 teflubenzuron 91 YKL150w Acetochlor 190 spirotetramat; 91 YKL150w Dimethenamid 190 clothianidin 91 YKL150w Metolachlor 190 imidacloprid 91 YKL150w Metazachlor 190 thiamethoxam WO 2008/129060 180 PCT/EP2008/054924 91 YKL150w Glyphosate 190 endosulfan 91 YKL150w Glufosinate 190 fipronil 91 YKL150w Sulfosate 190 abamectin 91 YKL150w Fenoxaprop 190 spinosad 91 YKL150w Paraquat 190 spinetoram 91 YKL150w Cycloxydim 190 hydramethylnon; 91 YKL150w Profoxydim 190 chlorfenapyr; 91 YKL150w Sethoxydim 190 indoxacarb 91 YKL150w Tepraloxydim 190 metaflumizone 91 YKL150w Pendimethalin 190 flubendiamide 91 YKL150w Acifluorfen 190 chlorantraniliprole 91 YKL150w Imazamethabenz 190 cyazypyr(HGW86) 91 YKL150w Imazamox 190 Azoxystrobin 91 YKL150w Imazapic 190 Dimoxystrobin 91 YKL150w Imazapyr 190 Kresoxim-methyl 91 YKL150w Imazaquin 190 Orysastrobin 91 YKL150w Imazethapyr 190 Pyraclostrobin 91 YKL150w 2,4-D 190 Trifloxystrobin 91 YKL150w Chloridazon 190 Bixafen 91 YKL150w Picloram 190 Boscalid 91 YKL150w Picolinafen 190 Isopyrazam 91 YKL150w Cyclosulfamuron 190 Metalaxyl 91 YKL150w Triflusulfuron 190 Penthiopyrad 91 YKL150w Atrazine 190 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid (2',4',5'-trifluoro biphenyl-2-yl)-amide 91 YKL150w Pyroxasulfone 190 Dimethomorph 91 YKL150w Bentazone 190 Difenoconazole 91 YKL150w Cinidon-ethly 190 Epoxiconazole 91 YKL150w Cinmethylin 190 Fluquinconazole 91 YKL150w Dicamba 190 Metconazol 91 YKL150w Diflufenzopyr 190 Propiconazole 91 YKL150w Quinclorac 190 Prothioconazole 91 YKL150w Quinmerac 190 Tebuconazole 91 YKL150w Mesotrione 190 Triticonazole 91 YKL150w Saflufenacil 190 Prochloraz 91 YKL150w Topramezone; 190 Carbendazim 105 YNL079C acephate 190 Cyprodinil WO 2008/129060 181 PCT/EP2008/054924 105 YNLO79C chlorpyrifos 190 Pyrimethanil 105 YNL079C dimethoate 190 Fenpropimorph 105 YNL079C methamidophos 190 Tridemorph 105 YNL079C terbufos 190 lprodione 105 YNL079C aldicarb 190 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 105 YNL079C carbofuran 190 Mancozeb 105 YNL079C bifenthrin 190 Maneb 105 YNL079C cypermethrin 190 Metiram 105 YNL079C alpha-cypermethrin 190 Dithianon 105 YNL079C deltamethrin 190 Chlorothalonil 105 YNL079C lambda-cyhalothrin 190 ThiophanateMethyl 105 YNL079C tefluthrin 190 Cymoxanil 105 YNL079C flufenoxuron 190 Metrafenone 105 YNL079C teflubenzuron 190 Acetochlor 105 YNL079C spirotetramat; 190 Dimethenamid 105 YNL079C clothianidin 190 Metolachlor 105 YNL079C imidacloprid 190 Metazachlor 105 YNL079C thiamethoxam 190 Glyphosate 105 YNL079C endosulfan 190 Glufosinate 105 YNL079C fipronil 190 Sulfosate 105 YNL079C abamectin 190 Fenoxaprop 105 YNL079C spinosad 190 Paraquat 105 YNL079C spinetoram 190 Cycloxydim 105 YNL079C hydramethylnon; 190 Profoxydim 105 YNL079C chlorfenapyr; 190 Sethoxydim 105 YNL079C indoxacarb 190 Tepraloxydim 105 YNL079C metaflumizone 190 Pendimethalin 105 YNL079C flubendiamide 190 Acifluorfen 105 YNL079C chlorantraniliprole 190 Imazamethabenz 105 YNL079C cyazypyr(HGW86) 190 Imazamox 105 YNL079C Azoxystrobin 190 Imazapic 105 YNL079C Dimoxystrobin 190 Imazapyr 105 YNL079C Kresoxim-methyl 190 Imazaquin 105 YNL079C Orysastrobin 190 Imazethapyr 105 YNL079C Pyraclostrobin 190 2,4-D 105 YNL079C Trifloxystrobin 190 Chloridazon 105 YNL079C Bixafen 190 Picloram WO 2008/129060 182 PCT/EP2008/054924 105 YNL079C Boscalid 190 Picolinafen 105 YNL079C Isopyrazam 190 Cyclosulfamuron 105 YNL079C Metalaxyl 190 Triflusulfuron 105 YNL079C Penthiopyrad 190 Atrazine 105 YNL079C 3-Difluoromethyl-1- 190 Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid (2',4',5'-trifluoro biphenyl-2-yl)-amide 105 YNL079C Dimethomorph 190 Bentazone 105 YNL079C Difenoconazole 190 Cinidon-ethly 105 YNL079C Epoxiconazole 190 Cinmethylin 105 YNL079C Fluquinconazole 190 Dicamba 105 YNL079C Metconazol 190 Diflufenzopyr 105 YNL079C Propiconazole 190 Quinclorac 105 YNL079C Prothioconazole 190 Quinmerac 105 YNL079C Tebuconazole 190 Mesotrione 105 YNL079C Triticonazole 190 Saflufenacil 105 YNL079C Prochloraz 190 Topramezone; 105 YNL079C Carbendazim 194 YIL172C acephate 105 YNL079C Cyprodinil 194 YIL172C chlorpyrifos 105 YNL079C Pyrimethanil 194 YIL172C dimethoate 105 YNL079C Fenpropimorph 194 YIL172C methamidophos 105 YNL079C Tridemorph 194 YlL172C terbufos 105 YNL079C lprodione 194 YIL172C aldicarb 105 YNL079C 5-ethyl-6-octyl-[1,2,4] 194 YIL172C carbofuran triazolo[1,5-a]pyri midine-7-ylamine 105 YNL079C Mancozeb 194 YIL172C bifenthrin 105 YNL079C Maneb 194 YIL172C cypermethrin 105 YNL079C Metiram 194 YIL172C alpha-cypermethrin 105 YNL079C Dithianon 194 YIL172C deltamethrin 105 YNL079C Chlorothalonil 194 YIL172C lambda-cyhalothrin 105 YNL079C ThiophanateMethyl 194 YlL172C tefluthrin 105 YNL079C Cymoxanil 194 YIL172C flufenoxuron 105 YNL079C Metrafenone 194 YIL172C teflubenzuron 105 YNL079C Acetochlor 194 YIL172C spirotetramat; 105 YNL079C Dimethenamid 194 YlL172C clothianidin 105 YNL079C Metolachlor 194 YIL172C imidacloprid 105 YNL079C Metazachlor 194 YIL172C thiamethoxam WO 2008/129060 183 PCT/EP2008/054924 105 YNL079C Glyphosate 194 YlL172C endosulfan 105 YNL079C Glufosinate 194 YIL172C fipronil 105 YNL079C Sulfosate 194 YIL172C abamectin 105 YNL079C Fenoxaprop 194 YlL172C spinosad 105 YNL079C Paraquat 194 YIL172C spinetoram 105 YNL079C Cycloxydim 194 YIL172C hydramethylnon; 105 YNL079C Profoxydim 194 YIL172C chlorfenapyr; 105 YNL079C Sethoxydim 194 YIL172C indoxacarb 105 YNL079C Tepraloxydim 194 YIL172C metaflumizone 105 YNL079C Pendimethalin 194 YlL172C flubendiamide 105 YNL079C Acifluorfen 194 YIL172C chlorantraniliprole 105 YNL079C Imazamethabenz 194 YIL172C cyazypyr(HGW86) 105 YNL079C Imazamox 194 YIL172C Azoxystrobin 105 YNL079C Imazapic 194 YlL172C Dimoxystrobin 105 YNL079C Imazapyr 194 YIL172C Kresoxim-methyl 105 YNL079C Imazaquin 194 YIL172C Orysastrobin 105 YNL079C Imazethapyr 194 YIL172C Pyraclostrobin 105 YNL079C 2,4-D 194 YIL172C Trifloxystrobin 105 YNL079C Chloridazon 194 YIL172C Bixafen 105 YNL079C Picloram 194 YIL172C Boscalid 105 YNL079C Picolinafen 194 YIL172C Isopyrazam 105 YNL079C Cyclosulfamuron 194 YIL172C Metalaxyl 105 YNL079C Triflusulfuron 194 YIL172C Penthiopyrad 105 YNL079C Atrazine 194 YIL172C 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid (2',4',5'-trifluoro biphenyl-2-yl)-amide 105 YNL079C Pyroxasulfone 194 YIL172C Dimethomorph 105 YNL079C Bentazone 194 YIL172C Difenoconazole 105 YNL079C Cinidon-ethly 194 YIL172C Epoxiconazole 105 YNL079C Cinmethylin 194 YIL172C Fluquinconazole 105 YNL079C Dicamba 194 YIL172C Metconazol 105 YNL079C Diflufenzopyr 194 YIL172C Propiconazole 105 YNL079C Quinclorac 194 YIL172C Prothioconazole 105 YNL079C Quinmerac 194 YIL172C Tebuconazole 105 YNL079C Mesotrione 194 YIL172C Triticonazole 105 YNL079C Saflufenacil 194 YIL172C Prochloraz 105 YNL079C Topramezone; 194 YiL172C Carbendazim 107 YMR100W acephate 194 YIL172C Cyprodinil WO 2008/129060 184 PCT/EP2008/054924 107 YMR100W chlorpyrifos 194 YlL172C Pyrimethanil 107 YMR100W dimethoate 194 YlL172C Fenpropimorph 107 YMR100W methamidophos 194 YIL172C Tridemorph 107 YMR100W terbufos 194 YlL172C lprodione 107 YMR100W aldicarb 194 YIL172C 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 107 YMR100W carbofuran 194 YIL172C Mancozeb 107 YMR100W bifenthrin 194 YiL172C Maneb 107 YMR100W cypermethrin 194 YIL172C Metiram 107 YMR100W alpha-cypermethrin 194 YIL172C Dithianon 107 YMR100W deltamethrin 194 YIL172C Chlorothalonil 107 YMR100W lambda-cyhalothrin 194 YlL172C ThiophanateMethyl 107 YMR100W tefluthrin 194 YlL172C Cymoxanil 107 YMR100W flufenoxuron 194 YIL172C Metrafenone 107 YMR100W teflubenzuron 194 YIL172C Acetochlor 107 YMR100W spirotetramat; 194 YIL172C Dimethenamid 107 YMR100W clothianidin 194 YIL172C Metolachlor 107 YMR100W imidacloprid 194 YIL172C Metazachlor 107 YMR100W thiamethoxam 194 YiL172C Glyphosate 107 YMR100W endosulfan 194 YIL172C Glufosinate 107 YMR100W fipronil 194 YIL172C Sulfosate 107 YMR100W abamectin 194 YIL172C Fenoxaprop 107 YMR100W spinosad 194 YIL172C Paraquat 107 YMR100W spinetoram 194 YIL172C Cycloxydim 107 YMR100W hydramethylnon; 194 YIL172C Profoxydim 107 YMR100W chlorfenapyr; 194 YIL172C Sethoxydim 107 YMR10OW indoxacarb 194 YIL172C Tepraloxydim 107 YMR100W metaflumizone 194 YIL172C Pendimethalin 107 YMR100W flubendiamide 194 YlL172C Acifluorfen 107 YMR100W chlorantraniliprole 194 YiL172C Imazamethabenz 107 YMR100W cyazypyr(HGW86) 194 YIL172C Imazamox 107 YMR100W Azoxystrobin 194 YIL172C Imazapic 107 YMR100W Dimoxystrobin 194 YIL172C Imazapyr 107 YMR100W Kresoxim-methyl 194 YIL172C Imazaquin 107 YMR100W Orysastrobin 194 YlL172C Imazethapyr 107 YMR100W Pyraclostrobin 194 YIL172C 2,4-D 107 YMR100W Trifloxystrobin 194 YIL172C Chloridazon 107 YMR100W Bixafen 194 YIL172C Picloram WO 2008/129060 185 PCT/EP2008/054924 107 YMR100W Boscalid 194 YIL172C Picolinafen 107 YMR100W Isopyrazam 194 YIL172C Cyclosulfamuron 107 YMR100W Metalaxyl 194 YIL172C Triflusulfuron 107 YMR100W Penthiopyrad 194 YlL172C Atrazine 107 YMR100W 3-Difluoromethyl-1- 194 YIL172C Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid (2',4',5'-trifluoro biphenyl-2-yl)-amide 107 YMR100W Dimethomorph 194 YIL172C Bentazone 107 YMR100W Difenoconazole 194 YIL172C Cinidon-ethly 107 YMR100W Epoxiconazole 194 YIL172C Cinmethylin 107 YMR100W Fluquinconazole 194 YIL172C Dicamba 107 YMR100W Metconazol 194 YIL172C Diflufenzopyr 107 YMR100W Propiconazole 194 YIL172C Quinclorac 107 YMR100W Prothioconazole 194 YlL172C Quinmerac 107 YMR100W Tebuconazole 194 YIL172C Mesotrione 107 YMR100W Triticonazole 194 YIL172C Saflufenacil 107 YMR100W Prochloraz 194 YIL172C Topramezone; 107 YMR100W Carbendazim 196 YMR217W acephate 107 YMR100W Cyprodinil 196 YMR217W chlorpyrifos 107 YMR100W Pyrimethanil 196 YMR217W dimethoate 107 YMR100W Fenpropimorph 196 YMR217W methamidophos 107 YMR100W Tridemorph 196 YMR217W terbufos 107 YMR100W Iprodione 196 YMR217W aldicarb 107 YMR100W 5-ethyl-6-octyl- 196 YMR217W carbofuran [1,2,4]triazolo[1,5 a]pyrimidine-7 ylamine 107 YMR100W Mancozeb 196 YMR217W bifenthrin 107 YMR100W Maneb 196 YMR217W cypermethrin 107 YMR100W Metiram 196 YMR217W alpha-cypermethrin 107 YMR100W Dithianon 196 YMR217W deltamethrin 107 YMR100W Chlorothalonil 196 YMR217W lambda-cyhalothrin 107 YMR100W ThiophanateMethyl 196 YMR217W tefluthrin 107 YMR100W Cymoxanil 196 YMR217W flufenoxuron 107 YMR100W Metrafenone 196 YMR217W teflubenzuron 107 YMR100W Acetochlor 196 YMR217W spirotetramat; 107 YMR100W Dimethenamid 196 YMR217W clothianidin 107 YMR100W Metolachlor 196 YMR217W imidacloprid 107 YMR100W Metazachlor 196 YMR217W thiamethoxam WO 2008/129060 186 PCT/EP2008/054924 107 YMR100W Glyphosate 196 YMR217W endosulfan 107 YMR100W Glufosinate 196 YMR217W fipronil 107 YMR100W Sulfosate 196 YMR217W abamectin 107 YMR100W Fenoxaprop 196 YMR217W spinosad 107 YMR100W Paraquat 196 YMR217W spinetoram 107 YMR100W Cycloxydim 196 YMR217W hydramethylnon; 107 YMR100W Profoxydim 196 YMR217W chlorfenapyr; 107 YMR100W Sethoxydim 196 YMR217W indoxacarb 107 YMR100W Tepraloxydim 196 YMR217W metaflumizone 107 YMR100W Pendimethalin 196 YMR217W flubendiamide 107 YMR100W Acifluorfen 196 YMR217W chlorantraniliprole 107 YMR100W Imazamethabenz 196 YMR217W cyazypyr(HGW86) 107 YMR100W Imazamox 196 YMR217W Azoxystrobin 107 YMR100W Imazapic 196 YMR217W Dimoxystrobin 107 YMR100W Imazapyr 196 YMR217W Kresoxim-methyl 107 YMR100W Imazaquin 196 YMR217W Orysastrobin 107 YMR100W Imazethapyr 196 YMR217W Pyraclostrobin 107 YMR100W 2,4-D 196 YMR217W Trifloxystrobin 107 YMR100W Chloridazon 196 YMR217W Bixafen 107 YMR100W Picloram 196 YMR217W Boscalid 107 YMR100W Picolinafen 196 YMR217W Isopyrazam 107 YMR100W Cyclosulfamuron 196 YMR217W Metalaxyl 107 YMR100W Triflusulfuron 196 YMR217W Penthiopyrad 107 YMR100W Atrazine 196 YMR217W 3-Difluoromethyl-1 methyl-1 H-pyrazole 4-carboxylic acid (2',4',5'-trifluoro biphenyl-2-yl)-amide 107 YMR100W Pyroxasulfone 196 YMR217W Dimethomorph 107 YMR100W Bentazone 196 YMR217W Difenoconazole 107 YMR100W Cinidon-ethly 196 YMR217W Epoxiconazole 107 YMR100W Cinmethylin 196 YMR217W Fluquinconazole 107 YMR100W Dicamba 196 YMR217W Metconazol 107 YMR100W Diflufenzopyr 196 YMR217W Propiconazole 107 YMR100W Quinclorac 196 YMR217W Prothioconazole 107 YMR100W Quinmerac 196 YMR217W Tebuconazole 107 YMR100W Mesotrione 196 YMR217W Triticonazole 107 YMR100W Saflufenacil 196 YMR217W Prochloraz 107 YMR100W Topramezone; 196 YMR217W Carbendazim 112 YNL024c acephate 196 YMR217W Cyprodinil WO 2008/129060 187 PCT/EP2008/054924 112 YNLO24c chlorpyrifos 196 YMR217W Pyrimethanil 112 YNL024c dimethoate 196 YMR217W Fenpropimorph 112 YNLO24c methamidophos 196 YMR217W Tridemorph 112 YNL024c terbufos 196 YMR217W lprodione 112 YNL024c aldicarb 196 YMR217W 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 112 YNL024c carbofuran 196 YMR217W Mancozeb 112 YNL024c bifenthrin 196 YMR217W Maneb 112 YNL024c cypermethrin 196 YMR217W Metiram 112 YNLO24c alpha-cypermethrin 196 YMR217W Dithianon 112 YNL024c deltamethrin 196 YMR217W Chlorothalonil 112 YNL024c lambda-cyhalothrin 196 YMR217W ThiophanateMethyl 112 YNL024c tefluthrin 196 YMR217W Cymoxanil 112 YNL024c flufenoxuron 196 YMR217W Metrafenone 112 YNL024c teflubenzuron 196 YMR217W Acetochlor 112 YNL024c spirotetramat; 196 YMR217W Dimethenamid 112 YNL024c clothianidin 196 YMR217W Metolachlor 112 YNL024c imidacloprid 196 YMR217W Metazachlor 112 YNL024c thiamethoxam 196 YMR217W Glyphosate 112 YNL024c endosulfan 196 YMR217W Glufosinate 112 YNL024c fipronil 196 YMR217W Sulfosate 112 YNL024c abamectin 196 YMR217W Fenoxaprop 112 YNL024c spinosad 196 YMR217W Paraquat 112 YNL024c spinetoram 196 YMR217W Cycloxydim 112 YNL024c hydramethylnon; 196 YMR217W Profoxydim 112 YNL024c chlorfenapyr; 196 YMR217W Sethoxydim 112 YNL024c indoxacarb 196 YMR217W Tepraloxydim 112 YNL024c metaflumizone 196 YMR217W Pendimethalin 112 YNL024c flubendiamide 196 YMR217W Acifluorfen 112 YNL024c chlorantraniliprole 196 YMR217W Imazamethabenz 112 YNL024c cyazypyr(HGW86) 196 YMR217W Imazamox 112 YNL024c Azoxystrobin 196 YMR217W Imazapic 112 YNL024c Dimoxystrobin 196 YMR217W Imazapyr 112 YNL024c Kresoxim-methyl 196 YMR217W Imazaquin 112 YNL024c Orysastrobin 196 YMR217W Imazethapyr 112 YNL024c Pyraclostrobin 196 YMR217W 2,4-D 112 YNL024c Trifloxystrobin 196 YMR217W Chloridazon 112 YNL024c Bixafen 196 YMR217W Picloram WO 2008/129060 188 PCT/EP2008/054924 112 YNLO24c Boscalid 196 YMR217W Picolinafen 112 YNL024c Isopyrazam 196 YMR217W Cyclosulfamuron 112 YNLO24c Metalaxyl 196 YMR217W Triflusulfuron 112 YNL024c Penthiopyrad 196 YMR217W Atrazine 112 YNL024c 3-Difluoromethyl-1- 196 YMR217W Pyroxasulfone methyl-1 H-pyrazole 4-carboxylic acid (2',4',5'-trifluoro biphenyl-2-yl)-amide 112 YNL024c Dimethomorph 196 YMR217W Bentazone 112 YNL024c Difenoconazole 196 YMR217W Cinidon-ethly 112 YNL024c Epoxiconazole 196 YMR217W Cinmethylin 112 YNL024c Fluquinconazole 196 YMR217W Dicamba 112 YNL024c Metconazol 196 YMR217W Diflufenzopyr 112 YNL024c Propiconazole 196 YMR217W Quinclorac 112 YNL024c Prothioconazole 196 YMR217W Quinmerac 112 YNL024c Tebuconazole 196 YMR217W Mesotrione 112 YNL024c Triticonazole 196 YMR217W Saflufenacil 112 YNL024c Prochloraz 196 YMR217W Topramezone; 112 YNL024c Carbendazim 203 GOlCDSC acephate 204 acephate DS1608 203 GOICDS C chlorpyrifos 204 chlorpyrifos DS1608 203 GOICDS C dimethoate 204 dimethoate DS1608 203 GOICDS C methamidophos 204 methamidophos DS1608 203 GOICDSC terbufos 204 terbufos DS1608 203 GOICDS_C aldicarb 204 aldicarb DS1608 203 GOICDSC carbofuran 204 carbofuran DS1608 203 GOICDSC bifenthrin 204 bifenthrin DS1608 203 GOICDS_C cypermethrin 204 cypermethrin DS1608 203 GOICDS_C alpha-cypermethrin 204 alpha-cypermethrin DS1608 203 GOICDSC deltamethrin 204 deltamethrin DS1608 203 GOICDS C lambda-cyhalothrin 204 lambda-cyhalothrin WO 2008/129060 189 PCT/EP2008/054924 DS1608 203 GOICDS C tefluthrin 204 tefluthrin DS1608 203 GOICDS C flufenoxuron 204 flufenoxuron DS1608 203 GOICDS C teflubenzuron 204 teflubenzuron DS1608 203 GOICDSC spirotetramat; 204 spirotetramat; DS1608 203 GOICDS C clothianidin 204 clothianidin DS1608 203 GOICDSC imidacloprid 204 imidacloprid DS1608 203 GOICDS C thiamethoxam 204 thiamethoxam DS1608 203 GOICDS C endosulfan 204 endosulfan DS1608 203 GOICDS_C fipronil 204 fipronil DS1608 203 GOICDS C abamectin 204 abamectin DS1608 203 GOICDS_C spinosad 204 spinosad DS1608 203 GOICDS_C spinetoram 204 spinetoram DS1608 203 GOICDS_C hydramethylnon; 204 hydramethylnon; DS1608 203 GOICDS_C chlorfenapyr; 204 chlorfenapyr; DS1608 203 GOICDSC indoxacarb 204 indoxacarb DS1608 203 GOICDSC metaflumizone 204 metaflumizone DS1608 203 GOICDSC flubendiamide 204 flubendiamide DS1608 203 GOICDS_C chlorantraniliprole 204 chlorantraniliprole DS1608 203 GOICDS_C cyazypyr(HGW86) 204 cyazypyr(HGW86) DS1608 203 GOICDS_C Azoxystrobin 204 Azoxystrobin DS1608 203 GOICDSC Dimoxystrobin 204 Dimoxystrobin DS1608 203 GOICDSC Kresoxim-methyl 204 Kresoxim-methyl DS1608 WO 2008/129060 190 PCT/EP2008/054924 203 GOICDSC Orysastrobin 204 Orysastrobin DS1608 203 GOICDS_C Pyraclostrobin 204 Pyraclostrobin DS1608 203 GOICDS_C Trifloxystrobin 204 Trifloxystrobin DS1608 203 GOICDS C Bixafen 204 Bixafen DS1608 203 GOICDS C Boscalid 204 Boscalid DS1608 203 GOICDS_C Isopyrazam 204 Isopyrazam DS1608 203 GOICDS_C Metalaxyl 204 Metalaxyl DS1608 203 GOICDS_C Penthiopyrad 204 Penthiopyrad DS1608 203 GOICDSC 3-Difluoromethyl-1- 204 3-Difluoromethyl-1 DS1608 methyl-1 H-pyrazole- methyl-1 H-pyrazole 4-carboxylic a- 4-carboxylic cid(2',4',5'-trifluoro- acid (2',4',5'-trifluoro biphenyl-2-yl)-amide biphenyl-2-yl)-amide 203 GOICDS_C Dimethomorph 204 Dimethomorph DS1608 203 GOICDS C Difenoconazole 204 Difenoconazole DS1608 203 GOICDS_C Epoxiconazole 204 Epoxiconazole DS1608 203 GOICDS_C Fluquinconazole 204 Fluquinconazole DS1608 203 GOICDSC Metconazol 204 Metconazol DS1608 203 GOICDS_C Propiconazole 204 Propiconazole DS1608 203 GOICDSC Prothioconazole 204 Prothioconazole DS1608 203 GOICDSC Tebuconazole 204 Tebuconazole DS1608 203 GOICDSC Triticonazole 204 Triticonazole DS1608 203 GOICDSC Prochloraz 204 Prochloraz DS1608 203 GOICDS_C Carbendazim 204 Carbendazim DS1608 203 GOICDS_C Cyprodinil 204 Cyprodinil DS1608 203 GOICDS_C Pyrimethanil 204 Pyrimethanil WO 2008/129060 191 PCT/EP2008/054924 DS1608 203 GOICDS_C Fenpropimorph 204 Fenpropimorph DS1608 203 GOICDS_C Tridemorph 204 Tridemorph DS1608 203 GOICDS_C lprodione 204 lprodione DS1608 203 GOICDSC 5-ethyl-6-octyl-[1,2,4] 204 5-ethyl-6-octyl-[1,2,4] DS1608 triazolo[1,5-a]pyri- triazolo[1,5-a]pyri midine-7-ylamine midine-7-ylamine 203 GOICDS C Mancozeb 204 Mancozeb DS1608 203 GOICDS C Maneb 204 Maneb DS1608 203 GOICDS C Metiram 204 Metiram DS1608 203 GOICDS C Dithianon 204 Dithianon DS1608 203 GOICDS C Chlorothalonil 204 Chlorothalonil DS1608 203 GOICDS_C ThiophanateMethyl 204 ThiophanateMethyl DS1608 203 GOlCDSC Cymoxanil 204 Cymoxanil DS1608 203 GOICDS C Metrafenone 204 Metrafenone DS1608 203 GOICDS C Acetochlor 204 Acetochlor DS1608 203 GOICDS C Dimethenamid 204 Dimethenamid DS1608 203 GOICDS_C Metolachlor 204 Metolachlor DS1608 203 GOICDS_C Metazachlor 204 Metazachlor DS1608 203 GOICDS_C Glyphosate 204 Glyphosate DS1608 203 GOICDSC Glufosinate 204 Glufosinate DS1608 203 GOICDSC Sulfosate 204 Sulfosate DS1608 203 GOICDS_C Fenoxaprop 204 Fenoxaprop DS1608 203 GOICDS_C Paraquat 204 Paraquat DS1608 203 GOICDSC Cycloxydim 204 Cycloxydim WO 2008/129060 1 92 PCT/EP2008/054924 DS1608 203 GOICDS_C Profoxydim 204 Profoxydim DS1608 203 GOICDS_C Sethoxydim 204 Sethoxydim DS1608 203 GOICDS_C Tepraloxydim 204 Tepraloxydim DS1608 203 GOICDS C Pendimethalin 204 Pendimethalin DS1608 203 GOICDS C Acifluorfen 204 Acifluorfen DS1608 203 GOICDS C Imazamethabenz 204 Imazamethabenz DS1608 203 GOICDS C Imazamox 204 Imazamox DS1608 203 GOICDSC Imazapic 204 Imazapic DS1608 203 GOICDS_C Imazapyr 204 Imazapyr DS1608 203 GOICDSC Imazaquin 204 Imazaquin DS1608 203 GOICDS_C Imazethapyr 204 Imazethapyr DS1608 203 GOICDS_C 2,4-D 204 2,4-D DS1608 203 GOICDSC Chloridazon 204 Chloridazon DS1608 203 GOICDSC Picloram 204 Picloram DS1608 203 GOICDSC Picolinafen 204 Picolinafen DS1608 203 GOICDS_C Cyclosulfamuron 204 Cyclosulfamuron DS1608 203 GOICDSC Triflusulfuron 204 Triflusulfuron DS1608 203 GOICDSC Atrazine 204 Atrazine DS1608 203 GOICDS_C Pyroxasulfone 204 Pyroxasulfone DS1608 203 GOICDSC Bentazone 204 Bentazone DS1608 203 GOICDSC Cinidon-ethly 204 Cinidon-ethly DS1608 203 GOICDSC Cinmethylin 204 Cinmethylin DS1608 WO 2008/129060 193 PCT/EP2008/054924 203 GOICDS C Dicamba 204 Dicamba DS1608 203 GOICDS_C Diflufenzopyr 204 Diflufenzopyr DS1608 203 GOICDS C Quinclorac 204 Quinclorac DS1608 203 GOICDS C Quinmerac 204 Quinmerac DS1608 203 GOICDS C Mesotrione 204 Mesotrione DS1608 203 GOICDS C Saflufenacil 204 Saflufenacil DS1608 203 GOICDS_C Topramezone; 204 Topramezone; DS1608 205 GOICDS_C acephate 206 acephate DS0644_7 205 GOICDSC chlorpyrifos 206 chlorpyrifos DS0644_7 205 GOICDS C dimethoate 206 dimethoate DS0644_7 205 GOICDS_C methamidophos 206 methamidophos DS0644_7 205 GOlCDS C terbufos 206 terbufos DS0644_7 205 GOICDS C aldicarb 206 aldicarb DS0644_7 205 GOICDSC carbofuran 206 carbofuran DS0644_7 205 GOICDSC bifenthrin 206 bifenthrin DS0644_7 205 GOICDSC cypermethrin 206 cypermethrin DS0644_7 205 GOICDS C alpha-cypermethrin 206 alpha-cypermethrin DS0644_7 205 GOICDSC deltamethrin 206 deltamethrin DS0644_7 205 GOICDSC lambda-cyhalothrin 206 lambda-cyhalothrin DS0644_7 205 GOICDSC tefluthrin 206 tefluthrin DS0644 7 205 GOICDSC flufenoxuron 206 flufenoxuron DS0644_7 205 GOICDSC teflubenzuron 206 teflubenzuron DS0644_7 205 GOICDS_C spirotetramat; 206 spirotetramat; WO 2008/129060 1 94 PCT/EP2008/054924 DS0644_7 205 GOICDS C clothianidin 206 clothianidin DS0644_7 205 GOICDSC imidacloprid 206 imidacloprid DS0644 7 205 GOICDS C thiamethoxam 206 thiamethoxam DS0644_7 205 GOICDS C endosulfan 206 endosulfan DS0644_7 205 GOICDSC fipronil 206 fipronil DS0644_7 205 GOICDS C abamectin 206 abamectin DS0644_7 205 GOICDSC spinosad 206 spinosad DS0644_7 205 GOICDSC spinetoram 206 spinetoram DS0644_7 205 GOICDSC hydramethylnon; 206 hydramethylnon; DS0644_7 205 GOICDSC chlorfenapyr; 206 chlorfenapyr; DS0644_7 205 GOICDS C indoxacarb 206 indoxacarb DS0644_7 205 GOICDS C metaflumizone 206 metaflumizone DS0644_7 205 GOICDSC flubendiamide 206 flubendiamide DS0644_7 205 GOICDS_C chlorantraniliprole 206 chlorantraniliprole DS0644_7 205 GOICDSC cyazypyr(HGW86) 206 cyazypyr(HGW86) DS0644_7 205 GOICDS_C Azoxystrobin 206 Azoxystrobin DS0644_7 205 GOICDSC Dimoxystrobin 206 Dimoxystrobin DS0644_7 205 GOICDS_C Kresoxim-methyl 206 Kresoxim-methyl DS0644_7 205 GOICDS_C Orysastrobin 206 Orysastrobin DS0644_7 205 GOICDS_C Pyraclostrobin 206 Pyraclostrobin DS0644_7 205 GOICDSC Trifloxystrobin 206 Trifloxystrobin DS0644_7 205 GOICDS C Bixafen 206 Bixafen DS0644_7 WO 2008/129060 195 PCT/EP2008/054924 205 GOICDS C Boscalid 206 Boscalid DS0644 7 205 GOICDS_C Isopyrazam 206 Isopyrazam DS0644 7 205 GOICDS_C Metalaxyl 206 Metalaxyl DS0644_7 205 GOICDS_C Penthiopyrad 206 Penthiopyrad DS0644_7 205 GOICDS_C 3-Difluoromethyl-1- 206 3-Difluoromethyl-1 DS0644_7 methyl-1 H-pyrazole- methyl-1 H-pyrazole 4-carboxylic a- 4-carboxylic cid(2',4',5'-trifluoro- acid(2',4',5'-trifluoro biphenyl-2-yl)-amide biphenyl-2-yl)-amide 205 GOICDS_C Dimethomorph 206 Dimethomorph DS0644_7 205 GOICDS C Difenoconazole 206 Difenoconazole DS0644_7 205 GOICDS_C Epoxiconazole 206 Epoxiconazole DS0644_7 205 GOICDS_C Fluquinconazole 206 Fluquinconazole DS0644_7 205 GOICDS C Metconazol 206 Metconazol DS0644_7 205 GOICDS_C Propiconazole 206 Propiconazole DS0644_7 205 GOICDSC Prothioconazole 206 Prothioconazole DS0644_7 205 GOICDSC Tebuconazole 206 Tebuconazole DS0644_7 205 GOICDSC Triticonazole 206 Triticonazole DS0644_7 205 GOICDS C Prochloraz 206 Prochloraz DS0644_7 205 GOICDSC Carbendazim 206 Carbendazim DS0644_7 205 GOICDS__C Cyprodinil 206 Cyprodinil DS0644_7 205 GOICDSC Pyrimethanil 206 Pyrimethanil DS0644_7 205 GOICDS__C Fenpropimorph 206 Fenpropimorph DS0644 7 205 GOICDS_C Tridemorph 206 Tridemorph DS0644 7 205 GOICDS_C lprodione 206 lprodione DS0644 7 205 GOICDS_C 5-ethyl-6-octyl-[1,2,4] 206 5-ethyl-6-octyl-[1,2,4] WO 2008/129060 196 PCT/EP2008/054924 DS0644_7 triazolo[1,5-a]pyri- triazolo[1,5-a]pyri midine-7-ylamine midine-7-ylamine 205 GOICDS C Mancozeb 206 Mancozeb DS0644 7 205 GOICDS C Maneb 206 Maneb DS0644_7 205 GOICDS C Metiram 206 Metiram DS0644_7 205 GOICDS C Dithianon 206 Dithianon DS0644_7 205 GOICDS C Chlorothalonil 206 Chlorothalonil DS0644_7 205 GOICDS_C ThiophanateMethyl 206 ThiophanateMethyl DS0644_7 205 GOICDS_C Cymoxanil 206 Cymoxanil DS0644_7 205 GOICDS C Metrafenone 206 Metrafenone DS0644_7 205 GOICDS C Acetochlor 206 Acetochlor DS0644_7 205 GOICDS C Dimethenamid 206 Dimethenamid DS0644_7 205 GOlCDS C Metolachlor 206 Metolachlor DS0644_7 205 GOICDSC Metazachlor 206 Metazachlor DS0644_7 205 GOICDSC Glyphosate 206 Glyphosate DS0644_7 205 GOICDSC Glufosinate 206 Glufosinate DS0644_7 205 GOICDSC Sulfosate 206 Sulfosate DS0644_7 205 GOICDS C Fenoxaprop 206 Fenoxaprop DS0644_7 205 GOICDSC Paraquat 206 Paraquat DS0644_7 205 GOICDSC Cycloxydim 206 Cycloxydim DS0644_7 205 GOICDS_C Profoxydim 206 Profoxydim DS0644 7 205 GOICDS_C Sethoxydim 206 Sethoxydim DS0644_7 205 GOICDS_C Tepraloxydim 206 Tepraloxydim DS0644_7 205 GOICDSC Pendimethalin 206 Pendimethalin WO 2008/129060 1 97 PCT/EP2008/054924 DS0644_7 205 GOICDS C Acifluorfen 206 Acifluorfen DS0644_7 205 GOICDS C Imazamethabenz 206 Imazamethabenz DS0644 7 205 GOICDS C Imazamox 206 Imazamox DS0644_7 205 GOICDSC Imazapic 206 Imazapic DS0644_7 205 GOICDSC Imazapyr 206 Imazapyr DS0644_7 205 GOICDSC Imazaquin 206 Imazaquin DS0644_7 205 GOICDSC Imazethapyr 206 Imazethapyr DS0644_7 205 GOICDSC 2,4-D 206 2,4-D DS0644_7 205 GOICDS C Chloridazon 206 Chloridazon DS0644_7 205 GOICDS C Picloram 206 Picloram DS0644_7 205 GOICDSC Picolinafen 206 Picolinafen DS0644_7 205 GOICDS_C Cyclosulfamuron 206 Cyclosulfamuron DS0644_7 205 GOICDSC Triflusulfuron 206 Triflusulfuron DS0644_7 205 GOICDSC Atrazine 206 Atrazine DS0644_7 205 GOICDSC Pyroxasulfone 206 Pyroxasulfone DS0644_7 205 GOICDSC Bentazone 206 Bentazone DS0644_7 205 GOICDSC Cinidon-ethly 206 Cinidon-ethly DS0644_7 205 GOICDS_C Cinmethylin 206 Cinmethylin DS0644_7 205 GOICDSC Dicamba 206 Dicamba DS0644_7 205 GOICDS_C Diflufenzopyr 206 Diflufenzopyr DS0644_7 205 GOICDSC Quinclorac 206 Quinclorac DS0644_7 205 GOICDSC Quinmerac 206 Quinmerac DS0644_7 WO 2008/129060 198 PCT/EP2008/054924 205 GOICDS C Mesotrione 206 Mesotrione DS0644 7 205 GOICDS C Saflufenacil 206 Saflufenacil DS0644 7 205 GOICDSC Topramezone; 206 Topramezone; DS0644_7 207 GOICDSC acephate 209 GOISCDS_ acephate DS2447 CDS3159 207 GOICDSC chlorpyrifos 209 GOISCDS_ chlorpyrifos DS2447 CDS3159 207 GOICDS C dimethoate 209 GOISCDS dimethoate DS2447 CDS3159 207 GOICDSC methamidophos 209 GOISCDS_ methamidophos DS2447 CDS3159 207 GOICDS C terbufos 209 GOISCDS terbufos DS2447 CDS3159 207 GOICDS C aldicarb 209 GOISCDS aldicarb DS2447 CDS3159 207 GOICDS C carbofuran 209 GOISCDS carbofuran DS2447 CDS3159 207 GOICDS C bifenthrin 209 GOISCDS bifenthrin DS2447 CDS3159 207 GOlCDSC cypermethrin 209 GOISCDS_ cypermethrin DS2447 CDS3159 207 GOICDSC alpha-cypermethrin 209 GOISCDS_ alpha-cypermethrin DS2447 CDS3159 207 GOICDS C deltamethrin 209 GOISCDS deltamethrin DS2447 CDS3159 207 GOICDS C lambda-cyhalothrin 209 GOISCDS_ lambda-cyhalothrin DS2447 CDS3159 207 GOICDSC tefluthrin 209 GOISCDS_ tefluthrin DS2447 CDS3159 207 GOICDSC flufenoxuron 209 GOISCDS_ flufenoxuron DS2447 CDS3159 207 GOICDSC teflubenzuron 209 GOISCDS_ teflubenzuron DS2447 CDS3159 207 GOICDSC spirotetramat; 209 GOISCDS_ spirotetramat; DS2447 CDS3159 207 GOICDSC clothianidin 209 GOISCDS clothianidin DS2447 CDS3159 207 GOICDS_C imidacloprid 209 GOISCDS_ imidacloprid DS2447 CDS3159 207 GOICDSC thiamethoxam 209 GOISCDS thiamethoxam DS2447 CDS3159 207 GOICDSC endosulfan 209 GOISCDS endosulfan WO 2008/129060 1 99 PCT/EP2008/054924 DS2447 CDS3159 207 GOICDS_C fipronil 209 GOISCDS_ fipronil DS2447 CDS3159 207 GOICDS C abamectin 209 GOISCDS abamectin DS2447 CDS3159 207 GOICDS_C spinosad 209 GOISCDS_ spinosad DS2447 CDS3159 207 GOICDSC spinetoram 209 GOISCDS_ spinetoram DS2447 CDS3159 207 GOICDSC hydramethylnon; 209 GOISCDS_ hydramethylnon; DS2447 CDS3159 207 GOICDSC chlorfenapyr; 209 GOISCDS_ chlorfenapyr; DS2447 CDS3159 207 GOICDS C indoxacarb 209 GOISCDS indoxacarb DS2447 CDS3159 207 GOICDS C metaflumizone 209 GOISCDS metaflumizone DS2447 CDS3159 207 GOICDS C flubendiamide 209 GOISCDS flubendiamide DS2447 CDS3159 207 GOICDSC chlorantraniliprole 209 GOISCDS_ chlorantraniliprole DS2447 CDS3159 207 GOICDS_C cyazypyr(HGW86) 209 GOISCDS_ cyazypyr(HGW86) DS2447 CDS3159 207 GOICDS_C Azoxystrobin 209 GOISCDS_ Azoxystrobin DS2447 CDS3159 207 GOICDS_C Dimoxystrobin 209 GOISCDS_ Dimoxystrobin DS2447 CDS3159 207 GOICDS_C Kresoxim-methyl 209 GOISCDS_ Kresoxim-methyl DS2447 CDS3159 207 GOICDS_C Orysastrobin 209 GOISCDS_ Orysastrobin DS2447 CDS3159 207 GOICDS_C Pyraclostrobin 209 GOISCDS_ Pyraclostrobin DS2447 CDS3159 207 GOICDSC Trifloxystrobin 209 GOISCDS Trifloxystrobin DS2447 CDS3159 207 GOICDSC Bixafen 209 GOISCDS_ Bixafen DS2447 CDS3159 207 GOICDSC Boscalid 209 GOISCDS_ Boscalid DS2447 CDS3159 207 GOICDS_C Isopyrazam 209 GOISCDS_ Isopyrazam DS2447 CDS3159 207 GOICDSC Metalaxyl 209 GOISCDS_ Metalaxyl DS2447 CDS3159 207 GOICDSC Penthiopyrad 209 GOISCDS Penthiopyrad DS2447 CDS3159 WO 2008/129060 200 PCT/EP2008/054924 207 GOICDSC 3-Difluoromethyl-1- 209 GOISODS_ 3-Difluoromethyl-1 DS2447 methyl-1 H-pyrazole- CDS3159 methyl-i H-pyrazole 4-carboxylic a- 4-carboxylic cid(2',4',5'-trifluoro- acid(2',4',5'-trifluoro biphenyl-2-yl)-amide biphenyl-2-yl)-amide 207 GOICDSC Dimethomorph 209 GOISODS_ Dimethomorph DS2447 CDS3159 207 GOICDS C Difenoconazole 209 GOISCOS Difenoconazole DS2447 CDS3159 207 GOICDS_C Epoxiconazole 209 GOISODS Epoxiconazole DS2447 CDS3159 207 GOICDSC Fluquinconazole 209 GOISODS Fluquinconazole DS2447 CDS3159 207 GOICDS C Metconazol 209 GOISODS Metoonazol DS2447 CDS3159 207 GOICDSC Propiconazole 209 GOISODS Propiconazole DS2447 CDS3159 207 GOICDS C Prothioconazole 209 GOISODS Prothioconazole DS2447 CDS3159 207 GOICDS C Tebuconazole 209 GOISODS Tebuconazole DS2447 00S3159 207 GOICDS C Triticonazole 209 GOISODS Triticonazole DS2447 0053159 207 GOICDS C Prochloraz 209 GOISODS Prochloraz DS2447 0053159 207 GOICDS C Carbendazim 209 GOISODS Carbendazim DS2447 CDS3159 207 GOICDS_C Cyprodinil 209 GOISODS Cyprodinil DS2447 CDS3159 207 GOICDS_C Pyrimethanil 209 GOISODS Pyrimethanil DS2447 CDS3159 207 GOICDS_C Fenpropimorph 209 GOISODS Fenpropimorph DS2447 0053159 207 GOICDSC Tridemorph 209 GOISCDS Tridemorph DS2447 CDS3159 207 GOICDSC lprodione 209 GOISODS iprodione DS2447 0053159 207 GOICDS__C 5-ethyl-6-octyl-[1,2,4] 209 GOISODS 5-ethyl-6-octyl-[i,2,4] DS2447 triazolo[1,5-a]pyri- 0053159 triazolo[1,5-a]pyri midine-7-ylamine midine-7-ylamine 207 GOICDSC Mancozeb 209 GOISODS Mancozeb DS2447 CDS3159 207 GOICDSC Maneb 209 GOISCOS Maneb DS2447 0053159 207 GOICDS C Metiram 209 GOISODS Metiram DS2447 CDS3159 WO 2008/129060 201 PCT/EP2008/054924 207 GOICDSC Dithianon 209 GOISCDS_ Dithianon DS2447 CDS3159 207 GOICDSC Chlorothalonil 209 GOISCDS_ Chlorothalonil DS2447 CDS3159 207 GOICDS_C ThiophanateMethyl 209 GOISCDS_ ThiophanateMethyl DS2447 CDS3159 207 GOICDS_C Cymoxanil 209 GOISCDS_ Cymoxanil DS2447 CDS3159 207 GOICDS C Metrafenone 209 GOISCDS Metrafenone DS2447 CDS3159 207 GOICDS C Acetochlor 209 GOISCDS Acetochlor DS2447 CDS3159 207 GOICDS C Dimethenamid 209 GOISCDS Dimethenamid DS2447 CDS3159 207 GOICDS C Metolachlor 209 GOISCDS Metolachlor DS2447 CDS3159 207 GOICDS C Metazachlor 209 GOISCDS Metazachlor DS2447 CDS3159 207 GOICDS_C Glyphosate 209 GOISCDS_ Glyphosate DS2447 CDS3159 207 GOICDS C Glufosinate 209 GOISCDS Glufosinate DS2447 CDS3159 207 GOlCDS C Sulfosate 209 GOISCDS' Sulfosate DS2447 CDS3159 207 GOICDSC Fenoxaprop 209 GOISCDS_ Fenoxaprop DS2447 CDS3159 207 GOICDS C Paraquat 209 GOISCDS Paraquat DS2447 CDS3159 207 GOICDS C Cycloxydim 209 GOISCDS_ Cycloxydim DS2447 CDS3159 207 GOICDSC Profoxydim 209 GOISCDS_ Profoxydim DS2447 CDS3159 207 GOICDSC Sethoxydim 209 GOISCDS_ Sethoxydim DS2447 CDS3159 207 GOICDSC Tepraloxydim 209 GOISCDS_ Tepraloxydim DS2447 CDS3159 207 GOICDSC Pendimethalin 209 GOISCDS_ Pendimethalin DS2447 CDS3159 207 GOICDSC Acifluorfen 209 GOISCDS Acifluorfen DS2447 CDS3159 207 GOICDS C lmazamethabenz 209 GOISCDS Imazamethabenz DS2447 CDS3159 207 GOICDSC Imazamox 209 GOISCDS Imazamox DS2447 CDS3159 207 GOICDSC Imazapic 209 GOISCDS_ Imazapic WO 2008/129060 202 PCT/EP2008/054924 DS2447 CDS3159 207 GOICDSC Imazapyr 209 GOISCDS_ Imazapyr DS2447 CDS3159 207 GOICDS_C Imazaquin 209 GOISCDS Imazaquin DS2447 CDS3159 207 GOICDS_C Imazethapyr 209 GOISCDS_ Imazethapyr DS2447 CDS3159 207 GOICDSC 2,4-D 209 GOISCDS_ 2,4-D DS2447 CDS3159 207 GOICDS C Chloridazon 209 GOISCDS Chloridazon DS2447 CDS3159 207 GOICDS C Picloram 209 GOISCDS Picloram DS2447 CDS3159 207 GOICDS C Picolinafen 209 GOISCDS Picolinafen DS2447 CDS3159 207 GOICDSC Cyclosulfamuron 209 GOISCDS_ Cyclosulfamuron DS2447 CDS3159 207 GOICDS C Triflusulfuron 209 GOISCDS Triflusulfuron DS2447 CDS3159 207 GOICDS C Atrazine 209 GOISCDS Atrazine DS2447 CDS3159 207 GOICDS_C Pyroxasulfone 209 GOISCDS_ Pyroxasulfone DS2447 CDS3159 207 GOICDS C Bentazone 209 GOISCDS Bentazone DS2447 CDS3159 207 GOICDS_C Cinidon-ethly 209 GOISCDS_ Cinidon-ethly DS2447 CDS3159 207 GOICDS_C Cinmethylin 209 GOISCDS Cinmethylin DS2447 CDS3159 207 GOICDSC Dicamba 209 GOISCDS_ Dicamba DS2447 CDS3159 207 GOICDS_C Diflufenzopyr 209 GOISCDS_ Diflufenzopyr DS2447 CDS3159 207 GOICDSC Quinclorac 209 GOISCDS Quinclorac DS2447 CDS3159 207 GOICDSC Quinmerac 209 GOISCDS_ Quinmerac DS2447 CDS3159 207 GOICDSC Mesotrione 209 GOISCDS_ Mesotrione DS2447 CDS3159 207 GOICDSC Saflufenacil 209 GOISCDS Saflufenacil DS2447 CDS3159 207 GOICDSC Topramezone; 209 GOISCDS_ Topramezone; DS2447 CDS3159 210 GOISCDS_ acephate 211 GOICDSC acephate DS0644 7 WO 2008/129060 203 PCT/EP2008/054924 210 GOISCDS_ chlorpyrifos 211 GOICDS_C chlorpyrifos DS0644_7 210 GOISCDS_ dimethoate 211 GOICDSC dimethoate DS0644_7 210 GOISCDS_ methamidophos 211 GOICDS_C methamidophos DS0644_7 210 GOISCDS_ terbufos 211 GOICDSC terbufos DS0644 7 210 GOISCDS_ aldicarb 211 GOICDSC aldicarb DS0644_7 210 GOISCDS_ carbofuran 211 GOICDSC carbofuran DS0644_7 210 GOISCDS_ bifenthrin 211 GOICDSC bifenthrin DS0644_7 210 GOISCDS_ cypermethrin 211 GOICDS_C cypermethrin DS0644_7 210 GOISCDS_ alpha-cypermethrin 211 GOICDS_C alpha-cypermethrin DS0644_7 210 GOISCDS_ deltamethrin 211 GOICDSC deltamethrin DS0644_7 210 GOISCDS_ lambda-cyhalothrin 211 GOICDS_C lambda-cyhalothrin DS0644_7 210 GOISCDS_ tefluthrin 211 GOICDSC tefluthrin DS0644_7 210 GOISCDS_ flufenoxuron 211 GOICDS C flufenoxuron DS0644_7 210 GOISCDS_ teflubenzuron 211 GOICDSC teflubenzuron DS0644_7 210 GOISCDS_ spirotetramat; 211 GOICDS C spirotetramat; DS0644_7 210 GOISCDS_ clothianidin 211 GOICDS C clothianidin DS0644_7 210 GOISCDS_ imidacloprid 211 GOICDSC imidacloprid DS0644_7 210 GOISCDS_ thiamethoxam 211 GOICDSC thiamethoxam DS0644_7 210 GOISCDS_ endosulfan 211 GOICDSC endosulfan DS0644_7 210 GOISCDS_ fipronil 211 GOICDS_C fipronil DS0644_7 210 GOISCDS_ abamectin 211 GOICDSC abamectin DS0644_7 210 GOISCDS_ spinosad 211 GOICDSC spinosad DS0644_7 210 GOISCDS_ spinetoram 211 GOICDSC spinetoram WO 2008/129060 204 PCT/EP2008/054924 DS0644_7 210 GOISCDS_ hydramethylnon; 211 GOICDS_C hydramethylnon; DS0644_7 210 GOISCDS_ chlorfenapyr; 211 GOICDS_C chlorfenapyr; DS0644_7 210 GOISCDS_ indoxacarb 211 GOICDSC indoxacarb DS0644_7 210 GOISCDS_ metaflumizone 211 GOICDSC metaflumizone DS0644_7 210 GOISCDS_ flubendiamide 211 GOICDSC flubendiamide DS0644_7 210 GOISCDS_ chlorantraniliprole 211 GOICDS_C chlorantraniliprole DS0644_7 210 GOISCDS_ cyazypyr(HGW86) 211 GOICDS_C cyazypyr(HGW86) DS0644_7 210 GOISCDS_ Azoxystrobin 211 GOICDSC Azoxystrobin DS0644_7 210 GOISCDS_ Dimoxystrobin 211 GOICDS_C Dimoxystrobin DS0644_7 210 GOISCDS_ Kresoxim-methyl 211 GOICDSC Kresoxim-methyl DS0644_7 210 GOISCDS_ Orysastrobin 211 GOICDS_C Orysastrobin DS0644_7 210 GOISCDS_ Pyraclostrobin 211 GOICDS_C Pyraclostrobin DS0644_7 210 GOISCDS_ Trifloxystrobin 211 GOICDS_C Trifloxystrobin DS0644_7 210 GOISCDS_ Bixafen 211 GOICDS C Bixafen DS0644_7 210 GOISCDS_ Boscalid 211 GOICDS C Boscalid DS0644_7 210 GOISCDS_ Isopyrazam 211 GOICDS_C Isopyrazam DS0644_7 210 GOISCDS_ Metalaxyl 211 GOICDS_C Metalaxyl DS0644_7 210 GOISCDS_ Penthiopyrad 211 GOICDS_C Penthiopyrad DS0644_7 210 GOISCDS_ 3-Difluoromethyl-1- 211 GOICDS_C 3-Difluoromethyl-1 methyl-1 H-pyrazole- DS0644_7 methyl-1 H-pyrazole 4-carboxylic a- 4-carboxylic cid(2',4',5'-trifluoro- acid (2',4',5'-trifluoro biphenyl-2-yl)-amide biphenyl-2-yl)-amide 210 GOISCDS_ Dimethomorph 211 GOICDS_C Dimethomorph DS0644_7 210 GOISCDS_ Difenoconazole 211 GOICDSC Difenoconazole DS0644 7 WO 2008/129060 205 PCT/EP2008/054924 210 GOISCDS_ Epoxiconazole 211 GOICOSC Epoxiconazole DS0644_7 210 GOISCDS_ Fluquinconazole 211 GOIODSC Fluquinconazole DS0644_7 210 GOISCDS_ Metconazol 211 GOICOSC Metconazol DS0644_7 210 GOISCDS_ Propiconazole 211 GOICOSC Propiconazole DS0644 7 210 GOISCDS_ Prothioconazole 211 GOICOSC Prothioconazole DS0644_7 210 GOISCDS_ Tebuconazole 211 GOICOSC Tebuconazole DS0644_7 210 GOISCDS_ Triticonazole 211 GOICOSC Triticonazole DS0644_7 210 GOISCDS_ Prochloraz 211 GOICOSC Prochloraz 0S0644_7 210 GOISCDS_ Carbendazim 211 GOICOSC Carbendazim 0S0644_7 210 GOISCDS_ Cyprodinil 211 GOICOS_C Cyprodinil 0S0644_7 210 GOISCDS_ Pyrimethanil 211 GOICOS_C Pyrimethanil 0S0644_7 210 GOISCDS_ Fenpropimorph 211 GOICDSC Fenpropimorph 050644_7 210 GOISCDS_ Tridemorph 211 GOICOSC Tridemorph DS0644_7 210 GOISCDS_ lprodione 211 GOIODSC Iprodione 0S0644_7 210 GOISCDS_ 5-ethyl-6-octyl-[1,2,4] 211 GOICOSC 5-ethyi-6-octyi-[1,2,4] triazolo[1,5-alpyri- 0S06447 triazolo[1,5-ajpyri midine-7-ylamine midine-7-ylamine 210 GOISCDS_ Mancozeb 211 GOICOSC Mancozeb 0S0644_7 210 GOISCDS_ Maneb 211 GOIODSC Maneb I 050644_7 210 GOISCDS_ Metiram 211 GOICOSC Metiram 050644_7 210 GOISCDS_ Dithianon 211 GOIODSC Dithianon 050644_7 210 GOISCDS_ Chlorothalonil 211 GOICOSC Chiorothalonil 050644_7 210 GOISCDS_ ThiophanateMethyl 211 GOICOSC ThiophanateMethyl DS0644_7 210 GOISODS_ Cymoxanil 211 GOICDSC Cymoxanil DS0644 7 WO 2008/129060 206 PCT/EP2008/054924 210 GOISCDS_ Metrafenone 211 GOICDSC Metrafenone DS0644_7 210 GOISCDS_ Acetochlor 211 GOICDSC Acetochlor DS0644_7 210 GOISCDS_ Dimethenamid 211 GOICDSC Dimethenamid DS0644_7 210 GOISCDS_ Metolachlor 211 GOICDSC Metolachlor DS0644 7 210 GOISCDS_ Metazachlor 211 GOICDSC Metazachlor DS0644_7 210 GOISCDS_ Glyphosate 211 GOICDS_C Glyphosate DS0644_7 210 GOISCDS_ Glufosinate 211 GOICDSC Glufosinate DS0644_7 210 GOISCDS_ Sulfosate 211 GOICDSC Sulfosate DS0644_7 210 GOISCDS_ Fenoxaprop 211 GOICDS_C Fenoxaprop DS0644_7 210 GOISCDS_ Paraquat 211 GOICDS_C Paraquat DS0644_7 210 GOISCDS_ Cycloxydim 211 GOICDS_C Cycloxydim DS0644_7 210 GOISCDS_ Profoxydim 211 GOICDS_C Profoxydim DS0644_7 210 GOISCDS_ Sethoxydim 211 GOICDSC Sethoxydim DS0644_7 210 GOISCDS_ Tepraloxydim 211 GOICDSC Tepraloxydim DS0644_7 210 GOISCDS_ Pendimethalin 211 GOICDSC Pendimethalin DS0644_7 210 GOISCDS_ Acifluorfen 211 GOICDS C Acifluorfen DS0644_7 210 GOISCDS_ Imazamethabenz 211 GOICDSC Imazamethabenz DS0644_7 210 GOISCDS_ Imazamox 211 GOICDSC Imazamox DS0644_7 210 GOISCDS_ Imazapic 211 GOICDSC Imazapic DS0644_7 210 GOISCDS_ Imazapyr 211 GOICDS_C Imazapyr DS0644_7 210 GOISCDS_ Imazaquin 211 GOICDS_C Imazaquin DS0644_7 210 GOISCDS_ Imazethapyr 211 GOICDSC Imazethapyr DS0644_7 210 GOISCDS_ 2,4-D 211 GOICDS C 2,4-D WO 2008/129060 207 PCT/EP2008/054924 DS0644_7 210 GOISCDS_ Chloridazon 211 GOICDSC Chloridazon DS0644_7 210 GOISCDS_ Picloram 211 GOICDSC Picloram DS0644_7 210 GOISCDS_ Picolinafen 211 GOICDSC Picolinafen DS0644_7 210 GOISCDS_ Cyclosulfamuron 211 GOICDS_C Cyclosulfamuron DS0644_7 210 GOISCDS_ Triflusulfuron 211 GOICDSC Triflusulfuron DS0644_7 210 GOISCDS_ Atrazine 211 GOICDSC Atrazine DS0644_7 210 GOISCDS_ Pyroxasulfone 211 GOICDS_C Pyroxasulfone DS0644_7 210 GOISCDS_ Bentazone 211 GOICDSC Bentazone DS0644_7 210 GOISCDS_ Cinidon-ethly 211 GOICDS_C Cinidon-ethly DS0644_7 210 GOISCDS_ Cinmethylin 211 GOICDSC Cinmethylin DS0644_7 210 GOISCDS_ Dicamba 211 GOICDSC Dicamba DS0644_7 210 GOISCDS_ Diflufenzopyr 211 GOICDS_C Diflufenzopyr DS0644_7 210 GOISCDS_ Quinclorac 211 GOICDSC Quinclorac DS0644_7 210 GOISCDS_ Quinmerac 211 GOICDS C Quinmerac DS0644_7 210 GOISCDS_ Mesotrione 211 GOICDS C Mesotrione DS0644_7 210 GOISCDS_ Saflufenacil 211 GOICDS C Saflufenacil DS0644_7 210 GOISCDS_ Topramezone; 211 GOICDS_C Topramezone; DS0644 7 213 acephate 213 methamidophos 213 chlorpyrifos 213 terbufos 213 dimethoate 213 aldicarb 213 carbofuran 213 alpha-cypermethrin 213 bifenthrin 213 deltamethrin 213 cypermethrin 213 lambda-cyhalothrin 213 tefluthrin 213 spirotetramat; 213 flufenoxuron 213 clothianidin 213 teflubenzuron 213 imidacloprid WO 2008/129060 208 PCT/EP2008/054924 213 thiamethoxam 213 abamectin 213 endosulfan 213 spinosad 213 fipronil 213 spinetoram 213 hydramethylnon; 213 metaflumizone 213 chlorfenapyr; 213 flubendiamide 213 indoxacarb 213 chlorantraniliprole 213 cyazypyr(HGW86) 213 Kresoxim-methyl 213 Azoxystrobin 213 Orysastrobin 213 Dimoxystrobin 213 Pyraclostrobin 213 Trifloxystrobin 213 Isopyrazam 213 Bixafen 213 Metalaxyl 213 Boscalid 213 Penthiopyrad 213 3-Difluoromethyl-1- 213 Epoxiconazole methyl-1 H-pyrazole 4-carboxylic acid(2',4',5'-trifluoro biphenyl-2-yl)-amide 213 Dimethomorph 213 Fluquinconazole 213 Difenoconazole 213 Metconazol 213 Propiconazole 213 Triticonazole 213 Prothioconazole 213 Prochloraz 213 Tebuconazole 213 Carbendazim 213 Cyprodinil 213 Tridemorph 213 Pyrimethanil 213 lprodione 213 Fenpropimorph 213 5-ethyl-6-octyl-[1,2,4] triazolo[1,5-a]pyri midine-7-ylamine 213 Mancozeb 213 Dithianon 213 Maneb 213 Chlorothalonil 213 Metiram 213 ThiophanateMethyl 213 Cymoxanil 213 Dimethenamid 213 Metrafenone 213 Metolachlor 213 Acetochlor 213 Metazachlor 213 Glyphosate 213 Paraquat 213 Glufosinate 213 Cycloxydim 213 Sulfosate 213 Profoxydim 213 Fenoxaprop 213 Sethoxydim 213 Tepraloxydim 213 Imazamethabenz 213 Pendimethalin 213 Imazamox 213 Acifluorfen 213 Imazapic WO 2008/129060 209 PCT/EP2008/054924 213 Imazapyr 213 2,4-D 213 Imazaquin 213 Chloridazon 213 Imazethapyr 213 Picloram 213 Picolinafen 213 Atrazine 213 Cyclosulfamuron 213 Pyroxasulfone 213 Triflusulfuron 213 Bentazone 213 Cinidon-ethly 213 Diflufenzopyr 213 Cinmethylin 213 Quinclorac 213 Dicamba 213 Quinmerac 213 Mesotrione 213 Topramezone; 213 Saflufenacil

权利要求:
Claims (28)
[1] 1. A method for increasing plant health and/or controlling pests in plants with at least one transgenic modification related to yield increase as compared to a corresponding wild-type plant comprising treating the location where the plant with at least one transgenic modification is growing or is expected to grow and/or the transgenic plant with at least one transgenic modification or propagation material of the plant with at least one transgenic modification with an effective amount of a chemical composition comprising at least one active ingredient.
[2] 2. The method of claim 1 whereby at least one transgenic modification of said plant does not confer resistance to the active ingredient which is employed.
[3] 3. The method of claim 1 whereby the method is a method for increasing plant health.
[4] 4. The method of claim 1 whereby the method is a method for controlling pests.
[5] 5. The method of any one of the preceding claims wherein the active ingredient is selected from the group consisting of insecticides, fungicides or herbicides.
[6] 6. The method of any one of the preceding claims wherein the active ingredient is a pesticide selected from the group consisting of insecticides and fungicides.
[7] 7. The method of any one of the preceding claims wherein the active ingredient is an insecticide selected from the group consisting of acephate, chlorpyrifos, diazinon, dichlorvos, dimethoate, fenitrothion, methamidophos, methidathion, methyl-parathion, monocrotophos, phorate, profenofos, terbufos, aldicarb, carbaryl, carbofuran, carbosulfan, methomyl, thiodicarb, bifenthrin, cyfluthrin, cypermethrin, alpha cypermethrin, zeta-cypermethrin, deltamethrin, esfenvalerate, lambda-cyhalothrin, permethrin, tefluthrin, diflubenzuron, flufenoxuron, lufenuron, teflubenzuron, spirotetramat; clothianidin, dinotefuran, imidacloprid, thiamethoxam, acetamiprid, thiacloprid; endosulfan, fipronil, abamectin, emamectin, spinosad, spinetoram, WO 2008/129060 PCT/EP2008/054924 211 hydramethylnon; chlorfenapyr; fenbutatin oxide, indoxacarb, metaflumizone, flonicamid, flubendiamide, chlorantraniliprole, cyazypyr (HGW86), cyflumetofen.
[8] 8. The method of any one of the preceding claims wherein the active ingredient is a fungicide selected from the group consisting of azoxystrobin, dimoxystrobin, kresoxim-methyl, orysastrobin, pyraclostrobin, trifloxystrobin, bixafen, boscalid, isopyrazam, metalaxyl, penthiopyrad, 3-difluoromethyl-1-methyl-1H-pyrazole-4 carboxylic acid (2',4',5'-trifluorobiphenyl-2-yl)-amide, N-(2-bicyclopropyl-2-yl-phenyl)-3 difluoromethyl-1-methyl-1 H-pyrazole-4-carboxylic acid amide, dimethomorph, fluopicolide, difenoconazole, epoxiconazole, fluquinconazole, flusilazole, flutriafol, metconazol, myclobutanil, propiconazole, prothioconazole, tebuconazole, tetraconazole, triticonazole, prochloraz, carbendazim, fluazinam, cyprodinil, pyrimethanil, fludioxonil, dodemorph, fenpropimorph, tridemorph, fenpropidin, iprodione, vinclozolin, famoxadone, probenazole, captan, folpet, 5-ethyl-6-octyl [1,2,4]triazolo[1,5-a]pyrimidine-7-ylamine, mancozeb, maneb, metiram, thiram, dithianon, fosetyl, fosetyl-aluminium, chlorothalonil, thiophanate methyl, cymoxanil, metrafenone, spiroxamine, bixafen, N-(3',4',5'-trifluorobiphenyl-2-yl)- 3-difluoromethyl 1-methyl-1 H-pyrazole-4-carboxamide, N-[2-(4'-trifluoromethylthio)-biphenyl]-3 difluoromethyl-1 -methyl-I H-pyrazole-4-carboxamide,N-{2-(1,3-dimethylbutyl)-phenyl] 1,3-dimethyl-5-fluoro-1 H-pyrazole-4-carboxamide, N-(2-bicyclopropyl-2-yl-phenyl)-3 difluoromethyl- 1-methyl-1 H-pyrazole-4-carboxamide, N-(cis-2-bicyclopropyl-2-yl phenyl)-3-difluoromethyl-1 -methyl-1 H-pyrazole-4-carboxamide, N-(trans-2 bicyclopropyl-2-yl-phenyl)-3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxamide , N [1,2,3,4-tetrahydro-9-(1 -methylethyl)-1,4-methanonaphthalen-5-yl]-3-(difluoromethyl) 1-methyl-1 H-pyrazole-4-carboxamide.
[9] 9. The method of any one of the preceding claims wherein the active ingredient is a herbicide selected from the group consisting of acetochlor, dimethenamid, metolachlor, metazachlor, glyphosate, glufosinate, sulfosate, clodinafop, fenoxaprop, fluazifop, haloxyfop, paraquat, phenmedipham, clethodim, cycloxydim, profoxydim, sethoxydim, tepraloxydim, pendimethalin, trifluralin, acifluorfen, bromoxynil, imazamethabenz, imazamox, imazapic, imazapyr, imazaquin, imazethapyr, 2,4-D, chloridazon, clopyralid, fluroxypyr, picloram, picolinafen, bensulfuron, chlorimuron ethyl, cyclosulfamuron, iodosulfuron, mesosulfuron, metsulfuron-methyl, nicosulfuron, rimsulfuron, triflusulfuron, atrazine, hexazinone, diuron, florasulam, pyroxasulfone, bentazone, cinidon-ethly, cinmethylin, dicamba, diflufenzopyr, quinclorac, quinmerac, mesotrione, saflufenacil, topramezone. WO 2008/129060 PCT/EP2008/054924 212
[10] 10. The method of any one of the preceding claims, wherein the active ingredient (B) is a strobilurin selected from pyraclostrobin, kresoxim-methyl, dimoxystrobin, 2 (ortho-((2,5-dimethylphenyl-oxymethylene)phenyl)-3-methoxy-acrylic acid methyl ester, picoxystrobin, trifloxystrobin, enestroburin, orysastrobin, metominostrobin, azoxystrobin and fluoxastrobin.
[11] 11. The method of any one of the preceding claims, wherein the active ingredient (B) is selected from thiamethoxam, fipronil and imidacloprid and clothianidin
[12] 12. The method of any one of the preceding claims, wherein the chemical composition comprises at least one active ingredient (B) and a component (A) which is a glucan or a glucan derivative.
[13] 13. The method of any one of the preceding claims wherein at least one transgenic modification is related to yield increase as compared to a corresponding wild-type plant
[14] 14. The method of any one of the preceding claims wherein at least one transgenic modification related to yield increase as compared to a corresponding wild type plant is a transgenic modification conferring one or more increased or generated activities selected from the group consisting of the polypeptides encoded by: a) a nucleic acid molecule encoding the polypeptide as depicted in any of the SEQ ID NO: 1 to 270 or the homologs as depicted in SEQ ID NO: 271 to 273; b) a nucleic acid molecule as depicted in table B, column 1 or 3; c) a nucleic acid molecule, which, as a result of the degeneracy of the genetic code, can be derived from a polypeptide sequence as depicted in table B, column 1 or 3 and/or in SEQ ID NO: 1 to 270; d) a nucleic acid molecule having at least 30 % identity with the nucleic acid molecule sequence of a polynucleotide comprising the nucleic acid molecule according to a) to c); e) a nucleic acid molecule encoding a polypeptide having at least 30 % WO 2008/129060 PCT/EP2008/054924 213 identity with the amino acid sequence of the polypeptide encoded by the nucleic acid molecule of (a) to (c) and having the activity represented by a nucleic acid molecule of (a) to (c); f) nucleic acid molecule whioh hybridizes with a nucleic acid molecule of (a) to (c) under stringent hybridization conditions; g) a nucleic acid molecule encoding a polypeptide which can be isolated with the aid of monoclonal or polyclonal antibodies made against a polypeptide encoded by one of the nucleic acid molecules of (a) to (e) and having the activity represented by the nucleic acid molecule comprising a polynucleotide of (a) to (c); h) a nucleic acid molecule encoding a polypeptide comprising the consensus sequence or one or more polypeptide motifs resulting from 2 ore more of the polypeptides as depicted in table B, column I or 3 and/or in SEQ ID NO: 1 to 270 and/or a consensus sequence as depicted in SEQ ID NO: 274 to 277; i) a nucleic acid molecule encoding a polypeptide having the activity represented by a protein as depicted in table B, column 1 or 3 or 5 and/or SEQ ID NO: 1 to 270; j) nucleic acid molecule which comprises a polynucleotide, which is obtained by amplifying a cDNA library or a genomic library using the primers for the polynucleotides as depicted in table B, column I or 3 and/or SEQ ID NO: 1 to 270 which do not start at their 5'-end with the nucleotides ATA; and k) a nucleic acid molecule which is obtainable by screening a suitable nucleic acid library under stringent hybridization conditions with a probe comprising a complementary sequence of a nucleic acid molecule of (a) or (b) or with a fragment thereof, having at least 15 nt, preferably 20 nt, 30 nt, 50 nt, 100 nt, 200 nt or 500 nt of a nucleic acid molecule complementary to a nucleic acid molecule sequence characterized in (a) to (e) and encoding a polypeptide having the activity represented by a protein comprising a polypeptide as depicted in table B, column 1 or 3 and/or SEQ ID NO: 1 to 270.
[15] 15. The method of any one of the preceding claims wherein at least one RECTIFIED SHEET (RULE 91) ISA/EP WO 2008/129060 PCT/EP2008/054924 214 transgenic modification related to yield increase as compared to a corresponding wild type plant is a transgenic modification conferring one or more increased or generated activities selected from the group consisting of polypeptides as depicted in SEQ ID NO: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 ,12 ,13 ,14 ,15 ,16 ,17 ,18, 19, 20 ,21 ,22, 23 ,24, 25, 26, 27, 28, 29, 30 ,31 ,32, 46, 53, 266.
[16] 16. The method of any one of the preceding claims wherein the propagation material is seed.
[17] 17. The method of any one of the preceding claims wherein the transgenic seed or transgenic plant contains one or more genes which lead to an increase in plant health.
[18] 18. The method of any one of the preceding claims wherein the transgenic seed or transgenic plant contains one or more genes which lead to an increase in stress resistance.
[19] 19. The method of any one of the preceding claims wherein the transgenic seed or transgenic plant contains one or more genes which lead to an increase in pest control.
[20] 20. The method of any one of the preceding claims wherein the transgenic seed or transgenic plant contains one or more genes which lead to an increase in yield.
[21] 21. The method of any one of the preceding claims, wherein the treatment(s) are carried out as foliar application.
[22] 22. The method of any one of the preceding claims, wherein the treatment(s) are carried out in furrow.
[23] 23. The method of any one of the preceding claims, wherein the application rate of the active compound is in the range from 0.0001 to 2000 g/ha.
[24] 24. The method of any one of the preceding claims, wherein the active compound is applied to seed. WO 2008/129060 PCT/EP2008/054924 215
[25] 25. The method of any one of the preceding claims, wherein the transgenic plant is a monocotyledonous plant.
[26] 26. The method of any one of the preceding claims, wherein the transgenic plant is a dicotyledonous plant.
[27] 27. The method of any one of the preceding claims, wherein the plant with the transgenic modification is selected from the group comprising maize, wheat, rye, oat, triticale, rice, barley, soybean, peanut, cotton, oilseed rape, canola/OSR, manihot, pepper, sunflower, flax, borage, sugar cane, safflower, linseed, primrose, rapeseed, turnip rape, tagetes, solanaceous plants, potato, tobacco, eggplant, tomato, lettuce, Vicia species, pea, alfalfa, coffee, cacao, tea, Salix species, oil palm, coconut, perennial grass, snip grass and forage crops.
[28] 28. The method of any one of the preceding claims, wherein the plant with the transgenic modification is selected from the group comprising maize, soybean, cotton, canola/OSR and snip grass.

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同族专利:

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公开号 | 公开日

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WO2008129060A3|2009-02-19|

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CN101668860B|2014-02-12|

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EA200901388A1|2010-04-30|

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ZA200908197B|2011-02-23|

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EP2392662A3|2012-03-14|

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BRPI0810144A2|2014-10-14|

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EA017621B1|2013-01-30|

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EP2392662A2|2011-12-07|

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CA2682294A1|2008-10-30|

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US20100093715A1|2010-04-15|

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WO2008129060A2|2008-10-30|

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CN101668860A|2010-03-10|

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EP2076602A2|2009-07-08|

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KR20100015796A|2010-02-12|

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JP2010524483A|2010-07-22|

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MX2009011456A|2009-11-05|

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CL2008001181A1|2009-10-23|

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AR067311A1|2009-10-07|

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法律状态:
2009-11-19| DA3| Amendments made section 104|Free format text: THE NATURE OF THE AMENDMENT IS: AMEND THE INVENTION TITLE TO READ PLANT PRODUCTIVITY ENHANCEMENT BYCOMBINING CHEMICAL AGENTS WITH TRANSGENIC MODIFICATIONS |

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2013-11-21| MK4| Application lapsed section 142(2)(d) - no continuation fee paid for the application|

优先权:

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申请号 | 申请日 | 专利标题

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US91334907P| true| 2007-04-23|2007-04-23||

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US60/913,349||2007-04-23||

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PCT/EP2008/054924|WO2008129060A2|2007-04-23|2008-04-23|Plant produtivity enhancement by combining chemical agents with transgenic modifications|

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